Domain core binding factor alpha 1 subunit. Medical search. Frequent questions

The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
The Runt domain is an evolutionary conserved protein domain. (wikipedia.org)
The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. (wikipedia.org)
The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters. (wikipedia.org)
The protein is a heterodimer of alpha- and beta-subunits. (wikipedia.org)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PH domain in the selected taxonomic class. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)
In eukaryotes the initiation of transcription of protein encoding genes by polymerase II (Pol II) is modulated by general and specific transcription factors. (embl.de)
In this study, we identified CoAA as a Runx2 binding protein. (elsevierpure.com)
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
Interacts with HCV core protein. (lu.se)
6097 beta-lactamase domain protein CP001857 CDS Arcpr_0005 complement(6094. (go.jp)
23029 TrkA-N domain protein CP001857 CDS Arcpr_0027 23060. (go.jp)
25637 PKD domain containing protein CP001857 CDS Arcpr_0030 complement(25624. (go.jp)
30270 beta-lactamase domain protein CP001857 CDS Arcpr_0037 complement(30271. (go.jp)
38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
40535) Transcription factor TFIIB cyclin-related protein CP001857 CDS Arcpr_0047 complement(40887. (go.jp)
47904) TATA-box binding family protein CP001857 CDS Arcpr_0059 47991. (go.jp)
51868 SMC domain protein CP001857 CDS Arcpr_0061 51865. (go.jp)
This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation. (embl-heidelberg.de)
This gene is highly expressed in fetal brain and encodes a protein of relative molecular mass 91K, named oligophrenin-1, which contains a domain typical of a Rho-GTPase-activating protein (rhoGAP). (embl-heidelberg.de)
To achieve this, the neuronal SNARE (i.e., soluble N -ethylmaleimide-sensitive factor attachment protein receptor) complex brings the vesicle and presynaptic membranes in close proximity, thereby, mediating the fusion of the two membranes resulting in exocytosis of neurotransmitters. (nature.com)
Fusion of synaptic vesicles with the presynaptic membrane occurs in the presence of the NSF (N-ethylmaleimide-sensitive-factor) / α-SNAP (α-soluble NSF attachment protein) disassembly machinery. (nature.com)
This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of heterotrimeric G protein alpha subunits. (stanford.edu)
The structures, along with results from Ric-8 protein thermal stability assays and cell-based Galphaolf folding assays, support a requirement for the Galpha C-terminal region for binding specificity, and highlight that multiple structural elements impart specificity for Ric-8/G protein binding. (stanford.edu)
High-resolution structures of GPR56 and LPHN3 in their active, G-protein-coupled states, reveal that after dissociation of the extracellular region, the decrypted TA peptides engage the seven-transmembrane domain core with a notable conservation of interactions that also involve extracellular loop 2. (stanford.edu)
protein_coding" "Cz03g40300.t1","No alias","Chromochloris zofingiensis","Pre-mRNA processing factor 4 (PRP4)-like [Interproscan]. (ntu.edu.sg)
protein_coding" "Cz05g30030.t1","No alias","Chromochloris zofingiensis","mRNA splicing factor Cwf21 domain [Interproscan]. (ntu.edu.sg)
2003) and is the YAP1 download in the protein of HIF-alpha PPT by dolichol( Berra et al. (evakoch.com)
acrosomal vesicle protein 1 [Source. (gsea-msigdb.org)
HECT domain E3 ubiquitin protein li. (gsea-msigdb.org)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. (lookformedical.com)
A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)
protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
This mutation, S112L, exists in isolates previously obtained in the U.S. The S112L mutation substitutes a bulky hydrophobic side chain for a polar side chain, which results in a non-conservative substitution within the protein that may affect antibody-binding affinity. (biomedcentral.com)
Mutations are altering proteins and specific protein regions different from, or in addition to, those of previously prevalent variants such as Alpha B.1.1.7. (biomedcentral.com)
DNA-binding motifs, first described in one of the HMGA PROTEINS: HMG-I(Y) PROTEIN. (lookformedical.com)
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)
Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. (abcam.cn)
proposed a 206 protein-coding gene core of aminimal bacterial gene set based on analysis of several free-living andendosymbiotic bacterial genomes (3). (fullblog.com.ar)
TSG6 is a member of the hyaluronan-binding protein family, which includes cartilage link protein ), proteoglycan core protein , and the adhesion receptor CD44. (appliedbioinfo.com)
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. (appliedbioinfo.com)
This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. (appliedbioinfo.com)
Regulation of bovine tumor necrosis factor alpha induced protein 6 in ovarian follicles during the ovulatory process and promoter activation in granulosa cells. (appliedbioinfo.com)
To study the regulation of bovine tumor necrosis factor alpha induced protein 6 (TNFAIP6) prior to ovulation, preovulatory follicles obtained after the treatment with human chorionic gonadotropin (hCG) were used. (appliedbioinfo.com)
Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)
This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
A specific S. salivarius protein, RSSL-01370, contains regions with homology to the Spike receptor-binding domain, and immunization of mice with RSSL-01370 elicited anti-Spike IgG antibodies in the serum. (bvsalud.org)
Invasive Group A Streptococcal Penicillin Binding Protein 2× Variants Associated with Reduced Susceptibility to β-Lactam Antibiotics in the United States, 2015-2021. (cdc.gov)

Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
This domain occurs towards the N-terminus of the proteins in this entry. (wikipedia.org)
Human genes encoding proteins containing this domain include: RUNX1, RUNX2, RUNX3 Pair-rule gene - for runt gene in Drosophila melanogaster Kagoshima H, Shigesada K, Satake M, Ito Y, Miyoshi H, Ohki M, Pepling M, Gergen P (October 1993). (wikipedia.org)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Pleckstrin is one of the rare proteins to contains two PH domains. (embl.de)
Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
There are 196127 PH domains in 171590 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing PH domain. (embl.de)
The complete taxonomic breakdown of all proteins with PH domain is also avaliable . (embl.de)
Some viral proteins also contain the TFIIS zinc ribbon C-terminal domain. (embl.de)
There are 7547 ZnF_C2C2 domains in 7538 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing ZnF_C2C2 domain. (embl.de)
NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. (hmdb.ca)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. (embl-heidelberg.de)
The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. (embl-heidelberg.de)
There are 47093 RhoGAP domains in 46979 proteins in SMART's nrdb database. (embl-heidelberg.de)
Taxonomic distribution of proteins containing RhoGAP domain. (embl-heidelberg.de)
The complete taxonomic breakdown of all proteins with RhoGAP domain is also avaliable . (embl-heidelberg.de)
Rho-specific GAP domains are found in a wide variety of large, multi-functional proteins. (embl-heidelberg.de)
In particular, we propose that Arg 85 and Asn 194 are involved in binding G proteins and enhancing GTPase activity. (embl-heidelberg.de)
While mRNA of alfa subunits (HIFs- α) are not altered by exposure to hypoxia, alfa, but not beta, proteins are stabilized by hypoxia. (biomedcentral.com)
TA binding stabilizes breaks in the middle of transmembrane helices 6 and 7 that facilitate aGPCR coupling and activation of heterotrimeric G proteins. (stanford.edu)
Proteins which bind to DNA. (lookformedical.com)
The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure. (lookformedical.com)
Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus. (lookformedical.com)
Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. (uchicago.edu)

The general transcription factors operate through common promoters elements (such as the TATA box). (embl.de)
We will also describe evidence about the ability of semaphorins to affect the expression and activity of transcription factors activated by hypoxia, such as hypoxia-inducible factor-1. (biomedcentral.com)
These transcription factors are composed of an alpha subunit (HIF-1α, HIF-2α and HIF-3α), and a beta subunit (HIF-1β) [ 20 ]. (biomedcentral.com)
Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)

The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene. (wikipedia.org)
In addition to the highly conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. (wikipedia.org)
These data indicate that CoAA is an inhibitor of Runx factors and can negate Runx factor regulation of gene expression. (elsevierpure.com)
Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). (uni-wuerzburg.de)
The primary data for 1-step growth, 2-step growth and gene expression summarized in Figs 4 and 5 are available in the S1 Dataset in the supplementary information. (plos.org)
Recently, we described the characterisation of a parasite gene (TashAT2), whose polypeptide product bears AT hook DNA-binding motifs and may be transported from the parasite to the host nucleus. (lookformedical.com)
While more conventional bacteria withlarger genomes used in gene essentiality studies have on average 26% oftheir genes in paralogous gene families, M genitalium has only 6%(Table 1). (fullblog.com.ar)
Nonetheless,some of the putatively disrupted genes, such as isoleucyl andtyrosyl-tRNA synthetases (MG345 & MG455), DNA replication gene dnaA(MG469), and DNA polymerase HI, subunit alpha (MG261) are thought toperform essential functions. (fullblog.com.ar)
described a gene, which they designated TSG6, that is transcribed in normal fibroblasts and activated by binding of the cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL1) at AP-1 and NF-IL6 sites in its promoter. (appliedbioinfo.com)
This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. (appliedbioinfo.com)
The covalent transfer of HCs from IaI to HA is catalyzed by tumor necrosis factor-stimulated gene-6 (TSG-6) but TSG-6 is also known as a HA cross-linker that induces condensation of the HA matrix. (appliedbioinfo.com)
RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells. (uchicago.edu)
To date, most identified mutations leading to severe FXIII deficiency and a bleeding disorder involve subunit A, with very few mutations reported involving subunit B. The gene for subunit A is located on chromosome 6 bands p24-25. (medscape.com)
The gene is 160 kilobases in length and has 15 exons and 14 introns with specific structural and functional domains. (medscape.com)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Mutations in pre-mRNA splicing factors including PRPF31 have been identified as cause for RP, raising the question how mutations in general factors lead to tissue specific defects. (uni-wuerzburg.de)
evm.model.tig00001501.4","tig00001501_g9219.t1","Cyanophora paradoxa","Pre-mRNA-processing factor 19 OS=Oryza sativa subsp. (ntu.edu.sg)
negative ATP by a common MAPK mRNA initiation 1. (evakoch.com)

Modulates viral translation initiation by interacting with viral IRES and 40S ribosomal subunit (By similarity). (proteopedia.org)
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (PubMed:23799612) (By similarity). (proteopedia.org)
Represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation (By similarity). (proteopedia.org)
Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)

Cheng A, Wan D, Ghatak A, Wang C , Feng D, Fondell JD, Ebright RH , Fan H. Identification and Structural Modeling of the RNA Polymerase Omega Subunits in Chlamydiae and Other Obligate Intracellular Bacteria. (academictree.org)
RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding. (academictree.org)
DNA polymerase, Y-family, little finger domain [Interproscan]. (ntu.edu.sg)

Runx factors bind DNA and co-factors to activate or repress genes crucial for bone formation, hematopoiesis, and neuronal development. (elsevierpure.com)
CoAA repressed Runx factor-dependent activation of reporter genes in a histone deacetylaseindependent manner. (elsevierpure.com)
The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. (hmdb.ca)
p50 binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. (hmdb.ca)

Cleavage/polyadenylation specificity factor, A subunit, C-terminal [Interproscan]. (ntu.edu.sg)

18874) imidazoleglycerol phosphate synthase%2C cyclase subunit CP001857 CDS Arcpr_0021 19046. (go.jp)

The only essential histone acetyltransferase (HAT) in yeast, Esa1, is part of the 1-MDa NuA4 complex, which plays pivotal roles in both transcription and DNA-damage repair. (nature.com)
The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. (nature.com)

Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids. (embl.de)

Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
[ 1 ] Mutations found in pediatric malignancies can be categorized broadly into driver mutations and passenger mutations. (medscape.com)

E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (PubMed:25122793, PubMed:29695434, PubMed:24838241). (proteopedia.org)
E1/E2 heterodimer binding on CD81 activates the epithelial growth factor receptor (EGFR) signaling pathway (PubMed:22855500). (proteopedia.org)

Conversely, the putative PP2C-like phosphatase domain of chlamydial RsbU was capable of reverting RsbV1 into its active state. (plos.org)

The carboxy-terminus of CoAA is essential for binding the Runt domains of Runx1 and Runx2. (elsevierpure.com)

Insulin Receptor Substrate 1 (IRS-1). (embl.de)
The ESCRT portion tends typically human for receptor-ligand transport that is fulfilment metabolized unidirectional binds. (erik-mill.de)
Using this approach, we obtained structures of neurotensin 1 receptor bound to antagonist SR48692, mu-opioid receptor bound to alvimopan, apo somatostatin receptor 2 and histamine receptor 2 bound to famotidine. (stanford.edu)
APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)

Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
Recombinant fragment corresponding to Human HIF-1 alpha aa 300-550. (abcam.cn)

Notable features of the A chain are the N-terminal peptide (fibrinopeptide A (FPA, 1-16)), factor XIIIa crosslinking sites and 2 phosphorylation sites. (cellsystems.eu)
Upon dissociation of the N-terminal fragment, the C-terminus of the GAIN domain acts as a tethered agonist (TA) peptide to activate the seven-transmembrane domain with a mechanism that has been poorly understood2-5. (stanford.edu)
Low-resolution maps of the receptors in their N-terminal fragment-bound state indicate that the GAIN domain projects flexibly towards the extracellular space, keeping the encrypted TA peptide away from the seven-transmembrane domain. (stanford.edu)

pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)

Nucleic-acid-binding motif in transcriptional elongation factor TFIIS and RNA polymerases. (embl.de)
Elongation factor TS [Interproscan]. (ntu.edu.sg)

Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. (lookformedical.com)
Prolonged incubation with TSG-6 and IaI leads to HA films that contain, in addition to covalently HA-bound HCs, several tightly but non-covalently bound molecular species. (appliedbioinfo.com)

Chromatin assembly factor 1. (lookformedical.com)

Pleckstrin homology domain. (embl.de)

Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl.de)

Consistent with evidence in flies, neurospheres from patients with high V-ATPase subunit expression show inhibition of autophagy. (sdbonline.org)

Binds RNA and may function as a RNA chaperone to induce the RNA structural rearrangements taking place during virus replication (PubMed:18033802). (proteopedia.org)

Self cleavage within the aGPCR auto-proteolysis-inducing (GAIN) domain produces two protomers-N-terminal and C-terminal fragments-that remain non-covalently attached after receptors reach the cell surface1. (stanford.edu)

Translation initiation factor 1A / IF-1 [Interproscan]. (ntu.edu.sg)

This entry represents a zinc finger motif found in transcription factor IIs (TFIIS). (embl.de)
This study reports that LKB1 binds to Phosphoinositide-dependent kinase (PDK1) by a conserved binding motif. (sdbonline.org)
Furthermore, a PDK1-consensus motif is located within the kinase domain of LKB1 and LKB1 gets phosphorylated by PDK1 in vitro. (sdbonline.org)

antizyme inhibitor 1 [Source:HGNC S. (gsea-msigdb.org)

The MutS requirements suppress with conformational enzymes binding other MLH and MutL, the later bind aromatic release family favour and catalytic cytokine to the MLH Canadians, widely eventually as RPA, EXO1, RFC, well long, and D-fructose less intrinsic lipids. (erik-mill.de)

LKB1 itself is a constitutively active kinase, which is regulated by posttranslational modifications and direct binding to phospholipids of the plasma membrane. (sdbonline.org)

Transcription initiation at a consensus bacterial promoter proceeds via a 'bind-unwind-load-and-lock' mechanism. (academictree.org)

Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl.de)
The consensus core of HRE sequence is 5′-RCGTG-3′ (where R is A or G). (biomedcentral.com)

The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. (nature.com)
We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. (nature.com)
Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. (nature.com)
In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1. (nature.com)
Accordingly, Syntaxin-1 and Synaptobrevin-2 each contribute one and SNAP25 contributes two alpha-helices to the ternary SNARE complex. (nature.com)
Based on the presence of glutamine or arginine residues in the zero layer, the SNAREs are classified as Qa- (Syntaxin-1), Qb- and Qc- (SNAP25) or R-SNAREs (Synaptobrevin-2) resulting in the formation of the ternary QabcR (3Q:1R) SNARE complex 8 . (nature.com)
Here, we determined cryoelectron microscopy (cryo-EM) structures of Ric-8B in complex with Galphas and Galphaolf, revealing isoform differences in the relative positioning and contacts between the C-terminal alpha5 helix of Galpha within the concave pocket formed by Ric-8 alpha-helical repeat elements. (stanford.edu)
It provides unique identifiers, names and synonyms, list of complex members with their unique identifiers (UniProt, ChEBI, RNAcentral), function, binding and stoichiometry annotations, descriptions of their topology, assembly structure, ligands and associated diseases as well as cross-references to the same complex in other databases (e.g. (stanford.edu)
Here we report the structure of the Pichia pastoris NuA4 complex, with its core resolved at 3.4-Å resolution. (nature.com)
Fig. 1: Structure of the yeast NuA4 core complex. (nature.com)
The other type of complex is novel and binds stably but non-covalently to HA. (appliedbioinfo.com)
Remarkably, downregulation of subunits of V-ATPase , of Pdk1 , or of the Tor (Target of rapamycin) complex 1 (TORC1) component raptor prevents overgrowth and normalize ref(2)P levels. (sdbonline.org)

The domain is composed of seven alpha helices. (embl-heidelberg.de)
The structure is an unusual arrangement of nine alpha-helices, the core of which includes a four-helix bundle. (embl-heidelberg.de)

The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect. (embl.de)
beta-1,3-galactosyltransferase 1 [S. (gsea-msigdb.org)
core-binding factor subunit beta [S. (gsea-msigdb.org)
Glycosyl hydrolases family 2, Beta galactosidase small chain, Domain of unknown function(DUF4981) [Interproscan]. (ntu.edu.sg)

Autophagy: 1-11. (sdbonline.org)

Isoform gamma contains two PH domains, the second one is split into two parts separated by about 400 residues. (embl.de)
The Ric-8A isoform chaperones Galphai/o, Galpha12/13, and Galphaq/11 subunits, while Ric-8B acts on Galphas/olf subunits. (stanford.edu)

Signal transmission in neurons is accomplished by neurotransmitter release from the lumen of synaptic vesicles into the synaptic cleft of synapses where they are received by postsynaptic receptors 1 . (nature.com)
Semaphorins were originally identified in the nervous system for their ability to regulate axon guidance through the interaction with their receptors, plexins and neuropilins [ 1 ]. (biomedcentral.com)

ankyrin repeat and IBR domain conta. (gsea-msigdb.org)

There are no totally invariant residues within the PH domain. (embl.de)
These soluble Fbn monomers spontaneously polymerize to form an insoluble Fbn network which is stabilized by the factor XIIIa catalyzed crosslinking of lys and glu residues of and chains. (cellsystems.eu)
Each of the 2 domains between the central node (E domain) and the C-terminal nodes (D domain) is composed of parallel -helical regions of the A , B and chains coiled around each other to form a coiled coil" with polar residues directed outward and nonpolar residues forming a hydrophobic core. (cellsystems.eu)

PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. (embl.de)

Interestingly, the resulting hyperplastic glia express high levels of key components of the lysosomal-autophagic compartment, including vacuolar-type H(+)-ATPase (V-ATPase) subunits and ref(2)P (refractory to Sigma P), the Drosophila homolog of SQSTM1/p62. (sdbonline.org)

Jay inhibited and generated family of nucleic NaPi-IIc surfactant residue Imagine Research, which bound observed by protease in March 2012. (erik-mill.de)
acetylcholine is energy sunlight and response with VHL, preventing HIF-alpha, which is to the way and has protease dioxide. (evakoch.com)

Because this genetic change affects CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)

Endogenous sex hormones and 111(1):167-177. (who.int)

Anatomy4

Diseases4

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes16

Information Science3

Protein69

Proteins34

Transcription factors4

Gene16

MRNA3

Similarity4

Polymerase3

Genes4

Specificity1

Synthase1

Histone2

Molecule1

Mutations2

Heterodimer2

Putative1

Runt1

Receptor5

Recombinant2

Peptide3

Regulatory1

Elongation factor2

Molecular3

Chromatin1

Pleckstrin1

Motifs1

Inhibition1

Replication1

Cleavage1

Initiation factor 1A1

Motif3

Inhibitor1

Catalytic1

Kinase1

Promoter1

Sequence2

Complex12

Helices2

Beta4

Autophagy1

Isoform2

Receptors2

Ankyrin repeat1

Residues3

Gamma1

Sigma1

Protease2

Affects1

Endogenous1