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Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticPaired Box Transcription FactorsPAX2 Transcription FactorSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceHomeodomain ProteinsTranscriptional ActivationBinding SitesTrans-ActivatorsRepressor ProteinsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerNuclear ProteinsProtein BindingGene Expression Regulation, DevelopmentalTranscription Factor AP-1PAX7 Transcription FactorForkhead Transcription FactorsCell LineSignal TransductionAmino Acid SequenceDNAMutationBasic-Leucine Zipper Transcription FactorsCell DifferentiationTranscription Factor AP-2PAX9 Transcription FactorCell NucleusTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationHeLa CellsYY1 Transcription FactorCells, CulturedSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDReverse Transcriptase Polymerase Chain ReactionActivating Transcription Factor 3NFATC Transcription FactorsTranscription Initiation SiteElectrophoretic Mobility Shift AssaySp3 Transcription FactorEnhancer Elements, GeneticNF-kappa BZinc FingersActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingCloning, MolecularE2F1 Transcription FactorRNA Polymerase IIRecombinant Fusion ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPlasmidsMEF2 Transcription FactorsGene ExpressionGATA3 Transcription FactorMicrophthalmia-Associated Transcription FactorTCF Transcription FactorsGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalGATA Transcription FactorsProtein Structure, TertiaryLuciferasesB-Cell-Specific Activator ProteinSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorEye ProteinsChromatinPhosphorylationHelix-Loop-Helix MotifsTranscription Factor RelAOligonucleotide Array Sequence AnalysisE2F Transcription FactorsModels, BiologicalSequence Homology, Amino AcidSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMice, KnockoutGene Expression Regulation, PlantTranscription Factor 7-Like 1 ProteinMice, TransgenicGATA6 Transcription FactorActivating Transcription Factor 4Activating Transcription Factor 1Blotting, WesternCyclic AMP Response Element-Binding ProteinProto-Oncogene ProteinsIn Situ Hybridization

RenalPathwaysGeneGenesProteinEpidermalAntigenMolecularMechanismsRolesPotentiallyFamilyGrowthMembersFunction

Renal2

• Lim1, an embryonal transcription factor, is absent in multicystic renal dysplasia, but reactivated in nephroblastomas. (medscape.com)
• The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)

Pathways2

• Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S. Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. (medscape.com)
• The objective of this work was the evaluation of muscle transcriptome profile in piglets of both genetic types, in order to identify genes, pathways and regulatory factors responsible for their phenotypic differences. (biomedcentral.com)

Gene6

• Transcription factors are essential for the regulation of gene expression and are, as a consequence, found in all living organisms. (wikipedia.org)
• The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
• Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikipedia.org)
• Depending on the transcription factor, the transcription of the adjacent gene is either up- or down-regulated. (wikipedia.org)
• Transcription factors use a variety of mechanisms for the regulation of gene expression. (wikipedia.org)
• They bind to the DNA and help initiate a program of increased or decreased gene transcription. (wikipedia.org)

Genes9

• TFs work alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes. (wikipedia.org)
• Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikipedia.org)
• Furthermore, genes are often flanked by several binding sites for distinct transcription factors, and efficient expression of each of these genes requires the cooperative action of several different transcription factors (see, for example, hepatocyte nuclear factors). (wikipedia.org)
• Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. (wikipedia.org)
• Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. (wikipedia.org)
• During nephrogenesis, multiple genes, transcription factors, and growth factors control the essential interaction between the ureteric bud and the metanephric mesenchyme. (medscape.com)
• Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. (bvsalud.org)
• Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
• The location specific Wnt signatures are dominated by genes which have been lowly expressed in the tissue of origin, and are the targets of transcription factors that are activated following enhanced Wnt signalling. (biomedcentral.com)

Protein2

• In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. (wikipedia.org)
• these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)

Epidermal4

• It is also frequently called HER2 (from human epidermal growth factor receptor 2 ) or HER2/neu . (iiab.me)
• HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. (iiab.me)
• HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. (iiab.me)
• The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)

Antigen1

• HIF-1α could bind to the promoter region of proliferating cell nuclear antigen ( PCNA ) and PROM1 (CD133) to mediate their transcription and expression. (bjbms.org)

Molecular1

• In characterizing the molecular differentiation of developing peripheral auditory structures, we discovered that hepatocyte growth factor ( Hgf ) is expressed in the future stria vascularis of the cochlear epithelium. (jneurosci.org)

Mechanisms1

• Transcription factors and regulatory mechanisms are proposed for these altered biological functions. (biomedcentral.com)

Roles2

• Below are some of the important functions and biological roles transcription factors are involved in: In eukaryotes, an important class of transcription factors called general transcription factors (GTFs) are necessary for transcription to occur. (wikipedia.org)
• SIGNIFICANCE STATEMENT We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. (jneurosci.org)

Potentially1

• Regulatory factors (RF) potentially involved in the expression differences were identified by calculating the regulatory impact factors . (biomedcentral.com)

Family1

• A family history of pancreatic cancer is an essential risk factor [ 20 ], and germline BRCA2 mutations comprise the highest proportion of known reasons for inherited pancreatic cancer [ 21 ]. (biomedcentral.com)

Growth1

• CD326 mediates calcium-independent, homophilic, cell-cell adhesion and may function as a growth factor receptor. (thermofisher.com)

Members1

• Transcription factors are members of the proteome as well as regulome. (wikipedia.org)

Function1

• There are approximately 2800 proteins in the human genome that contain DNA-binding domains, and 1600 of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)