• Neuronal vacuolation, while it may be seen in any population of neurons undergoing degeneration, is a particular concern for its neuropathologic significance in the dorsal root ganglia. (nih.gov)
  • For each experiment, 20 dorsal root ganglia (DRG) are minced, then sequentially dissociated in collagenase and trypsin, which digest all the intercellular connections. (nih.gov)
  • The present study investigated the effects of iberiotoxin (IbTx), a peptide toxin blocker of large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels and NS1619, a BK(Ca) channel opener, on action potential firing of small and medium size afferent neurons from L6 and S1 dorsal root ganglia of adult rats. (nih.gov)
  • Many patients suffer from neuropathic pain due to injury to the peripheral nervous system (including dorsal root ganglia and dorsal roots) or the CNS. (qiagen.com)
  • We examined the effectiveness of these scaffolds to stimulate neurite extension in vitro by measuring neurite outgrowth from whole and dissociated dorsal root ganglia (DRG). (frontiersin.org)
  • TRPA1 is expressed by nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia but its tasks in chilly and mechanotransduction are controversial. (bio-cavagnou.info)
  • Morphometric analyses of the double labeling mixtures in dorsal root ganglia (DRG) were performed with Neurolucida software (MBF Biosciences Inc. Colchester VT) relating to methods explained in detail (Cannon et al. (bio-cavagnou.info)
  • The cell bodies of the sensory nerves are located in the dorsal root ganglia. (medscape.com)
  • Charts based on injection of local anesthetics into single dorsal root ganglia show bands of hypalgesia to be continuous longitudinally from the periphery to the spine. (medscape.com)
  • The transcription factor Sox10 is a key regulator in the fate determination of a subpopulation of multipotent trunk neural crest (NC) progenitors toward glial cells instead of sensory neurons in the dorsal root ganglia (DRG). (edu.au)
  • Canine Dorsal Root Ganglia Satellite Glial Cells Represent an Exceptional Cell Population with Astrocytic and Oligodendrocytic Properties. (worthington-biochem.com)
  • Dorsal root ganglia assessment and treatment. (cancer.org)
  • Paulsen N, Matsumoto SG Progenitor cells with the capacity to differentiate into sympathetic-like neurons are transiently detected in mammalian embryonic dorsal root ganglia. (ohsu.edu)
  • 2010. Vacuolation of sensory ganglion neuron cytoplasm in rats with long-term exposure to organophosphates. (nih.gov)
  • Hyperexcitability develops in the CNS dorsal horn neurons, and both peripheral and spinal elements contribute to neuropathic pain, so that spontaneous pain occurs or normally innocuous stimuli produce pain. (qiagen.com)
  • Inflammatory mediators and aberrant neuronal activity activate several signaling pathways in postsynaptic dorsal horn neurons that mediate the induction and maintenance of neuropathic pain through both post-translational and transcriptional mechanisms. (qiagen.com)
  • Inflammatory mediators and aberrant neuronal activity activate several signaling pathways in postsynaptic dorsal horn neurons that mediate the induction and maintenance of neuropathic pain through both post-translational and transcriptional mechanisms.Peripheral nerve injury induces release of the neurotransmitter glutamate and the neuromodulators Tachykinin 1 (Tac1) and brain-derived neurotrophic factor (BDNF) from the central terminals of primary afferents. (qiagen.com)
  • These posttranslational steps result in an overall increased sensitivity of dorsal horn neuron to afferent input, contributing to the generation of central sensitization. (qiagen.com)
  • ERK activation in dorsal horn neuron is nociceptive-specific and can be suppressed by several analgesics. (qiagen.com)
  • Do α Adrenergic Systems Participate in Tonic Modulation of Spinal Dorsal Horn Neurons? (bmj.com)
  • Dorsal horn neurons, no. (cdc.gov)
  • Quantitative analysis of substance P-immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord. (ulaval.ca)
  • A quantitative analysis of substance P (SP)-immunoreactive (IR) terminals contacting physiologically characterized dorsal horn neurons was performed. (ulaval.ca)
  • Double immunofluorescence studies revealed that the numbers of pNR1-immunoreactive neurons and microglial cells were significantly increased in all laminae (I-II and III-VI) of the dorsal horn from DH animals. (bioseb.com)
  • Task-related responses of monkey medullary dorsal horn neurons. (nih.gov)
  • Three different types of neurons within the dorsal horn of the spinal cord. (nih.gov)
  • alpha-synuclein immunoreactive inclusions are found in nociceptive neurons of the dorsal horn in confirmed cases of PD. (kcl.ac.uk)
  • We showed that the responses are fiber-specific, located ipsilaterally in the dorsal horn, and that they follow the somatotopy of afferent fiber entries in the dorsal horn and that the C-fiber response is an N-methyl-D-aspartate receptor-dependent mechanism. (lww.com)
  • The spinal dorsal horn is the first site of integration of multiple sensory modalities and their modulation. (lww.com)
  • Hurtful stimuli activate special pain-sensing it, and the many ways it can be treated can nerve cells, or nociceptors, which generate impulses that convey word of the trouble to nerve cells in the dorsal horn be helpful to patients and caregivers when region of the spinal cord. (cancer.org)
  • Dorsal horn nerve cell something is wrong. (cancer.org)
  • In particular, we are interested in the mechanisms by which transcription factors expressed in the post-mitotic neurons drive differentiation of molecularly, anatomically and functionally distinct subsets of dorsal raphe serotonergic neurons. (helsinki.fi)
  • Consistent with this hypothesis, virtually all serotonergic neurons within the medullary nuclei raphe obscurus and raphe pallidus in cats are activated in response to specific motor challenges. (erowid.org)
  • To determine whether the response profile of serotonergic neurons in the midbrain is similar to that observed in the medulla, the single-unit activity of serotonergic dorsal raphe nucleus cells was studied during three specific motor activities: treadmill-induced locomotion, hypercarbia-induced ventilatory response and spontaneous feeding. (erowid.org)
  • In contrast to the medullary serotonergic neurons, only a minority of dorsal raphe nucleus serotonergic neurons responded to a motor challenge. (erowid.org)
  • Overall, the above results suggest very different roles for the midbrain and medullary serotonergic neurons in response to motor activities. (erowid.org)
  • A unique subdivision of serotonergic neurons in the dorsal raphe nucleus projects to the basolateral amygdala complex to enhance fear-conditioned behaviors. (atsbio.com)
  • This was done to not only verify loss of serotonergic neurons in DRN subdivisions, but also to specifically verify BLC projecting serotonergic neurons. (atsbio.com)
  • The dorsal raphe contains diverse neurons, including serotonergic, glutamatergic and GABAergic neurons, important for regulation of mood and motivation. (helsinki.fi)
  • Importantly, transfection of GABAergic neurons with DNA encoding VGLUT 1 [ 23 ] or VGLUT 2 [ 29 ] conferred the capacity to release both glutamate and GABA, confirming their role in glutamate loading of synaptic vesicles. (hindawi.com)
  • Three types of neuron were studied: nociceptive specific (NS) from lamina I (n = 3), wide dynamic range (WDR) from laminae II-IV (n = 3), and nonnociceptive (NN) from lamina IV (n = 3). (ulaval.ca)
  • Both Nociceptive-Specific neurons and Wide-Dynamic-Range neurons increase their rates of firing as the intensity of the pain stimulus (the hot pot) increases. (nih.gov)
  • I suppose the authors can pretend as they wish, but I think comparisons to actual subtypes of sensory neuron on the basis of what is presented here is specious. (peerj.com)
  • These results indicated that CPA inhibited P2X3 receptor activity in rat primary sensory neurons by activating A1 adenosine receptors, G i/o -proteins and intracellular cAMP signaling, revealing a novel peripheral mechanism underlying its analgesic effect. (researchsquare.com)
  • Figure Legend: Figure 1 Normal appearance of rat dorsal root ganglionic neurons (cresyl violet). (nih.gov)
  • Figure 2 Genuine dorsal root ganglionic vacuoles, appearing as variably sized, but generally large, clear vacuoles in the perikaryon of the affected neurons, may be accompanied by chromatolysis (arrow). (nih.gov)
  • Figure 1 shows the normal appearance of rat dorsal root ganglionic neurons. (nih.gov)
  • These results indicate that IbTx-sensitive BK(Ca) channels exist in both small and medium diameter dorsal root ganglion (DRG) neurons and play important roles in the repolarization of action potential and firing frequency. (nih.gov)
  • We characterized KNa channels in adult rat dorsal root ganglion (DRG) neurons. (nih.gov)
  • The present results showed that the A1 adenosine receptor agonist N 6 -cyclopentyladenosine (CPA) concentration-dependently suppressed P2X3 receptor-mediated and α,β-methylene-ATP (α,β-meATP)-evoked inward currents in rat dorsal root ganglion (DRG) neurons. (researchsquare.com)
  • To investigate the isolation method of Dorsal Root Ganglion(DRG) neurons in rats and their electrophysiological characteristics, DRGs were obtained by double enzymatic dissociation. (kjdb.org)
  • Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. (ox.ac.uk)
  • We have generated double mutant mice deficient in pairs of two different Trk receptors and have analysed the effects on survival and differentiation of dorsal root ganglion (DRG), inner ear cochlear and vestibular sensory neurons. (ox.ac.uk)
  • It has been assumed that nucleus pulposus-induced activation of the dorsal root ganglion (DRG) may be related to an activation of sodium channels in the DRG neurons. (openorthopaedicsjournal.com)
  • Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including the L5-spinal nerve axotomy (L5-SNA) model, suggest that it is partly caused by excitability changes in dorsal root ganglion (DRG) neurons. (edu.qa)
  • Each dorsal root contains the input from all the structures within the distribution of its corresponding body segment (ie, somite). (medscape.com)
  • Several decades of research established that glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) [ 1 ] and PNS, including dorsal root ganglion (DRG) and spinal cord neurons [ 2 , 3 ]. (hindawi.com)
  • The PIEZO2 gene may help dorsal root ganglion neurons relay full bladder signals to the brain. (nih.gov)
  • 1987. The influence of skeletal muscle on the electrical excitability of dorsal root ganglion neurons in culture. (cdc.gov)
  • 12. Functional Expression of Piezo1 in Dorsal Root Ganglion (DRG) Neurons. (nih.gov)
  • Consistent with this hypothesis, we found (7 days post-SNA), in SNA rats with established pain hypersensitivity, slower AP kinetics in axotomized L5-neurons and faster AP kinetics in L4-nociceptive neurons including decreased rise time in Aδ-and Aβ-fiber nociceptors, and after-hyperpolarization duration in Aβ-fiber nociceptors. (edu.qa)
  • In 10 rats, bipolar electrodes were implanted in the dorsal raphe nuclei. (erowid.org)
  • My project centers on the functional characterization of a specialized population of spinal neurons (the postsynaptic dorsal column neurons) that mediate touch and proprioception. (nih.gov)
  • Using whole-cell patch-clamp recording and immunohistochemistry, we tested whether serotonin circuitry in the dorsal and median raphe was functionally mature during the first 3 postnatal weeks in mice. (jneurosci.org)
  • Serotonin neurons at postnatal day 4 (P4) were hyperexcitable. (jneurosci.org)
  • Because serotonin affects circuit development in other brain regions, altering the developmental trajectory of serotonin neuron excitability and release could have many downstream consequences. (jneurosci.org)
  • We conclude that serotonin neuron structure and function change substantially during the first 3 weeks of life during which external stressors could potentially alter circuit formation. (jneurosci.org)
  • Serotonin-containing neurons in brain: depression of firing by monoami. (erowid.org)
  • Serotonin-containing neurons in rat brain: effects of microintophoreti. (erowid.org)
  • Serotonin is a chemical messenger that influences neuron functions. (sciencedaily.com)
  • In the study, serotonin-producing neurons were optogenetically stimulated in a part of the brain called the dorsal raphe nucleus (DRN), which output widely to the forebrain. (sciencedaily.com)
  • The result was that increasing the activity of serotonin neurons in the DRN drastically increased the amount of time mice were willing to wait for a food reward. (sciencedaily.com)
  • The extended waiting times by serotonin neuron stimulation were more prominent when the reward timing was randomized. (sciencedaily.com)
  • We have shown that the function of the transcription factors, required by embryonic precursors to adapt a serotonergic identity, is modified by transcriptional cofactors to promote differentiation of serotonergic neuron subtypes. (helsinki.fi)
  • Haugas M, Tikker L, Achim K, Salminen M, Partanen J. Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. (helsinki.fi)
  • However, recent work with genetic technology and single-cell genomics suggests that genetically distinct subtypes of neurons may be the functional units of the efferent vagus. (qigonginstitute.org)
  • In contrast to the results obtained for medullary raphe cells, none of the serotonergic dorsal raphe cells studied (n=26) demonstrated increased firing during treadmill-induced locomotion. (erowid.org)
  • Although the proportions of serotonergic cells activated by hypercarbia or feeding in the dorsal raphe nucleus were similar to those found in the medullary raphe, there were several major distinctions in the response characteristics for the two cell groups. (erowid.org)
  • NS1619 modulates action potential firing and suppresses 4-AP-evoked hyperexcitability in DRG neurons, in part, by opening BK(Ca) channels. (nih.gov)
  • These results suggest that opening BK(Ca) channels might be sufficient to suppress hyperexcitability of afferent neurons as those evoked by stimulants or by disease states. (nih.gov)
  • These data together suggest that nucleus pulposus induces hyperexcitability in DRG neurons. (openorthopaedicsjournal.com)
  • The faster AP kinetics (decreased refractory period) in L4-nociceptive neurons that are consistent with their reported hyperexcitability may lead to repetitive firing and thus provide enhanced afferent input necessary for initiating and/or maintaining PNP development. (edu.qa)
  • Before focusing on the presence and role of vesicular glutamate transporters in neurons in the periphery and the spinal cord, it is important to begin with some historical facts on how it was that glutamatergic neurons were identified in the nervous system. (hindawi.com)
  • However, the morphological phenotyping of glutamatergic neurons as well as glial cells was not to be a trivial matter. (hindawi.com)
  • This pioneering work led to the distinction of a "transmitter pool" in glutamatergic terminals, a "metabolic pool" in nonglutamatergic neurons, and a "glial pool" [ 7 - 9 ]. (hindawi.com)
  • Subsequent methods to identify glutamatergic neurons were based on the immunohistochemical detection of enzymes like glutaminase, involved in the synthesis of glutamate [ 15 , 16 ]. (hindawi.com)
  • However, since glutamate is a major participant in cell metabolism, even for the synthesis of the inhibitory neurotransmitter GABA [ 7 , 20 ], and not always the visualization of associated molecules guarantees the glutamatergic nature of neurons, an ideal marker was still sought. (hindawi.com)
  • Here, to systematically examine complete single-neuron morphologies on a brain-wide scale, we established a pipeline encompassing sparse labelling, whole-brain imaging, reconstruction, registration and analysis. (nature.com)
  • Thus, characterizing single neuron axonal projections through reconstruction of complete morphologies provides ground-truth information not only for cell classification, but also for charting global networks and local circuits. (nature.com)
  • We report here the largest set of complete single-neuron reconstructions to date. (nature.com)
  • Here we leveraged human single neuron recordings in ventromedial prefrontal, dorsomedial frontal, hippocampus and amygdala neurons while patients performed a sequential Pavlovian condi. (researchgate.net)
  • The functional significance of adult-born neurons in this region has been characterized using context fear conditioning, a Pavlovian paradigm in which animals learn to associate a location with danger. (nih.gov)
  • We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. (elifesciences.org)
  • Using electrophysiological recordings from dorsal and ventral PCC subregions, the authors provide compelling evidence for a dorsal-executive and ventral-episodic functional subdivision. (elifesciences.org)
  • Using pharmacological and genetic techniques, we identified the mechanosensory channel, DmPiezo, in this functional role in dbd neurons, with TRPA1 playing a subsidiary role. (ed.ac.uk)
  • The genes higher in the dorsal/resistant SNpc tier neurons displayed coordinated patterns of expression across the human brain, their protein products had more interactions than expected by chance, and they demonstrated evidence of functional convergence. (ox.ac.uk)
  • INTERPRETATION: Our results highlight functional enrichments of vesicular trafficking, ion transport/homeostasis and oxidative stress genes showing higher expression in the resistant neurons of the SNpc dorsal tier. (ox.ac.uk)
  • Densities of the total population (SP immunoreactive+nonimmunoreactive) of apposed boutons were similar in all three regions (cell body, proximal and distal dendrites) for the three functional types of neuron. (ulaval.ca)
  • Its efferent neurons, which project their axons from the brainstem to the viscera, are thought to comprise "functional units" - neuron populations dedicated to the control of specific vagal reflexes or organ functions. (qigonginstitute.org)
  • non-hunger-driven feeding activates VTA-projecting 5-HTDRN neurons through reducing a potassium outward current. (nih.gov)
  • Motor neuron that innervates the internal dorsal acute, dorsal oblique and LL1 muscles of larval abdominal segments A1 to A7 (Landgraf et al. (virtualflybrain.org)
  • 1999), we infer A1 motor neuron innervation patterns from those of A2-7. (virtualflybrain.org)
  • Vagal motor neuron. (qigonginstitute.org)
  • These results indicate for the first time that increased expression of pNR1 is regulated by ERK and the NMDAR via a feedforward mechanism in spinal neurons and microglia and represents one mechanism involved in central sensitization and somatic mechanical hyperalgesia after diabetes. (bioseb.com)
  • Some of my daily tasks in the lab include performing stereotaxic surgeries to target and label these spinal neurons in the gracile nucleus of the mouse brain. (nih.gov)
  • Analysis of action potential profile revealed that IbTx significantly prolonged the duration of action potential and increased firing frequency of afferent neurons. (nih.gov)
  • Stretch-activated afferent neurons, such as those of mammalian muscle spindles, are essential for proprioception and motor co-ordination, but the underlying mechanisms of mechanotransduction are poorly understood. (ed.ac.uk)
  • We identified 11 major projection neuron types with distinct morphological features and corresponding transcriptomic identities. (nature.com)
  • Whether these two groups of DRG neurons exhibit similar or distinct electrophysiological changes after L5-SNA remains unresolved. (edu.qa)
  • Here, we recorded somatic action potentials (APs) intracellularly from C- and A-fiber L4/L5 DRG neurons to examine our hypothesis that L5-SNA would induce distinct electrophysiological changes in the two populations of DRG neurons. (edu.qa)
  • A discrete dorsal raphe to basal amygdala 5-HT circuit calibrates aversive memory. (nih.gov)
  • Receptor potential changes in dbd neurons in response to stretch showed a complex, dynamic profile with similar characteristics to those previously observed for mammalian muscle spindles. (ed.ac.uk)
  • Application of IbTx (100 nM) reduced whole-cell outward currents in 67% of small and medium size neurons. (nih.gov)
  • Neurons differentiating from murine neural crest in culture exhibit sensory or sympathetic-like calcium currents. (ohsu.edu)
  • Dorsal striatum (DS) medial spiny neurons(MSN) of direct pathway (expressing D1 receptor, D1-MSN) and indirect pathway (expressing D2 receptor, D2-MSN) are involved in motor skill learning, however, the underlying neural mechanism remains largely unknown. (nih.gov)
  • We have developed an in vivo protocol to obtain receptor potential recordings from intact dbd neurons in response to stretch. (ed.ac.uk)
  • In summary, we show that the dbd neuron is a stretch receptor and demonstrate that this neuron is a tractable model for investigating mechanisms of mechanotransduction. (ed.ac.uk)
  • The dorsal attention network (DAN), also known anatomically as the dorsal frontoparietal network (D-FPN), is a large-scale brain network of the human brain that is primarily composed of the intraparietal sulcus (IPS) and frontal eye fields (FEF). (wikipedia.org)
  • As part of the BRAIN Initiative Cell Census Network (BICCN) efforts to characterize brain cell types across multiple modalities, we established a pipeline to label, image, reconstruct and classify single neurons in mice. (nature.com)
  • These neurons are genetically modified to a produce a light-sensitive protein that are then stimulated by shining light along a fiber optic implanted in the brain. (sciencedaily.com)
  • Distribution of chemical messengers within axons descending from the brain (blue), primary afferent fibers transmitting from skin and tissues (pink), and intrinsic 'relay' neurons. (nih.gov)
  • There are several variations of this network's name in neuroscience literature, such as the dorsal attention system, dorsal frontoparietal attention network, and frontoparietal attention network. (wikipedia.org)
  • Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. (elifesciences.org)
  • NS neurons received a significantly higher density of appositions from SP-IR boutons than NN cells in all three regions. (ulaval.ca)
  • The changes in axotomized L5-neurons may contribute to the central mechanisms of PNP via enhanced neurotransmitter release in the central nervous system (CNS). (edu.qa)
  • It may help certain bladder cells gauge expansion while also sparking neurons to relay tension signals to the rest of the nervous system. (nih.gov)
  • UCMS exposure also increased Fos-ir and the number of double-labeled neurons in the mid-rostral subdivision of the dorsal part of the DR and in the mid-caudal region of the lateral wings. (unesp.br)
  • KBF severity scores at this time also negatively predicted DCX + cell numbers on an individual level, while hens that acquired fractures earlier in their lives had fewer DCX + neurons in the caudal hippocampal formation. (nature.com)
  • The frequency of spontaneous inhibitory and excitatory events increased as neurons extended and refined their dendritic arbor. (jneurosci.org)
  • Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons. (ed.ac.uk)
  • The dorsal bipolar dendritic (dbd) sensory neurons are putative stretch receptors in the Drosophila larval body wall. (ed.ac.uk)
  • The files comprise the raw data that are the basis of our work "Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons. (ed.ac.uk)
  • Dendritic and axonal morphology reflects the input and output of neurons and is a defining feature of neuronal types 1 , 2 , yet our knowledge of its diversity remains limited. (nature.com)
  • Focal hens with severe KBFs at 3-4 weeks prior to sampling (n = 15) had lower densities of immature doublecortin-positive (DCX + ) multipolar and bipolar neurons in the hippocampal formation than focal hens with minimal fractures (n = 9). (nature.com)
  • 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. (nih.gov)
  • Erowid.org: Erowid Reference 2964 : Discrimintaive Control of Behavior by Electrical Stimulation of the Dorsal Raphe Nucleus: Generalization to Lysergic Acid Diethylamide (LSD). (erowid.org)
  • These results corroborate the idea that neurons of specific subnuclei of the DR regulate anxiety responses and are differently activated by chronic stress exposure. (unesp.br)
  • To further decode the neural mechanism of DS MSN underlying motor skill learning, we developed a custom miniature fluorescent microscope (miniScope) to concurrently record calcium activities of hundreds of striatal neurons longitudinally from mice training on accelerating rotarod. (nih.gov)
  • However, double homozygous trkA-/-;trkB-/- DRG and trkB-/-;trkC-/- vestibular neurons showed the same degree of survival as single trkA-/- and trkB-/- mice, respectively, suggesting that those neurons required both Trk signaling pathways for survival. (ox.ac.uk)
  • In situ hybridisation analysis of DRG neurons of double mutant mice revealed differential expression of excitatory neuropeptides. (ox.ac.uk)
  • Using an intranasal instillation model in mice, we found that acute SG exposure specifically induced apoptosis of olfactory sensory neurons (OSNs) in the olfactory epithelium. (nih.gov)
  • Finally, epistasis analysis further demonstrated that Fbxo9 and probably other F-box members mediated the role of Sox10 in destabilizing Neurog2 protein and directing the lineage of NC progenitors toward glial cells rather than sensory neurons. (edu.au)
  • Pathology of peripheral neuron cell bodies. (nih.gov)
  • Secondly, and in order to provide an appropriate framework, there will be a synthetic description of the neuroanatomy and neurochemistry of peripheral neurons and the spinal cord. (hindawi.com)
  • This will be followed by a succinct description of the current knowledge on the expression of VGLUTs in peripheral sensory and autonomic neurons and neurons in the spinal cord. (hindawi.com)
  • Activation of ERKs by TRKB, PKA, PKC and PI3K, an activation that involves NMDARs, AMPA receptors, and MGLURs, can suppress the activity of potassium channel KCND2, which generally suppresses excitability of the neuron. (qiagen.com)
  • In the inner ear, TrkB- and TrkC-dependent neurons were shown to at least partially depend on each other for survival, most likely indirectly due to abnormal development of their common targets. (ox.ac.uk)
  • Any abdominal dorsal multidendritic neuron ddaD (FBbt:00002410) that is part of some larval abdominal segment 1 (FBbt:00001748). (virtualflybrain.org)
  • Lesion studies indicate that CFC depends on neural activity in both the dorsal and ventral hippocampus, subregions with unique extrahippocampal connectivity and behavioral functions. (nih.gov)
  • Because most studies of adult neurogenesis have relied on methods that permanently ablate neurogenesis throughout the entire hippocampus, little is known about how the function of adult-born neurons varies along the dorsal-ventral axis. (nih.gov)
  • The activation of the intrinsic regenerative program of DRG neurons is at least partly associated with upregulation of IL-6. (muni.cz)
  • Activation of intrinsic regeneration capacities of cervical DRG neurons induced by a sciatic nerve injury (compression or transection for 7 days) was evidenced by upregulation of GAP-43, SCG-10 and STAT-3 mRNAs and proteins. (muni.cz)
  • These neurons were identified in one EM reconstruction of abdominal segment 3 of a 12-24h old first instar larva (Heckscher et al. (virtualflybrain.org)
  • Changes of the nerve activity of the sympathetic renal and vertebral nerves were elicited by microinjection of sodium glutamate (50 nmol/100 nl) into the pressor areas of the dorsal (DM) and rostral ventrolateral medulla (RVLM) in cats under urethane-chloralose anesthesia. (ntnu.edu.tw)
  • We also verified that almost all CtB-immunoreactive BLC projecting neurons in DRN were also positive for tryptophan hydroxylase (TPH: a serotonergic specific enzyme). (atsbio.com)
  • We further determined that BLC projecting neurons immunoreactive for both CtB and TPH were primarily located within the midline DRD and DRV divisions of the DRN, and not in the lateral wing (DRVL) divisions of DRN. (atsbio.com)
  • Regardless of location, the SERT-SAP group had 72% to 74% less CtB/TPH-double immunoreactive neurons than control-SAP group. (atsbio.com)
  • 2009). It receives input from the ipsilateral larval A02b, A27j, eIN-4 (A03a1) and A27e and contralateral larval A08e1-3 local neurons and A31k neuron. (virtualflybrain.org)
  • This result supports the notion that neurons located in different pressor areas of the brainstem exert differential effects over different sympathetic nerve activities. (ntnu.edu.tw)
  • Basal KNa channel activity could be recorded from cell-attached patches of acutely dissociated neurons bathed in physiological saline, and yet in excised inside-out membrane patches, the Na+ EC50 for KNa channels was typically high, approximately 50 mM. (nih.gov)
  • On page 14, in the section Approaches to investigate physiological roles of DAT DR-PAG neurons in various behaviors , Stuber et al. (eneuro.org)