• Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. (nih.gov)
  • Calmodulin Binding Domain Ca2+ is a fragment of aa290-309 of Calmodulin-dependent Protein Kinase II (CaMKII). (echelon-inc.com)
  • We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
  • In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
  • CAMKII contains an N-terminal catalytic domain which binds ATP and substrate protein, regulatory domain (CBD) and association domain (ASD). (proteopedia.org)
  • Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. (proteopedia.org)
  • This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. (nih.gov)
  • There are 5198 Ca_chan_IQ domains in 5178 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing Ca_chan_IQ domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with Ca_chan_IQ domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing Ca_chan_IQ domain in the selected taxonomic class. (embl.de)
  • Calcium binds to and regulates the small regulatory protein calmodulin that in turn binds to and regulates several hundred calmodulin binding proteins. (biomedcentral.com)
  • Many of these proteins are linked to multiple neurodegenerative diseases indicating that calmodulin binding proteins lie at the heart of neuroinflammatory events associated with multiple neurodegenerative diseases. (biomedcentral.com)
  • The small calcium-binding protein calmodulin (CaM) is a primary effector of calcium function and works in turn by binding to and regulating CaM-binding proteins (CaMBPs) [ 53 ]. (biomedcentral.com)
  • The Calcium Hypothesis was thus extended as the Calmodulin Hypothesis since CaM not only binds to and regulates CaMBPs critical to learning and memory but also proteins involved in the formation of amyloid plaques and tangles, hallmarks of AD [ 41 ]. (biomedcentral.com)
  • The intimate role of CaMBPs in AD was recently reviewed reinforcing the role of CaM in binding to and regulating multiple key proteins adding further support for the Calmodulin Hypothesis of O'Day and Myre [ 41 , 47 ]. (biomedcentral.com)
  • Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). (embl.de)
  • A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). (embl.de)
  • Proteins containing only a single amino terminal CH domain. (embl.de)
  • In addition, the CH domain occurs also in a number of proteins not known to bind actin, a notable example being the vav protooncogene. (embl.de)
  • There are 66728 CH domains in 45684 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing CH domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with CH domain is also avaliable . (embl.de)
  • Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. (nih.gov)
  • Rat GAP-43 is a 226 amino acid (aa) protein that contains an N-terminal lipid binding motif, an 11 aa IQ domain (IQ:Ile-Gln-X-Ser-etc) (aa 38 - 48), and a C-terminus with four potential serine phosphorylation sites. (neuromics.com)
  • Calmodulin Mutations in Human Disease. (nih.gov)
  • Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain Zhang Z, Weed S, Gallagher P, Morrow J . Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain. (yale.edu)
  • Other choices include calmodulin-binding peptide, Strep-tag (oxtapeptide binding to streptavidini), chitin-binding domain, and FLAG-tag (another octapeptide that binds to anti-FLAG mAbs). (genengnews.com)
  • AJ249352) encodes a 1,074 amino acid protein with 10 putative transmembrane domains, which contains all of the characteristic motifs of Ca2+-transporting P-type Ca2+-ATPases. (unimi.it)
  • With a series of deletion/point mutants, we identified CaM antagonist-responsive region in the putative Sp1-binding domain between -295 to -300 base pairs of DR5 gene. (oncotarget.com)
  • Pires I, Hung YF, Bergmann U, Molloy JE & Kursula I (2022) Analysis of Plasmodium falciparum myosin B ATPase activity and structure in complex with the calmodulin-like domain of its light chain MLC-B. J Biol Chem 298: 102634. (uib.no)
  • At-ACA8 encodes a plasma membrane-localized calcium-ATPAse of arabidopsis with a calmodulin-binding domain at the N terminus / M.C. Bonza, P. Morandini, L. Luoni, M. Geisler, M.G. Palmgren, M.I. De Michelis. (unimi.it)
  • The variant was in a gene called CALM2 [that encodes for calmodulin]. (abc.net.au)
  • Ca2+/Calmodulin dependent protein kinase (CaMK) are mammalian calmodulin-dependent calcium-dependent protein kinases activated by elevation of Ca+2 and calmodulin concentration to phosphorylate Ser and Thr. (proteopedia.org)
  • Subtype Differences in the Interaction of HIV-1 Matrix with Calmodulin: Implications for Biological Functions. (nih.gov)
  • Indeed, while the isolated catalytic domain was spherical and hydrated, it underwent a significant elongation as well as compaction and dehydration upon calmodulin interaction. (pasteur.fr)
  • Changes in activity-dependent calcium flux through voltage-gated calciumchannels (Ca(V)s) drive two self-regulatory calcium-dependent feedbackprocesses that require interaction between Ca(2+)/calmodulin (Ca(2+)/CaM)and a Ca(V) channel consensus isoleucine-glutamine (IQ) motif:calcium-dependent inactivation (CDI) and calcium-dependent facilitation(CDF). (embl.de)
  • In the enterocyte microvillus, the structural core is attached to the plasma membrane along its length by lateral arms made of myosin 1a and Ca 2+ binding protein calmodulin . (wikipedia.org)
  • Myosin 1a functions through a binding site for filamentous actin on one end and a lipid binding domain on the other. (wikipedia.org)
  • In molecular biology, calmodulin binding domain (CaMBD) is a protein domain found in small-conductance calcium-activated potassium channels (SK channels). (wikipedia.org)
  • However, as the structure of the catalytic domain in the absence of calmodulin is still lacking, the molecular basis of AC activation by calmodulin remains largely unknown. (pasteur.fr)
  • The IQ domain engages hydrophobicpockets in the N-terminal and C-terminal Ca(2+)/CaM lobes through sets ofconserved 'aromatic anchors. (embl.de)
  • Titration calorimetry experiments reveal competition betweenthe lobes for IQ domain sites. (embl.de)
  • Sequence analysis suggests that a 36-amino acid N-terminal regulatory domain may be present in all Arabidopsis CAX-like genes. (manchester.ac.uk)
  • We report a unique crystal structure of a 77-residue fragment of the Ca(V)1.2 alpha(1) subunit carboxyl terminus, which includes a tandem of the pre-IQ and IQ domains, in complex with Ca(2+).CaM in 2 distinct binding modes. (rcsb.org)
  • C-domain helices HA and HB of the cross-subunit bind the C-lobe of CaM. (elifesciences.org)
  • The results showed that if the FMN, in the isolated FMN domain, is assumed to be fully accessible, then it is 100% accessible in the CaM-bound enzyme, 45% accessible in the uncompleted enzyme and only 3% accessible in the NADPH-bound nNOSrd in the absence of CaM. (ndltd.org)
  • Unphosphorylated, calmodulin-bound GAP-43 is always associated with neurite retraction, while S41 phosphorylated GAP-43 stabilizes actin filaments and promotes growth cone extension. (neuromics.com)
  • Time-resolved DEER EPR and solid-state NMR afford kinetic and structural elucidation of substrate binding to Ca(2+)-ligated calmodulin. (nih.gov)
  • Structural Basis for Simultaneous Binding of Two Carboxy-terminal Peptidesof Plant Glutamate Decarboxylase to Calmodulin. (expasy.org)
  • This suggests that the binding of CaM is responsible for a structural reorganisation of nNOS rd that "unlocks" the conformation of the enzyme and enables the FMN sub-domain motion in order to shuttle an electron from FAD cofactor to the heme. (ndltd.org)
  • The present studies identify distinct functional domains that confer differential sensitivities of Kv7.4 and Kv7.5 to stimulatory and inhibitory signaling and reveal structural features of the channel subunits that determine their biophysical properties. (aspetjournals.org)
  • A Ca2+-ATPase was purified from plasma membranes (PM) isolated from Arabidopsis cultured cells by calmodulin (CaM)-affinity chromatography. (unimi.it)
  • Calmodulin Interactions with Voltage-Gated Sodium Channels. (nih.gov)
  • Each single ABD, comprising two CH domains, is able to bind one actin monomer in the filament. (embl.de)
  • The N-terminal CH domain has the intrinsic ability to bind actin, albeit with lower affinity than the complete ABD, whereas the C-terminal CH bind actin extremely weakly or not at all. (embl.de)
  • At-ACA8 is the first plant PM localized Ca2+-ATPase to be cloned and is clearly distinct from animal PM Ca2+-ATPases due to the localization of its CaM-binding domain. (unimi.it)
  • CaM overlay assays localized the CaM-binding domain of At-ACA8p to a region of the N terminus of the enzyme around tryptophan-47. (unimi.it)
  • In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP 2 ) binding domains, or the entire C terminus, was without effect on the forskolin response, but the latter conferred responsiveness to arginine-vasopressin (an inhibitory PKC-dependent response). (aspetjournals.org)
  • A calponin homology domain is predicted in yeasst Cdc24p. (embl.de)
  • Bordetella pertussis, the causative agent of whooping cough, secretes among various toxins an adenylate cyclase (CyaA) that displays a unique mechanism of cell invasion, which involves a direct translocation of its N-terminal catalytic domain (AC, 400 residues) across the plasma membrane of the eukaryotic targeted cells. (pasteur.fr)
  • To characterize this activation mechanism, we investigated here the biophysical properties of the isolated catalytic domain in solution with or without calmodulin. (pasteur.fr)
  • In order to investigate the CaM activation mechanism of nNOS, the effect of the conformational changes of nNOSrd and the binding of NADP(H) on the redox potential of the flavins, cofactors were assessed for the isolated FAD and FMN sub-domains by OTTLE potentiometry. (ndltd.org)
  • No InterPro domain matches or not analyzed. (cornell.edu)
  • We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying mechanisms. (oncotarget.com)
  • Insights into voltage-gated calcium channel regulation from the structureof the CaV1.2 IQ domain-Ca2+/calmodulin complex. (embl.de)
  • Electrophysiological examination ofCa(2+)/N lobe aromatic anchors uncovers their role in Ca(V)1.2 CDF.Together, our data suggest that Ca(V) subtype differences in CDI and CDFare tuned by changes in IQ domain anchoring positions and establish aframework for understanding CaM lobe-specific regulation of Ca(V)s. (embl.de)
  • The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin ( PUBMED:16299511 ). (embl.de)
  • These domains cross-link actin filaments into bundles and networks. (embl.de)
  • The structure of this domain complexed with CaM is known. (wikipedia.org)
  • The structure of AC in complex with the C-terminal part of calmodulin has recently been determined. (pasteur.fr)
  • We found that calmodulin triggered only minor modifications of the protein secondary and tertiary structure but had a pronounced effect on the hydrodynamic properties of AC. (pasteur.fr)
  • Here, we report the high-resolution structure of theCa(2+)/CaM-Ca(V)1.2 IQ domain complex. (embl.de)
  • Solution structure of the N-terminal EGF-like domain from human factor VII. (lu.se)
  • It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. (curehunter.com)
  • Voltage-dependent calcium channels (Ca(V)) open in response to changes in membrane potential, but their activity is modulated by Ca(2+) binding to calmodulin (CaM). (rcsb.org)
  • both the FAD sub-domain and the nNOSrd formed the charge-transfer complex with a long-wavelength absorption band centred at 780nm. (ndltd.org)
  • Transmembrane helices are shown as S1-S6, and SK C-domain helices are shown as HA-HC. (elifesciences.org)
  • When the models being compared have substantial differences, and especially if they have multiple domains, more tolerant estimates of the closenss of fit have been employed, notably in CASP . (proteopedia.org)
  • redox couple was found to be stabilised by the presence of the FAD sub-domain (increase of 80 mV). (ndltd.org)
  • The isolated FAD sub-domain was found to have similar redox potentials to the isolated nNOSrd. (ndltd.org)
  • We provide evidence that KRas translocation occurs through sequestration of the polybasic-prenyl motif by Ca 2+ /calmodulin (Ca 2+ /CaM) and subsequent release of KRas from the PM, in a process reminiscent of GDP dissociation inhibitor-mediated membrane recycling of Rab and Rho GTPases. (rupress.org)
  • A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. (curehunter.com)
  • the E-value for the Ca_chan_IQ domain shown below is 3.28e-15. (embl.de)
  • the E-value for the CH domain shown below is 1.86e-28. (embl.de)
  • This analysis revealed the presence of at least one binding domain within which visual scanning demonstrated the presence of valid binding motifs. (biomedcentral.com)