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Muscular Disorders, AtrophicMuscular AtrophyAtrophyEstivationHindlimb SuspensionImmobilizationMuscle, SkeletalMuscle Fibers, SkeletalOptic AtrophyMuscle ProteinsMuscular Atrophy, SpinalMultiple System AtrophySpinal Muscular Atrophies of ChildhoodOlivopontocerebellar AtrophiesGyrate AtrophyUrsidaeHibernationGeographic AtrophyMuscle DenervationSurvival of Motor Neuron 1 ProteinSKP Cullin F-Box Protein LigasesMagnetic Resonance ImagingOptic Atrophy, Autosomal DominantSMN Complex ProteinsHypogravityBed RestOrgan SizeSurvival of Motor Neuron 2 ProteinWeightlessness CountermeasuresQuadriceps MuscleWeightlessnessSpace FlightMyostatinBulbo-Spinal Atrophy, X-LinkedSarcopeniaBrainMuscle Fibers, Slow-TwitchGastritis, AtrophicExerciseMusclesMotor Activity

Skeletal muscleTreat muscle atrophyMuscularMechanically ventilated patientsMuscles atrophyMusculoskeletalInduce muscleExtracellularHypertrophyInducesAcuteOlder adultsSpinalNutritionalDisordersMuscle tissueOccursPromotesMechanismsPeriodsPhenomenonSpaceflightPhysicalRecoveryOrganHumansIllnessGeneticSmallerLossBackPresentHealth

Skeletal muscle11

• This study was performed to evaluate the effects of nandrolone decanoate (ND) on immobilized skeletal muscle atrophy and on bone healing in dogs. (vin.com)
• Mechanisms regulating skeletal muscle growth and atrophy . (nih.gov)
• The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans. (nih.gov)
• Chromium bound to d-phenylalanine minimizes skeletal muscle atrophy associated with long periods of muscle disuse. (greenmedinfo.com)
• Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
• Skeletal muscle disuse atrophy is the decline of muscle mass that occurs after periods of extended bed rest or immobilization. (illinois.edu)
• Transcutaneous electrical stimulation (ES) of human nerves and muscles has long been used as a nonpharmacological treatment for pain relief [1] and/or as a rehabilitation modality to either preserve or restore skeletal muscle mass and function during and after a period of disuse due to injury, surgery or illness [2]. (bmj.com)
• Muscle disuse induces a wide array of structural, biochemical, and neural adaptations in skeletal muscle, which can affect its function. (duke.edu)
• The goal of this study was to determine the direct effect of disuse on the basal phosphate content in skeletal muscle in an animal model, avoiding the confounding effects of injury/surgery. (duke.edu)
• The increase in P(i) with muscle disuse has a significant effect on the cytosolic phosphorylation potential during transient ischemia and increases the intracellular buffering capacity of skeletal muscle. (duke.edu)
• Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy. (harvard.edu)

Treat muscle atrophy1

• Physical therapy interventions are designed to treat muscle atrophy in your legs and help rebuild lost muscle without aggravating your underlying condition. (livestrong.com)

Muscular1

• 728.2 is a legacy non-billable code used to specify a medical diagnosis of muscular wasting and disuse atrophy, not elsewhere classified. (icdlist.com)

Mechanically ventilated patients2

• Atrophy of the diaphragm has been observed in organ donors and in small series of mechanically ventilated patients, and laboratory data suggest that atrophy results from diaphragm inactivity. (atsjournals.org)
• However, the prevalence, magnitude, and impact of diaphragm atrophy in mechanically ventilated patients are unknown, as is whether diaphragm inactivity is an important contributor to this process in the clinical setting. (atsjournals.org)

Muscles atrophy2

• Calf muscles atrophy for a number of reasons. (livestrong.com)
• with time, muscles atrophy. (msdmanuals.com)

Musculoskeletal2

• To gain new insights into the underpinning mechanisms of CP symptoms we investigated the long-term effects of PA and disuse on the hind limb musculoskeletal histology and topographical organization in the primary somatosensory cortex (S1) of adult rats. (cdc.gov)
• Mechanisms and nutritional countermeasures to musculoskeletal disuse atrophy. (bham.ac.uk)

Induce muscle2

• We found that these two factors also induce muscle atrophy in the nematode. (lancs.ac.uk)
• Similarly, in preclinical models treated with multiple intramuscular injections of Botulinum Toxin A to induce muscle weakness and atrophy, there is also an infiltration of the muscle with fat. (scirp.org)

Extracellular1

• Developmental disuse (i.e. hind limb immobilization) associated with PA induced muscle fiber atrophy, extracellular matrix changes in the muscle, and mild to moderate ankle and knee joint degeneration at levels greater than disuse alone. (cdc.gov)

Hypertrophy2

• There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. (frontiersin.org)
• Neural plasticity use hypertrophy and disuse atrophy. (vijayvaani.com)

Induces1

• We found that space microgravity induces muscle atrophy in C. elegans from two independent spaceflight missions. (lancs.ac.uk)

Acute1

• As a comparison to spaceflight-induced muscle atrophy, we assessed the effects of acute nutritional deprivation and muscle disuse on C. elegans muscle cells. (lancs.ac.uk)

Older adults1

• These results represent an important step in the design of a cell-free therapy to recover muscle health in older adults after periods of disuse. (illinois.edu)

Spinal1

• For example, leg muscle atrophy can be caused by a herniated disc, causing pressure on a nerve that feeds your leg muscle as it exits your spinal cord. (livestrong.com)

Nutritional1

• Disuse following leg surgery, disease, nutritional deficiencies and genetic problems can cause the muscles in the calves to become weak and soft. (livestrong.com)

Disorders1

• Neuroscience 129, 141-156, CP-like movement disorders were more reliably reproduced in rats by hind limb sensorimotor restriction (disuse) during development rather than perinatal asphyxia (PA). (cdc.gov)

Muscle tissue2

• Muscle atrophy in the legs is a loss of muscle tissue due to disuse, disease or injury. (livestrong.com)
• Atrophy may result from diseases intrinsic to muscle tissue (e.g. (bvsalud.org)

Occurs1

• The bone alveolar reabsortion occurs after lost dental by many factors such as: exodontic, traumatism, pathologic process or even atrophy due to disuse. (bvsalud.org)

Promotes1

• Finally, we identified clp-4, which encodes a calpain protease that promotes muscle atrophy. (lancs.ac.uk)

Mechanisms1

• This review will focus on muscle deterioration with ageing and highlight the two underpinning mechanisms regulating declines in muscle mass and function: muscle fibre atrophy and muscle fibre loss (hypoplasia) - and their measurement. (nih.gov)

Periods1

• Therefore, it is necessary to develop novel approaches to facilitate recovery of muscle mass and function after periods of disuse. (illinois.edu)

Phenomenon1

• This phenomenon is called disuse atrophy. (wikipedia.org)

Spaceflight2

• Astronauts experience muscle atrophy after spaceflight, but the exact reasons for this and solutions are unknown. (lancs.ac.uk)
• This muscle atrophy is a known problem in spaceflight. (scrippsnews.com)

Physical3

• Atrophy i.e. wasting and weakening of the muscles is very common after this surgery due to surgical shock and lack of physical activity due to an underlying health condition or after surgery with post-operative precautions as advised by the surgeon. (advancedpmr.com)
• Even after muscle loss, the atrophy in your legs can be reversed through physical activity. (livestrong.com)
• Increasing physical activity is the key to both preventing and treating muscle atrophy in your legs. (livestrong.com)

Recovery1

• What was the mechanistic basis by which pericyte transplantation assisted in the recovery of muscle after disuse? (illinois.edu)

Organ1

• The loss of an organ in evolution purely as a result of disuse, also called Lamarckian Evolution, has now been thoroughly disproved. (creation.com)

Humans1

• Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. (atsjournals.org)

Illness2

• Atrophy can occur more suddenly with illness or injury to the muscles or their nerves, and the muscles in the legs are among the first to weaken. (livestrong.com)
• Muscle atrophy, or muscle loss, can occur with disuse of your legs during extended illness or because of underlying medical conditions. (livestrong.com)

Genetic1

• Such comparative analyses of different factors causing muscle atrophy in C. elegans could provide a way to identify novel genetic factors regulating space microgravity-induced muscle atrophy. (lancs.ac.uk)

Smaller1

• Generally, people become less active as they get older and muscles will atrophy (get smaller) from this disuse. (yogilates.com)

Loss1

• Many researchers have reported that atrophy is accompanied by the dramatic loss of myonuclei via apoptosis. (frontiersin.org)

Back1

• The muscles that stabilize the back shrink from disuse after months in space. (scrippsnews.com)

Present1

• The present study suggested that ND was effective for immobilized disuse muscle atrophy in dogs. (vin.com)

Health1

• The consequences of atrophy have obvious implications for health. (frontiersin.org)