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Epitopes, B-LymphocyteEpitopesEpitopes, T-LymphocyteDatabases, ProteinEpitope MappingImmunodominant EpitopesAntibodies, MonoclonalMolecular Sequence DataAmino Acid SequenceImmune SystemAntibody SpecificityMice, Inbred BALB CCross ReactionsInformation DisseminationT-Lymphocytes, CytotoxicEnzyme-Linked Immunosorbent AssayPeptide FragmentsImmune ToleranceNeutralization TestsT-LymphocytesPeptidesMice, Inbred C57BLImmunoglobulin GAntigens, ViralAntibodies, ViralLymphocyte ActivationImmunizationAntigen PresentationHLA-A2 AntigenImmune SeraAntigen-Antibody ComplexCD4-Positive T-LymphocytesAntigens, BacterialHLA-A AntigensImmunity, InnateCell LineBinding Sites, AntibodyImmune EvasionInterferon-gammaAntibodies, NeutralizingImmunity, CellularAutoantigensAutoantibodiesAntibody FormationSpleenCD8-Positive T-LymphocytesHIV-1Antibodies, BacterialCytokinesRecombinant ProteinsB-LymphocytesPeptide LibraryBase SequenceDendritic CellsAntigens, NeoplasmVaccines, SyntheticCells, CulturedFlow CytometryViral Envelope ProteinsAntibody AffinityRecombinant Fusion ProteinsHybridomasDisease Models, AnimalImmunityBacterial ProteinsViral VaccinesHIV AntibodiesHistocompatibility Antigens Class IProtein BindingCytotoxicity, ImmunologicHLA-DR AntigensProtein ConformationVaccines, DNAMice, TransgenicAntigen-Antibody ReactionsVaccinationMolecular MimicrySpecies SpecificityRabbitsMembrane GlycoproteinsAntigensBinding, CompetitiveCapsid ProteinsClone CellsModels, MolecularAIDS VaccinesBlotting, WesternH-2 AntigensPeritoneal NeoplasmsHIV AntigensAntigens, SurfaceAntigens, ProtozoanCancer VaccinesHistocompatibility Antigens Class IIHLA-B AntigensAntigenic VariationLymph NodesBacterial Outer Membrane ProteinsMice, KnockoutAdjuvants, Immunologic
Induce an immune responseResponsesMetastaticAdaptive immuneCellTumorAntibodiesProteinContributesSystemResearchTargetCellsProtectionRiskVaccineMyelinTumor-immuneInfectiousAntibodySelf-antigensBiomarkersDefinePathwaysActivationResponseCytokinesInfectionIntracellularOutcomesSpecificDataAdditionHostResearchDevelopmentJournalControl
Induce an immune response2
  • It is thought that an HIV vaccine could either induce an immune response against HIV (active vaccination approach) or consist of preformed antibodies against HIV (passive vaccination approach). (wikipedia.org)
  • Other tools are available to further help predict if a therapeutic will induce an immune response. (pegsummit.com)
Responses4
  • We also show that recombinant adenovirus vaccination induced T cell responses to the same epitopes, and led to memory T cell differentiation. (biomedcentral.com)
  • Therefore, the immune responses raised by any vaccine need to be broad enough to account for this variability. (wikipedia.org)
  • Platforms include Epibase™ In Silico for the prediction of T cell epitopes and Epibase™ In Vitro for the assessment of T cell and B cell responses in human donor PBMC. (pegsummit.com)
  • Imaging cytomegalovirus infection and ensuing immune responses. (resist-cluster.de)
Metastatic2
  • In addition, it generates cancer stem cells (CSCs) that have the ability, following dissemination, to serve as founders of new metastatic colonies. (pegsummit.com)
  • The relationship between these CSCs and the SCs residing in normal tissues, and the participation of the CSCs in metastatic dissemination will be described. (pegsummit.com)
Adaptive immune2
Cell4
  • In the present work, we identified several CD4 + and CD8 + T cell epitopes in sheep infected with PPRV. (biomedcentral.com)
  • In this review we will discuss how combinations and fusions of different -omic workflows on a single cell level can be used to examine cellular phenotypes, immune effector functions, and even dynamic changes, such as metabolomic state of different cells in a sample or even in a defined tissue location. (frontiersin.org)
  • Background Excessive extracellular matrix (ECM) remodeling and a reactive stroma can affect T-cell infiltration and T-cell activity in the tumor and hereby influence response to immune checkpoint inhibitors (ICI). (bmj.com)
  • Epitope mapping identified T cell and B cell epitopes with low binding energies, ensuring their immunogenicity and safety. (htlv.net)
Tumor1
  • Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
Antibodies1
  • Furthermore, the functionally important epitopes of the gp120 protein are masked by glycosylation, trimerisation and receptor-induced conformational changes making it difficult to block with neutralizing antibodies. (wikipedia.org)
Protein2
  • An important consideration when developing a new protein therapeutic is the potential and consequences of the therapeutic inducing an immune response. (pegsummit.com)
  • The vaccine was designed by focusing on the envelope glycoprotein gp62, a crucial protein involved in the infectious process and immune mechanisms of HTLV inside the human body. (htlv.net)
Contributes1
  • However, poorly understood immune correlates of protection against placental transmission contributes to the current lack of an approved vaccine to prevent cCMV. (bvsalud.org)
System1
  • Only the functional portions of Env remain constant, but these are generally hidden from the immune system by the molecule's structure. (wikipedia.org)
Research2
  • A data integration and dissemination resource for carbohydrate and glycoconjugate related data which provides computational and informatics resources and tools for glycosciences research. (rcsb.org)
  • The mission of the International Retrovirology Association (IRVA) is to encourage research in retrovirology, especially the study of human T-lymphotropic virus (HTLV) infections and the associated diseases, to foster collaborations between research groups, provide a platform for critical analysis of new data, and contribute to the dissemination of knowledge about these infections. (htlv.net)
Target1
  • Thus, the design of CARs needs to consider both the epitope within the target and the nature and length of the spacer and TM regions. (nature.com)
Cells1
  • This study demonstrates the potential of V H H-based CAR T for pancreatic cancer therapy and provides an engineering strategy for developing potent CAR T cells targeting membrane-distal epitopes. (nature.com)
Protection1
  • At this time, it has yet to be established whether there is a long-term immune response against SARS-CoV-2 (12) or protection against reinfection (17). (researchgate.net)
Risk2
  • The model was then used to study the effect of the timing of inoculation, maternal immune suppression, and hyper-immune globulin infusion on the risk of placental transmission in the context of primary and reactivated chronic maternal CMV infection. (bvsalud.org)
  • The possible consequences of an immune response are also evaluated when completing a risk assessment. (pegsummit.com)
Vaccine5
  • However, the rational design of a Chlamydia vaccine would be aided by improved understanding of the cellular immune response to infection of the female reproductive tract. (prolekarniky.cz)
  • VEL (Variable Epitope Library) vaccine technology was developed to address the need for effective immunization strategies against antigenically variable targets. (pharmaceutical.report)
  • gB is one of the main candidate antigens for a potential recombinant vaccine since it induces a strong and persistent immune response. (biomedcentral.com)
  • The vaccine candidate protein (Domains-gB) was recognized by a monoclonal antibody from a commercial ELISA kit used for IBR diagnostic, which may suggest that the epitopes are conserved of the entire infectious virus. (biomedcentral.com)
  • The purpose of this work was to design an improved vaccine for T. cruzi using a novel epitope capsid incorporation strategy. (paijournal.com)
Myelin4
  • Thus the myelin-derived self-antigen is basically the bio-marker of myelin itself, which ensures myelin-specific immune activation. (medscape.com)
  • Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20-25 years in more than 30% of patients. (medscape.com)
  • Injection of T-cell clones specific for the immunodominant epitope of myelin basic protein (MBP) derived from sick animals is the most efficient protocol to transmit the disease to healthy animals. (brainkart.com)
  • These clones generally recognize an epitope lo-cated at amino acids 87-99, but clones specific for other groups of 12 amino acids in the MBP molecule and to other myelin components, such as proteolipid protein and myelin-associated glycoprotein, are also expanded. (brainkart.com)
Tumor-immune2
  • These findings indicate that M032 modulates the tumor-immune microenvironment in the canine glioma model. (oaepublish.com)
  • Despite the widespread use of tumor immune cell infiltrates as prognostic biomarkers in many cancers, their use in prostate cancer remains relatively unexplored. (springeropen.com)
Infectious2
  • The Immune Epitope Database and Analysis Resource (IEDB) is a project hosted by scientists at the La Jolla Institute for Allergy and Immunology (LIAI), with support from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health[permanent dead link] (NIH), and Department of Health and Human Services (HHS). (wikipedia.org)
  • In addition, epitopes from other infectious agents, allergens and autoantigens are being curated. (wikipedia.org)
Antibody1
  • The IEDB contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. (wikipedia.org)
Self-antigens1
  • Apoptosis leading to increased production or decreased clearance of immunogenic intracellular self-antigens and defective apoptosis of autoreactive immune cells both have been implicated in the loss of self-tolerance. (nih.gov)
Biomarkers1
  • The Network activities will be facilitated by the CIDC in the following main areas: optimization of data collection methodologies suitable for immune-related biomarkers, data integration and building a biomarker database for the secondary use by the large immuno-oncology community. (nih.gov)
Define2
  • The long term goal of the CIMACs-CIDC Network is to develop molecular signatures that define immune response categories to correlate with the clinical outcomes of immunotherapy in cancer. (nih.gov)
  • They utilized chimeric viral clones and site-specific mutagenesis to define an epitope made up of the initial and second variable region (V12) of the HIV-1 Env. (healthdisparitiesks.org)
Pathways1
  • As with anti-viral immunity, protective mechanisms may be accompanied by the activation of immune signaling pathways and we will discuss the suitability of such activation in the neurological setting. (frontiersin.org)
Activation1
  • The virus is taken up by dendritic cells, which, after antigen processing, presents it to T cells, leading to immune activation and release of a cascade of cytokines that are believed to mediate the systemic effects of plasma leakage and circulatory insufficiency. (who.int)
Response4
  • Moore and co-workers studied four people and discovered that the first NAb response was limited to two epitopes in the HIV-1 Env. (healthdisparitiesks.org)
  • The power of to subvert the web host immune system response within murine types of infections in addition has been previously reported. (immune-source.com)
  • The proteins works as a damage-associated molecular design (Wet) secreted by immune system cells in response to injury caused by damage, necrosis, or infections (18). (immune-source.com)
  • By modulating the known degrees of HMGB1 within the web host, we directed to dampen the web host immune response pursuing infections with and possibly increase the efficiency of antibiotics to take care of the disease. (immune-source.com)
Cytokines1
  • The organism seems to stop the production of proinflammatory cytokines to 72 h p up.i., and rigtht after this immune system modulatory event there's a rapid upsurge in cytokines, such as for example tumor necrosis aspect alpha (TNF-), gamma interferon (IFN-), interleukin-6 (IL-6), as well CXXC9 as the GS-9901 chemokine CCL2, that's similar to a cytokine surprise (14, 15). (immune-source.com)
Infection1
  • Previously we reported that a hexon-modified adenovirus (Ad) vector containing the invasive neutralizing epitope of Trypanosoma cruzi ( T. cruzi ) trypomastigote gp83 (Ad5-gp83) provided immunoprotection against T. cruzi infection. (paijournal.com)
Intracellular1
  • Common mechanisms that may contribute to protection against self-propagating protein conformations include blocking the entry of protein "seeds" to cells, clearance of immune complexes by microglia, and the intracellular protein degradation pathway initiated by cytoplasmic antibodies via the Fc receptor TRIM21. (frontiersin.org)
Outcomes1
Specific2
  • In addition, specific amino acid changes and alterations in glycosylation in these two epitopes were found to be associated with neutralization escape. (healthdisparitiesks.org)
  • Overall, these results suggest that the combination of gp83 and ASP-M specific epitopes onto the capsid-incorporated adenoviruses would provide superior protection against Chagas disease as compared with Ad5-gp83 alone. (paijournal.com)
Data1
  • The database also contains MHC binding data from a variety of different antigenic sources and immune epitope data from the FIMM (Brusic), HLA Ligand (Hildebrand), TopBank (Sette), and MHC binding (Buus) databases. (wikipedia.org)
Addition1
  • In addition to the database, the IEDB website hosts an Analysis Resource, which contains a collection of tools to predict and analyze epitopes. (wikipedia.org)
Host1
Research1
  • The focus is dissemination of immune epitope information to facilitate the generation of new research tools, diagnostic techniques, vaccines and therapeutics. (wikipedia.org)
Development2
  • This leads to immune enhancement leading to the development of dengue shock syndrome (DSS). (who.int)
  • Poised to give our readers and advertisers better services in spite of the COVID19 pandemic, Pharmanews-your global health journal has continued to improve on its services in terms of healthcare information dissemination, by keeping readers abreast of latest development in public health, especially on how to stay safe from the novel Coronavirus, as well as expanding our reach to over 250,000 readers per month. (pharmaceutical.report)
Journal1
Control2
  • WNV dissemination and immune system control. (nih.gov)
  • This review summarizes the innate and adaptive effectors that contribute to susceptibility, immune control and pathogenesis of HSV, and highlights the delicate interplay between these two important arms of immunity. (mdpi.com)