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  • renal
  • and the kidney participates in blood pressure regulation and in the maintenance of steady whole-organism water volume Fluid flow through the nephron must be kept within a narrow range for normal renal function in order to not compromise the ability of the nephron to maintain salt and water balance. (wikipedia.org)
  • Bartter syndrome is caused by mutations of genes encoding proteins that transport ions across renal cells in the thick ascending limb of the nephron. (wikipedia.org)
  • Surface expression of Renal Outer Medullary Potassium (ROMK) channels has been found to be enhanced in the plasma membrane of the distal nephron of the kidney by miR-802 expression. (wikipedia.org)
  • secretion
  • Amiloride also blocks the Na+/H+ antiporter on the apical surface of the proximal tubule cells, in the nephron, abolishing more than 80% of the action of angiotensin II on the secretion of hydrogen ions in proximal tubule cells. (wikipedia.org)
  • The metabolic acidosis that results from RTA may be caused either by failure to reabsorb sufficient bicarbonate ions (which are alkaline) from the filtrate in the early portion of the nephron (the proximal tubule) or by insufficient secretion of hydrogen ions (which are acidic) into the latter portions of the nephron (the distal tubule). (wikipedia.org)
  • Distal RTA is characterized by a failure of H+ secretion into lumen of nephron by the alpha intercalated cells of the medullary collecting duct of the distal nephron. (wikipedia.org)
  • transport
  • In particular, the kidney of Amphiuma has been used as a model for vertebrate distal tubule transport studies (for a review, see Dietl and Stanton, 1993 ). (biologists.org)
  • Because cAMP appears to be the key second messenger leading to the increase in salt and water transport in the CCD, the alpha -2-mediated reduction in cellular cAMP has been viewed as the functional evidence for the alpha -2-induced inhibition of transport in this nephron segment. (aspetjournals.org)
  • cells
  • This along with the concomitant increase in passive water reabsortion due to the increased salt load in the distal convluted tubule cells will ultimately increase circulating volume. (wikipedia.org)
  • Aldosterone receptors are present on the epithelial cells of the distal nephron in the kidney. (wikipedia.org)
  • The distal intercalated cells function normally, so the acidemia is less severe than dRTA and the alpha intercalated cells can produce H+ to acidify the urine to a pH of less than 5.3. (wikipedia.org)
  • water
  • Although decreased intravascular oncotic (i.e. osmotic) pressure partially explains the patient's edema, more recent studies have shown that extensive sodium retention in the distal nephron (collecting duct) is the predominant cause of water retention and edema in the nephrotic syndrome. (wikipedia.org)
  • flow
  • The macula densa's position enables it to rapidly alter afferent arteriolar resistance in response to changes in the flow rate through the distal nephron. (wikipedia.org)
  • system
  • Scientists at The University of Texas Health Science Center San Antonio demonstrated that sodium handling by the distal nephron is under the control of a local regulatory system. (rxpgnews.com)
  • usually
  • Play media An overview of types 1, 2, and 4 is presented below (type 3 is usually excluded from modern classifications): Distal RTA (dRTA) is the classical form of RTA, being the first described. (wikipedia.org)
  • increase
  • On its own, spironolactone is only a weak diuretic because it primarily targets the distal nephron (collecting tubule), where only small amounts of sodium are reabsorbed, but it can be combined with other diuretics to increase efficacy. (wikipedia.org)