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LipogenesisDown-RegulationDown SyndromeLipidsLiverSterol Regulatory Element Binding Protein 1Fatty Acid SynthasesFatty AcidsAdipose TissueRNA, MessengerInsulinLipid MetabolismAcetyl-CoA CarboxylaseLipolysisGene Expression RegulationCells, CulturedCell LineGlucoseFatty Acid Synthase, Type ICell Line, TumorTriglyceridesGene Expression Regulation, NeoplasticStarvationStearoyl-CoA DesaturaseFatty LiverSignal TransductionSebaceous GlandsReverse Transcriptase Polymerase Chain ReactionPhorbol EstersCitric AcidGene Expression ProfilingReceptor, InsulinAdipocytesPhorbol 12,13-DibutyrateRNA InterferenceAntigens, CD46KineticsRNA, Small InterferingTranscription FactorsDose-Response Relationship, DrugDietary CarbohydratesOrphan Nuclear ReceptorsAcetatesCell ProliferationTranscription, GeneticBlotting, WesternGene ExpressionCell DifferentiationDietary FatsApoptosisTime FactorsRats, Inbred StrainsATP Citrate (pro-S)-LyaseMolecular Sequence DataPhosphorylationLactationLiver GlycogenGlucosephosphate DehydrogenasePregnancyMice, Inbred C57BLMalate DehydrogenasePhorbolsPromoter Regions, GeneticOligonucleotide Array Sequence AnalysisProtein Kinase CTumor Cells, CulturedReceptors, Cell SurfaceFructoseBase SequenceTransfectionSebumDNA-Binding ProteinsAdipose Tissue, BrownTetradecanoylphorbol AcetateFoodObesityHepatocytesKetone BodiesMammary Glands, AnimalFatty Acids, NonesterifiedHydrocarbons, FluorinatedEnzyme ActivationMeasles virusRats, WistarCell DivisionAdipose Tissue, WhiteProto-Oncogene Proteins c-aktCarrier ProteinsRats, Sprague-DawleySterol Regulatory Element Binding Protein 2Disease Models, AnimalPyruvatesMembrane ProteinsMutationLipoproteins, VLDLFlow CytometryAcetoacetatesInsulin ResistanceGluconeogenesisBody Weight
Novo LipogenesisSynthesisInhibition of lipogenesisOxidationLeptinLiverGlycolysisFatty acidLipolysisMiceAccumulationMetabolicHepatic lipidGlucose uptakeStimulatesLipidsMetabolismTranscriptionalHepatocytesInhibitorStimulationMechanismsPromotesTriglycerideGlucocorticoidStarvationThyroidGene expressionHormoneDeficiencyAffectCalciumCarrierCell
Novo Lipogenesis10
  • Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. (princeton.edu)
  • We examined the hypothesis that muscle insulin resistance in healthy aging promotes increased hepatic de novo lipogenesis (DNL) and hyperlipidemia by altering the distribution pattern of postprandial energy storage. (diabetesjournals.org)
  • In young, normal weight, healthy individuals, muscle insulin resistance has been proposed to be an important predisposing factor for atherogenic dyslipidemia and NAFLD by changing the pattern of energy storage from ingested carbohydrate away from skeletal muscle glycogen synthesis into hepatic de novo lipogenesis (DNL), resulting in an increase in plasma triglyceride (TG) concentrations and increased hepatic TG synthesis ( 3 ). (diabetesjournals.org)
  • In Drosophila, all growth occurs during the larval stage when larvae constantly feed, and as a result their body mass increases approximately 200-fold within 4 d, largely due to de novo lipogenesis. (sdbonline.org)
  • 2008). Elevated peripheral free fatty acids (FFA) and de novo lipogenesis predominantly contribute to the accumulation of lipids in the liver at NAFLD. (webmedcentral.com)
  • Abstract title:Regulation of de novo lipogenesis through the control of nuclear SREBP-1c protein stability. (csh-asia.org)
  • The body is capable of synthesizing fatty acids (FAs) endogenously via de novo lipogenesis in the liver. (endocrine-abstracts.org)
  • effects of GH/STAT5B on hepatic de novo lipogenesis (NIH R01) and the development of NAFLD and NASH. (uic.edu)
  • This adaption involves changes in the expression of genes involved in glycolysis, de-novo lipogenesis, fatty acid elongation, desaturation and oxidation. (oregonstate.edu)
  • De novo lipogenesis (DNL) is a fatty acid synthesis process that requires several genes, including sterol regulatory element binding protein (SREBP), ATP-citrate lyase (ACLY), and acetyl-CoA carboxylase (ACC). (gov.scot)
Synthesis8
  • Lipogenesis encompasses both fatty acid and triglyceride synthesis, with the latter being the process by which fatty acids are esterified to glycerol before being packaged into very-low-density lipoprotein (VLDL). (wikipedia.org)
  • Insulin is an anabolic hormone that promotes glucose uptake, glycogenesis, lipogenesis, and protein synthesis of skeletal muscle and fat tissue through the tyrosine kinase receptor pathway. (medscape.com)
  • We therefore assessed B12 regulation of de novo fatty acid synthesis and the profile of various FAs in hepatocytes. (endocrine-abstracts.org)
  • The main difference between lipogenesis and lipolysis is that lipogenesis is the fat synthesis, whereas lipolysis is the fat breakdown. (pediaa.com)
  • Lipogenesis is responsible for the fatty acid synthesis and the subsequent triglyceride synthesis in liver and adipose tissue . (pediaa.com)
  • Lipogenesis refers to a process of fatty acid and triglyceride synthesis from glucose or other substrates. (pediaa.com)
  • Lipogenesis is the synthesis of fatty acids. (pediaa.com)
  • Similarly, PPARδ-mediated attenuation of FA synthesis was partially due to AMPK activation, as GW1516 reduced lipogenesis in WT hepatocytes but not AMPKβ1−/−hepatocytes. (edu.au)
Inhibition of lipogenesis2
Oxidation3
  • Through the promotion of fatty acid oxidation and lipogenesis inhibition, leptin was found to control the release of stored glucose from adipose tissues. (wikipedia.org)
  • Moreover, caffeine treatment was associated with upregulation of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) and autophagy associated genes (ATG12 and Beclin-1). (biomedcentral.com)
  • We induced hepatoteatosis in zebrafish by overfeeding regimen and demonstrated caffeine have a role in suppression of hepatosteatosis by downregulation of genes associated with lipogenesis, ER stress, inflammatory response and enhancement of lipid oxidation, indicating zebrafish model may be used to identify putative pharmacological targets and to test novel drugs for human NAFLD treatment. (biomedcentral.com)
Leptin2
Liver5
Glycolysis1
Fatty acid3
  • 2007). Suppression of the genes, which are involved in lipogenesis (ATP-citrate lyase (ACL), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA-desaturase 1 or sterol regulatory element-binding protein 1(SREBP-1)), reduced proliferation and survival of hepatic carcinoma cells (Calvisi et al. (webmedcentral.com)
  • N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. (oregonstate.edu)
  • This review brings together metabolic and molecular studies that help explain n-3 (omega-3) polyunsaturated fatty acid regulation of hepatic gene transcription. (oregonstate.edu)
Lipolysis13
Mice1
  • Our studies in mice have shown that this upregulation results in mTOR activation, lipogenesis and development of NASH and dyslipidemia. (yale.edu)
Accumulation3
  • Elevated lipogenesis and subsequent lipid accumulation were demonstrated in several animal models of obesity and insulin-independent diabetes mellitus (Levadovwski et al. (webmedcentral.com)
  • DNL up-regulation is able to induce fat accumulation through an increase in fatty acids. (gov.scot)
  • To investigate the relationship between DNL up-regulation and the accumulation of fatty acids and lipid droplets in response to 2,2⿲,4,4⿲ tetrabrominated diphenyl ether (BDE-47), we examined DNL in the copepod Tigriopus japonicus. (gov.scot)
Metabolic3
  • In biochemistry, lipogenesis is the conversion of fatty acids and glycerol into fats, or a metabolic process through which acetyl-CoA is converted to triglyceride for storage in fat. (wikipedia.org)
  • These results thus reveal a novel role of mTORC1-SRPK2 signaling in post-transcriptional regulation of lipid metabolism and demonstrate that SRPK2 is a potential therapeutic target for mTORC1-driven metabolic disorders. (princeton.edu)
  • Lipogenesis is a metabolic process stimulated by a high-carbohydrate diet. (pediaa.com)
Hepatic lipid1
  • Regulation of hepatic lipid and glucose metabolism in mouse models. (uic.edu)
Glucose uptake1
Stimulates1
Lipids1
  • Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. (nature.com)
Metabolism2
Transcriptional1
  • The depletion of ORP2 led to dysregulated transcriptional regulation of lipogenesis in both of the studied cell types. (helsinki.fi)
Hepatocytes1
  • However, relationship between circulating and intracellular B12 levels as well as regulation of hepatic uptake of B12 is unexplored.Objective: To assess the regulation of cellular uptake and storage of B12 in hepatocytes in. (endocrine-abstracts.org)
Inhibitor1
  • Lipid droplet area significantly increased in Nile red staining analysis after 24h of exposure to 2.5μg/L BDE-47 in T. japonicus, while DNL was down-regulated in response to 500μM salicylate (a lipogenesis inhibitor), indicating that BDE-47 exposure is closely associated with an increase in fatty acids in this copepod. (gov.scot)
Stimulation1
Mechanisms2
  • The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. (frontiersin.org)
  • Drosophila has been a powerful system for deciphering the conserved mechanisms that regulate hormone signaling, sugar and lipid homeostasis, and the molecular mechanisms underlying the nutritional regulation of development. (sdbonline.org)
Promotes1
Triglyceride1
  • At the same time, carbohydrate-rich diets stimulate lipogenesis leading to postprandial triglyceride levels in the plasma. (pediaa.com)
Glucocorticoid2
Starvation1
  • Molecular regulation of the autophagic process in normal and starvation conditions is presented. (hindawi.com)
Thyroid2
Gene expression3
  • 2017 ) Right time, right place: the temporal regulation of developmental gene expression. (academictree.org)
  • Recent data show that these extrinsic environmental factors synergize with intrinsic age-related changes to influence epigenetic regulation of gene expression, ultimately contributing to the visible-and invisible-signs of skin aging (Chevalier 2019). (ernolaszlo.com)
  • Subsequent sections focus on the epigenetic regulation of gene expression and its relevance to skin aging. (ernolaszlo.com)
Hormone1
  • Prostaglandins are hormone-like compounds produced in body tissue that help control blood pressure, smooth muscle activity, inflammation, glandular secretion, calcium movement, hormone regulation, and cell growth control. (bodybuilding.com)
Deficiency1
  • Background: Vitamin B12 (B12) deficiency results in disturbance of 1-carbon metabolites [methylmalonyl coenzyme A (MMA), homocysteine and S-adenosyl homocysteine (SAH), S-adenosyl methionine (SAM) and methionine] that collectively affect lipogenesis leading to risk of cardiovascular diseases. (endocrine-abstracts.org)
Affect1
Calcium1
Carrier1
  • 2019 ) Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier. (academictree.org)
Cell2
  • 2010). Blocking of lipogenesis with siRNA or FAS-specific inhibitors cerulenin and C75 attenuates the cell senescence. (webmedcentral.com)
  • Furthermore, it mediates the formation of macromolecules in cells which are used in cell structure, energy stores, and regulation of many cell functions. (weeksmd.com)