Administration, OralBiological AvailabilityArea Under CurveDose-Response Relationship, DrugDrug Administration ScheduleDelayed-Action PreparationsHalf-LifeDrug InteractionsChromatography, High Pressure LiquidDouble-Blind MethodTime FactorsTreatment OutcomeInjections, IntravenousRats, Sprague-DawleyUnited States Food and Drug AdministrationDisease Models, AnimalDrug Administration RoutesRats, WistarAbnormalities, MultipleInjections, IntraperitonealBrainLiverChromosome AberrationsInjections, SubcutaneousInfusions, IntravenousAdministration, IntranasalMice, Inbred C57BLPregnancyLethal Dose 50Injections, IntramuscularMagnetic Resonance ImagingDogsRadiation DosageKidneyAdministration, RectalBlood PressureCongenital AbnormalitiesMice, Inbred BALB CBody WeightAnalysis of VarianceRats, Inbred StrainsAdministration, TopicalChromosome DisordersInjections, IntraventricularKaryotypingProspective StudiesBehavior, AnimalEye AbnormalitiesAdministration, IntravenousMice, KnockoutRandom AllocationLungAdministration, InhalationAntineoplastic AgentsMetabolic Clearance RateAdministration, CutaneousRNA, MessengerInfusions, ParenteralRetrospective StudiesRecombinant ProteinsDrug Therapy, CombinationRadiometryHeart RateTissue DistributionDrug TolerancePlant ExtractsHemodynamicsRabbitsInfant, NewbornDrug CombinationsMotor ActivityMorphineCells, CulturedPhenotypeMice, Inbred ICRMice, Inbred StrainsNeoplasmsRats, Inbred F344InjectionsMice, TransgenicOrgan SizeImmunohistochemistryAdministration, SublingualElectrocardiographyAntibodies, MonoclonalFollow-Up StudiesMutationSyndromeAnalgesics, OpioidBlood GlucoseEthanolCross-Over StudiesInjections, SpinalDose-Response Relationship, RadiationReference ValuesCardiovascular AbnormalitiesTomography, X-Ray ComputedSpleenAnimals, NewbornDrug Evaluation, Preclinical