Doses study self concept. Medical search. Frequent questions

They are designed to determine dose level and toxicity. (nanowerk.com)
If one of these drug-naive participants were to experience a highly morbid or even fatal dose-limiting toxicity (DLT) at this first-in-human escalation dose, this practice might well appear incoherent in retrospect. (biorxiv.org)
Under any realistic conception of the heterogeneity of toxicity, participants who have already tolerated lower doses of the study drug must be presumed less likely than a drug-naive participant to experience a severe DLT. (biorxiv.org)
Very well-documented study which allows derivation of a NOAEL value for chronic toxicity. (europa.eu)
Most reliable study for NOAEL deriviation for repeated dose toxicity effects of sodium metabisulfite. (europa.eu)
Using our new decision framework, altered DPF doses were proposed for piperacillin (better PTA with loading dose plus continuous infusion), but not for amikacin (studied and target population were not comparable and risk for toxicity with higher dose). (eur.nl)
During early development, potentially useful compounds are studied in animals to evaluate desired effects and toxicity. (msdmanuals.com)
Different amounts of the compound are given to a small number (often 20 to 80) of healthy, young volunteers to determine the dose at which toxicity first appears. (msdmanuals.com)

The applied rigorous thermodynamical considerations show the proper terminology and dose concept of hyperthermia, which is based on the energy‑absorption (such as in the case of ionizing radiation) instead of the temperature‑based ideas. (spandidos-publications.com)
On the whole, according to the present study, the appropriate dose in oncological hyperthermia must use an energy‑based concept, as it is well‑known in all the ionizing radiation therapies. (spandidos-publications.com)

This open-label study of the pharmacokinetics of psilocybin was performed to describe the pharmacokinetics and safety profile of psilocybin in sequential, escalating oral doses of 0.3, 0.45, and 0.6 mg/kg in 12 healthy adults. (researchgate.net)
The pharmacokinetics of psilocin were linear within the twofold range of doses, and the elimination half-life of psilocin was 3 h (standard deviation 1.1). (researchgate.net)
One of the first studies was designed to test the safety profile, pharmacokinetics and pharmacodynamics of single oral doses of riociguat (0.25-5 mg). 58 healthy male subjects were given riociguat orally (oral solution or immediate-release tablet) in a randomised, placebo-controlled trial. (wikipedia.org)
A proof-of-concept study, reported by the University of Gießen Lung Center, was the first small study (in 4 PAH patients) to investigate safety, tolerability, pharmacokinetics and efficacy parameters. (wikipedia.org)
Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. (eur.nl)

In fact, it was nearly 20 years ago when several forward thinking scientists began testing lower doses of chemotherapy given more frequently than full dose regimens. (drstegall.com)
Concentration-time profiles were simulated for various dosing regimens for a virtual PICU patient dataset, including the current DPF dose and doses proposed in the studied publications. (eur.nl)
Probability of target attainment (PTA) was compared between the different dosing regimens. (eur.nl)
90% only for continuous infusion regimens of 400 mg/kg/day vs. 9.7% for the current DPF dose (80 mg/kg/6 h, 30 min infusion). (eur.nl)

As a natural course of progression, more and more sophistication was incorporated into the toxicology studies of chemical mixtures. (cdc.gov)

single-center dose-escalation study of dronabinol. (frontiersin.org)
Therefore, by design, dose-escalation of dronabinol was permitted only if the lower dose was not associated with adverse events. (frontiersin.org)
Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
Though initial studies showed a benefit to dose escalation, phase III studies examining dose escalation using standard fractionation or hyperfractionation have failed to show a benefit. (frontiersin.org)
More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
Indeed, a new coherence criterion emerges naturally when the near-universal practice of cohort-wise dose escalation is examined from a clinical perspective. (biorxiv.org)
A new coherence criterion thereby emerges, requiring that an escalation dose be tried preferentially in participants who have already tolerated a lower dose, rather than in new enrollees who are drug-naive. (biorxiv.org)
Results Under the PC criterion, the 3+3 dose-escalation design necessarily transmutes into a dose titration design. (biorxiv.org)
Two simple rules suffice to enable abandonment of low starting doses, and termination of escalation. (biorxiv.org)
Bartroff and Leung Lai 2011 ), the particular notion introduced by ( Cheung 2005 ) is by no means the only possible such criterion in dose-escalation trials, nor even the most pertinent. (biorxiv.org)
In any of the standard dose-escalation designs, when a dose escalation occurs it is common practice to enroll new, drug-naive participants at the escalated dose. (biorxiv.org)
Escalation doses should be tried preferentially in participants who have already tolerated lower doses of the study drug, as opposed to newly-enrolled, drug-naive participants. (biorxiv.org)

With recent resurgence of SARS-CoV-2 cases, the role of booster doses of the vaccine needs to be highlighted. (nih.gov)

Earlier studies utilized conventional toxicology protocol and methods, and they were mainly descriptive in nature. (cdc.gov)
The Committee also discussed procedures for assessing the effects of antimicrobial drug residues in food on the human intestinal microflora, including in vitro methods, such as determination of minimum inhibitory concentrations and continuous and semi-continuous culture systems, and in vivo methods, such as studies on conventional laboratory animals, human microflora associated with germ-free rodents, and volunteers. (who.int)
The problem with the application of conventional hyperthermia in oncology is firmly connected to the dose definition, which conventionally uses the concept of the homogeneous (isothermal) temperature of the target. (spandidos-publications.com)
A clear clarification of the proper dose concept must begin with the description of the limitations of the present doses in conventional hyperthermia applications. (spandidos-publications.com)
Compared with conventional FBP, IR of head CT is associated with significant improvement of objective and subjective IQ and may allow dose reductions in the range of 20% without compromising standard image quality. (ajnr.org)
By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
We're going to talk about the origins of this form of therapy, why I use it and how it compares to full dose conventional chemotherapy. (drstegall.com)
in effect, turning the conventional concept of a linear dose-response on its head. (microwavenews.com)

Initiated a Phase 1 first-in-human randomized, double-blind, placebo-controlled clinical study of EQ102 administered subcutaneously in single ascending dose (SAD) and multiple ascending dose (MAD) cohorts in up to 64 healthy volunteers. (businesswire.com)
The project will conduct a multicentre, randomized, placebo-controlled, double-blinded Phase II clinical study to provide proof of concept and clinical validation for a new, percutaneous, cost-efficient therapy for refractory angina patients. (europa.eu)

As a result, there is a growing concern regarding the associated radiation dose. (ajnr.org)
If you want actual radiation dose numbers from the facility where the CT scan was performed, you can request a dose estimate from the facility's radiologist or medical physicist. (hps.org)

Conclusions The small amount of psilocin renally excreted suggests that no dose reduction is needed for subjects with mild-moderate renal impairment. (researchgate.net)
Conclusions Dose individualization can be accomplished within a trial conducted along 'algorithmic' lines resembling those of the inveterate 3+3 design. (biorxiv.org)
Conclusions: We show the feasibility to develop model-informed dosing guidelines for clinical implementation using existing pharmacokinetic data. (eur.nl)

Although doses of 0.6 mg/kg are in excess of likely therapeutic doses, no serious physical or psychological events occurred during or within 30 days of any dose. (researchgate.net)
This change in understanding the pathogenesis of idiopathic pulmonary fibrosis was translated into the therapeutic options studied in the last two decades, especially with the development of two novel antifibrotic therapies, pirfenidone and nintedanib, that have been developed and approved in the last 8 years, providing treatment options for many patients with idiopathic pulmonary fibrosis. (medscape.com)
The alliance spans all activities from target discovery through to completion of proof-of-concept clinical trials for novel therapeutic antibodies. (beursonline.nl)
This study aimed to evaluate the informed consent process, therapeutic misconception and motivation for participation among Egyptians participating in clinical trials. (who.int)

In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
A value below 0% means that receiving that dose of a vaccine was less effective at preventing serious outcomes than if the dose was not given. (ed.ac.uk)
Our study focused on STEM learning opportunities and outcomes. (kqed.org)
The higher dose group was significantly more likely to earn each of these outcomes than the lower dose group. (kqed.org)
To determine definitively whether long-term aspirin use improves prostate cancer outcomes, future research should evaluate aspirin exposures longer than those studied to date," said Murtola and VeitonmÃ¤ki. (cancernetwork.com)

An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
The 3+3/PC trial also yields an interval-censored 'dose-survival curve' having a semantics that should prove familiar to oncology trialists. (biorxiv.org)
The dose-survival curve arising from this '3+3/PC' design has semantics that should prove familiar and conceptually accessible to oncology trialists, and also seems capable of supporting more formal statistical treatments of the design. (biorxiv.org)

The ReGenHeart project is based on extensive preclinical work and a phase I safety, feasibility and dose-finding clinical study recently completed by the consortium. (europa.eu)

Experimental methods under discussion include dosimetry and time motion studies, to determine when an operator accumulates the most noise dose. (cdc.gov)
Ongoing efforts to improve the accuracy of dosimetry calculations are discussed, as well as studies examining the relationship between absorbed dose and response. (snmjournals.org)
The term "dose" does not have a precise meaning in radionuclide dosimetry. (snmjournals.org)

What matters is that you get the appropriate dose. (kqed.org)
Second, it may not be any one educational intervention, but an appropriate dose of different educational experiences that matter. (kqed.org)
In clinical practice, the WHO-enforced six-step method has proven to be a valuable tool to systematically choose the best pharmacotherapy available and the most appropriate dose for each individual patient. (springer.com)

This threshold, in addition to early versus late dose reductions, are poorly defined for third-generation anthracycline/taxane-based chemotherapy. (jnccn.org)
Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)
In today's episode, I'm going to talk about the importance of low dose or fractionated chemotherapy in a method I use called insulin potentiation and therapy or IPT. (drstegall.com)
Today's show is going to be foundational to this podcast and reveal the basics behind my personalized approach to low dose chemotherapy. (drstegall.com)
We also refer to this as full dose chemotherapy. (drstegall.com)

Simulation of fixed doses using the pharmacokinetic parameters suggest that an oral dose of 25 mg should approximate the drug exposure of a 0.3 mg/kg oral dose of psilocybin. (researchgate.net)
Another common question is whether getting a higher virus dose upon infection-for example, through prolonged exposure to an infected person, like health care workers' experience-will result in more severe disease. (medicalxpress.com)
For the rest of us, regardless of the viral load of patients or the SARS-CoV-2 infectious dose, it is best to reduce exposure to any amount of virus, since it is clear the virus is transmitted efficiently from person to person. (medicalxpress.com)
The Heart study by Akyea et al has known limitations inherent to cohort studies, such as the possibility of bias due to unmeasured confounders, although the authors accounted for several potential confounders in the analyses (eg, year of statin initiation, frequency of LDL-c measurements, change of statin potency within the exposure period and deprivation status). (bmj.com)
Calls for a new IARC evaluation have been mounting for some years following the release of two large animal studies showing elevated tumor counts after lifelong exposure to RF radiation. (microwavenews.com)

The aim of this in vitro study was to evaluate the fluoride concentration in mouthrinses and their capacity to intervene with the caries process. (bvsalud.org)
This is the principal study used to evaluate biliary-type pain and detect gallbladder disease and biliary dilatation. (medscape.com)

In the past decade, various dose-reduction strategies, such as automated tube current modulation, low voltage scanning, and noise-reduction filters, have been explored but could not prevent a steady increase of average effective dose with advanced scanner technology. (ajnr.org)
Many of your answers state that the effective dose of an abdominal CT scan is 10 mSv. (hps.org)
According to Wall and Hart (1997), abdominal or pelvic CT results in an effective dose of about 10 mSv and can vary from 3 to 14 mSv. (hps.org)

Initiated EQUATOR, a pivotal Phase 3 randomized, double-blind clinical study of up to 200 patients to assess the efficacy and safety of itolizumab versus placebo as a first-line therapy for acute graft-versus-host disease (aGVHD) in combination with corticosteroids. (businesswire.com)
A 12-month, phase 2 trial, completed by Richeldi and colleagues, assessed the efficacy and safety of four different oral doses of the tyrosine kinase inhibitor nintedanib (formerly BIBF 1120) compared with placebo in patients with idiopathic pulmonary fibrosis. (medscape.com)

Part of the problem is that "oral methotrexate absorption from the gut reduces as the doses go up," Dhir noted, because the transport mechanism gets saturated. (medscape.com)
Dronabinol treatment is safe and well-tolerated in OSA patients at doses of 2.5-10 mg daily and significantly reduces AHI in the short-term. (frontiersin.org)
Proactive treatment with high-dose intravenous (IV) iron reduces the risk for classic atherothrombotic myocardial infarction - a type 1 MI - in dialysis patients, an analysis of data from the PIVOTAL trial shows. (medscape.com)

Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
A simulation study is performed, evaluating the long-run performance of this new design, relative to optimal 1-size-fits-all dosing. (biorxiv.org)
Simulated 3+3/PC trials yield DTAs over a median of 6 dose levels, achieving 50% improved population-level efficacy compared to optimal 1-size-fits-all dosing. (biorxiv.org)
In the presence of sufficient heterogeneity in individualized optimal dosing, a 3+3/PC trial outperforms any conceivable 1-size-fits-all dose-finding design. (biorxiv.org)
An additional goal is to determine an optimal dose-response range. (msdmanuals.com)

We found that rates of type 1 MI were 2.5 times higher than type 2 MIs, while non-STEMIs were 6.6 times more common than STEMIs, but that patients randomized to the high-dose iron group had a substantial reduction in fatal and nonfatal MI, compared with those in the low-dose group," Mark said. (medscape.com)
IR has recently demonstrated its capacity to reduce noise and permit dose reduction in abdominal and thoracic CT applications. (ajnr.org)
CTDI, 42.3) dose reduction. (ajnr.org)
Linear regression analysis of CNR against tube current suggests that standard CNR may be obtained until approximately 20.4% dose reduction when IR is used. (ajnr.org)
4 - 9 Unfortunately, the most straightforward technique in lowering dose, notably the reduction of tube current, is associated with unacceptable increase of image noise. (ajnr.org)
In patients with COPD receiving multi-inhaler triple therapy, higher ICS doses were not associated with a further reduction in exacerbations, whereas we found an increased risk of pneumonia. (dovepress.com)

Methods Eligible healthy adults received 6-8 h of preparatory counseling in anticipation of the first dose of psilocybin. (researchgate.net)
Until such methods are developed and validated, absorbed dose remains an important variable-but still one of several- likely to predict response in an individual patient. (snmjournals.org)

About three quarters (76.6%) of patients in the split-dose group experienced an improvement of at least 20% in ACR response criteria (ACR20), compared with 52% in the single-dose group. (medscape.com)
About one third of the split-dose group (35%) added an additional DMARD at 16 weeks, compared with 54.5% of the single-dose group ( P = .005). (medscape.com)
While there were no major adverse events, the split-dose group had higher rates of transaminitis (elevated liver enzymes) during the study, and low white blood cell count was higher in the single-dose group at 24 weeks. (medscape.com)

The concepts, basic definitions, and different approaches to the clinical implementation of absorbed dose estimation are reviewed in this article. (snmjournals.org)

Where does the uncertainty on viral loads and infectious dose leave us? (medicalxpress.com)

In this study, we matched people who received a vaccine dose with people who didn't that were in same age group lived in the same area, and had a similar likelihood to receive that dose. (ed.ac.uk)
While the RVE of SARS-CoV-2 mRNA booster vaccine dose in preventing infection against the Omicron variant is low, it is substantial in preventing hospitalization and high in preventing the most severe/critical disease. (nih.gov)

Using a retrospective cohort study design emulating a target trial, we determined the relative vaccine effectiveness (RVE) of a homologous booster dose of a SARS-CoV-2 messenger RNA (mRNA) vaccine compared with the primary vaccine series alone in preventing infection, hospitalization, and intensive care unit admission, and death in the Department of Veterans Affairs healthcare system in the United States. (nih.gov)
Among infection-free survivors who received 2 doses of a mRNA vaccine before 30 April 2021, we identified those who received a booster between 22 September and 25 December 2021 and matched them 1:1 with individuals who did not receive a booster. (nih.gov)
The infectious dose is the amount of virus needed to establish an infection. (medicalxpress.com)
COVID-19 is clearly very contagious, but this may be because few particles are needed for infection (the infectious dose is low), or because infected people release a lot of virus in their environment. (medicalxpress.com)
Collectively, these data show that oral administration of 4'-ethynyl-2-fluoro-2'-deoxyadenosine protects BLT mice from HIV infection following multiple high-dose vaginal HIV challenges (P = 0.0002) (Figure 2h). (natap.org)

From these datasets, we selected people who were aged 18 or older on 8 December 2020 and followed them until the end of the study period on 30 June 2021. (ed.ac.uk)
Among 2 384 272 previously uninfected persons with 2 doses of an mRNA vaccine by 30 April 2021, we identified 462 950 booster recipients between 22 September and 25 December 2021, who were matched 1:1 with non-booster recipients. (nih.gov)

Co-Editor-in-Chief Dr Millie Long interviews Dr Christopher Ma of the Cumming School of Medicine at the University of Calgary (Canada) on the most recent population-based multicenter cohort study on postendoscopy care for patients with food bolus impactions (8:41). (gi.org)
Initiated a multicenter, Phase 2 open-label, proof-of-concept clinical study of EQ101 in adult subjects with at least 35% scalp hair loss due to alopecia areata. (businesswire.com)

There is pharmacokinetic data dating back 20 years that suggest split-dose MTX could be more efficacious. (medscape.com)
Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these doses, using piperacillin and amikacin in critically ill children as proof of concept. (eur.nl)

In the past, observational studies have suggested that high doses of IV iron could have negative effects on dialysis patients, and there was no good evidence to support the practice, said Lucia Del Vecchio, MD, from Alessandro Manzoni Hospital in Lecco, Italy. (medscape.com)
This approach could complement literature and consensus-based dosing guidelines for off-label drugs in the absence of stronger evidence to support pediatricians in daily practice. (eur.nl)
This science has given rise to the practice of "precision medicine," which combines pharmacology (the study of medication) and genomics (the study of genes and their functions) to help prescribers make more personalized medication choices. (fhea.com)
In practice, this term has been used to describe administered activity as well as absorbed dose. (snmjournals.org)

Normally, researchers like us determine the characteristics of a virus from a combination of highly controlled experimental studies in animal models and epidemiological observations from patients. (medicalxpress.com)
Power-frequency magnetic fields can promote brain tumors, according to the largest epidemiological study of its kind ever undertaken. (microwavenews.com)
Deltour argued that the trends are mostly not "compatible" with those seen in the epidemiological studies -principally, Interphone and Lennart Hardell's- that were the basis of IARC's 2011 designation of RF radiation as a possible, or 2B, human carcinogen. (microwavenews.com)

The study indicates the possibility of using heated yoga as a viable treatment option for depression, as 44% of the participants who took up the sessions indicated signs of remission. (medicaldaily.com)
Using a new technique developed at Caltech, the team was able to detect and image nanoparticles inside cells biopsied from the tumors of several study participants. (nanowerk.com)
Remarkably, this holds true even when the dosing interval has elapsed for some earlier-enrolled participants who have already tolerated a lower dose of the drug and are ready to receive their next dose. (biorxiv.org)
ABSTRACT Few studies have explored the informed consent process among research participants in developing countries. (who.int)
In a cross-sectional qualitative pilot study 103 participants in 10 clinical trials responded to a questionnaire. (who.int)
RÉSUMÉ Les études ayant examiné le processus du consentement éclairé chez les participants à des études de recherche dans les pays en développement sont peu nombreuses. (who.int)

From a sample of 1,467 academically advanced students, we formed two groups: those with a relatively higher educational dose and those with a relatively lower educational dose. (kqed.org)
Alternatively, it might be that the high-dose iron group required lower doses of an ESA than the low-dose iron group, which might also have been beneficial, he added. (medscape.com)
ESAs have been associated with an increased risk for cardiovascular events in patients with chronic kidney disease, so it is "plausible" that lower doses of ESA are associated with a lower risk for MI, he said. (medscape.com)
Compared with FBP, IR resulted in lower image noise ( P ≤ .02), higher CNR ( P ≤ .03), and improved subjective image quality ( P ≤ .002) at all dose levels. (ajnr.org)
Moreover, the results fit well with the ample evidence from prospective cohort studies and Mendelian randomisation studies favouring 'the lower the LDL-c, the better' concept, even in primary prevention. (bmj.com)
Lerchl found higher rates of cancer among mice exposed to SARs of 0.04 W/Kg, 0.4 W/Kg and 2 W/Kg -and in some cases, the lower the dose, the more cancer. (microwavenews.com)

COVID-19 Cases from the First Local Outbreak of the SARS-CoV-2 B.1.1.7 Variant in China May Present More Serious Clinical Features: A Prospective, Comparative Cohort Study. (cdc.gov)

Complicating the picture further, other studies found that some asymptomatic patients had similar viral loads to patients with COVID-19 symptoms. (medicalxpress.com)

In this review, we describe the concept of genotoxicity and its laboratory measurements, summarise hydroxyurea-associated data from both preclinical and clinical studies, and discuss carcinogenic potential. (cdc.gov)
Both compounds were tested in various preclinical studies on different animal models and appeared to improve systemic arterial oxygenation. (wikipedia.org)
If these studies are successful, the alliance will select antibody programs for preclinical and clinical development. (beursonline.nl)
We examined comprehensive plasma amino acid panel measurements in healthy immunodeficient/immunocompetent mice as well as in preclinical mouse models of acute myeloid leukemia (AML) and pancreatic ductal adenocarcinoma (PDAC) using long-acting crisantaspase, and in an AML clinical study (NCT02283190) using short-acting crisantaspase. (bvsalud.org)

Two basic virological concepts have gotten a lot of attention recently-the "infectious dose" and the "viral load" of SARS-CoV-2. (medicalxpress.com)
Multiple studies have reported that patients have the highest viral load of the coronavirus at the time they are diagnosed. (medicalxpress.com)
The maximal virologic decline (approximately 1.5 log decrease in viral load) was seen with weekly doses of 3.9 to 18.2 mg/kg once weekly, and was correlated with intracellular-triphosphate concentrations of MK-8591 of ≥ 0.53 pmol/10 million cells. (natap.org)

CDC emphasizes sound iron nutrition for infants and young children, screening for anemia among women of childbearing age, and the importance of low-dose iron supplementation for pregnant women. (cdc.gov)

A total of 253 patients were randomly assigned to a single 25-mg dose or a split-dose of MTX once weekly (10 mg in the morning and 15 mg in the evening on the same day). (medscape.com)
A total of 432 patients were randomly assigned to receive one of four doses of nintedanib (50 mg once a day, 50 mg twice a day, 100 mg twice a day, or 150 mg twice a day) or placebo. (medscape.com)

The purpose of our study was to assess the potential benefit of IR in head CT by comparing objective and subjective image quality with standard FBP at various dose levels. (ajnr.org)
It includes studies to determine the margin of safety or the reactions accompanying administration at various dose levels. (bvsalud.org)

Because large clinical trials have shown that statins do not provide either primary or secondary prevention of cardiovascular events, "it is worth considering that what we are showing here is that high-dose IV iron is one of the few therapies that might actually reduce MI in patients on maintenance dialysis," Mark said. (medscape.com)

Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
Moreover, the team provided the first demonstration that this new type of therapy can make its way to human tumors in a dose-dependent fashion, meaning a higher number of nanoparticles sent into the body results in a higher number of nanoparticles found in the tumor cells. (nanowerk.com)
In addition, Davis and his colleagues were able to show that the higher the nanoparticle dose administered to the patient, the higher the number of nanoparticles found in tumor cells-the first example of dose-dependent response using targeted nanoparticles. (nanowerk.com)
As has been recognized in radiotherapy and is beginning to be appreciated in radionuclide therapy, the rate at which the absorbed dose is delivered, the manner by which it is delivered (β-particles, α-particles, or Auger electrons), the radiobiologic characteristics of the tumor or normal organ, and the treatment history of the patient all affect response to a specific total absorbed dose ( 2 ). (snmjournals.org)

Variation in psilocin clearance was not predicted by body weight, and no serious adverse events occurred in the subjects studied. (researchgate.net)

Among 169 people starting PD urgently, 111 had fewer than four exchanges per day (intermittent) and 58 received full-dose PD. (homedialysis.org)
Cancers such as breast, prostate and colorectal do not respond nearly as consistently to full dose. (drstegall.com)

To our knowledge, all COVID-19 vaccine waning studies in the UK thus far have analysed data from a single nation (England, Northern Ireland, Scotland or Wales). (ed.ac.uk)
This study is the first of its kind to do a pooled analysis using data from all 4 nations of the UK. (ed.ac.uk)
We used health data from across the UK to carry out this study. (ed.ac.uk)
For their prespecified secondary analysis of PIVOTAL data, Mark and his colleagues compared proactive high-dose IV iron with reactive low-dose IV iron in 2141 hemodialysis patients. (medscape.com)
Pooled data from seven studies identified "a statistically significant reduced risk of all-cause mortality in patients undergoing urgent-start PD as compared to urgent-start HD. (homedialysis.org)
A new proof-of-concept study enrolled 13 training centers and analyzed data from 80 patients and 249 treatment sessions. (homedialysis.org)
In data from 10 studies of 12,595 people, risk factors for EPS included younger age for starting PD, higher transport rates, longer PD duration, longer peritonitis duration, and history of glomerulonephritis. (homedialysis.org)
2. Macaque pharmacokinetic and virologic data support weekly oral dosing of MK-8591. (natap.org)
We plan to announce data from both studies in the second half of this year. (businesswire.com)
Based on the initiation of EQUATOR, our pivotal study of itolizumab in first-line acute graft-versus-host disease, and positive interim data from the EQUALISE study of itolizumab in patients with lupus nephritis, we secured a strategic partnership with Ono Pharmaceutical under which they purchased an exclusive option to acquire our rights for the development and commercialization of itolizumab. (businesswire.com)
The deal "supports PRA's commitment to provide deep, data-driven insights to optimize global clinical studies and drug commercialization from concept to compound to cure," PRA said. (wraltechwire.com)
Symphony Health will also provide us with rich data insights that will allow us to customize our clinical studies to be as unique as the patients who they are designed around. (wraltechwire.com)
We expect to complete patient enrollment in this European study by the end of the year and to provide safety and target-engagement data from the full 10-patient, low-dose cohort in the U.S. trial in the second quarter of this year. (biospace.com)
However, variability in animal study data represents a barrier to an objective evaluation of NAM accuracy. (nih.gov)
While the data only come from a phase 1 study, Alnylam thinks they are strong enough to move straight into a phase 3 trial. (foxbusiness.com)

Each different type of pre-college educational opportunity was summed to determine the dose level. (kqed.org)

Patients had active disease, defined as at least four tender joints and at least two swollen joints, and were not taking any DMARDs except for hydroxychloroquine and/or low-dose prednisolone . (medscape.com)
However, in the year 2010, the Prednisolone, Azathioprine, and N-Acetylcysteine: A Study That Evaluates Response (PANTHER) was published and found that patients taking this triple-combination therapy were at increased risk of death and hospitalization compared with patients receiving placebo alone. (medscape.com)

Long- and well-established cancer treatment experience in radiotherapy has provided ample evidence that absorbed dose may be used to predict biologic response ( 1 ). (snmjournals.org)

The escalating oral psilocybin doses were administered at approximately monthly intervals in a controlled setting and subjects were monitored for 24 h. (researchgate.net)
Abstract #O_13 evaluated the virologic activity of MK-8591 in macaques given once weekly oral doses ranging from 1.3 to 18.2 mg/kg, or a once daily oral dose of 0.19 mg/kg. (natap.org)
This study provides proof of concept for a once weekly oral dosing strategy of MK-8591. (natap.org)

Two studies in The Lancet reported people who develop more severe pneumonia tend to have, on average, higher viral loads when they are first admitted to the hospital. (medicalxpress.com)
These studies also reported that the viral loads remain higher for more days in patients with more severe disease. (medicalxpress.com)
LEXINGTON, Mass. and AMSTERDAM, Feb. 07, 2022 (GLOBE NEWSWIRE) -- uniQure (NASDAQ: QURE), a leading gene therapy company advancing transformative therapies for patients with severe medical needs, today announced the dosing of the first two patients in its European open-label Phase Ib/II clinical trial of AMT-130, a potential one-time gene-therapy approach for the treatment of Huntington's disease. (biospace.com)

But in the 7.5-year analysis, the reductions in mortality were greatest among those with long-term use (at least 1,096 days), with an HR of 0.79 (95% CI, 0.67-0.93), and among those with the highest cumulative dose (at least 1,096 tablets), with an HR of 0.77 (95% CI, 0.65-0.91). (cancernetwork.com)

Rather, its genotoxic effects are limited to indirect clastogenicity occurring in select cell types, and only when high dose and time thresholds are exceeded. (cdc.gov)

In the 5-year analysis, there was no association between duration of use or cumulative dose and added benefit. (cancernetwork.com)

Results: Three studies for piperacillin (critically ill children) and one for amikacin (critically ill pediatric burn patients) were included. (eur.nl)

First, this study suggests a higher educational dose may be beneficial for real-world achievements. (kqed.org)
The study suggests the possibility of using trans-vaccenic acid found in red meat and dairy products as a nutritional supplement to complement treatments for cancer. (medicaldaily.com)
However, recent science.de) confirmed resistance to rifampin and ad- studies have reported the emergence of bedaquiline ditional resistance to isoniazid, whereas there was no resistance, which suggests that BPaL(M) may be un- resistance to fluoroquinolones. (cdc.gov)

However, high-dose iron does not protect against type 2 MIs, which are caused by an acute imbalance in myocardial oxygen supply and demand without accompanying atherothrombosis, the same analysis shows. (medscape.com)
The 1093 patients randomized to the high-dose group received a monthly maximum of 400 mg iron sucrose. (medscape.com)
The investigators are still trying to understand why high-dose iron is protective against at least type 1 MI. (medscape.com)
Patients were grouped according to inhaled corticosteroid (ICS) dose (low/medium/high) and particle size device (extrafine/non-extrafine particles). (dovepress.com)
Of these, 849 (38.9%) patients received low-dose ICS, 612 medium-dose ICS (28.0%) and 724 (33.1%) high-dose ICS. (dovepress.com)
The annual mean cost/unit was € 2383 for low dose, € 2401 for medium dose and € 2625 for high dose (p=0.024). (dovepress.com)
we did not detect HIV-RNA in any of the 4'-ethynyl-2-fluoro-2'-deoxyadenosine-treated BLT mice exposed to three consecutive high-dose vaginal challenges, once each with HIV-1JR-CSF, HIV-1CH040 and HIV-1RHPA (Figure 2g). (natap.org)
First, the high rate of suboptimal LDL-c response is clearly alarming, although it is probably overestimated for the present day, once the studied cohort was not contemporary (over 40% of the subjects were recruited before 2006 and managed under older guidelines). (bmj.com)
None of the protocol variables such as test type, skin patch size, sample size, or dose applied were associated with high or low variability. (nih.gov)

This presentation integrates concepts of neurobiology and neuropathology with genetics and genomics to produce new models for diagnosis and personalized treatment for commonly recurring mental health problems. (fhea.com)

4 Process evaluation can help to distinguish between interventions that are inherently faulty (failure of intervention concept or theory) and those that are badly delivered (implementation failure). (bmj.com)
The RIPPLE (randomised intervention of pupil peer led sex education) study is a cluster RCT designed to investigate whether peer delivered sex education is more effective than teacher delivered sessions at decreasing risky sexual behaviour. (bmj.com)

Next, updated dosing recommendations for the DPF were proposed, and evaluated using a new framework based on PK study quality and benefit-risk analysis of clinical implementation. (eur.nl)

SAN DIEGO - A split dose of methotrexate (MTX) given orally once per week showed significantly higher efficacy in patients with rheumatoid arthritis (RA) at 16 weeks compared with a single MTX dose weekly, according to new research. (medscape.com)
001), and a higher percentage of patients in the split-dose group had a EULAR good response. (medscape.com)
The split-dose group also had higher proportion of patients achieving ACR50 and ACR70. (medscape.com)
The European Phase Ib/II clinical trial of AMT-130 for the treatment of Huntington's disease will explore the safety, proof of concept, and dosing in 15 total patients with early manifest Huntington's disease split into a five person, low-dose open-label cohort, followed by a nine patient, higher-dose open-label cohort. (biospace.com)
40% within 24 months (over half of the population study) had a higher risk of ASCVD events during a median follow-up of 6.2 years. (bmj.com)

Anatomy14

Organisms7

Diseases9

Chemicals and Drugs8

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Psychiatry and Psychology12

Phenomena and Processes29

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Humanities4

Information Science15

Health Care28

Geographicals3

Toxicity8

Ionizing radiation2

Pharmacokinetics5

Regimens4

Toxicology studies1

Escalation12

Booster doses1

Conventional8

Placebo-controlled2

Radiation dose2

Conclusions3

Therapeutic4

Outcomes5

Oncology3

Feasibility1

Dosimetry3

Appropriate dose3

Chemotherapy5

Exposure5

Evaluate2

Effective dose3

Efficacy and safety2

Reduces3

Optimal5

Reduction6

Methods2

Single-dose3

Estimation1

Uncertainty1

Vaccine dose2

Infection5

20212

Multicenter2

Pharmacokinetic data2

Practice4

Epidemiological3

Participants6

Lower6

Cohort study1

Complicating1

Preclinical4

Viral load3

Importance of low dose1

Patients were randomly assigned2

Various dose levels2

Dialysis1

Tumor4

Adverse events1

Full-dose2

Data15

Determine the dose1

Prednisolone2

Ample evidence1

Oral3

Severe3

Reductions1

Thresholds1

Cumulative dose1

Pediatric1

Suggests3

High9

Genomics1

Intervention2

Clinical implementation1

Higher5