Domain beta catenin. Medical search. Frequent questions

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
Thus, β-catenin became one of the first examples of moonlighting: a protein performing more than one radically different cellular function. (wikipedia.org)
Termed armadillo repeats, all these elements fold together into a single, rigid protein domain with an elongated shape - called armadillo (ARM) domain. (wikipedia.org)
The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. (nih.gov)
The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. (nih.gov)
Click on the protein counts, or double click on taxonomic names to display all proteins containing ARM domain in the selected taxonomic class. (embl.de)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)
β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. (ptglab.com)
Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. (embl-heidelberg.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
The PHD finger and the bromodomain are small protein domains that occur in many proteins associated with phenomena related to chromatin. (embl-heidelberg.de)
HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. (eu.org)
PHAT domain, found in the RNA-binding protein Smaug. (eu.org)
Pumilo repeat domain, found in Pumilo protein. (eu.org)
MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)
Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta (GSK3beta) phosphorylation consensus motif of beta-catenin inhibits ubiquitination and results in stabilization of the protein. (bioseek.eu)
Its output is outlined primarily by β-catenin's phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the multi-protein β-catenin destruction advanced. (medmk.com)
Dsh has three highly conserved protein domains, which interact differently based on which Wnt pathway it is interacting with [44]. (scdinhibitor.com)
The canonical pathway will be the only 1 to involve beta-catenin, which can be the TCF/LEF binding protein responsible for improved transcription and EMT [57,58]. (scdinhibitor.com)
It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. (betalifesci.com)
This protein is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. (betalifesci.com)

A prominent example for the decisive impact of lipid rafts on signaling is LRP6, whose localization to the same lipid rafts domain as the kinase CK1γ is crucial for its successful phosphorylation and the subsequent activation of the signalosome, hence WNT/β-catenin signaling. (frontiersin.org)
To analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation, we present a computational modeling study, that for the first time employs realistic raft numbers in a compartment-based pathway model. (frontiersin.org)
Here, we apply computational modeling to analyze whether and how the quantitative ratio between receptor and rafts affects LRP6 phosphorylation and WNT/β-catenin pathway activation. (frontiersin.org)
This motif in beta-catenin resembles a motif in IkappaB (inhibitor of NFkappaB) which is required for the phosphorylation-dependent degradation of IkappaB via the ubiquitin-proteasome pathway. (bioseek.eu)
We reveal that AXIN1 polymerization and APC promote β-catenin seize, phosphorylation, and ubiquitylation. (medmk.com)

Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. (nih.gov)

Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. (bioss.com.cn)

Not only their ARM domains resemble each other in both architecture and ligand binding capacity, but the N-terminal β-TrCP-binding motif is also conserved in plakoglobin, implying common ancestry and shared regulation with β-catenin. (wikipedia.org)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
According to one study, down-regulation of Axin and GSK-3β in the β-catenin pathway was associated with the development of spiradenomas. (medscape.com)
This entry represents the PHD (homeodomain) zinc finger domain [ ( PUBMED:7701562 ) ], which is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
Here we show that the ubiquitin-dependent proteolysis system is involved in the regulation of beta-catenin turnover. (bioseek.eu)
We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. (bioseek.eu)

There are 167287 ARM domains in 29030 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing ARM domain. (embl.de)
The complete taxonomic breakdown of all proteins with ARM domain is also avaliable . (embl.de)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)
There are 144042 PHD domains in 86307 proteins in SMART's nrdb database. (embl-heidelberg.de)
The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
Domains and repeats with an ARM-like fold have been found in a number of proteins, including: ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins. (eu.org)
Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. (oftalmic.ru)

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)
Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)
Even though LRP6 is homogenously distributed in the membrane and only a minor fraction is raft-associated, its localization to lipid rafts is vital for the activation of the LRP6 signalosome, hence wnt/β-catenin signaling. (frontiersin.org)
Researchers report cells in a high salt environment show activation of the beta catenin/Wnt signaling pathway, a pathway previously implicated in disrupting regulatory T cells and triggering inflammation. (neurosciencenews.com)
First author Tomokazu Sumida, a researcher in the lab of David Hafler, the William S. and Lois Stiles Edgerly Professor of Neurology and professor of immunobiology, and colleagues report that cells in a high-salt environment show activation of the beta-catenin/Wnt signaling pathway. (neurosciencenews.com)
beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling pathway. (bioseek.eu)
These findings exemplify the ability of biochemical reconstitution to interrogate the molecular mechanisms of Wnt/β-catenin signaling. (medmk.com)
The canonical Wnt pathway contains the beta-catenin destruction complex, which is normally down-regulated or disrupted following the activation of Wnt signaling. (scdinhibitor.com)
Although beta-catenin provides essential structural and signaling functions during development and adult homeostasis, its contributions to in vivo SMC activities in vascular assembly and remodeling have not been characterized. (yu.edu)
Using a series of beta-catenin knock-in mutant alleles, we found further that SMC beta-catenin signaling function was essential, while its structural role was not sufficient. (yu.edu)
Altogether, our developmental and adult mouse studies show that beta-catenin signaling function, especially that mediated by its C-terminal domain, promotes proliferation and survival of vascular SMCs in vivo, in part by repressing p53 activity in these cells. (yu.edu)
Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. (oftalmic.ru)
This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. (nih.gov)
RSPO1 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. (betalifesci.com)
Moreover, as is the case in vertebrate embryos, confining the ANE to the anterior end of the embryo requires a Wnt/β- catenin -dependent signaling mechanism. (echinobase.org)
Starting with a luciferase assay, insights gleaned from the Cancer Genome Atlas transcriptome sequencing efforts, and a rapid amplification of cDNA ends experiment, the researchers found a LINC00673 isoform that appeared to influence WNT/beta-catenin signaling in lung adenocarcinoma cells. (genomeweb.com)
Together," they write, "our data suggest that LINC00673-v4 is a driver molecule for metastasis via constitutively activating WNT/beta-catenin signaling in [lung adenocarcinoma] and may represent a potential therapeutic target against the metastasis of [lung adenocarcinoma]. (genomeweb.com)
Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1 (TCF7L1), an important regulator of the WNT/ß-catenin signaling pathway, is expressed in the developing forebrain and pituitary gland, but its role during hypothalamo-pituitary (HP) axis formation or involvement in human CH remains elusive. (bvsalud.org)

Signal transduction of beta-catenin. (embl.de)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)

Plakoglobin (also called γ-catenin) has a strikingly similar architecture to that of β-catenin. (wikipedia.org)
In plakoglobin arm repeats bind alpha-catenin and N-cadherin. (embl.de)

Liver Specification in the Absence of Cardiac Differentiation Revealed by Differential Sensitivity to Wnt/β Catenin Pathway Activation. (xenbase.org)

Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove. (embl.de)
Without association with the catenins, the cadherins are non-adhesive. (rndsystems.com)
Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium-dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. (rndsystems.com)

Right here we describe the in vitro reconstitution of an energetic human β-catenin destruction advanced from purified parts, recapitulating advanced meeting, β-catenin modification, and degradation. (medmk.com)
Intracellular beta-catenin levels are maintained through continuous creation and destruction, the processes of that are suggested to be regulated differently in between our parity groups. (scdinhibitor.com)
Our evaluation showed an increased methylation of LRP5 within parous females, which suggests a decreased expression of LRP5/6 plus a decreased cellular capability to stop the beta-catenin destruction complex within this way. (scdinhibitor.com)
The beta-catenin destruction complicated starts using the binding of GSK3 to Axin, which leaves GSK3's active website open to phosphorylate beta-catenin. (scdinhibitor.com)
This suggests a rise in expression of GSK3 within parous females and subsequently a rise within the activity of the beta-catenin destruction complicated. (scdinhibitor.com)

β-catenin is a multipurpose and evolutionarily conserved molecule that plays a critical role by metazoans in a variety of processes in development and homeostasis. (chemdiv.com)

The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. (ptglab.com)

Neuronal production in the midbrain-hindbrain domain (MH) of the vertebrate embryonic neural tube depends on a progenitor pool called the `intervening zone' (IZ), located at the midbrain-hindbrain boundary. (biologists.com)
Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. (ptglab.com)
We found that complete loss of beta-catenin in SMCs in the mouse decreased their proliferation and survival, limited arterial wall formation, and caused embryonic lethality. (yu.edu)
Interestingly, beta-catenin inhibited p53 transcriptional activity in SMCs in culture and in vivo, as concurrent loss of p53 improved arterial morphogenesis and embryonic development. (yu.edu)

β-catenin belongs to the catenin molecule family. (chemdiv.com)

Degradation of β-catenin is thus mediated by this N-terminal segment. (wikipedia.org)

Abstract for "Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity" by Tomokazu Sumida, Matthew R. Lincoln, Chinonso M. Ukeje, Donald M. Rodriguez, Hiroshi Akazawa, Tetsuo Noda, Atsuhiko T. Naito, Issei Komuro, Margarita Dominguez-Villar & David A. Hafler in Nature Immunology . (neurosciencenews.com)

Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. (embl.de)

Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)

The core of β-catenin consists of several very characteristic repeats, each approximately 40 amino acids long. (wikipedia.org)
Due to the complex shape of individual repeats, the whole ARM domain is not a straight rod: it possesses a slight curvature, so that an outer (convex) and an inner (concave) surface is formed. (wikipedia.org)
The primary structure of beta-catenin consists of an NH2-terminal domain (NDT), a central region represented by 12 Arm-repeats (R1-12), and a COOH-terminal end (CTD). (chemdiv.com)
The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. (eu.org)

A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. (bvsalud.org)

The three pathways will be the canonical Wnt/beta-catenin pathway, the noncanonical planar cell polarity (PCP) pathway, along with the noncanonical Wnt/calcium pathway. (scdinhibitor.com)
Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. (uchicago.edu)
Here we use morpholino- or dominant negative-mediated interference to demonstrate that the early sea urchin embryo integrates information not only from Wnt/β- catenin but also from Wnt/Fzl5/8- JNK and Fzl1/2/7-PKC pathways to provide precise spatiotemporal control of neuroectoderm patterning along its AP axis. (echinobase.org)

Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. (embl.de)
In the current model of this pathway, the amount of beta-catenin (or its invertebrate homolog Armadillo) is tightly regulated and its steady-state level outside the cadherin-catenin complex is low in the absence of Wingless/Wnt signal. (bioseek.eu)

inhibits dimerization of the kinase domain and autophosphorylation. (bioss.com.cn)

The Wnt/β-catenin pathway is a extremely conserved, incessantly mutated developmental and most cancers pathway. (medmk.com)

ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)
Antihypertensives that may be given include diuretics, beta-blockers, calcium channel blockers, and ACE inhibitors. (medscape.com)

HelixC is not necessary for β-catenin to function in cell-cell adhesion. (wikipedia.org)

In these vessels, beta-catenin function was dispensable to maintain their structure and state of SMC differentiation. (yu.edu)
We found that the expression of Wnt2b or constitutively active (CA) β-catenin inhibited retinal progenitor gene(RPG) expression and the differentiation of retinal neurons. (biologists.com)
BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. (uchicago.edu)

ab109185 detects the 17 kDa carboxy-terminal subunit (subunit beta). (abcam.com)

At the nuclear periphery, the genome is anchored to A- and B-type nuclear lamins in the form of heterochromatic lamina-associated domains. (frontiersin.org)
The periphery of the mammalian nucleus is delineated by the nuclear envelope and by subjacent domains of compact and repressed heterochromatin separated by more open and active regions in the vicinity of nuclear pores. (frontiersin.org)
(A) Lamina-associated domains (LADs), at the nuclear envelope, schematized from analyses of cell populations using genome-wide approaches such as DamID- or ChIP-sequencing. (frontiersin.org)
This suggests that LADs constitute domains that dynamically anchor to, or detach from, the nuclear lamina. (frontiersin.org)
How NADs arise remains uncertain, but may involve interchangeability of heterochromatic domains between the nuclear envelope and nucleolar borders. (frontiersin.org)

A representative example of a 'druggable' 'hot spots' included specific topological features of the β -catenin interaction. (chemdiv.com)
Each chromosome is differently colored and modeled as a chain of beads, each bead representing a topological domain determined from chromosome conformation capture (Hi-C) data. (frontiersin.org)

Alterations in the localization and expression levels of β-catenin have been associated with various forms of heart disease, including dilated cardiomyopathy. (wikipedia.org)
Alterations in the beta-catenin pathway, which is involved in several epidermal tumors, are thought to play a role. (medscape.com)

Moreover, we identified prostaglandin E receptor 2 (PTGER2) as a regulator of IFN-γ and IL-10 production under a high-salt environment, with skewed activation of the β-catenin-SGK1-Foxo axis. (neurosciencenews.com)

A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. (embl.de)
Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)

beta-catenin, but not E-cadherin, p120(cas) or alpha-catenin, becomes stabilized when proteasome-mediated proteolysis is inhibited and this leads to the accumulation of multi-ubiquitinated forms of beta-catenin. (bioseek.eu)

RNA-sequencing analysis on human Treg subpopulations revealed β-catenin as a key regulator of IFN-γ and IL-10 expression. (neurosciencenews.com)

Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. (cancerindex.org)

This inner surface serves as a ligand-binding site for the various interaction partners of the ARM domains. (wikipedia.org)
The cylindrical structure features a positively charged grove, which presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin. (embl.de)

In cardiac muscle, β-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes. (wikipedia.org)
C-E) Cardiac and liver domains are adjacent in AC/AE conjugates and (F) age matched sibling controls. (xenbase.org)

The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. (embl.de)
The N-terminal fragment of adaptin alpha-C and beta subunits. (eu.org)

This small structural element (HelixC) caps the C-terminal end of the ARM domain, shielding its hydrophobic residues. (wikipedia.org)
Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. (nih.gov)

All the diversity of catenins forms a complex functional network. (chemdiv.com)

Three AC/AE examples are shown demonstrating adjacent expression domains of myl7 in the AC-derived tissue and nr1h5 in the AE-derived component of the explant (12/12 specimens showed the same pattern). (xenbase.org)
We found that beta-catenin expression was undetectable in SMCs of normal arteries. (yu.edu)
Moreover, loss of beta-catenin in vascular SMCs decreased the expression of a set of pro-migration/invasion genes. (yu.edu)
Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis. (nih.gov)
B) The foxq2 expression domain is not restricted in embryos injected with a Wnt1 (b) or Wnt8 (c) morpholino. (echinobase.org)

Large T antigen ) in the absence of Importin subunit beta-1 (KAP95) by hiding of the NLS-binding pocket. (eu.org)
Binding of the IBB of Importin subunit alpha (SRP1) to Importin subunit beta-1 (KAP95) relieves this auto-inhibitory interaction and increases the affinity of Importin subunit alpha (SRP1) for NLS cargo. (eu.org)

[ 7 ] Additionally, a recurrent missense mutation in the kinase domain of the ALPK1 gene has been found in both spiradenomas and spiradenocarcinomas. (medscape.com)

Immunofluorescent analysis of (4% PFA) fixed human liver cancer tissue using CoraLite®555 Beta Catenin antibody (CL555-51067) at dilution of 1:100, CoraLite® Plus 647 CD3 antibody (CL647-60181, Clone: 3F3A1, Magenta), CoraLite® Plus 488 CD163 antibody (CL488-16646, green). (ptglab.com)

Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian and endometrial cancer. (wikipedia.org)
Uclear beta-catenin in about 60 of breast cancers. (scdinhibitor.com)

Yet these intrinsically disordered regions play a crucial role in β-catenin function. (wikipedia.org)

As sketched above, the ARM domain of β-catenin acts as a platform to which specific linear motifs may bind. (wikipedia.org)

Notably, the C-terminal segment of β-catenin can mimic the effects of the entire Wnt pathway if artificially fused to the DNA binding domain of LEF1 transcription factor. (wikipedia.org)

Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)

Our findings reveal a novel PTGER2-β-catenin loop in Treg cells linking environmental high-salt conditions to autoimmunity. (neurosciencenews.com)

In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)

Nonetheless, even essentially the most severely truncated APC variant promotes β-catenin recruitment. (medmk.com)

Anatomy18

Organisms10

Diseases6

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

Protein32

Phosphorylation5

Member of the catenin1

CTNNB11

Regulation6

Proteins9

Signaling24

Signal transduction2

Plakoglobin2

Pathway Activation1

Cadherins3

Destruction5

Evolutionarily conserved1

Intracellular1

Embryonic4

Molecule1

Degradation1

Abstract1

Ligands1

Vertebrate1

Repeats4

Transcriptional1

Pathways3

Wingless2

Inhibits1

Developmental1

Inhibitors2

Cell-cell adhesion1

Differentiation3

Carboxy-terminal1

Nuclear5

Topological2

Alterations2

Activation1

Sequence2

Accumulation1

Regulator1

Receptor1

Interaction partners2

Cardiac2

Fragment2

Structural2

Complex1

Expression5

Subunit beta2

Kinase domain1

Tissue1

Cancers2

Role1

Motifs1

LEF11

Tumor1

Findings1

Bind1

Recruitment1