• AQP1
  • Around active NMO lesions AQP4 may selectively be lost in the absence of aquaporin 1 (AQP1) loss or other structural damage (lesion type 4). (wikipedia.org)
  • chronic
  • However, these changes will likely only develop after chronic PPD associated with severe mental illness, as opposed to less severe forms of the disorder as seen in those with anxiety and affective disorders. (wikipedia.org)
  • psychiatric
  • Psychiatric symptoms such as depression and generalized anxiety disorder with phobias and panic attacks are common. (hindawi.com)
  • This includes psychogenic polydipsia (PPD - not to be confused with postpartum depression), which is caused by psychiatric disorders, often schizophrenia, and often accompanied by the sensation of dry mouth. (wikipedia.org)
  • In diagnosis, primary polydipsia is usually categorised as: Psychogenic (PPD) - caused by underlying psychiatric symptoms, including those caused by psychoses and rarely by affective disorders Non-psychogenic - another non-psychological cause, including idiopathic (unknown cause) The terms primary polydipsia and psychogenic polydipsia are sometimes incorrectly used interchangeably - to be considered psychogenic, the patient needs to have some other psychiatric symptoms, such as delusions involving fluid intake or other unusual behaviours. (wikipedia.org)
  • pore
  • For example, the aquaporin 3 channel has a pore width of 8-10 Ångströms and allows the passage of hydrophilic molecules ranging between 150 and 200 Da. (wikipedia.org)
  • symptoms
  • The time of onset of the early features, characterized by neuropsychiatric symptoms and seizures preceded by a median of 10-20 days, the onset of movement disorders, reduction in consciousness and dysautonomia. (pubmedcentralcanada.ca)
  • syndrome
  • Stiff person syndrome (SPS) is a rare neurological disorder characterized by progressive rigidity of axial and limb muscles associated with painful spasms. (hindawi.com)
  • Stiff person syndrome (SPS) is a rare neurological disorder, which classically is characterized by persistent skeletal muscular stiffness [ 1 , 2 ]. (hindawi.com)
  • Caselli RJ in 1999 reported five patients, age 54 to 80 years, presented between 3 weeks and 18 months after symptomatic onset of progressive cognitive decline, psychosis, and unsteady gait that proved to be due to a steroid-responsive nonvasculitic autoimmune inflammatory meningoencephalitic syndrome. (wikipedia.org)
  • patients
  • Furthermore, it is common that patients with classic SPS suffer from other autoimmune disorders such as type I insulin-dependent diabetes mellitus (DM) or Hashimoto's thyroiditis. (hindawi.com)
  • therefore, a careful neurological evaluation is usually recommended in the global assessment of SS patients [ 4 ]. (hindawi.com)
  • Psychogenic polydipsia is found in patients with mental illnesses, most commonly schizophrenia, but also anxiety disorders and rarely affective disorders, anorexia nervosa and personality disorders. (wikipedia.org)
  • variants
  • In Anti-AQP positive variants, CNS astrocytes, which are the basis for the glymphatic system are the target of the autoimmune attack. (wikipedia.org)
  • clinical
  • In recent years, combined clinical, radiological, pathological, and serological findings have resulted in the identification of novel and distinct inflammatory central nervous system (CNS) disorders. (jamanetwork.com)
  • central
  • Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. (wikipedia.org)
  • water
  • The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
  • astrocyte
  • In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
  • Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikipedia.org)
  • Receptor
  • However, for finding quick solutions of optical- neuronal disorders more advanced biomaterial cell scaffolds and concurrent efforts are needed to revitalize visual-neural receptor system. (ommegaonline.org)
  • cells
  • HEK293 cells were used as antigenic substrate after transfected with full-length human AQP4 and mocktransfected cells were used as control substrate [ 4 ]. (jneuropsychiatry.org)
  • Visual impairment in human eye is also occurred due to accumulation of 'ceroid-lipofuscin' in surface conjunctival cells, and in ganglion and neuronal cells [4] . (ommegaonline.org)