• disruption
  • Anticoagulants: Warfarin Overdose: Used as a treatment for prevention of blood clots, however, like most drugs, side effects have been shown to increase risk of excessive bleeding by functioning in the disruption of hepatic synthesis of coagulation factors II, VII, IX, and X. Vitamin K is an antagonist to warfarin drug, reversing its activity, causing it to be less effective in the process of blood clotting. (wikipedia.org)
  • Endothelial
  • Activated protein C binds to endothelial protein C receptor and subsequently cleaves the endothelial cell protease activated receptor-1, not only altering coagulation profiles but down-regulating pro-inflammatory and pro-apoptotic mediators, up-regulation of anti-inflammatory and anti-apoptotic pathways and stabilization of the endothelial cell barrier functions. (wikipedia.org)
  • liver
  • Specific cases include: Vitamin-K Deficiency: In the liver, vitamin K plays an important role in the synthesis of coagulation factor II. (wikipedia.org)
  • studies
  • Examinations including detailed coagulation studies were performed on 30 selected patients and 14 showed characteristic signs of DIC. (jimmunol.org)