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NorfenfluramineFenfluramineDopamineReceptor, Serotonin, 5-HT2BMetergolineSerotonin 5-HT2 Receptor AntagonistsReceptors, Dopamine D2ErgolinesReceptors, Dopamine D1KetanserinReceptor, Serotonin, 5-HT2CBiogenic MonoaminesReceptor, Serotonin, 5-HT2ADopamine AgonistsDopamine AntagonistsReceptors, DopamineNorepinephrine Plasma Membrane Transport ProteinsReceptors, Dopamine D3SympathectomySerotoninDopamine Plasma Membrane Transport ProteinsDopamine Agents

Serotonin receptorsPotentEffects

Serotonin receptors2

• Since fenfluramine and its active metabolite norfenfluramine stimulate serotonin receptors, this may have led to the valvular abnormalities found in patients using fenfluramine. (wikipedia.org)
• [4] It activates serotonin receptors as well as dopamine and adrenergic receptors . (mdwiki.org)

Potent2

• In particular norfenfluramine is a potent inhibitor of the re-uptake of 5-HT into nerve terminals. (wikipedia.org)
• Discovered at Janssen Pharmaceutica in 1961, droperidol is a butyrophenone which acts as a potent D 2 (dopamine receptor) antagonist with some histamine and serotonin antagonist activity. (cloudfront.net)

Effects1

• Anti-obesity treatments targeting the serotonin (5-HT) system are typically derived from β-phenethylamine, which has the same basic structure as the neurotransmitters dopamine, noradrenaline and adrenaline and mediate their effects by influencing noradrenergic, dopaminergic and serotonergic neurotransmission. (medscape.com)