DesorptionQuadrupole massChromatography-mass spectrometryCharacterizationProteinsMolecularLiquidDESIMetabolitesSpectrometerProteomicQuantitative AnalysisAnalyticalLAESIStructuralAnalysisPositive ionSpectrometricSolid-phase extrDetectionOrganismsMatricesSpatial DistributionDetectorsSpeciesReaction2017CompoundsTandem massAdvancesStudyRapidRangeTissuesClassificationResearchDevelopmentJournalSurfacesTissue
Desorption15
- Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI). (wikipedia.org)
- Arbejdet omfatter især anvendelse og udvikling af teknikker til at lave billeder af kemiske forbindelse i biologiske prøver ved brug af massespektrometri (billeddannende massespektrometri, MSI), hvor jeg arbejder med teknikkerne Desorption Electrospray Ionization (DESI) MSI og Matrix Assisted Laser Desorption Ionization (MALDI)-MSI. (ku.dk)
- More specifically, I am working with the two techniques Desorption Electrospray Ionization (DESI) MSI og Matrix Assisted Laser Desorption Ionization (MALDI)-MSI. (ku.dk)
- Slide 4: Desorption electrospray ionization- mass spectrometry imaging (DESI-MSI) on a female mouse heart reveals specific distribution of metabolites. (columbia.edu)
- Desorption electrospray ionization- mass spectrometry imaging (DESI-MSI) on a female mouse heart reveals specific distribution of metabolites. (columbia.edu)
- Application of mass spectrometry to the characterization of compounds with molecular weights greater than 1000 Da was rare prior to the development of desorption ionization methods. (docksci.com)
- More recently, matrix-assisted laser desorption [S, 91 and electrospray ionization (ESI) [lo-121 processes have appeared as new technology for high-mass analysis by mass spectrometry. (docksci.com)
- By utilizing a cutting-edge technique called desorption electrospray ionization mass spectrometry imaging (DESI-MSI), they have identified diacylglycerols as potent biomarkers for the rapid detection of breast cancer. (chromatographyonline.com)
- Desorption electrospray ionization-mass spectrometry imaging of carnitine and imidazole dipeptides in pork chop tissues. (laboratory-of-food-science-teikyo-university.com)
- Unique localization of jasmonic acid-related compounds in developing Phaseolus vulgaris L. (common bean) seeds revealed through desorption electrospray ionization-mass spectrometry imaging. (laboratory-of-food-science-teikyo-university.com)
- Spatial analysis of phosphatidylinositol molecular species in pork chop tissues using matrix-assisted laser desorption/ionization-mass spectrometry imaging. (laboratory-of-food-science-teikyo-university.com)
- Adhesive film applications help to prepare strawberry fruit sections for desorption electrospray ionization-mass spectrometry imaging. (laboratory-of-food-science-teikyo-university.com)
- The Clinical Pharmacology Core has recently installed a novel analytical instrument for mass spectrometry imaging (MSI) of biological matrices based on infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI). (unccfar.org)
- Dickinson, Zare, and Noll adapted the technology-called "desorption electrospray ionization mass spectrometry imaging" or DESI -MSI-to probe plant roots for the chemicals involved in growth and energy production. (scitechdaily.com)
- MALDI (Matrix Assisted Laser Desorption/Ionization) tandem mass spectrometer specially designed for automated MS and MS/MS high throughput identification of proteins and peptides. (coremarketplace.org)
Quadrupole mass3
- The confirmation method is a liquid-liquid extraction with detection by liquid chromatography triple quadrupole mass spectrometry using electrospray ionization in multiple reaction monitoring mode. (erowid.org)
- Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS) Normal mass spectra and ion mobility experiments were performed on an instrument IL-13 Purity & Documentation constructed "in-house" that comprises a nano-electrospray ionization (N-ESI) supply, an ion funnel, a temperature-controlled drift cell as well as a quadrupole mass filter followed by an electron multiplier for ion detection (24). (rockinhibitor.com)
- Single quadrupole mass spectrometer is used for fragment spectra for volatile compounds. (coremarketplace.org)
Chromatography-mass spectrometry4
- High-efficiency headspace sampling of volatile organic compounds in explosives using capillary microextraction of volatiles (CMV) coupled to gas chromatography-mass spectrometry (GC-MS) . 406:2189-2195. (fiu.edu)
- Interestingly, gas chromatography-mass spectrometry (GC-MS) and positive ion electrospray high resolution mass spectrometry (ESI+-HRMS) analyses showed that both the MI and DI subfractions were lignin-derived oligomers, which accounted for 25.0% of the total mass of the original PO. (ncsu.edu)
- Interestingly, gas chromatography-mass spectrometry (GC-MS) and positive ion electrospray high resolution mass spectrometry (ESI + -HRMS) analyses showed that both the MI and DI subfractions were lignin-derived oligomers, which accounted for 25.0% of the total mass of the original PO. (ncsu.edu)
- Distribution analysis of jasmonic acid-related compounds in developing Glycine max L. (soybean) seeds using mass spectrometry imaging and liquid chromatography-mass spectrometry. (laboratory-of-food-science-teikyo-university.com)
Characterization3
- Cell-Lineage Guided Mass Spectrometry Proteomics in the Developing (Frog) Embryo Aparna B. Baxi 1,2 , Leena R. Pade 1 , Peter Nemes 1,2 1 Department of Chemistry & Biochemistry, University of Maryland, 2 Department of Anatomy & Cell Biology, The George Washington University Here we describe a mass spectrometry-based proteomic characterization of cell lineages with known tissue fates in the vertebrate Xenopus laevis embryo. (jove.com)
- Modern analytical techniques have been applied in structural characterization of ARPs, such as circular dichroism, infrared spectroscopy, fluorescence spectroscopy, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy [ 12 ]. (hindawi.com)
- Mass spectrometer that is designed for automated protein identification and characterization, biomarker detection, oligonucleotide quality control, and SNP genotyping. (coremarketplace.org)
Proteins1
- Molecular imaging by mass spectrometry (MS) is emerging as a tool to determine the distribution of proteins, lipids, and metabolites in tissues. (bindesh.com)
Molecular9
- He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry. (wikipedia.org)
- One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS. (wikipedia.org)
- This means that we can now investigate molecular distributions on a much bigger range of accessible surfaces. (labmanager.com)
- Electrospray ionization mass spectrometry (ESI-MS) analysis of filter-collected particles indicates the formation of high molecular weight products. (chemistryviews.org)
- They include high-molecular mass drugs comprising polymers of nucleotides, i.e. (technologynetworks.com)
- DESI-MSI has been utilized in a wide range of applications, including cancer diagnostics, drug distribution studies, and environmental analysis, contributing to our understanding of molecular composition and spatial distribution in complex samples. (chromatographyonline.com)
- Lipid entities revealed by mass spectrometry and associated with development of therapy resistance can thus support molecular diagnosis and provide a potential complementary cancer biomarker. (unica.it)
- Liquid chromatography/adverse electrospray ionization mass spectrometry [LC/(-)ESI-MS] is routinely employed to characterize the id and abundance of molecular merchandise in secondary natural aerosol (SOA) derived from monoterpene oxidation. (chipab.com)
- Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry Nature Communications, 13(), 5884. (coremarketplace.org)
Liquid8
- In this study, we applied two-dimensional liquid chromatography electrospray ionization tandem mass spectrometry (2D LC-MS/MS) to characterize the protein profiles of M. gallinarum. (usda.gov)
- In this study, an efficient and simple method was developed and validated for the first time to analyze six OAs in bakery products by high-performance liquid chromatography-tandem mass spectrometry. (bvsalud.org)
- The morphological characteristics and endogenous hormone contents of normal roots (no root cutting, CK) and cut roots (cut by 1/3 of the length of the main root, RP) were determined by liquid chromatography, which was combined with mass spectrometry at different levels of different developmental stages. (techscience.com)
- The N-methylated tryptamine derivatives were identified and quantitated in leaves, peel, juice, and seeds by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. (dmt-nexus.me)
- The method is based on the solid phase extraction (SPE) of the analytes by a styrene-divinylbenzene (SDB) copolymer material, and the analysis by liquid chromatography-electrospray ionization tandem mass-spectrometry (LC-ESI- MS/MS). The sensitivity in negative ionization mode was considerably enhanced by postcolumn addition of the alkaline modifier tris(hydroxymethyl) aminomethane. (leuphana.de)
- Determination of alachlor and its metabolites in rat plasma and urine using solid phase extraction and liquid chromatography/electrospray ionization-mass spectrometry. (cdc.gov)
- Measurement of folic acid and 5-methyltetrahydrofolate (5-methylTHF) in a subset of stored serum samples from NHANES 2001-2002 to allow comparison of CDC liquid chromatography tandem mass spectrometry (LC-MS/MS) method to data generated previously by Tufts University HPLC method with electrochemical detection. (cdc.gov)
- An isotope-dilution tandem mass spectrometry method coupled to liquid chromatography (LC-MS/MS) was used to measure folate forms in serum. (cdc.gov)
DESI1
- The imaging aspect of DESI-MSI allows for the spatial distribution of molecules to be mapped, providing valuable information about their localization within a sample. (chromatographyonline.com)
Metabolites1
- The OPLS-DA analysis of mass spectra, containing over 300 peaks each, provided guidance in identifying a small number of metabolites most responsible for the variance between the cell populations. (bindesh.com)
Spectrometer8
- The formed cloud is subsequently ionized by an electrically charged mist to make the vapor contents detectable in a mass spectrometer. (labmanager.com)
- For MALDI-MSI the group has a special MALDI instrument, which by means of sophisticated laser optics and an excellent Orbitrap mass spectrometer enables imaging of biological samples with a very high detail level and very accurate identification of chemical compounds in the sample. (ku.dk)
- It involves the use of a high-energy spray of charged solvent droplets that desorb and ionize molecules from the sample, which are then transferred into a mass spectrometer for analysis. (chromatographyonline.com)
- The high-resolution 13C isotope distributions for every peak in the mass spectra were obtained on a Q-TOF mass spectrometer (Micromass, UK) equipped with an N-ESI supply (25, 26). (rockinhibitor.com)
- A mass spectrometer collects the droplet splash and tells us what those dissolved chemicals are. (scitechdaily.com)
- Benchtop Q-Tof mass spectrometer for small molecule accurate mass determination (HRMS), intact protein analysis, and peptide mapping. (coremarketplace.org)
- Tandem Mass Spectrometry is a technique that utilizes more than one mass selective stage in a mass spectrometer. (coremarketplace.org)
- Synapt G2 Mass Spectrometry (MS) system is a hybrid, quadrapole/orthogonal acceleration, time-of-flight (oa-TOF) mass spectrometer controlled by MassLynx software. (coremarketplace.org)
Proteomic1
- Heeren's academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry-based proteomic imaging techniques for the life sciences. (wikipedia.org)
Quantitative Analysis1
- As the last installment of 'Mass Spectrometry Forum' stated (3): 'In a quantitative analysis using values measured with mass spectrometry [MS] - usually values associated with ion intensities - a nonlinear regression (weighted or nonweighted) might model the proportionality between measured instrument response and sample amount more accurately. (spectroscopyonline.com)
Analytical2
- Analytical techniques, for example chromatography and mass spectrometry, along with various tools such as cloning, CRISPR/Cas, single-use equipment, machine learning [and] use of advanced sensors and automation have helped in the advancement of biopharma research," said Dr. Johannes Buyel , head of the department of Bioprocess Engineering at the Fraunhofer IME and associate professor at the RWTH Aachen University. (technologynetworks.com)
- Mass spectrometry is the favored analytical technology for SL analysis. (encyclopedia.pub)
LAESI4
- Custom-built laser source for mass spectrometry imaging: By means of improved Laser Ablation Electrospray Ionization (LAESI) the surfaces of non-flat samples-for example this coarse piece of savoy cabbage-can now be chemically analyzed. (labmanager.com)
- Laser ablation electrospray ionization (LAESI) is a method that can be applied in mass spectrometry imaging to investigate the distribution of many different chemical compounds found in a biological sample. (labmanager.com)
- Benjamin Bartels and Aleš Svatoš, who heads the Mass Spectrometry Research Group, have therefore adapted the LAESI technique to non-flat surfaces to open up the possibility of performing chemical imaging of samples with pronounced three-dimensional shapes while maintaining the reliability of classical measurements. (labmanager.com)
- Here we demonstrate that laser ablation electrospray ionization (LAESI) MS can be utilized for in situ cell-by-cell imaging of plant tissues. (bindesh.com)
Structural1
- Mass spectrometry exhibits a variety of unique capabilities for a broad range of applications and is commonly used for solving bioanalytical problems when high sensitivity and structural information are required [13]. (docksci.com)
Analysis9
- This strategy has been successfully from large groupings of organisms, electrospray ionization used with consensus 16S ribosomal RNA primers for deter- mass spectrometry for accurate mass measurements of PCR products, and base composition signature analysis to mining bacterial diversity, both in environmental samples identify organisms in a sample. (cdc.gov)
- Typical preparation steps include sectioning a sample into thin, flat slices because flatness is required to guarantee optimal laser focus, a key parameter in reliable analysis," Benjamin Bartels, the first author of the study and PhD student in the Mass Spectrometry Research Group, points out. (labmanager.com)
- I am working with instrumental development of mass spectrometry for use in pharmaceutical analysis. (ku.dk)
- At present, mass spectrometric analysis of lipid extracts, mainly by infusion electrospray ionization, is utilized to determine sensitive and quantitative information of specific SLs in biological processes. (encyclopedia.pub)
- Our objective is to diagnose infectious diseases, with a focus on pneumonia, by combining our high resolution/high mass accuracy real-time breath analysis technology combined with Artificial Intelligence to provide a positive/negative response within 15 minutes. (sinueslab.ch)
- The key to the detection of the IFN-y dimer is the use of an alkaline solution (pH -9) for sample preparation and for mass spectrornetry analysis. (docksci.com)
- The obvious advantage is that a protein sample can be introduced directly from solution in its biologically active form for mass spectrometry analysis. (docksci.com)
- The experimental conditions have been further refined by the use of a biological buffer solution to stabilize the noncovalent complexes of rus~GDP and ras-GTP in solution prior to mass spectrometry analysis [25]. (docksci.com)
- Combines quadrupole, ion trap, and Orbitrap mass analysis into Tribrid architecture to provide depth of analysis. (coremarketplace.org)
Positive ion1
- Gilson Inc.). Samples were eluted from the SPE plate with an organic elution buffer containing ascorbic acid and analyzed overnight by LC-MS/MS in positive ion mode using electrospray ionization on an AB Sciex 5500 triple-quadrupole MS system (Applied Biosystems) coupled to a HP1200C LC system (Agilent Technologies). (cdc.gov)
Spectrometric1
- 2011. Sequence-Specific Capture of Protein-DNA Complexes for Mass Spectrometric Protein Identification . (wisc.edu)
Solid-phase extr1
- METHODS The phospholipid content of cell membranes of cancer cell lines CCRF-CEM and A2780, both responsive and resistant to cisplatin, was analysed by solid phase extraction (SPE) and electrospray ionization mass spectrometry (ESI-MS and tandem MS-MS). Extracts were obtained by disruption of cells with a dounce tissue grinder set followed by centrifugation. (unica.it)
Detection1
- A number of byproducts were identified by HPLC electrospray ionization tandem mass spectrometry after a post-extraction cleanup based on a molecularly imprinted polymer phase, for a more accurate detection. (mipdatabase.com)
Organisms2
- Because of this wide host distribution and the organisms low pathogenesis together with the weak immunological response it induces, the study of its protein profiles may aid in our understanding of why other poultry mycoplasmas are very pathogenic. (usda.gov)
- We prior knowledge of nucleic acid sequence information is use broad-range PCR to generate amplification products required to develop these tests, they are not able to identi- from the broadest possible grouping of organisms, followed fy unanticipated, newly emergent, or previously unknown by electrospray ionization mass spectrometry and base infectious organisms. (cdc.gov)
Matrices1
- Data will be presented on the distribution of some of these cathinones in various matrices. (erowid.org)
Spatial Distribution2
- The Spatial Distribution of Alkaloids in Psychotria prunifolia (Kunth) Steyerm and Palicourea coriacea (Cham. (ku.dk)
- Chemical imaging using single-cells as voxels reflects the spatial distribution of biochemical differences within a tissue without the distortion stemming from sampling multiple cells within the laser focal spot. (bindesh.com)
Detectors2
- Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. (wikipedia.org)
- The H2 Receptor Species intensity correlation function and the diffusion coefficient (D) frequency distribution had been determined applying Precision Deconvolve application (Precision Detectors, Bellingham, MA). (rockinhibitor.com)
Species1
- Aerosol mass spectrometry (AMS) measurements indicated a large contribution of particulate chlorine species. (chemistryviews.org)
Reaction1
- The team measured limonene and its volatile reaction products online with proton transfer reaction mass spectrometry (PTR-MS). They characterized the particles by the evolution of their size distribution and composition with both online and off-line techniques. (chemistryviews.org)
20171
- He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017. (wikipedia.org)
Compounds3
- The distribution of chemical compounds in flowers, leaves, stalks, and other parts of a plant are of major importance in ecological research. (labmanager.com)
- In particular, the work comprises idevelopment and application of techniques for imaging of chemical compounds in biological samples by means of mass spectrometry (mass spectrometry imaging, MSI). (ku.dk)
- In addition, the study of the distribution of tryptophan, tryptamine, N-methyltryptamine, N,N-dimethyltryptamine, and N,N,N-trimethyltryptamine indicated that these compounds are differently expressed in the various tissues of the bergamot plant. (dmt-nexus.me)
Tandem mass1
- 2011. Discovery of Neuropeptides in the Nematode Ascaris suum by Database Mining and Tandem Mass Spectrometry . (wisc.edu)
Advances1
- S ome of the most significant advances in mass spectrometry technology in recent years have been in the development and application of new ionization techniques. (docksci.com)
Study3
- He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions. (wikipedia.org)
- While working as a visiting scientist at Stanford University , Dickinson began collaborating with study co-first author Sarah Noll and Professor Richard Zare, who developed a mass spectrometry imaging system that helps surgeons distinguish between cancerous and benign tissue during tumor-removal operations. (scitechdaily.com)
- Coming into the study, the researchers expected a relatively uniform distribution of chemicals. (scitechdaily.com)
Rapid2
- JOURNAL INFO: Rapid communications in mass spectrometry: RCM 23 (17), 2839-2845YEAR: 2009LINK. (sinueslab.ch)
- Researchers have discovered diacylglycerols as potent biomarkers for the rapid diagnosis of breast cancer, using mass spectrometry imaging. (chromatographyonline.com)
Range3
- 0 1993American Society 104&0305/93/$6.00 for Mass Spectrometry range of mass spectrometry applications to the field of biomedical research [ 166201. (docksci.com)
- The 1H NMR spectral range of 1 includes a indication distribution Bemegride in keeping with an acylated peptide, filled with signals in locations for alpha- and beta-carbon protons, aswell simply because additional methylene and methyl signals and oxygenated methine and methylene signals. (engineering-gdfsuez.com)
- Samples were selected based on their folic acid concentration (as measured in a previous surplus specimen project by Tufts University) to ensure a folic acid distribution throughout the reported concentration range. (cdc.gov)
Tissues1
- Mass spectrometry imaging of diacyl-, alkylacyl-, and plasmalogen-phosphatidylethanolamines in pork chop tissues. (laboratory-of-food-science-teikyo-university.com)
Classification1
- Various descriptive classification systems were proposed based on the organ distribution of amyloid deposits and clinical findings. (medscape.com)
Research3
- He led a FOM-AMOLF research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995-2014). (wikipedia.org)
- The newly developed technique of ES/MS, which allows the formation of gas-phase macromolecular ions directly from solution at atmospheric pressure via ion evaporation 114, 151, represents an important advancement in mass spectrometry technology that significantly extends the Address reprint requests to Birendra N. Pramanik, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033. (docksci.com)
- However, the latest research offers a promising solution by harnessing the power of mass spectrometry imaging. (chromatographyonline.com)
Development1
- They developed a "chemical roadmap" detailing the distribution of critical small molecules along the plant's stem cells and their impact on the plant's development. (scitechdaily.com)
Journal2
- Journal of The American Society for Mass Spectrometry. (wikipedia.org)
- International Journal of Mass Spectrometry. (wisc.edu)
Surfaces1
- Researchers at the Max Planck Institute for Chemical Ecology in Jena, Germany, have now improved mass spectrometry imaging in such a way that the distribution of molecules can also be visualized on rippled, hairy, bulgy, or coarse surfaces. (labmanager.com)
Tissue1
- By combining the resulting maps of analyte distribution with serial images of tissue morphology and immunohistochemistry, drug penetration to sites of action and therapeutic efficacy can be evaluated. (unccfar.org)