AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesInformation Science
BronchiectasisBronchographySputumCiliary Motility DisordersAspergillosis, Allergic BronchopulmonaryHemoptysisBipolar DisorderMucociliary ClearanceKartagener SyndromeMental DisordersCystic FibrosisTomography, X-Ray ComputedAnxiety DisordersMood DisordersRespiratory Function TestsForced Expiratory VolumeCoughBronchitisVital CapacityMucusDiagnostic and Statistical Manual of Mental DisordersCommon Variable ImmunodeficiencySuppurationLung DiseasesPseudomonas InfectionsRespiratory Tract Infections
Patients with bronchiectasisCysticEmphysemaInterstitialPneumoniaDevelopment of bronchiectasisCOPDTuberculosisCongenitalCoughAirwaysAsthmaAirwayRisk of bronchiectasisExacerbationsRecurrentDiffuse bronchiectasisIdiopathic bronchiectasisCylindrical bronchiectasisInfectionsAllergicClinicalDilationSevereDiseaseCommonlySputumBronchial DisordersGeneticShortnessPrimaryNeuromuscularSyndromeAbnormalitiesCiliaUncommonComplicationsInfectionPulmonary rehabilitation
Patients with bronchiectasis4
  • A recent multicentre European study of 1310 patients with bronchiectasis identified an annual exacerbation frequency of 1.8-3 per patient per year, with a hospitalisation rate of 26.6-31.4% over 2 years follow-up [ 7 ]. (ersjournals.com)
  • Most of the patients with bronchiectasis died within two years. (bmj.com)
  • During the same period, the European Lung Foundation collected 711 questionnaires from adult patients with bronchiectasis and their carers from 22 European countries reporting important research priorities from their perspective. (ersjournals.com)
  • Priorities identified in this consensus statement provide the clearest possible roadmap towards improving our understanding of the disease and the quality of care for patients with bronchiectasis. (ersjournals.com)
Cystic6
  • Very severe (advanced) cases of bronchiectasis occur more commonly in people who have advanced cystic fibrosis and, in areas where people live in crowded conditions and/or lack access to medical care, those with tuberculosis. (merckmanuals.com)
  • Two readers blinded to diagnosis measured anterior-posterior and transverse dural sac diameter using L1-L5 magnetic resonance images of 71 patients with idiopathic bronchiectasis, 72 control subjects without lung disease, 29 patients with cystic fibrosis, and 24 patients with Marfan syndrome. (nih.gov)
  • Bronchiectasis not due to cystic fibrosis ("non-CF bronchiectasis", henceforth referred to simply as bronchiectasis) is characterised radiologically by permanent dilation of the bronchi, and clinically by a syndrome of cough, sputum production and recurrent respiratory infections [ 1 ]. (ersjournals.com)
  • Bronchiectasis may result from a number of infectious and acquired causes, including measles, pneumonia, tuberculosis, immune system problems, as well as the genetic disorder cystic fibrosis. (wikipedia.org)
  • Cystic fibrosis eventually results in severe bronchiectasis in nearly all cases. (wikipedia.org)
  • and AffloVest, a portable high frequency chest wall oscillation vest for the treatment of retained pulmonary secretions, such as bronchiectasis, cystic fibrosis, and various neuromuscular disorders. (etfdailynews.com)
Emphysema4
  • If the disorder is severe, progressive pulmonary emphysema may precipitate cor pulmonale. (merckmanuals.com)
  • Chronic cough / Thoracic surgery second opinion / Chronic interstitial lung disease / Management of bronchiectasis / Management of asthma or emphysema / Recurrent or enresolved pneumonia. (panhandleparade.com)
  • Parenchymal diseases include congenital lobar emphysema, bronchogenic cyst, pneumatocele, bronchiectasis with air trapping and emphysema secondary to bronchospasm. (pediatriconcall.com)
  • In the most severe form, the disease can clinically manifest with chronic liver disorders (cirrhosis, fibrosis), respiratory disorders (emphysema, bronchiectasis), and rarely panniculitis or vasculitis. (orpha.net)
Interstitial6
  • PR can benefit people diagnosed with COPD (chronic obstructive pulmonary disease), bronchiectasis, pulmonary hypertension, interstitial lung disease, and other chronic pulmonary disorders. (copdfoundation.org)
  • CT Chest HRCT CT Chest WO Indication: Interstitial lung disease, chronic progressive dyspnea/shortness of breath, bronchiectasis, abnormal PFTs, history of connective tissue/rheumatologic disorder, etc. (desertdingo.com)
  • Another paper from Saudi Arabia examined the impact of pulmonary rehabilitation among 51 patients with chronic lung diseases (interstitial lung diseases, bronchiectasis, asthma and scoliosis). (who.int)
  • The respiratory department has well established services in lung cancer diagnostics, tuberculosis, sleep and non-invasive ventilation, interstitial lung disease, bronchiectasis, asthma, COPD and other aspects of general respiratory medicine. (swbh.nhs.uk)
  • We work closely with allied specialties and tertiary referrals to provide specialist services to include home antibiotic services for bronchiectasis, anti Immunoglobin E (Anti-IgE) injections for asthma, disease modifying therapies for sarcoidosis and other interstitial lung disease, as well as advanced respiratory physiology testing. (swbh.nhs.uk)
  • We offer services in the full range of respiratory disorders including chronic cough, COPD, asthma (including biologic therapy), bronchiectasis including patients on long term nebulised antibiotics, sleep apnoea and home non-invasive ventilation, tuberculosis, non-tuberculous mycobacteria and multi-drug resistant tuberculosis, sarcoid and other interstitial lung diseases and investigation of suspected lung cancer. (swbh.nhs.uk)
Pneumonia2
  • Patients with pneumonia describe symptoms of short duration (7 to 10 days), as opposed to years in bronchiectasis. (kieran101.com)
  • Auscultation findings (rhonchi, wheezing, crackles) may be similar in bronchiectasis and pneumonia, especially multi-lobar pneumonia. (kieran101.com)
Development of bronchiectasis3
  • There are many causes that can induce or contribute to the development of bronchiectasis. (wikipedia.org)
  • Recurrent respiratory infections are a common and challenging comorbidity, often leading to the development of bronchiectasis in individuals with A-T. The role of ATM in development of immune memory in response to recurrent respiratory viral infections is not well understood. (nih.gov)
  • His thesis work investigated risk factors for the development of bronchiectasis in children with recurrent pulmonary aspiration and was recently published in the journal Pediatric Pulmonology. (chop.edu)
COPD6
  • In adults, disorders that can raise the risk of bronchiectasis include chronic obstructive pulmonary disease (COPD) , asthma , gastroesophageal reflux disease (GERD) , rheumatoid arthritis, and inflammatory bowel disease. (nih.gov)
  • The results of NIPPV in patients with COPD and progressive neuromuscular disorders show benefit in some subgroups. (bmj.com)
  • Chronic obstructive pulmonary disease (COPD), a heterogeneous disorder causing progressively irreversible airflow limitation, is strongly related to smoking. (biomedcentral.com)
  • With more than 20 years of experience, Brooke helps patients manage a broad spectrum of lung conditions, including chronic obstructive pulmonary disease (COPD), shortness of breath, chronic cough, bronchiectasis (damaged airways in the lungs) and other long-term lung conditions that cause discomfort. (uwhealth.org)
  • Rhonchi in combination with diminished breath sounds, characterising COPD, are not found in bronchiectasis. (kieran101.com)
  • Patients with COPD may also develop bronchiectasis. (kieran101.com)
Tuberculosis1
  • CRDs are an emerging public health and the sequelae of respiratory problem in urbanised areas of Low- infections such as occurs after and Middle-income countries tuberculosis, or for instance with bronchiectasis occurring after early childhood infections. (who.int)
Congenital4
  • Congenital bronchiectasis affects infants and children. (nih.gov)
  • Acquired bronchiectasis is more common than the congenital type. (nih.gov)
  • Congenital vascular disorders such as pulmonary artery agenesis or hypoplasia are the differentials for the condition. (pediatriconcall.com)
  • He has joined efforts with the Division of Otolaryngology through The Center for Pediatric Airway Disorders, a multidisciplinary team dedicated to improving health outcomes in children with aerodigestive disorders including tracheostomy dependence, congenital and acquired airway abnormalities, and recurrent aspiration. (chop.edu)
Cough3
Airways6
  • Bronchiectasis is an irreversible widening (dilation) of portions of the breathing tubes or airways (bronchi) resulting from damage to the airway wall. (merckmanuals.com)
  • Typically, bronchiectasis causes widening of medium-sized airways, but often smaller airways become scarred and destroyed. (merckmanuals.com)
  • Diffuse bronchiectasis develops most often in patients with genetic, immunologic, or anatomic defects that affect the airways. (msdmanuals.com)
  • Bronchiectasis is an uncommon disease, most often secondary to an infectious process, that results in the abnormal and permanent distortion of one or more of the conducting bronchi or airways. (medscape.com)
  • Damage to the walls of the airways - for example, from a more severe lung infection or repeated infections - usually causes acquired bronchiectasis. (nih.gov)
  • Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung. (wikipedia.org)
Asthma3
  • a hypersensitivity reaction to Aspergillus species that occurs most commonly in people with asthma, but sometimes in patients with CF, can cause or contribute to bronchiectasis. (msdmanuals.com)
  • There is insufficient evidence to support or refute the effectiveness of exercise therapy for patients with neck pain, shoulder pain, repetitive strain injury, rheumatoid arthritis, asthma, and bronchiectasis. (nih.gov)
  • Inspiratory squeaks and crackles, often present in bronchiectasis, are not present in asthma. (kieran101.com)
Airway8
  • Bronchiectasis is best considered the common end-point of various disorders that cause chronic airway inflammation. (msdmanuals.com)
  • Rare abnormalities in airway structure may lead to diffuse bronchiectasis. (msdmanuals.com)
  • Identifying the primary cause of bronchiectasis can be difficult, since different factors lead to injury to the airway walls. (nih.gov)
  • Other conditions, such as an airway blockage, also can lead to bronchiectasis. (nih.gov)
  • Chronic airway infection results in bronchiectasis that may be apparent in some young children and is almost uniformly present in adulthood on chest CT examination [ Knowles et al 2013 , Davis et al 2015 ]. (nih.gov)
  • In bronchiectasis, there is characteristic dilatation of bronchi without airway thickening. (kieran101.com)
  • Joseph Piccione, DO, MS, is the Pulmonary Director for the Center for Pediatric Airway Disorders and an attending pulmonologist at Children's Hospital of Philadelphia who cares for children with airway disorders. (chop.edu)
  • Bronchoscopy and Airway Disorders. (chop.edu)
Risk of bronchiectasis2
  • Even patients who are heterozygous, who typically have no clinical manifestations of CF, may have an increased risk of bronchiectasis. (msdmanuals.com)
  • If you have a condition that damages your lungs or increases the risk of lung infections, you may have a higher risk of bronchiectasis. (nih.gov)
Exacerbations1
  • 3) A comprehensive study enrolling patients when stable and during exacerbation should be conducted, evaluating the impact of bacteria, viruses, fungi and noninfectious stimuli to identify the cause(s) of bronchiectasis exacerbations. (ersjournals.com)
Recurrent1
Diffuse bronchiectasis2
Idiopathic bronchiectasis2
  • Patients with idiopathic bronchiectasis are predominantly female and have an asthenic body morphotype and frequent nontuberculous mycobacterial respiratory infections. (nih.gov)
  • To determine whether lumbar dural sac size is increased in patients with idiopathic bronchiectasis as compared with control subjects, and to assess whether dural sac size is correlated with phenotypic characteristics seen in individuals with heritable connective tissue disorders. (nih.gov)
Cylindrical bronchiectasis4
  • [ 1 ] Cylindrical bronchiectasis involves diffuse mucosal edema, with resultant bronchi that are dilated but have straight, regular outlines that end squarely and abruptly (see the image below). (medscape.com)
  • Cylindrical bronchiectasis with signet-ring appearance. (medscape.com)
  • High resolution chest CT scans showed heterogeneous air trapping, cylindrical bronchiectasis, and patchy ground-glass opacities. (cdc.gov)
  • Cylindrical bronchiectasis: refers to bronchi that are uniformly dilated and do not taper, but rather end abruptly. (syrianclinic.com)
Infections4
  • Bronchiectasis has also been associated with infections from nontuberculous mycobacteria (NTM) (organisms found in soil, dust, and water). (nih.gov)
  • To prevent bronchiectasis, it's important to prevent lung infections and lung damage. (nih.gov)
  • These vaccines also reduce complications from these infections, such as bronchiectasis. (nih.gov)
  • Treat lung infections in children to help preserve lung function and prevent lung damage that can lead to bronchiectasis. (nih.gov)
Allergic2
  • Bronchiectasis represents the final common pathway of a number of infectious, genetic, autoimmune, developmental and allergic disorders and is highly heterogeneous in its aetiology, impact and prognosis. (ersjournals.com)
  • What do you know about bronchiectasis in allergic bronchopulmonary aspergillosis? (syrianclinic.com)
Clinical5
  • Formerly regarded as a rare disease, bronchiectasis is now increasingly recognised and a renewed interest in the condition is stimulating drug development and clinical research. (ersjournals.com)
  • The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration, funded by ERS to promote high-quality research in bronchiectasis. (ersjournals.com)
  • 9) We suggest studies of the microbiome (incorporating bacteria and potentially fungi) in bronchiectasis linked to detailed clinical phenotyping data. (ersjournals.com)
  • She sees adult patients with a range of lung diseases and disorders in a clinical setting. (uwhealth.org)
  • Piccione Joseph C, McPhail Gary L, Fenchel Matthew C, Brody Alan S, Boesch Richard P: Bronchiectasis in chronic pulmonary aspiration: risk factors and clinical implications. (chop.edu)
Dilation1
  • Bronchiectasis is dilation and destruction of larger bronchi caused by chronic infection and inflammation. (msdmanuals.com)
Severe1
  • Very severe bronchiectasis may impair breathing enough to cause abnormally low levels of oxygen and/or high levels of carbon dioxide in the blood, a condition called chronic respiratory failure. (merckmanuals.com)
Disease10
  • Vitamin D deficiency is common in bronchiectasis and correlates with markers of disease severity. (medscape.com)
  • People aged 5-45 who have a tentative diagnosis of PID or PCD or have suppurative lung disease compatible with one of these disorders. (nih.gov)
  • METHODS--The outcome of long term domiciliary NIPPV has been analysed in 180 patients with hypercapnic respiratory failure predominantly due to chest wall restriction, neuromuscular disorders, or chronic obstructive lung disease. (bmj.com)
  • RESULTS--Five year acturial probability of continuing NIPPV for individuals with early onset scoliosis (n = 47), previous poliomyelitis (n = 30), following tuberculous lung disease (n = 20), general neuromuscular disorders (n = 29), and chronic obstructive pulmonary disease (n = 33) was 79% (95% CI 66 to 92), 100%, 94% (95% CI 83 to 100), 81% (95% CI 61 to 100), 43% (95% CI 6 to 80), respectively. (bmj.com)
  • One year after starting NIPPV electively the mean (SD) PaO2 compared with the pretreatment value was +1.8 (1.9) kPa, mean PaCO2 -1.4 (1.3) kPa in patients with extrapulmonary restrictive disorders, and PaO2 +0.8 (1.0) kPa, PaCO2 -0.9 (0.8) kPa in patients with obstructive lung disease. (bmj.com)
  • Bronchiectasis is a disease of renewed interest in light of an increase in prevalence and increasing burden on international healthcare systems. (ersjournals.com)
  • Common indications for high-resolution CT are evaluation of suspected pulmonary fibrosis (where the chest X-ray is either normal or abnormal), solitary pulmonary nodule (PET/CT may be more accurate where nodules are larger than 8-10 mm), bronchiectasis and, finally, response to treatment of diffuse lung disease (eg alveolitis or bronchiectasis). (desertdingo.com)
  • Anti-IL-8 monoclonal antibodies are described for use in diagnostic applications and in the treatment of inflammatory disorders such as inflammatory bowel disease and bacteria pneumonias. (justia.com)
  • The instant invention demonstrates that the anti-IL-8 monoclonal antibodies of the invention can be used therapeutically in the treatment of other inflammatory disorders, such as bacterial pneumonias and inflammatory bowel disease. (justia.com)
  • Neuropathic disorders (namely Riley-Day syndrome, Chagas' disease). (syrianclinic.com)
Commonly1
  • They also demonstrate phenotypic features (scoliosis, pectus deformity, mitral valve prolapse) that are commonly seen in individuals with heritable connective tissue disorders. (nih.gov)
Sputum1
Bronchial Disorders1
Genetic2
  • Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (merckmanuals.com)
  • 1) DNA biobanks linked to well-phenotyped patient cohorts should be established to enable underlying genetic susceptibility to bronchiectasis to be established. (ersjournals.com)
Shortness1
  • A major symptom associated with chronic breathing disorders is shortness of breath. (copdfoundation.org)
Primary1
  • Disorders that affect cilia function, such as primary ciliary dyskinesia , can cause bronchiectasis. (nih.gov)
Neuromuscular1
  • Myoid cells demonstrate acetylcholine receptors and have a possible role in myasthenia gravis, an autoimmune disorder of neuromuscular transmission first recognized by Wilks in 1877 [ 1 ]. (hindawi.com)
Syndrome2
  • Sjögren Syndrome Sjögren syndrome is a relatively common chronic, autoimmune, systemic, inflammatory disorder of unknown cause. (msdmanuals.com)
  • IL-8 can play an important role in the pathogenesis of inflammatory disorders, such as adult respiratory distress syndrome (ARDS), septic shock, and multiple organ failure. (justia.com)
Abnormalities1
Cilia1
  • In bronchiectasis, mucus production increases, the cilia are destroyed or damaged, and areas of the bronchial wall become chronically inflamed and are destroyed. (merckmanuals.com)
Uncommon2
Complications2
Infection3
Pulmonary rehabilitation1
  • 4) Studies are required to optimise compliance, and access to chest physiotherapy and pulmonary rehabilitation in bronchiectasis. (ersjournals.com)