AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation Science
ChromosomesChromosomes, Human, YChromosome MappingY ChromosomeX ChromosomeChromosome BandingSex ChromosomesChromosome AberrationsChromosomes, Human, Pair 1Chromosomes, HumanChromosome DeletionChromosomes, BacterialChromosome SegregationChromosomes, Human, Pair 7Chromosomes, Human, Pair 11Chromosomes, Human, Pair 17Chromosomes, Human, Pair 6Chromosomes, Human, Pair 9Receptors, Neuropeptide YChromosomes, Human, Pair 21Chromosomes, PlantChromosomes, FungalChromosomes, Human, 6-12 and XChromosomes, Human, Pair 2Chromosomes, Human, Pair 16Chromosomes, Human, Pair 22Chromosome PairingChromosomes, MammalianChromosomes, Human, Pair 13Chromosomes, Human, Pair 4Chromosomes, Human, Pair 10Seminal Plasma ProteinsChromosomes, Human, Pair 8Chromosomes, Human, Pair 19In Situ Hybridization, FluorescenceChromosome DisordersChromosomes, Human, XChromosomes, Artificial, BacterialGenes, Y-LinkedChromosomes, Human, 1-3Chromosome PaintingChromosomes, Human, Pair 12Chromosomes, Human, Pair 5Chromosomes, Human, Pair 15Genetic MarkersKaryotypingMolecular Sequence DataChromosomes, Human, Pair 14Chromosomes, Human, Pair 18Chromosomes, Human, 16-18Chromosomes, Human, Pair 20Chromosomes, Artificial, YeastBase SequenceGenes, sryChromosomes, Human, 13-15Sequence Tagged SitesGenetic LinkageChromosome BreakageChromosomes, Human, 21-22 and YRing ChromosomesMicrosatellite RepeatsChromosome InversionChromosome PositioningRecombination, GeneticChromosomes, Human, 4-5HaplotypesX Chromosome InactivationEvolution, MolecularRetinoblastomaCentromereGenetic LociMutationGonadal DysgenesisOligospermiaChromosomes, InsectTranslocation, GeneticMeiosisHybrid CellsGenetic VariationChromosomes, Human, 19-20Chromosome StructuresCloning, MolecularAneuploidyMetaphaseMitosisInfertility, MaleSex-Determining Region Y ProteinPolymorphism, GeneticSex Chromosome AberrationsRepetitive Sequences, Nucleic AcidDNASex Determination AnalysisAmino Acid SequenceLod ScoreRNA, Small CytoplasmicCrosses, GeneticModels, GeneticPedigreeGene DuplicationSequence Analysis, DNA
MitosisGenesHomologous chromosomesNucleusChromosomalZygotePairsSegregationLocus on chromosomeInterphaseCellsOrganismCancerGenetically distinctGeneticsTranslocationPopulationsMitoticGenomeDifferCharacteristicsLociMechanismsAbnormalitiesSpermGenomicMicronucleiProteinsGene ExpressionIndependent assortmentMeioticSequenceMeiosisEmbryoAssemblyProgenitorCell proliferationAdenocarcinomaEncodesConsistsSpermatogenesisIdenticalGenetic materialOccurVariantConsortiumEvidenceEmbryosProteinProbesCharacterizationEvolutionRevealsFoundComes into existenceMalesAdultClusterImplicationsStructuralPseudogene
Mitosis8
Genes16
  • Not only do they possess genes controlling sex determination that are restricted to either the X or Y (or Z or W) chromosomes, but in many taxa they also include recombining regions. (nih.gov)
  • It is now clear that the evolution of the PAR differs in important ways from that of genes in either the non-recombining regions of sex chromosomes or the autosomes. (nih.gov)
  • Different family members are highly related products of distinct genes, and are usually expressed together. (nih.gov)
  • This is essential in determining the genes carried by a gamete, as each will solely obtain one of many two homologous chromosomes. (styleslicker.com)
  • In a directed manner we manipulate genes that we know or suspect will influence the structure of chromosomes, then assess the consequences of these changes. (wesleyan.edu)
  • Each chromosome contains many genes, the basic physical and functional units of heredity. (jainworld.com)
  • Genes comprise only about 2% of the human genome, the remainder consists of non coding regions, whose functions may include providing chromosomal structural integrity and regulating where, when and in what quantity proteins are made. (jainworld.com)
  • The human genome is estimated to contain about 30000 genes. (jainworld.com)
  • These chromosomes carry heredity factors or genes. (jainworld.com)
  • Chromosomes are pairs and each chromosome contain 1000 or so genes that also occur in pairs. (jainworld.com)
  • In the human genome, which is estimated to contain 25 000 genes, DNA is arranged into 24 distinct chromosomes (courtesy U.S. Department of Energy, Genome Management Information System). (thecanadianencyclopedia.ca)
  • The gene is localized on the same chromosome at the distance of about 50 kb from telomeric sequences of IL-17A gene, and both genes are in a tail-to-tail orientation [ 3 ]. (hindawi.com)
  • The recent transposition to the Y chromosome of the autosomal DAZL1 gene, potentially involved in germ cell development, created a unique opportunity to study the rate of Y chromosome evolution and assess the selective forces that may act upon such genes, and provided a new estimate of the male-to-female mutation rate (alpham). (pasteur.fr)
  • Here, we use whole exome sequencing and copy number variation (CNV) analysis coupled with RNA-Seq to stratify VQ lines into corresponding clusters: Cluster I VQ cells carried recurrent amplification of chromosome (chr) 3 and displayed upregulation of growth pathways and high-risk myeloma gene signatures, whereas Cluster II cells had monosomy chr5 and overexpressed genes and pathways associated with positive response to bortezomib (Btz) treatment in human MM patients. (biorxiv.org)
  • Watkins PA, Maiguel D, Jia Z, Pevsner J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. (medlineplus.gov)
  • Genes, chromosomes & cancer 2022 11 62 (3): 131-138. (cdc.gov)
Homologous chromosomes8
Nucleus6
Chromosomal3
  • Aneuploidy is defined as the loss and/or gain of chromosomes to produce a numerical deviation from multiples of the haploid chromosomal complement ( King and Stansfield, 1990 ). (jneurosci.org)
  • With the development and progression of MM, several distinct patterns of genetic aberration are recognized, including cytogenetic abnormalities, chromosomal aberration and signaling pathway disorders ( 4 ). (spandidos-publications.com)
  • Its overall evaluation, however, was that "Ethylene oxide is carcinogenic to humans (Group 1)," which was based in part upon the observation that ethylene oxide is associated with a dose-related increase in hemoglobin adducts, chromosomal aberrations, and sister chromosome exchanges in peripheral lymphocytes, and micronuclei in bone marrow cells of exposed workers. (cdc.gov)
Zygote8
  • The expression of wild-type I-PpoI during spermatogenesis in transgenic mosquitoes causes cleavage of the paternal X chromosome but also results in complete male sterility because the protein's stability and persistence in mature sperm cells leads to subsequent cleavage of the maternal X chromosome in the zygote 9 . (nature.com)
  • There is enough information in this tiny zygote to control human growth and development for the rest of its life. (abort73.com)
  • Every human being begins as a single-cell zygote, grows through the embryonic stage, then the fetal stage, is born and develops through infancy, through childhood, and through adulthood, until death. (actionlife.org)
  • The egg is then stimulated by an electrical charge, creating a living human zygote. (actionlife.org)
  • From its first moment, supplied with its complete set of chromosomes, each new zygote directs its own integral functioning and development. (actionlife.org)
  • Human life begins at fertilization, the process during which a male gamete or sperm (spermatozoo developmentn) unites with a female gamete or oocyte (ovum) to form a single cell called a zygote. (blogspot.com)
  • and) A zygote is the beginning of a new human being (i.e., an embryo). (blogspot.com)
  • The development of a human being begins with fertilization, a process by which two highly specialized cells, the spermatozoon from the male and the oocyte from the female, unite to give rise to a new organism, the zygote. (blogspot.com)
Pairs6
  • This is because, at the end of meiotic prophase I, CO recombination provides a physical link that holds homologous chromosome pairs together. (wikipedia.org)
  • I think it's 23 pairs of chromosomes in the human body. (coderanch.com)
  • Genomes vary widely in size: the smallest known genome for a free-living organism (a bacterium) contains about 600000 DNA base pairs, while human and mouse genomes have some 3 billion. (jainworld.com)
  • DNA in the human genome is arranged into 24 distinct chromosomes, physically separate molecules that range in length from about 50 million to 250 million base pairs. (jainworld.com)
  • Distinct populations of second-order neurons integrate tibia vibration signals across pairs of legs, suggesting a role in detecting external substrate vibration. (janelia.org)
  • 23 pairs of chromosomes. (cdc.gov)
Segregation9
Locus on chromosome1
  • This translocation involves the immunoglobulin heavy-chain gene on chromosome 14 and the BCL1 locus on chromosome 11. (medscape.com)
Interphase3
Cells29
  • In support of this, a study of aneuploidy in single spermatozoa by whole genome sequencing found that, on average, human sperm cells with aneuploid autosomes exhibit significantly fewer crossovers than normal cells. (wikipedia.org)
  • The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
  • Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (nih.gov)
  • Chromosome 21 aneuploid cells constitute ∼4% of the estimated one trillion cells in the human brain and include non-neuronal cells and postmitotic neurons identified by the neuronspecific nuclear protein marker. (jneurosci.org)
  • Together, these data demonstrate that human brain cells (both neurons and non-neuronal cells) can be aneuploid and that the resulting genetic mosaicism is a normal feature of the human CNS. (jneurosci.org)
  • Toward determining the presence of constitutional aneuploidy in the human brain, we report here an analysis of the frequency of chromosome 21 gain and loss among neurons and non-neuronal cells isolated from the cerebral cortex and hippocampus of normal individuals ranging from 2 to 86 years of age. (jneurosci.org)
  • Chromosome 21 was chosen for examination because of the availability of trisomy 21 cells ( Bhattacharyya and Svendsen, 2003 ) that could serve as a positive control for fluorescence in situ hybridization (FISH). (jneurosci.org)
  • While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)
  • The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
  • Meiosis is a sequence of events that organize and separate chromosomes into daughter cells. (styleslicker.com)
  • A number of scientific papers have been published indicating that LSD might cause structural changes in the chromosomes, genetic mutations, disturbances of embryonic development, and malignant degeneration of cells. (druglibrary.net)
  • 22) * After my arrival in the United States, I participated in a major study concentrating on structural changes of the chromosomes in the white blood cells following LSD administration. (druglibrary.net)
  • The first group includes papers describing structural changes of the chromosomes produced by LSD in vitro , ** in these experiments various concentrations of LSD are added to cultures of cells from human, animal, or plant tissues in a test-tube. (druglibrary.net)
  • The cells studied were in most cases human white blood cells (lymphocytes). (druglibrary.net)
  • We use both human cells and fission yeast as model systems for our studies. (ens-lyon.fr)
  • We are currently developing innovative approaches to do just that using human cells as a model system. (ens-lyon.fr)
  • They began with five distinct, normal cell types found in the bone marrow in both mice and humans: long-term hematopoietic stem cells (HSCs), short-term HSCs, multipotent progenitors, common myeloid progenitors and granulocyte macrophage progenitors. (news-medical.net)
  • To profile the open chromatin in these distinct AML samples, and compare them to open chromatin patterns in normal cells, Trowbridge collaborated with Duygu Ucar, Ph.D., an assistant professor at JAX who develops computational models to study gene regulation including chromatin structure. (news-medical.net)
  • Our DNA is present in our cells in structures known as chromosomes. (wesleyan.edu)
  • Epigenetics refers to situations in which two cells or organisms have identical DNA sequences, yet establish distinct patterns of gene expression and exhibit different characteristics. (wesleyan.edu)
  • Epigenetic mechanisms explain how humans can have over 200 distinct cell types despite the fact that all our cells have exactly the same DNA. (wesleyan.edu)
  • Much of what we know about the fundamental nature of chromosome structure and gene expression in humans was first discovered in yeast cells. (wesleyan.edu)
  • Except for mature red blood cells, all human cells contain a complete genome. (jainworld.com)
  • These two cells like all other carry within them material that forms a definite number of chromosomes. (jainworld.com)
  • 1 In just six weeks time, the human embryo goes from looking like a "bunch of cells" to looking like a baby - though only a half inch tall! (abort73.com)
  • It's a mush of rapidly dividing cells with enormous potential to be a human, if nothing intervenes, like a miscarriage or a D&C. But to me, that uninhabited scrunch of cells is no more human than an acorn is an oak tree. (jillstanek.com)
  • I do think, Rachael, that you honestly believe that these cells are human. (jillstanek.com)
  • In the ongoing debate about cloning human embryos for research, and about destroying them in order to harvest their stem cells, it is important to keep some basic facts in mind. (actionlife.org)
  • The human body has nearly 1013 cells. (cdc.gov)
Organism4
  • it's also a great model organism for addressing basic questions of chromosome structure and gene expression. (wesleyan.edu)
  • The new organism thus produced is genetically distinct from all other human beings and has embarked upon its own distinctive development. (actionlife.org)
  • Whether the new organism is produced by fertilization or by cloning, each new human organism is a distinct entity. (actionlife.org)
  • Although life is a continuous process, fertilization… is a critical landmark because, under ordinary circumstances, a new genetically distinct human organism is formed when the chromosomes of the male and female pronuclei blend in the oocyte. (blogspot.com)
Cancer8
  • These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
  • Mitotic clustering drives the unequal inheritance of acentric fragments by a single daughter cell, providing an explanation for the origins of distinct patterns of chromothripsis found across diverse cancer types and congenital disorders. (nature.com)
  • in other words, a valuable human cancer biomarker. (news-medical.net)
  • Immunohistochemical analysis of paraffin-embedded human breast cancer using 15617-1-AP (PRC1 antibody) at dilution of 1:50 (under 40x lens). (ptglab.com)
  • Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 15617-1-AP (PRC1 antibody) at dilution of 1:200 (under 10x lens). (ptglab.com)
  • This work enlarges the functional landscape of known long noncoding RNAs in human cancer and provides novel insights into the suppressive roles of these long noncoding RNAs. (cancerindex.org)
  • Furthermore, since DNA adduct formation is considered a critical step in the initiation of cancer for many compounds, the observation that a suspected carcinogen has the capability to form macromolecular adducts in exposed humans has important public health policy implications in and of itself. (cdc.gov)
  • After considering available epidemiologic studies of cancer, it concluded that there is only limited evidence in humans for the carcinogenicity of ethylene oxide. (cdc.gov)
Genetically distinct1
  • First, Cenk begins by writing off the scientific evidence that a genetically distinct, living, and whole human being comes into existence at conception. (blogspot.com)
Genetics4
  • Markers on the non-recombining portion of the human Y chromosome continue to have applications in many fields including evolutionary biology, forensics, medical genetics, and genealogical reconstruction. (thegeneticgenealogist.com)
  • Professor Holmes, you are an expert on genetics, molecular biology and chromosome structure. (wesleyan.edu)
  • A genome-wide survey does not show the genetic distinctiveness of Basques ", Human Genetics , published online 1/16/2010. (upenn.edu)
  • www.thecanadianencyclopedia.ca/en/article/genetics. (thecanadianencyclopedia.ca)
Translocation2
  • Her lab worked with a mouse model of acute myeloid leukemia (AML) driven by expression of MLL-AF9, a fusion oncogene formed by a chromosome translocation between human chromosomes 9 and 11. (news-medical.net)
  • Most cases of MCL are associated with chromosome translocation t(11;14)(q13;q32). (medscape.com)
Populations4
  • Because we know that Neandertal and modern human populations diverged more than 300,000 years ago, we would have guessed that these changes in FOXP2 would have happened after we separated from Neandertals," Pääbo said, noting that the human version of FOXP2 differs from that of chimps in two places. (sciencedaily.com)
  • and researchers from Thomas Jefferson to Luigi Luca Cavalli-Sforza and beyond have been excited about the idea of combining linguistic, biological, and geographical evidence to shed light on the history of human populations. (upenn.edu)
  • A worldwide survey of 67 men from five continents representing 19 distinct populations showed that most males have both DAZ variants. (pasteur.fr)
  • Three overlapping but distinct populations of B. burgdorferi corresponded to the geographic regions. (cdc.gov)
Mitotic3
  • Mitotic clustering facilitates the reassembly of acentric fragments into rearranged chromosomes lacking the extensive DNA copy-number losses that are characteristic of canonical chromothripsis. (nature.com)
  • In particular, we investigate: how the efficiency of RNA polymerase elongation can influence the distribution of the SMC complex condensin during mitotic chromosome condensation and, how the transcription by-product R-loop can interfere with chromosome integrity. (ens-lyon.fr)
  • R-loops have also recently been linked to the formation of Common Fragile Sites (CFS) on mitotic chromosomes. (ens-lyon.fr)
Genome6
  • The work is part of the ongoing Human Genome Project, an international effort to sequence (read) the genetic make-up of humans. (bbc.co.uk)
  • Once again, we are seeing the fruits of the two key commitments of the Human Genome Project: to make the sequence freely available and to produce a quality finished sequence. (bbc.co.uk)
  • The first draft of the entire human genome, the instructions needed to make a human being, was unveiled in the spring. (bbc.co.uk)
  • The work was carried out by two groups, the publicly funded International Human Genome Sequencing Consortium, and a private US company, Celera Genomics. (bbc.co.uk)
  • For example, growing evidence strongly suggests that transcription can interfere locally with genome duplication by DNA polymerases or with the SMC-driven 3D organization of chromosomes (Fig. 1). (ens-lyon.fr)
  • This study took advantage of cutting-edge genomic and genome sequencing technologies that were new to us, and allowed us to rapidly extract the maximum value from these technologies, integrate and compare our findings to human genomic data, and reveal novel underlying biological mechanisms with the most promising translational relevance that we will continue to study. (news-medical.net)
Differ3
  • Sex chromosomes differ from other chromosomes in the striking divergence they often show in size, structure, and gene content. (nih.gov)
  • The 23rd pair, the intercourse chromosomes, differ between men and women. (styleslicker.com)
  • The current results show that the Neandertals carried a FOXP2 protein that was identical to that of present-day humans in the only two positions that differ between human and chimpanzee," the researchers concluded. (sciencedaily.com)
Characteristics3
  • What most people don't realize is how quickly the developing human takes on the characteristics that are so familiar to us in human beings outside the womb. (abort73.com)
  • Culture of the transplanted tumor yielded a human cell line with characteristics identical to those used initially to produce the tumor. (scienceopen.com)
  • Sex and gender are not the same thing, and they should be considered clinically as distinct characteristics. (msdmanuals.com)
Loci1
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)
Mechanisms3
  • Epigenetic mechanisms also explain how humans can have more than 200 distinct cell types. (wesleyan.edu)
  • The Yokomori laboratory investigates the mechanisms of chromosome structural organization and how they affect DNA repair and gene regulation in human health and disease. (uci.edu)
  • However, the drivers of community structure, assembly mechanisms, co-occurrence patterns, and the associations with human pathogens and different protistan trophic groups remain unknown. (bvsalud.org)
Abnormalities1
  • The genetic controversy about LSD started in 1967 when Cohen, Marinello and Back (22) published a paper suggesting that LSD should be added to the list of substances capable of causing abnormalities in the chromosomes. (druglibrary.net)
Sperm1
  • Shredding of the X chromosome favours the unaffected Y-bearing sperm and results in the production of a male-biased progeny. (nature.com)
Genomic2
  • We and other groups discovered the human IL-17F gene from a human EST sequence, a genomic DNA clone, and T-cell cDNA sequences in 2001 [ 3 , 8 , 9 ]. (hindawi.com)
  • Of note, recent genomic studies demonstrate activating, somatic BRAF mutations in the majority of human specimens. (medscape.com)
Micronuclei1
  • Thus, distinct patterns of chromothripsis can be explained by the spatial clustering of pulverized chromosomes from micronuclei. (nature.com)
Proteins1
  • Genetic testing encompasses a broad range of laboratory tests performed to analyze DNA, RNA, chromosomes, proteins, and certain metabolites using biochemical, cytogenetic, or molecular methods or a combination of these methods. (cdc.gov)
Gene Expression2
  • epigenetic controls are essential in maintaining the specific patterns of gene expression that distinguish hundreds of distinct cell types in skin, muscles and other types of tissue. (wesleyan.edu)
  • Associate Professor Scott Holmes uses budding yeast to study chromosome structure and gene expression. (wesleyan.edu)
Independent assortment1
  • How many homologous chromosome alignments are potential for independent assortment throughout meiosis? (styleslicker.com)
Meiotic2
Sequence3
  • High-level congruence between S. aureus of animal and human lineages has been demonstrated ( 6 ), and nearly every sequence type (ST) reported for MRSA associated with infections in companion animals was also commonly found in humans ( 1 ). (cdc.gov)
  • The sequence of chromosome 22 was revealed two years ago. (bbc.co.uk)
  • A multicopy target sequence (black bars) on the X chromosome (but not present on the Y chromosome) is targeted by an endonuclease (red triangle) during spermatogenesis. (nature.com)
Meiosis2
  • Although a detailed molecular understanding of these distorters has remained elusive, cytological observations indicated that a bias towards male gamete production in Aedes is associated with preferential breakage of the X chromosome during male meiosis, thus suggesting one possible mechanism of action 6 . (nature.com)
  • We therefore hypothesized that the selective induction of DNA double-stranded breaks in the X chromosome during male meiosis might be a potential strategy to distort the sex ratio of the progeny towards male mosquitoes, if the normal production of Y-bearing gametes was unaffected ( Fig. 1a ). (nature.com)
Embryo2
  • The author seriously thinks that an embryo is not human . (jillstanek.com)
  • They just prevent the already existing human embryo who is traveling through the woman's or young girl's fallopian tube (uterine tube) from eventually implanting in the uterus. (lifeissues.net)
Assembly1
  • Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. (uci.edu)
Progenitor1
  • These results bear out indications in human data that the stage of a progenitor cell when it becomes transformed to leukemia has an impact on its clinical progression, with earlier-stage cell of origin cancers being more aggressive. (news-medical.net)
Cell proliferation1
  • Circle RNA circCSPP1 promotes human osteosarcoma cell proliferation and increases glucose metabolism by suppressing miR-200c maturation. (nih.gov)
Adenocarcinoma1
  • The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic adenocarcinoma metastatic to bone is reported. (scienceopen.com)
Encodes3
  • The mouse Pitx2 gene encodes three distinct protein isoforms (Pitx2a, b, c), and Pitx2c plays a determinant role in left-right atrium signaling from early somitogenesis onward 5 . (nature.com)
  • The staphylococcal cassette chromosome mec (SCC mec ) harbors the mec A gene, which encodes an additional penicillin-binding protein 2a. (cdc.gov)
  • It is linked to the TBCE gene on chromosome 1q42-43 which encodes for the tubulin-specific chaperone E protein [2-4]. (who.int)
Consists1
  • The fourth group consists of publications describing the consequences of LSD administration on the growth, development and differentiation of human and animal embryos. (druglibrary.net)
Spermatogenesis1
Identical1
  • They then extracted DNA and sequenced the Neandertal FOXP2 gene, revealing that it was identical to the version found in modern humans. (sciencedaily.com)
Genetic material1
  • Scientists have deciphered the complete genetic instructions of a third chromosome, one of the 24 distinct bundles of DNA that carry our genetic material. (bbc.co.uk)
Occur2
  • For example, non-human primates develop many of the same cognitive deficits and neuropathologic changes as occur in humans. (stanford.edu)
  • These animal models may occur in non-human primates, dogs, cats, goats, mice in which mutations have been induced, or in other less common laboratory species such as bears. (stanford.edu)
Variant5
  • The novel MRSA variant is not restricted to ruminants or humans, and contact with companion animals might pose a zoonotic risk. (cdc.gov)
  • This lack of detection might have led to underestimation of the novel MRSA variant among clinical samples of human and animal origin. (cdc.gov)
  • It could also give an insight into variant Creutzfeldt-Jakob disease (vCJD), the human form of mad cow disease. (bbc.co.uk)
  • Previous analyses indicated that a very recent rise in the human FOXP2 variant had occurred as a result of strong selection, less than 200,000 years ago, added Svante Pääbo, also of the Max Planck Institute. (sciencedaily.com)
  • The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals. (sciencedaily.com)
Consortium2
  • In 2002, the Y Chromosome Consortium published a single parsimony tree showing the relationships among 153 haplogroups based on 243 binary markers and devised a standardized nomenclature system to name lineages nested within this tree. (thegeneticgenealogist.com)
  • We describe major changes in the topology of the parsimony tree and provide names for new and rearranged lineages within the tree following the rules presented by the Y Chromosome Consortium in 2002. (thegeneticgenealogist.com)
Evidence2
  • Here, using double-label fluorescence in situ hybridization for the autosome chromosome 21 (chromosome 21 point probes combined with chromosome 21 "paint" probes), along with immunocytochemistry and cell sorting, we present evidence for chromosome gain and loss in the human brain. (jneurosci.org)
  • The date of the emergence of these genetic changes therefore must be older than that estimated with only extant human diversity data, thus demonstrating the utility of direct evidence from Neandertal DNA sequences for understanding recent modern human evolution. (sciencedaily.com)
Embryos1
  • They might argue that even though human embryos and fetuses are human beings, they are not developed enough to be morally significant. (abort73.com)
Protein1
  • Calpain-3 is a protein that in humans is encoded by the CAPN3 gene . (wikidoc.org)
Probes1
  • FISH "paint" probes against the whole q arm of chromosome 21 and a point probe against a region on the q arm of 21 (21q22.13-q22.2) were obtained from Vysis (Downer's Grove, IL). (jneurosci.org)
Characterization2
  • Establishment and characterization of a human prostatic carcinoma cell line (PC-3). (scienceopen.com)
  • My research focused on the identification and characterization of animal models of human diseases. (stanford.edu)
Evolution2
  • In addition to its potential implications for the acquisition of language, the study also marks the first time a specific nuclear gene has been retrieved from Neandertals--opening the door to other breakthroughs in scientists' understanding of human and Neandertal evolution, the researchers said. (sciencedaily.com)
  • For decades, evolutionists pointed to dozens of 'useless artifacts' of the human body to make their questionable case for evolution. (icr.org)
Reveals2
  • A new study in Current Biology reveals that adaptive changes in a human gene involved in speech and language were shared by our closest extinct relatives, the Neandertals. (sciencedaily.com)
  • The finding reveals that the human form of the gene arose much earlier than scientists had estimated previously. (sciencedaily.com)
Found6
  • The gene that appears to make some people more susceptible to contracting vCJD is found on chromosome 20. (bbc.co.uk)
  • The XX/XY sex determination system is found in humans. (gopusa.com)
  • To ensure that the Neandertal DNA samples hadn't been contaminated with human DNA, they also sequenced parts of their Y chromosome, which was found to be distinct from that of men today. (sciencedaily.com)
  • Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
  • It was found that human DAZ exons and introns are evolving at the same rate, implying neutral genetic drift and the absence of any functional selective pressures. (pasteur.fr)
  • The ACSF3 gene is found on chromosome 16 . (medlineplus.gov)
Comes into existence1
  • At the moment of fertilization, a new and unique human being comes into existence with its own distinct genetic code. (abort73.com)
Males1
Adult2
  • Here, we describe the StemCellFactory, an automated, modular platform covering the entire process of hiPSC production, ranging from adult human fibroblast expansion, Sendai virus-based reprogramming to automated isolation, and parallel expansion of hiPSC clones. (frontiersin.org)
  • It proceeds, unless death intervenes, through every stage of human development until one day it reaches the adult stage. (actionlife.org)
Cluster1
  • Our study highlights Cluster I VQ lines as highly representative of human high-risk MM subset. (biorxiv.org)
Implications1
Structural2
  • It is also reported that human PITX2 insufficiency results in cellular and molecular changes leading to atrial electrical and structural remodeling linked to arrhythmogenesis 6 . (nature.com)
  • The possibility of inducing structural changes in the chromosomes by exogenous agents such as radiation, viruses, and a variety of chemicals, has been a subject of great scientific interest for a long time. (druglibrary.net)
Pseudogene2
  • A pseudogene of this gene has been defined on chromosome 1. (nih.gov)
  • A famous example of this is the L-gulonolactone oxidase that synthesizes vitamin C . All simians, including humans , share one pseudogene of inactivated L-gulonolactone oxidase, but the guinea pig has a different pseudogene indicating a different mutation. (rationalwiki.org)