• polymerase
  • In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). (genome.jp)
  • DNA primase forms a permanent complex with DNA polymerase alpha. (genome.jp)
  • Human DNA polymerase kappa (pol κ) is a translesion synthesis (TLS) polymerase that catalyzes TLS past various minor groove lesions including N 2 -dG linked acrolein- and polycyclic aromatic hydrocarbon-derived adducts, as well as N 2 -dG DNA-DNA interstrand cross-links introduced by the chemotherapeutic agent mitomycin C. It also processes ultraviolet light-induced DNA lesions. (pubmedcentralcanada.ca)
  • form
  • The DNA primase (DnaG) is needed to form RNA primers. (genome.jp)
  • Candesartan cilexetil, manoalide, and MK-886 were selected as proof-of-principle compounds and further characterized for their specificity toward pol κ by primer extension assays using DNAs containing a site-specific acrolein-derived, ring-opened reduced form of γ-HOPdG. (pubmedcentralcanada.ca)