• spasms
  • After baseline observations, the following drugs were given intravenously at a time when dystonic spasms had reached maximum severity: 75 mg Ldopa, 0.1 mg lisuride (a synthetic ergoline with dopamine receptor agonist properties), 1 mg haloperidol (a dopamine receptor antagonist), 5 mg procyclidine (a centrally active anticholinergic drug), and 1 mg physostigmine (a central inhibitor of acetylcholinesterase). (docme.ru)
  • An acute dystonic reaction consists of sustained, painful muscular spasms, producing twisting of the trunk/body and abnormal posture. (wikipedia.org)
  • collectively
  • The term mental illness refers collectively to all diagnosable mental disorders -health conditions characterized by alterations in thinking, mood, or behavior associated with distress or impaired functioning. (wikipedia.org)
  • uncommon
  • Before this movement, it was not uncommon that people affected by mental illness in the 19th century would be considerably neglected, often left alone in deplorable conditions, barely even having sufficient clothing. (wikipedia.org)
  • dysfunction
  • The effects of cerebral palsy fall on a continuum of motor dysfunction, which may range from slight clumsiness at the mild end of the spectrum to impairments so severe that they render coordinated movement virtually impossible at the other end of the spectrum. (wikipedia.org)
  • Primary
  • The studies hypothesize the hyper activation of the cortical areas is due to reduced pallidal inhibition of the thalamus, leading to over activity of the medial and prefrontal cortical areas and under activity of the primary motor cortex during movement. (wikipedia.org)
  • Studies of local field potentials have also shown an increase of 4-10 Hz oscillatory activity in the globus pallidus internus during myoclonic episodes and an increase of 5-7 Hz activity in dystonic muscles when compared to other primary dystonias. (wikipedia.org)
  • spectrum
  • In addition, the categorization of disorders discussed in this review needs to be harmonized with recommendations from other DSM-V workgroups and the DSM-V Task Force for the overall structure of DSM-V. This article builds upon and extends prior reviews of this topic that were prepared for and discussed at a DSM-V Research Planning Conference on Obsessive Compulsive Spectrum Disorders. (docplayer.net)
  • development
  • The discovery of effective therapies for these disorders has been challenging and has also involved the development and characterization of accurate animal models for the screening of new drugs. (frontiersin.org)
  • Dorothea Dix (1802-1887) was an important figure in the development of "mental hygiene" movement. (wikipedia.org)
  • major
  • The chronic administration of sertraline was found in animals to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. (nih.gov)
  • central
  • Therefore, it is central to critically analyze these zebrafish lines and understand their suitability as models of movement disorders. (frontiersin.org)
  • While movement problems are the central feature of CP, difficulties with thinking, learning, feeling, communication and behavior often co-occur, with 28% having epilepsy, 58% having difficulties with communication, at least 42% having problems with their vision, and 23-56% having learning disabilities. (wikipedia.org)
  • The present invention is directed to aryl aminopyridine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). (patentsencyclopedia.com)
  • treatment
  • It is now most frequently encountered as a drug-induced phenomenon appearing in the course of sustained L-dopa treatment [ 151. (docme.ru)
  • early
  • The disorder is categorized as early onset if the patient is diagnosed before the age of 27, and late onset thereafter. (wikipedia.org)
  • social
  • The mental hygiene movement, related to the social hygiene movement , had at times been associated with advocating eugenics and sterilisation of those considered too mentally deficient to be assisted into productive work and contented family life. (wikipedia.org)
  • studies
  • A systematic review of the literature was conducted by including all studies reporting the characterization of zebrafish models of the movement disorders selected from five bibliographic databases. (frontiersin.org)
  • light
  • Dix was a school teacher who endeavored throughout her life to help people with mental disorders, and to bring to light the deplorable conditions into which they were put. (wikipedia.org)
  • field
  • Emil Kraepelin in 1896 developed the taxonomy mental disorders which has dominated the field for nearly 80 years. (wikipedia.org)