• Dihydrolipoamide dehydrogenase (DLD), also known as dihydrolipoyl dehydrogenase, mitochondrial, is an enzyme that in humans is encoded by the DLD gene. (wikipedia.org)
  • dihydrolipoyl dehydrogenase [Ensembl]. (ntu.edu.sg)
  • DLDH_CANFA Dihydrolipoyl dehydrogenase, mit. (nig.ac.jp)
  • DLDH_MOUSE Dihydrolipoyl dehydrogenase, mit. (nig.ac.jp)
  • DLHD_MANSE Dihydrolipoyl dehydrogenase (Dih. (nig.ac.jp)
  • DLDH_PEA Dihydrolipoyl dehydrogenase, mito. (nig.ac.jp)
  • Isolation and sequence determination of cDNA clones for porcine and human lipoamide dehydrogenase. (wikipedia.org)
  • lipoamide dehydrogenase [Sus scrofa. (nig.ac.jp)
  • lipoamide dehydrogenase [Capsicum ann. (nig.ac.jp)
  • The in situ enzymatic digestion of the two proteins separated in 2D-SDS-PAGE gels, followed by microsequencing of the peptides, resulted in the identification of these two proteins as related to human lipoamide dehydrogenase and thiol: protein disulfide oxidoreductase (TPDO). (psu.edu)
  • In common, both these proteins have a bis (cysteinyl) sequence motif cys-X-X-cys (for lipoamide dehydrogenase it is cys-X-X-X-X-cys) which is also an integral part of several other proteins such as thioredoxin, protein disulfide isomerase, endoplasmic reticulum protein (ERp72), selenoprotein W, 56 kDa acetaminophen binding protein and formate dehydrogenase. (psu.edu)
  • Additionally, DLD is a flavoenzyme oxidoreductase that contains a reactive disulfide bridge and a FAD cofactor that are directly involved in catalysis. (wikipedia.org)
  • Pyridine nucleotide-disulphide oxidoreductase [Interproscan]. (ntu.edu.sg)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • Aldehyde dehydrogenase family, Iron-containing alcohol dehydrogenase [Interproscan]. (ntu.edu.sg)
  • short chain dehydrogenase [Interproscan]. (ntu.edu.sg)
  • Lipoamide Dihydrolipoamide The protein encoded by the DLD gene comes together with another protein to form a dimer in the central metabolic pathway. (wikipedia.org)
  • DLD deficiency manifests itself in a great degree of variability, which has been attributed to varying effects of different DLD mutations on the stability of the protein and its ability to dimerize or interact with other components of the three α-ketoacid dehydrogenase complexes. (wikipedia.org)
  • Glyceraldehyde 3-phosphate dehydrogenase [Interproscan]. (ntu.edu.sg)
  • Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase [Ensembl]. (ntu.edu.sg)
  • Dihydrolipoamide dehydrogenase [Ensembl]. (ntu.edu.sg)
  • Acidification of the mitochondrial matrix, as a result of ischemia-reperfusion injury, can disrupt the quaternary structure of DLD leading to decreased dehydrogenase activity and increased diaphorase activity. (wikipedia.org)
  • The dihyrolipamide dehydrogenase gene is known to have multiple splice variants. (wikipedia.org)
  • DLD is a flavoprotein enzyme that oxidizes dihydrolipoamide to lipoamide. (wikipedia.org)
  • The DLD homodimer functions as the E3 component of the pyruvate, α-ketoglutarate, α-adipate and branched-chain amino acid-dehydrogenase complexes and the glycine cleavage system, all in the mitochondrial matrix. (wikipedia.org)
  • Dihydrolipoamide dehydrogenase (DLD) is a mitochondrial enzyme that plays a vital role in energy metabolism in eukaryotes. (wikipedia.org)
  • Acetoin dehydrogenase E3 component (dihydrolipoamide. (ntu.edu.sg)
  • The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex. (yeastrc.org)
  • Dichloroacetate (DCA) is a structural analog of pyruvate that has been recommended for the treatment of primary lactic acidemia, particularly in patients with pyruvate dehydrogenase (PDHC) deficiency. (nature.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Pyruvate Dehydrogenase Alpha (PDHa) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (ksiazkiwnauce.pl)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Pyruvate Dehydrogenase Alpha (PDHa) in samples from tissue homogenates, cell lysates or other biological fluids. (ksiazkiwnauce.pl)
  • Dihydrolipoamide dehydrogenase (DLD), also known as dihydrolipoyl dehydrogenase, mitochondrial, is an enzyme that in humans is encoded by the DLD gene. (wikipedia.org)
  • Dihydrolipoamide dehydrogenase (DLD) is a mitochondrial enzyme that plays a vital role in energy metabolism in eukaryotes. (wikipedia.org)
  • The DLD homodimer functions as the E3 component of the pyruvate, α-ketoglutarate, α-adipate and branched-chain amino acid-dehydrogenase complexes and the glycine cleavage system, all in the mitochondrial matrix. (wikipedia.org)
  • Acidification of the mitochondrial matrix, as a result of ischemia-reperfusion injury, can disrupt the quaternary structure of DLD leading to decreased dehydrogenase activity and increased diaphorase activity. (wikipedia.org)
  • Human dihydrolipoamide dehydrogenase (hE3) is an enzymatic component common to the mitochondrial alpha-ketoacid dehydrogenase and glycine decarboxylase complexes. (nih.gov)
  • Dihydrolipoamide often locates in Mitochondria, Mitochondrial matrix and Chloroplasts. (cmdm.tw)
  • Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. (cmdm.tw)
  • Guo S, Popowicz GM, Li D, Yuan D, Wang Y, Lid mobility in lipase SMG1 validated using a thiol/disulfide redox potential probe. (whispermovie.com)
  • The three-dimensional solution structure of a 51-residue synthetic peptide comprising the dihydrolipoamide dehydrogenase (E3)-binding domain of the dihydrolipoamide succinyltransferase (E2) core of the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli has been determined by nuclear magnetic resonance spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations. (nih.gov)
  • dihydrolipoamide branched chain acyltransferase activity. (yeastrc.org)
  • To catalyze the oxidation of dihydrolipoamide, hE3 uses two molecules: non-covalently bound FAD and a transiently bound substrate, NAD+. (nih.gov)