• In patients older than 40 years, preferred regimens often combine doxorubicin, cisplatin, and ifosfamide without high-dose methotrexate. (medscape.com)
  • In this study, we demonstrated that NSCLC-derived CAFs were innately resistant to cisplatin treatment and CAFs-conditioned medium significantly promoted the survival rate of NSCLC cells after cisplatin treatment. (dovepress.com)
  • 9 , 10 As such, it is urgent to improve the efficacy of chemotherapy to NSCLC and explore the molecular mechanism underlying cisplatin resistance of NSCLC. (dovepress.com)
  • For example, a study using human Burkitt lymphoma cells found that oxidative stress actually interferes with the ability of the chemotherapy drugs doxorubicin, cisplatin, etoposide, and cytarabine to cause cancer cell death. (pinestreetfoundation.org)
  • The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
  • In combination with the chemotherapy agents, TCEE treatment further enhanced the tumor suppression efficiency of cisplatin and doxorubicin. (hindawi.com)
  • Chemotherapy agents such as doxorubicin, cisplatin, and 5-fluorouracil are the primary choices for treating liver cancer cases but the response rate and overall survival remained poor [ 3 , 4 ]. (hindawi.com)
  • Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
  • 55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
  • The aim of this study is to evaluate the prognostic factors of the group who received neoadjuvant chemotherapy with a taxane-anthracycline combination regimen. (kjco.org)
  • We retrospectively analyzed for locally advanced breast cancer patients who received neoadjuvant chemotherapy with adjuvant extension with taxane-anthracycline combination regimen. (kjco.org)
  • 101 patients received neoadjuvant chemotherapy with docetaxel and doxorubicin, 46 patients received with epirubicin and paclitaxel. (kjco.org)
  • The adjuvant chemotherapy regimen was adjusted when the response to neoadjuvant chemotherapy was in disease progression. (kjco.org)
  • In order to predict an oncologic outcome from locally advanced breast cancer patients who are treated with neoadjuvant chemotherapy with taxane-anthracycline based regimen, we can use pathologic complete response, an early response to neoadjuvant chemotherapy. (kjco.org)
  • Neoadjuvant chemotherapy (NC) is a standard therapy for locally advanced breast cancer patients [ 1 ]. (kjco.org)
  • Neoadjuvant chemotherapy (NAC) is one of the standard care regimens for patients with resectable early-stage breast cancer. (biomedcentral.com)
  • Overexpression of these two genes was associated with poor tumor response to anthracycline treatment in a neoadjuvant chemotherapy trial in women with primary breast cancer. (bioseek.eu)
  • In addition, a deeper characterization of immune infiltrates, including the presence of a high number of cytotoxic (CD8 + ) TILs or a high CD8 + /FOXP3 + ratio, is able to define TNBC patients with a better prognosis following neoadjuvant chemotherapy [ 6 ]. (biomedcentral.com)
  • In addition to conventional radiotherapy, chemotherapy, and surgery, there are currently more and more popular neoadjuvant chemotherapy and molecular targeted therapies. (biomedcentral.com)
  • 42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
  • In patients with limited disease, radiotherapy (RT) including new techniques (eg, proton and carbon ion beam RT) should be considered, particularly for unresectable primary tumors. (medscape.com)
  • Complete surgical resection of the tumor and preoperative radiotherapy and chemotherapies can be used for non-metastatic RPS. (biomedcentral.com)
  • This report describes a case of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma that was favorably controlled by debulking surgery followed by combination chemotherapy and radiotherapy. (biomedcentral.com)
  • Approximately 50 Gy of radiotherapy was delivered to the remaining tumor. (biomedcentral.com)
  • Multimodal therapy with debulking surgery, combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. (biomedcentral.com)
  • Maintaining dose intensity of the chemotherapy and radiotherapy might contribute to overall tumor control. (biomedcentral.com)
  • Multimodal therapy incorporating surgery, radiotherapy, and chemotherapy is thus expected to improve survival in patients with RPS. (biomedcentral.com)
  • Preoperative radiotherapy was not administered because a large treatment volume could otherwise lead to late radiation-related damage of critical organs, such as the kidneys, liver and small bowel and because the patient required a therapeutic strategy that would produce more rapid relief of symptoms. (biomedcentral.com)
  • Background: Chemotherapy is the most important treatment method against cancer, in addition to surgery and radiotherapy. (eurekaselect.com)
  • Management modalities for Kaposi sarcoma include nonintervention, surgical removal of skin nodules or severely affected areas (eg, areas of the extremities, intussuscepted bowel), laser surgery, conventional and megavoltage radiotherapy, chemotherapy, immunotherapy, antiviral drugs, and cessation of immunosuppressive therapy in iatrogenically immunosuppressed patients. (medscape.com)
  • Localized nodular disease may respond well to surgical excision, radiotherapy, and intralesional and outpatient low-dose vinblastine chemotherapy. (medscape.com)
  • Radiotherapy and chemotherapy, as the routine treatment, face substantial challenges of resistance. (biomedcentral.com)
  • Combining some of these neoadjuvant approaches with standard-of-care chemotherapy or radiotherapy appears to "sensitize" tumor cells to treatment. (cancerbiomed.org)
  • Metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. (drugs.com)
  • Among these miRNAs, we focused on miRNA-31 (miR-31) because miR-31 was the only miR that has been reported to regulate tumor phenotype, an anti-metastatic effect in breast cancer. (nature.com)
  • Adjuvant chemotherapy for breast cancer after surgery has effectively lowered metastatic recurrence rates. (bioseek.eu)
  • However, a considerable proportion of women suffer recurrent cancer at distant metastatic sites despite adjuvant treatment. (bioseek.eu)
  • Several new treatment options have emerged over the past five years for metastatic melanoma. (nadph-oxidasesignaling.com)
  • 11 ] demonstrated a substantial overall survival (OS) benefit in patients with PD-L1-positive (PD-L1 + ) metastatic or inoperable locally advanced TNBC through the addition of the anti-PD-L1 agent atezolizumab to first-line chemotherapy with nab-paclitaxel. (biomedcentral.com)
  • A Phase Ib/II, open label, multi-center, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations in patients with locally advanced unresectable or metastatic G/GEJ cancer (hereafter referred to as gastric cancer) and esophageal cancer. (ucbraid.org)
  • It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)
  • We review clinical data on the benefit of RASi in primary and metastatic tumors and propose that, by activating immunostimulatory pathways, these inhibitors can enhance immunotherapy of cancer. (nutriforce.cn)
  • Ewing sarcoma (ES) is a rare tumor and is usually treated with specific chemotherapy regimens. (medscape.com)
  • chemotherapy (see regimens below) prior to excision is not typically recommended but could be considered for periosteal lesions. (medscape.com)
  • All chemotherapy regimens require that the recipient be capable of undergoing the treatment. (worldsbest.rehab)
  • Current chemotherapy regimens apply drug treatment in cycles, with the frequency and duration of treatments limited by toxicity. (worldsbest.rehab)
  • By using integrated genomics, we identified a small number of overexpressed and amplified genes from chromosome 8q22 that were associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
  • Using integrated genomics, we identified a small number of over-expressed and amplified genes from chromosome 8q22 significantly associated with early disease recurrence despite anthracycline-based adjuvant chemotherapy. (bioseek.eu)
  • One example is a human study in which researchers discovered that higher levels of the antioxidant selenium in the blood of patients with aggressive B-cell non-Hodgkin's lymphoma correlated with increased achievable doses of anthracycline based chemotherapy, better treatment response, achievement of long term remission, and longer overall survival. (pinestreetfoundation.org)
  • In this study, we confirmed the importance of mesothelin and examined the relationship between mesothelin and the immune landscape of the tumor microenvironment (TME) in two MPM cohorts. (bvsalud.org)
  • Therefore, novel strategies must be developed to enhance T cell persistence and trafficking within the OC tumor microenvironment. (bvsalud.org)
  • Zhao, Y. Chemotherapy and tumor microenvironment of pancreatic cancer. (eurekaselect.com)
  • Cancer-associated fibroblasts (CAFs) have been demonstrated to be essential stromal components in the tumor microenvironment, regulating cancer cell growth, migration, invasion, and chemo-response through various mechanisms. (dovepress.com)
  • 11 Chemoresistance, either acquired or intrinsic, is associated with a complicated and multifactorial process, including decreases of intracellular drugs, changes of drug targets, aberrant regulation of cell survival or death, and crosstalks between tumor microenvironment and cancer cells. (dovepress.com)
  • The microenvironment of a developing tumor is composed of proliferating cancer cells, blood vessels, stromal cells, infiltrating inflammatory cells, and a variety of associated tissue cells. (nutriforce.cn)
  • Accumulating data also suggest that hypoxic stress in the tumor microenvironment promotes tumor escape mechanisms through the emergence of immune-resistant tumor variants and immune suppression. (nutriforce.cn)
  • Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
  • The RAS plays a crucial role in cancer biology and affects tumor growth and dissemination directly and indirectly by remodeling the tumor microenvironment. (nutriforce.cn)
  • [ 6 ] Chemotherapy combinations, such as gemcitabine plus docetaxel and epirubicin plus interferon, have demonstrated possible efficacy. (medscape.com)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (wikipedia.org)
  • CNTs can not only increase drug delivery accuracy and efficiency but also promote drug uptake, decrease drug efflux, improve tumor hypoxia conditions, and induce autophagy and apoptosis in tumor cells, which make the tumor more sensitive to antitumor agents. (eurekaselect.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
  • Quercetin acts as a potent anti-cancer agent by attenuating processes related to tumor growth, including oxidative stress, apoptosis, proliferation, angiogenesis, and metastasis. (imuno-medica.ro)
  • Quercetin increases susceptibility to NK cell-mediated tumor cell lysis" (5) and can chemosensitize tumor cells (6) through cell cycle changes (7) and intervention in several signaling pathways related to apoptosis (8). (imuno-medica.ro)
  • The authors of the above-mentioned study on Burkitt lymphoma cells and chemotherapy suggest that including antioxidants in the treatment protocol may enhance chemotherapy-induced apoptosis and phagocytosis. (pinestreetfoundation.org)
  • 2000) A second study, involving the chemotherapy drugs etoposide and calcimycin, confirms this finding: Human Burkitt's lymphoma cells were unable to die quickly by apoptosis in the presence of oxidative stress and instead died using the slower and messier method of necrosis. (pinestreetfoundation.org)
  • This TCEE also demonstrates antitumor properties such as the induction of cell cycle arrest and activation of apoptosis on human colon, lung, melanoma, osteosarcoma, and pancreatic cancer cells [ 16 - 19 ]. (hindawi.com)
  • Weinberg characterized "aberrant metabolic phenotype" with "autologous proliferation signaling, apoptosis resistance, evasion of proliferation inhibition, continuous angiogenesis, infiltration and migration, unlimited replication capacity, immune escape" in tumor cells. (biomedcentral.com)
  • Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
  • Furthermore, immune checkpoint inhibitor therapy has shown limited efficacy in the treatment of patients with OC, and CAR-T therapy has also demonstrated modest results owing to inadequate T cell infiltration. (bvsalud.org)
  • Enhanced drug delivery efficiency and improved treatment efficacy have been observed through CNT-based drug delivery systems. (eurekaselect.com)
  • However, some reports have shown that the simple administration of CNTs can reverse MDR in cancer and enhance chemotherapy efficacy without anticancer agents attached to the surface of the CNTs. (eurekaselect.com)
  • continued to use CP either alone or in combination with other agents in cancer chemotherapy due to its efficacy. (researchwap.com)
  • doxorubicin, inducing G2/M cell cycle arrest in human colon cancer, (15) and increasing the therapeutic efficacy of doxorubicin. (imuno-medica.ro)
  • docetaxel, improving its anticancer efficacy (20). (imuno-medica.ro)
  • This is a Phase 1/2 study to assess the safety and efficacy of ELI-002 7P immunotherapy (a lipid-conjugated immune-stimulatory oligonucleotide [Amph-CpG-7909] plus a mixture of lipid-conjugated peptide-based antigens [Amph-Peptides 7P]) as adjuvant treatment in subjects with solid tumors with mutated KRAS/NRAS. (ucbraid.org)
  • Deletions in the gene coding for the tumor suppressor PTEN also induce the persistent activation of PKB/cAkt since it is the negative regulator of this enzyme. (justia.com)
  • Actually, the entire metabolic network reprograms under the control of oncogenes and tumor suppressor genes, and the flow of nutrient in metabolic networks is also redefined in the process of tumorigenesis. (biomedcentral.com)
  • Although PP2A has historically been identified as a tumor suppressor, inhibition of PP2A has paradoxically demonstrated potential as a therapeutic target for various cancers. (cancerbiomed.org)
  • For example, inhibitors of MEK, as Selumetinib also used to treat pancreatic cancer, breast cancer and other cancers such as h Dermatological b Sartigen tumors confinement Investigated Lich multiple myeloma. (nartsignaling.com)
  • Pharmacokinetic-guided (PKG) dosing has demonstrated beneficial effects in other tumors, but scarce data is available in pancreatic cancer. (unav.edu)
  • Findings of other lesions indicates a non-bone primary tumor. (medscape.com)
  • and microtubule-disturbing agents paclitaxel and docetaxel. (jcancer.org)
  • The use of the newer agents in the taxane class (paclitaxel and docetaxel) is being explored in veterinary medicine as these agents are highly effective in human medicine. (vin.com)
  • Rates of tumor progression vary according to the particular study, but more than 75% of patients who initially have a complete response remain disease free for more than 5 years. (medscape.com)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. (biomedcentral.com)
  • The crosstalk between stromal cells and malignant cells within this environment crucially determines the fate of tumor progression, its hostility, and heterogeneity. (nutriforce.cn)
  • The inhibition of angiogenesis is emerging as a new, attractive therapeutic approach to control tumour progression [ 1 ]. (biomedcentral.com)
  • Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
  • Furthermore, upon interaction with ovarian tumors, the ability of CR and CAR T cells to release activation markers and functional cytokines increased significantly. (bvsalud.org)
  • Similarly, CR and CAR co-expressing T cells persistently controlled the growth of transplanted ovarian cancer tumors in NSG mice and significantly prolonged the overall survival of tumor-challenged mice. (bvsalud.org)
  • Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
  • Ovarian cancer is one of the most aggressive female reproductive tract tumors. (nature.com)
  • Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. (nature.com)
  • 5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
  • This test filters circulating tumor cells from a patient's blood sample and gives a numerical probability of metastasis for colon, breast, prostate and ovarian adenocarcinomas. (dunphynunley.com)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
  • Therefore, inhibition of angiogenesis is an attractive strategy for treatment of cancer. (biomedcentral.com)
  • Thus, angiogenesis is a necessary and required step for transition from a small harmless cluster of cells to a large tumour and is also required for the spread of a tumour, invasion and/or metastasis. (biomedcentral.com)
  • It is clear, Raf inhibitors may be therapeutically useful selective B, the pre-screening patients may be required for RAS mutations, and perhaps also for which added embroidered treatment. (nartsignaling.com)
  • Furthermore, co-treatment of KFr13Tx cells with MET inhibitors sensitized the tumor cells to PTX both in vitro and in vivo . (nature.com)
  • Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed. (justia.com)
  • BET inhibitors (BETi especially JQ1) gained a lot of interest in last decade due to its promising anticancer efficacy in number of preclinical cancer models including hematologic malig- nancies and solid tumors (Delmore et al. (nadph-oxidasesignaling.com)
  • This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. (biomedcentral.com)
  • Renin-angiotensin system (RAS) inhibitors (RASi) widely prescribed for the treatment of cardiovascular diseases have considerable potential in oncology. (nutriforce.cn)
  • This review focusses on clinical aspects of treatment of breast cancer with monoclonal antibodies, and tyrosine kinase and mammalian target of rapamycin (mTOR) inhibitors. (biomedcentral.com)
  • Targeting these pathways via small molecule inhibitors or monoclonal antibodies has been a focus of more contemporary approaches to cancer treatment. (cancerbiomed.org)
  • Background: The combination of immunobiological agents with immune checkpoint proteins is a promising treatment for malignant pleural mesothelioma (MPM). (bvsalud.org)
  • Soft tissue sarcomas (STS) are malignant tumors that arise from mesoderm-derived tissues, such as fat, muscle, and connective tissue. (biomedcentral.com)
  • [ 2 ] Under the WHO classification system, tumors are further classified as benign, intermediate or malignant. (medscape.com)
  • Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)
  • After curative surgery, adjuvant chemotherapy with the same regimen was performed. (kjco.org)
  • 40 mg/m 2 on day 1 and 30 mg/m 2 on day 8 every 28 days (as part of the VCAP-AMP-VECP multiagent chemotherapy regimen) for 6 cycles (Tsukasaki 2007). (medilib.ir)
  • Two cohorts of patients with gastric cancer have been enrolled in parallel in this study: the second-line (2L) Gastric Cancer Cohort consists of patients with gastric cancer who have progressed after receiving a platinum-containing or fluoropyrimide-containing chemotherapy regimen in the first-line setting, and the first-line (1L) Gastric Cancer Cohort consists of patients with gastric cancer who have not received prior chemotherapy in this setting. (ucbraid.org)
  • Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (wikipedia.org)
  • This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (wikipedia.org)
  • Numerous phytochemicals and their determined analogs have been recognized as possible contender for anticancer treatment and the present review article sheds light on few of these phytocompounds. (researchsquare.com)
  • Additionally, TAMs in the hypoxic niches within the tumor are known to mediate resistance to several anticancer treatments and to promote cancer relapse. (nutriforce.cn)
  • Conclusion: Tumor mesothelin expression associated with the TME immune landscape predicts the risk of death for patients with MPM and could be a new target for immunotherapy in MPM. (bvsalud.org)
  • However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
  • These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. (biomedcentral.com)
  • The phase III IMpassion130 trial comparing chemotherapy plus atezolizumab versus chemotherapy plus placebo brought breast cancer into the immunotherapy era. (biomedcentral.com)
  • The aim of our review is to present recent advances in TNBC treatment and to discuss open issues in order to better define potential future directions for immunotherapy in TNBC. (biomedcentral.com)
  • New and relevant evidence on the implementation of immune checkpoint-based treatments in TNBC has emerged over the last year, with the results of the IMpassion130 trial bringing breast cancer into the immunotherapy era. (biomedcentral.com)
  • Eligible patients will be randomized to chemotherapy or the combination of chemotherapy with checkpoint inhibitor immunotherapy. (ucbraid.org)
  • Identification of the genes crucial for tumor response to specific chemotherapy drugs is a challenge but is necessary to improve outcomes. (bioseek.eu)
  • Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
  • These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • Low tumor mesothelin expression was associated with tumor necrosis and nuclear grade 1, whereas high mesothelin expression was significantly associated with the epithelioid histotype and high density of T cells CD8+, macrophages CD68+, and collagen type I fibers. (bvsalud.org)
  • A high proliferation rate of the tumor cells was also seen on immunohistochemical analysis (Figure 2 ). (biomedcentral.com)
  • Chemotherapy drugs can kill cancerous cells through several mechanisms. (medicalnewstoday.com)
  • Chemotherapy drugs are unable to differentiate between healthy and cancerous cells, which can cause side effects during treatment. (medicalnewstoday.com)
  • Healthy cells typically rebound from the effects of chemotherapy, but cancer cells usually do not. (medicalnewstoday.com)
  • Effective chemotherapy agents need to be delivered efficiently, distributed mostly in the tumor tissue, and highly internalized by tumor cells to eventually inhibit proliferation or promote death of the tumor cells. (eurekaselect.com)
  • Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)
  • Dense compact collagen, elastic tissue and cartilage are some of the Other instances, because of obstruction of the lymphatics by tissues that are sufficiently proof against invasion by tumour cells, the lymph flow is disturbed and tumour cells tumours. (ehd.org)
  • LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). (aacrjournals.org)
  • Quercetin works at the cellular level, interfering with the process that turns healthy cells into tumor cells. (imuno-medica.ro)
  • Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70. (imuno-medica.ro)
  • SiRNA-mediated knockdown of either of two of these genes, the antiapoptotic gene YWHAZ and a lysosomal gene LAPTM4B, sensitized tumor cells to anthracyclines, and overexpression of either of the genes induced anthracycline resistance. (bioseek.eu)
  • Two of these genes, the anti-apoptotic gene YWHAZ , and LAPTM4B , a novel lysosomal gene, sensitized tumor cells to anthracyclines when either was depleted by siRNA knockdown and induced drug resistance when either was over-expressed. (bioseek.eu)
  • In the present study, the TCEE treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. (hindawi.com)
  • In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
  • At present, a European lab offers a blood test which filters and isolates circulating tumor cells (a.k.a. micrometastatic cells) from a patient's blood, genetically fingerprints them, then pharmacogenetically tests the cells for the effectiveness of various medical therapies. (dunphynunley.com)
  • One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
  • Successful TIL therapy starts with the identification, enrichment, stimulation, and expansion of potent tumor-reactive T cells. (biomedcentral.com)
  • In the early 1920s, German biochemist and physiologist Otto Warburg conducted groundbreaking research and proposed the famous "Warburg effect": Tumor cells prefer to use glycolysis for glucose metabolism even in oxygen-rich conditions, rather than more efficient mitochondrial oxidative phosphorylation for ATP production [ 3 ]. (biomedcentral.com)
  • Metabolic reprogramming refers to the redefinition of the flow and flux of nutrient in tumor cells in the metabolic network to meet the needs of tumor cells for energy and anabolism [ 8 ]. (biomedcentral.com)
  • Moreover, cancer cells found within hypoxic regions are presumed to represent the most aggressive and therapy-resistant fractions of the tumor. (nutriforce.cn)
  • Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect. (jcancer.org)
  • In the ImunoMedica Clinic, we administer quercetin in large doses for its chemoprotective, potent vasodilator, vascular protective, anti-inflammatory effect, and especially its direct anti-tumor effect. (imuno-medica.ro)
  • 5 To date, platinum-based chemotherapy is the most effective therapy to treat advanced NSCLC patients, 6 with a significantly higher survival and response rate. (dovepress.com)
  • However, Multidrug Resistance (MDR) in cancer always results in the failure of chemotherapy. (eurekaselect.com)
  • 1. Resistance of tumors to multiple chemotherapeutic agents is often due to the MDR (Multiple Drug Resistance) gene. (examyear.com)
  • Such activity would result in increased cell death of tumor tissue where PKB is elevated, and in decreased resistance to chemotherapy agents. (justia.com)
  • Direct correlation between resistance to chemotherapy and activation of PKB was shown in several prostate cancer cell lines and in human tumorogenic tissues, and elevation of PKB levels in prostate tumor tissues, is clinically associated with HRPC (Yongde et al. (justia.com)
  • Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. (bioseek.eu)
  • Overexpression of these two genes may predict anthracycline resistance and influence selection of chemotherapy. (bioseek.eu)
  • The overwhelming majority of studies find a favorable interaction between antioxidants and chemotherapy, providing evidence that antioxidants can decrease chemotherapy side effects, increase treatment effectiveness, and decrease resistance to chemotherapy. (pinestreetfoundation.org)
  • Limited therapeutic interventions and development of resistance to targeted therapy within few months of therapy pose a great challenge in the treatment of melanoma. (nadph-oxidasesignaling.com)
  • Among many reasons, the treatment resistance is the one of major drawbacks. (biomedcentral.com)
  • Herein, this review updates the mechanisms of metabolic reprogramming involved in tumor chemo- and radio-resistance. (biomedcentral.com)
  • Calcitriol has been studied in various combination treatments and shown synergistic or additive antitumor activities. (jcancer.org)
  • Results: CNTs can increase the antitumor effects of chemotherapy agents. (eurekaselect.com)
  • iii) The hypoxic tumor environment is immunosuppressive and prevents an antitumor response. (nutriforce.cn)
  • 5-Fluorouracil (5-FU) dosage was adjusted throughout neoadjuvant treatment according to pharmacokinetic parameters and Irinotecan (CPT-11) pharmacokinetic variables were retrospectively estimated. (unav.edu)
  • Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
  • Most OC cases are typically diagnosed at advanced stages, which has led to a 5-year overall survival rate of less than 35% following conventional treatment. (bvsalud.org)
  • Combination of BRAFi and MEKi is currently in clinical practice and show exceptional tumor response rate and extend patient survival leading to a new era of melanoma therapy (Cebollero et al. (nadph-oxidasesignaling.com)
  • Conclusions: Pharmacokinetically-guided dose adjustment of standard chemotherapy treatments might improve survival outcomes in patients with pancreatic ductal adenocarcinoma. (unav.edu)
  • The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (wikipedia.org)
  • According to the stage of cancer and the degree of the complication, current treatment methods rely on the success of chemotherapy either alone or combined with surgical resection or radiation therapy. (frontiersin.org)
  • Surgical resection for the purpose of tumor debulking was then performed. (biomedcentral.com)
  • Chemotherapy-induced alopecia (CIA) is a common side effect of conventional chemotherapy and represents a major problem in clinical oncology. (mdpi.com)
  • Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)
  • The study is designed with the flexibility to open new treatment arms as new treatments become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, modify the participant population, or introduce additional cohorts of participants with other types of advanced primary liver cancer. (ucbraid.org)
  • Participants who experience loss of clinical benefit or unacceptable toxicity during Stage 1 may be eligible to receive treatment with a different treatment combination (Stage 2). (ucbraid.org)
  • One third of the patients had at least 1 dose reduction of docetaxel due to toxicity. (unav.edu)
  • Conclusion: We report for the first time a relation between docetaxel exposure and toxicity and recommend specific targets of drug exposure with implications for the clinical management of early breast cancer patients. (unav.edu)
  • In this article, we turn our focus to lymphoma, conducting a systematic search for published research that would support or discourage the use of antioxidants in combination with chemotherapy. (pinestreetfoundation.org)
  • Table 1 summarises the results from phase II trials utilizing bevacizumab in combination with chemotherapy, many of which are still preliminary. (biomedcentral.com)
  • Endoscopic surgery, which is the initial treatment of papillary cancers, is not effective for CIS because the disease is often so diffuse and difficult to visualize that surgical removal is not feasible. (medscape.com)
  • The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)
  • Extravasation of doxorubicin can result in severe local tissue injury and necrosis requiring wide excision of the affected area and skin grafting. (medilib.ir)
  • Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
  • In 1949, nitrogen mustard (mechlorethamine) became the first chemotherapeutic agent approved by the U.S. Food & Drug Administration, which was rapidly followed by a wave of chemotherapy development 1 . (cancerbiomed.org)
  • Plants are natural reservoirs of novel compounds and provide a promising therapeutic approach for treatment of cancer. (researchsquare.com)
  • ARV-SNEP could be potentially novel therapeutic approach for the treatment of drug-resistant melanoma. (nadph-oxidasesignaling.com)
  • or alternative therapeutic approaches for the treatment of melanoma. (nadph-oxidasesignaling.com)
  • Given the lack of effective treatments in this subtype of breast cancer, several efforts have been conducted in recent years to increase the therapeutic opportunities for TNBC patients. (biomedcentral.com)
  • The treatment of recurrent osteosarcoma is primarily surgical in the case of isolated lung metastases, although stereotactic RT, radiofrequency ablation, or cryotherapy might be alternative options in patients unfit for surgery. (medscape.com)
  • A failure to respond to BCG vaccine may be defined as persistent or recurrent tumor when a BCG vaccine reaction is evident. (medscape.com)
  • Most advanced and recurrent cases therefore will receive systemic chemotherapies as the alternative approach. (hindawi.com)
  • Preclinical success has led to a profusion of clinical trials on LB100 adjuvant therapies, including a phase I trial in extensive-stage small-cell lung cancer, a phase I/II trial in myelodysplastic syndrome, a phase II trial in recurrent glioblastoma, and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid tumors. (cancerbiomed.org)
  • Using RNA expression profiling, we identified the membrane protein leucine-rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. (aacrjournals.org)
  • Most people receive chemotherapy drugs through an injection or infusion. (medicalnewstoday.com)
  • Performance status is often used as a measure to determine whether a person can receive chemotherapy, or whether dose reduction is required. (worldsbest.rehab)
  • Mor, G. Targeted cancer therapy--are the days of systemic chemotherapy numbered? (eurekaselect.com)
  • Understanding the mechanism underlying the role of tumor stroma, especially cancer-associated fibroblasts (CAFs), during chemoresistance would significantly contribute to the clinical application of chemotherapy agents. (dovepress.com)
  • The development of alternative or adjuvant treatments to improve the clinical outcome of the conventional therapy for liver cancer is therefore in urgent need. (hindawi.com)
  • In clinical practice, a key challenge for generating TIL products is the accessibility, quantity, and quality of tumor tissue in the era of neo-adjuvant therapy. (biomedcentral.com)
  • We describe existing clinical trials of antiangiogenic agents and the challenges facing the clinical development and optimal use of these agents for the treatment of breast cancer. (biomedcentral.com)
  • The risk of cardiomyopathy is proportional to the cumulative exposure with incidences from 1% to 20% for cumulative doses from 300 mg/m 2 to 500 mg/m 2 when doxorubicin is administered every 3 weeks. (medilib.ir)
  • Low doses of systemic corticosteroids may be prescribed for short periods if the symptoms are severe (see Treatment). (medscape.com)
  • Docetaxel area under the curve (AUC) and maximum concentration (Cmax) in each cycle and total cumulative AUC (AUCcum) were calculated and related to the incidence of adverse effects and tumour recurrence. (unav.edu)
  • 4.5 mg*h/L was associated with tumour recurrence. (unav.edu)
  • Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
  • National Comprehensive Cancer Network (NCCN) guidelines recommend that a one-half or one-third dose may be considered for BCG induction and should be used for BCG maintenance, if supply allows. (medscape.com)
  • Current trials employ 3-6 cycles of initial combination chemotherapy after biopsy, followed by local therapy, and another 6-10 cycles of chemotherapy, usually given at 2- to 3-week intervals. (medscape.com)
  • Doctors administer chemotherapy in cycles of treatment and recovery. (medicalnewstoday.com)
  • Results: Docetaxel clearance showed no change over the 4 treatment cycles, but a gradual increase in the volume of distribution was observed. (unav.edu)
  • Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
  • Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (wikipedia.org)
  • This type of chemotherapy is used for curative intent. (wikipedia.org)
  • 55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
  • Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. (wikipedia.org)
  • Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
  • 55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
  • Maintenance BCG should be prioritized for patients with high-risk non-muscle-invasive bladder cancer, including CIS, in the early maintenance period (eg, 3- and 6-months post-induction). (medscape.com)
  • Naturally occurring compounds from plants known as phytochemicals, fill in as indispensable assets for novel medications and are likewise rich sources for cancer treatment. (researchsquare.com)
  • Generally, tumor size and axillary lymph node metastasis status are the most important prognostic factors for breast cancer patients. (kjco.org)
  • This article discusses some of the most common chemotherapy medications for use during cancer treatment. (medicalnewstoday.com)
  • There are several main types of chemotherapy drugs that doctors use to target different types of cancer. (medicalnewstoday.com)
  • These were some of the earliest cancer treatments, and they are still common today. (medicalnewstoday.com)
  • Most cancer types have standard protocols that a doctor can follow when beginning treatment. (medicalnewstoday.com)
  • The following sections look at some common chemotherapy medications for each common type of cancer. (medicalnewstoday.com)
  • Doctors only use chemotherapy for prostate cancer if it spreads outside of the prostate and if hormone therapy is unsuccessful. (medicalnewstoday.com)
  • Objective: Through an extensive review of previous reports in regard to CNTs and chemotherapy, this paper aims to identify the various mechanisms of CNTs that inhibit MDR in cancer and enhance chemotherapy sensitivity. (eurekaselect.com)
  • Chemoresistance is a significant barrier to the treatment and management of non-small cell lung cancer (NSCLC). (dovepress.com)
  • The efficiency of chemotherapy depends on the type of cancer and the stage. (worldsbest.rehab)
  • Breast cancer (BC) is the most frequent oncologic cause of death among women and the improvement of its treatments is compelling. (mdpi.com)
  • Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type-specific protein markers. (aacrjournals.org)
  • Quercetin in cancer treatment, alone or in combination with conventional terapeutics. (imuno-medica.ro)
  • It has long been known that oxidative stress is an essential mechanism by which chemotherapy works to treat cancer. (pinestreetfoundation.org)
  • These results together suggested that TCEE is a potential ingredient for developing an integrated chemotherapy for human liver cancer. (hindawi.com)
  • Moreover, treatment with TCEE is found to enhance the cytotoxic effects of amphotericin B in human colon cancer cell both in vitro and in vivo [ 17 ]. (hindawi.com)
  • The results not only help the practitioner and patient choose an effective combination of therapies, but also helps them understand which cancer genes (oncogenes) are blocked by which treatments. (dunphynunley.com)
  • It is the same for the treatment and regulation of cancer. (dunphynunley.com)
  • These magneto-responsive devices can be used for a multitude of biomedical applications, from diagnostic to the treatment of tumors, and are actively being developed and tested for cancer theranostics. (researchgate.net)
  • Eralp Y, Aydıner A,Kizir A,Kaytan E,Oral EN,Topuz E, "Resectable thymoma: treatment outcome and prognostic factors in the late adolescent and adult age group," Cancer Investigation 21(5),737-43 (2003). (yesimeralp.com)
  • This is the very first paper investigating a PROTAC class of molecule for the treatment of drug resistant cancer, preformulation and formulation studies. (nadph-oxidasesignaling.com)
  • The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. (biomedcentral.com)
  • Additionally, a cohort of patients with esophageal cancer who have not received prior systemic treatment for their disease will be enrolled in this study. (ucbraid.org)
  • These treatment options can cure early and part of the intermediate tumors in certain degrees, but are not ideal for most of cancer in middle and late stages [ 2 ]. (biomedcentral.com)
  • The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor prognosis, even though this statement should be interpreted with care, as the effects of macrophages primarily depend on their localization within the tumor. (nutriforce.cn)
  • Indications for single-agent therapy, preferred second-line therapy, subsequent therapy, relapsed or refractory therapy, pediatric and adult treatment, and limitations of use are all addressed within each section of specific cancer. (ibx.com)
  • Aims: We aimed to study the relation between pharmacokinetics (PK) and pharmacodynamics (PD) of docetaxel in early breast cancer and recommend a target exposure. (unav.edu)
  • Sensitivity of the tumor to chemotherapy are predictable and NC treats micrometastasis earlier. (kjco.org)
  • If a doctor treats a systemic infection without first doing a culture and sensitivity test to determine which bacteria is involved and which antibiotics the bacteria is sensitive to, then he might prescribe the wrong treatment and thereby strengthen the infection. (dunphynunley.com)
  • There are many types of chemotherapy drugs, including alkylating agents and antimetabolites. (medicalnewstoday.com)
  • Treatment of patients with extraskeletal ES follows the same principles as treatment for bone ES and incorporates chemotherapy in all cases, as well as postoperative RT in most cases. (medscape.com)
  • Low-grade intramedullary and surface osteosarcoma and periosteal sarcomas with pathological findings of high-grade disease - The NCCN recommends postoperative chemotherapy. (medscape.com)
  • On the other hand, the decreased levels of antioxidants (or oxidative stress) that are caused by many chemotherapy treatments correlates with increased side effects. (pinestreetfoundation.org)
  • According to the data provided, it appears that dasatinib can sensitize KRAS mutant tumors, cetuximab. (nartsignaling.com)