Exposure of iron foundry workers to polycyclic aromatic hydrocarbons: benzo(a)pyrene-albumin adducts and 1-hydroxypyrene as biomarkers for exposure. (bmj.com)
Exposure to polycyclic aromatic hydrocarbons (PAHs) in foundry workers has been evaluated by determination of benzo(a)pyrene-serum albumin adducts and urinary 1-hydroxypyrene. (bmj.com)
Benzo(a)pyrene binding to albumin and 1-hydroxypyrene were quantitatively measured by enzyme linked immunosorbent assay (ELISA) and reverse phase high performance liquid chromatography (HPLC), respectively. (bmj.com)
Median benzo(a)pyrene-albumin adduct concentrations (10-90% percentiles) were similar in foundry workers (smokers 0.55 (0.27-1.00) and non-smokers 0.58 (0.17-1.15)) pmol/mg albumin and age matched controls (smokers 0.57 (0.16-1.45) and non-smokers 0.70 (0.19-1.55) pmol/mg albumin). (bmj.com)
There was no correlation between the concentrations of 1-hydroxypyrene and benzo(a)pyrene-albumin adducts. (bmj.com)
Smoking did not affect the concentrations of 1-hydroxypyrene or benzo(a)pyrene-albumin adducts. (bmj.com)
In this study, the human bronchial epithelial cells (16HBE) were treated five times with 1 ?M benzo(a)pyrene (BaP), followed by 2 passages culture, and thein vitroBaP-induced malignant transformation of 16HBE cells was established. (eurekamag.com)
This report presents key data and expert opinions on the toxicity and intake of Benzo a pyrene (BaP). (eugris.info)
Epidermal hyperplasia after topical application of benzo(a)pyrene, ben" by E Bresnick, T F. Donald et al. (jax.org)
Epidermal hyperplasia after topical application of benzo(a)pyrene, benzo(a)pyrene diol epoxides, and other metabolites. (jax.org)
In a preclinical study published in the journal Frontiers in Pharmacology , researchers from the USA investigated the potential chemopreventive effects of a mushroom - Ganoderma lucidum (GL)-derived commercial product named GLSF in vitro and in mice with lung carcinogenesis induced by two tobacco smokecarcinogens, namely benzo[a]pyrene (B[a]P) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). (news-medical.net)
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. (biomedcentral.com)
Benzo(a)pyrene, a potent carcinogen, is commonly used as an environmental indicator for PAHs. (cdc.gov)
Coal tar pitch and creosote, which are complex mixtures of liquid and solid aromatic hydrocarbons produced in coke ovens, contain significant amounts of benzo(a)pyrene and other PAHs. (cdc.gov)
Benzo(a)pyrene, a potent carcinogen, is generally used as an environmental indicator for PAHs. (cdc.gov)
Proposition 65 WARNING: This product can expose you to chemicals such as Benzo[a]pyrene and Chrysene, which are known to the State of California to cause cancer and birth defects or other reproductive harm. (mandmsalesinc.com)
Benzo(a)pyrene metabolites: effects on viral interferon induction. (cdc.gov)
Inhibition of benzo(a)pyrene and benzo(a)pyrene-trans-7,8-diol metabolism and DNA binding in mouse lung explants by ellagic acid. (cdc.gov)
The concentrations of benzo(a)pyrene, anthracene and fluoranthene representing the concentration of polyaromatic hydrocarbons (PAH), achieve the threshold value in ten out of the assessed 15 open sea and in 73 of 95 coastal assessment units (Figure 1). (helcom.fi)
In general a larger proportion of evaluations in the sediment monitoring matrix (evaluations of fluoranthene (circa 17% of assessment units) and anthracene (circa 42%)) exhibited concentrations above the threshold value (i.e. failed to achieve Good Environmental Status, sub-GES) as compared to evaluations carried out in biota (fluoranthene and benzo(a)pyrene, both circa 3% of the evaluated assessment units). (helcom.fi)
The summary map provides a One-Out-All-Out (OOAO) overview of benzo(a)pyrene in biota, fluoranthene in biota, fluoranthene in sediment, and anthracene in sediment. (helcom.fi)
Indeno(1,2,3-c,d)pyrene and chrysene have been shown to cause carcinogenic effects in experiments on animals (IARC class 2b), and benzo(a)pyrene to cause cancer in humans (IARC class 1). (helcom.fi)
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Dose-response relations between total PAH, pyrene, carcinogenic PAHs, and 1-hydroxypyrene for smokers, and polycyclic aromatic hydrocarbons adsorbed to dust for non-smokers are suggested. (bmj.com)
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