Diseases splenomegaly. Medical search. Frequent questions

Hepatomegaly and splenomegaly, that can become massive, are frequent. (fundacionmapfre.org)
Myelofribrosis or myeloid metaplasia causes during its evolution asthenia, anemia, weight loss of weight, splenomegaly, and in half of the cases hepatomegaly. (fundacionmapfre.org)
Hepatomegaly, splenomegaly, or enlarged lymph nodes may be detected on physical examination (Batchelder, M.A. et al . (vin.com)

Splenomegaly is a larger-than-normal spleen. (medlineplus.gov)
In a child whose spleen is palpable without underlying disease, the organ will be elastic, soft, porous, homogenous, nontender, and less than 2 cm inferior to the left costal margin. (medscape.com)
Autosomal recessive disease due to accumulation of glucocerebroside / glucosylceramine (a sphingolipid) in reticuloendothelial cells in liver, spleen and bone marrow, due to a defect in lysosomal beta glucocerebrosidase. (uab.edu)
As the disease negatively impacts blood cell production, certain organs - usually the spleen - attempt to compensate by producing red blood cells. (gsk.com)
This results in an enlarged spleen, known as splenomegaly, which causes uncomfortable, painful bloating and inflammation. (gsk.com)
Involvement of the spleen in malaria that results in splenomegaly renders this organ prone to complications such as rupture. (ispub.com)
Whatever the process is that leads to destruction of RBC's, eventually the spleen will filter out these damaged RBC's leading to swelling of the spleen (splenomegaly) and anemia (a lowered RBC count in the blood). (nethealthbook.com)
When the splenomegaly becomes chronic, hypersplenism sets in , which means that the chronically enlarged spleen is now so effective in removing RBC's that this condition becomes a new entity and removal of the enlarged spleen may become part of the treatment plan. (nethealthbook.com)
A wide variety of diseases are associated with splenomegaly, or enlargement of the spleen, with many of the mechanisms leading to this condition being exaggerated forms of normal spleen function. (medscape.com)
A spleen weight of 400-500 g indicates splenomegaly, and some authors consider spleens weighing more than 1000 g to have massive splenomegaly. (medscape.com)

Approach to the patient with lymphadenopathy and splenomegaly. (medlineplus.gov)
RALD is characterized by splenomegaly, persistent monocytosis, hypergammaglobulinemia and cytopenia, but can also include autoimmune features and lymphadenopathy. (biomedcentral.com)
Others develop a more chronic course with persistent or intermittent infectious mononucleosis-like symptoms including fever, persistent lymphadenopathy, splenomegaly, and EBV hepatitis. (frontiersin.org)
Because a finding of generalized lymphadenopathy can be associated with such a wide range of diseases and conditions, determining its cause can sometimes be challenging. (cancernetwork.com)
At that time-and at another hospital-she received intravenous gammaglobulin for presumed Kawasaki disease (she had right cervical lymphadenopathy, an erythematous rash, and chapped lips). (cancernetwork.com)
1992). In the most commonly seen form of lymphoma, the lymph nodes are the most affected sites, resulting in peripheral lymphadenopathy, with visceral spread and organ failure occurring late in the course of the disease (Willians & Weiss, 2004). (vin.com)
infection of cats has also been associated directly or indirectly with a variety of clinical manifestations like fever, lethargy, lymphadenopathy, uveitis, gingivitis, and neurological diseases. (vin.com)

Patients with chronic liver disease experience a slow deterioration in liver function that leads to symptoms of end-stage liver disease, such as variceal bleeding, ascites, spontaneous bacterial peritonitis , and HE. (medscape.com)
Even with development of these symptoms, the immediate mortality is lower for decompensated liver disease than for ALF, which is why patients with ALF receive top priority of the liver transplant waitlist (status 1A). (medscape.com)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
Call your health care provider if you have symptoms of hemoglobin C disease. (stlukes-stl.com)
Chronic myeloid leukemia is characterized by splenomegaly and leukocytosis, and shows first a chronic phase with few symptoms, and then the blastic phase that is similar to acute leukemia of fatal prognosis. (fundacionmapfre.org)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases, including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses. (medscape.com)

In this report, we describe a non-malignant somatic variant in KRAS with prominent clinical features of massive splenomegaly, thrombocytopenia and lymphopenia. (biomedcentral.com)
After consulting for the first time at 5 years of age, she was discovered to have massive splenomegaly. (biomedcentral.com)
Here we report the discovery of a non-malignant somatic KRAS variant using whole exome sequencing in a minimally symptomatic then-8-year-old girl with unexplained massive splenomegaly. (biomedcentral.com)

This case of idiopathic splenomegaly in childhood due to a somatic variant in KRAS expands our understanding of the clinical spectrum of RAS-associated autoimmune leukoproliferative disorder and emphasizes the value of securing a molecular diagnosis in children with unusual early-onset presentations with a suspected monogenic origin. (biomedcentral.com)
Systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), gout, and pseudogout: rheumatologist. (aetna.com)
Cold agglutinin disease may be idiopathic or may be transient due to infections such as Mycoplasma pneumoniae , infectious mononucleosis and HIV. (ispub.com)

Splenomegaly decreases in frequency with age because the ratio of the splenic volume to the abdominal volume reduces over time. (medscape.com)
Splenomegaly is usually the result of a systemic disorder rather than primary splenic disease. (medscape.com)
Splenomegaly, which occurs in about 50% of cases, is maximal during the 2nd and 3rd week and usually results in only a barely palpable splenic tip. (merckmanuals.com)
The splenic involvement in malaria causing splenomegaly makes it more prone to complications such as rupture. (ispub.com)

Splenomegaly usually accompanies cirrhosis. (health-care-clinic.org)

Circulatory overload occurs in patients with anemia and with heart disease, where the transfusion causes congestive heart failure requiring specific treatment. (fundacionmapfre.org)

There were significant associations between malaria infection, anaemia and splenomegaly and fever. (who.int)
Malaria has long been among the most common diseases in Southeast Asia. (ispub.com)
Babesiosis is mainly transmitted by deer ticks and often referred to as a "malaria-like" disease. (cooperpest.com)
The Centers for Disease Control and Prevention (CDC) provides information about specific countries where malaria is transmitted (see CDC: Yellow Fever and Malaria Information, by Country ), types of malaria, resistance patterns, and recommended prophylaxis (see CDC: Malaria ). (msdmanuals.com)
Briefly, Hodgkin's disease and polycythemia vera can cause splenomegaly, but so can chronic infectious diseases like tuberculosis, malaria, syphilis and brucellosis. (nethealthbook.com)

He had a fever and splenomegaly, suggesting an underlying infection or lymphoma. (ispub.com)
As you can see, New Jersey and Pennsylvania both suffered from anaplasmosis, babesiosis, ehrilchiosis, Lyme disease, and spotted fever rickettsiosis in 2016. (cooperpest.com)

Current studies to find a cause of this disease focus on immune defects and genetic abnormalities associated with the disease. (frontiersin.org)
Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)
Two ferrets had also clinical signs and histological abnormalities related to adrenal gland disease. (vin.com)

Acute liver failure (ALF) is a rare condition occurring in people without preexisting liver disease that can result in hepatic failure. (medscape.com)
How do you distinguish ALF from acute-on-chronic liver failure (ACLF) in a patient with chronic liver disease? (medscape.com)
However, development of an acute insult, such as infection or bleeding, in preexisting chronic liver disease can lead to development of ACLF, which has been elegantly described by Bajaj and colleagues in the most recent ACG guidelines on ACLF . (medscape.com)
An acute case of Chagas disease was studied in 1944, with clinical and laboratory follow-up until 2007, in Bambuí, Minas Gerais, Brazil. (scielo.br)
Untreated human Chagas disease normally evolves in such a way that the parasitic infection persists and is maintained throughout the host's life, independent of clinical features, both in the acute and in the chronic phase. (scielo.br)
Sickle cell crisis is an acute form of sickle cell disease where pain and sickling are extensive (Byar, 2013). (bartleby.com)
Thus, it is acute in nature and frequently presents with the telltale sign of disease, namely, a vesicular rash, although this may fail to develop in many infants. (lww.com)
More than 900 children and teens with a wide range of liver diseases, from acute hepatitis to a chronic liver disease that may require transplant, are receiving ongoing care in our clinics. (childrensmercy.org)
Acute disease is seen more often in the young with high parasitemia and when black flies or biting midges are most abundant. (merckvetmanual.com)
Objective: We assessed the efficacy and safety of the standard of care (SoC) plus oral obefazimod (SoC plus ABX464), 50 mg once daily, versus the SoC plus placebo for prevention of severe acute respiratory syndrome in patients with coronavirus disease 2019 (COVID-19) who are at risk for severe disease. (bvsalud.org)

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
Our findings indicate that reversal of splenomegaly by regular exercise and genistein treatment may be important in the clinical management of HFSD-induced obesity. (researchgate.net)
Can you help clinicians differentiate when massive collapse is present vs "normal liver disease" or other radiographic findings? (medscape.com)
Clinical findings: Palpable splenomegaly was observed in 4 ferrets. (vin.com)
Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) is advising hospitals to notify patients who underwent open-heart (open-chest) surgery involving a Stöckert 3T heater-cooler that the device was potentially contaminated, possibly putting patients at risk for a life threatening infection. (cdc.gov)
Cases were defined as those having long COVID according to the Centers for Disease Control and Prevention definition. (bvsalud.org)

Clinical manifestations of common variable immunodeficiency (CVID) include recurrent infections, autoimmune disease, lymphoid hyperplasia, granulomatous diseases, and malignancy. (medscape.com)
Approximately 20% of patients have a severe gastroenteropathy with severe malabsorption, nodular lymphoid hyperplasia, and chronic inflammatory bowel disease, such as ulcerative colitis and Crohn disease . (medscape.com)

Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)
In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)
As no randomized clinical trials, case control or cohort studies regarding splenectomy in these disorders were found in the literature, recommendations for each disease were based on expert opinion and were subsequently critically revised and modified by the Splenectomy in Rare Anemias Study Group, which includes hematologists caring for both adults and children. (haematologica.org)
Secondary erythrocytosis occurs due to arterial hypoxemia in chronic pulmonary disease, smoking, some neoplasms or hemoglobin disorders. (fundacionmapfre.org)
Cold agglutinin disease can also be associated with lymphoproliferative disorders and multiple myeloma. (ispub.com)
The organism is the most common cause of cat scratch disease as well as bacillary angiomatosis, and bacillary peliosis, common disorders in humans with AIDS. (vin.com)
Other common complications include central or peripheral nervous system involvement, hepato- and/or splenomegaly, and coagulation disorders. (orpha.net)
This includes milder phenotypes of congenital disorders such as hemophilia and von Willebrand disease (VWD). (medscape.com)

[ 6 ] Patients with bacterial infections alone have markedly improved survival compared with those that have other disease-related complications. (medscape.com)
Infections with Leucocytozoon spp can occasionally cause clinical and rarely fatal disease in turkeys, ducks, and chickens. (merckvetmanual.com)
Infections with Leucocytozoon spp are most often subclinical but can occasionally cause clinical and even fatal disease. (merckvetmanual.com)
Examples include splenomegaly from lupus and Felty syndrome, and from viral infections such as Epstein-Barr virus-induced mononucleosis. (medscape.com)
Internists, infectious disease specialists, cardiologists, cardiothoracic surgeons, and other clinicians should suspect NTM infections among patients who have signs of infection and a history of open-chest cardiac surgery. (cdc.gov)

People can develop confusion related to liver disease or hepatic encephalopathy (HE). (medscape.com)

A 7 y/o M with pancytopenia and splenomegaly. (uab.edu)

Splenomegaly and hypersplenism are another reason why hemolytic anemias from changes outside of the RBC occur. (nethealthbook.com)

Thought you might appreciate this item(s) I saw in The Pediatric Infectious Disease Journal. (lww.com)
For discussion of splenomegaly in children, see Pediatric Splenomegaly. (medscape.com)

These include Wilson disease, autoimmune hepatitis , and Budd-Chiari syndrome. (medscape.com)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)
Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. (cooperpest.com)

Fatty liver is also known as NASH, which stands for Non- Alcoholic Steatorrhoeic Hepatosis or Non-Alcoholic-Fatty-Liver-Disease (NAFLD) but don't be put off by these big terms - they just mean that your liver is being invaded with fat! (health-care-clinic.org)
The most common cause of fatty liver in the United States and Europe is chronic alcoholism, with the severity of liver disease directly related to the amount of alcohol consumed. (health-care-clinic.org)
Opioid use is a topic of growing concern among patients with nonalcoholic fatty liver disease (NAFLD). (karger.com)
In the present study, we investigated the difference in the platelet counts of patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic liver disease due to hepatitis C virus (CLD-HCV). (go.jp)

The serum thrombopoietin levels, the distribution of splenomegaly grades, and liver stiffness did not differ between the two LC groups to a statistically significant extent. (go.jp)

In addition to liver disease, heart problems are one of the most common features of Alagille syndrome. (childliverdisease.org)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
GIS (Granulomatous Inflammatory Syndrome) may produce gross lesions identical to lymphoma, but it has been linked to hypergammaglobulinemia in ferrets and it is a differential diagnosis for this new ferret disease (Perpiñán & López 2008). (vin.com)
Here you see conditions such as irritable bowel syndrome (IBS), ischemic bowel, inflammatory bowel disease (IBD), celiac disease, and diverticulitis. (dummies.com)
Cold agglutinin disease or syndrome is a relatively uncommon autoimmune hemolytic anemia presenting in the middle aged or elderly (1). (ispub.com)
For discussion of hyperreactive malarial syndrome, see Tropical Splenomegaly Syndrome. (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)

Other solid organ-specific autoimmune diseases (eg, pernicious anemia, thyroid diseases, vitiligo) have prevalence rates of more than 5% in patients with common variable immunodeficiency, which is higher than in the general population. (medscape.com)
This chapter teaches me that Sickle-Cell Anemia is a painful disease in which oxygen-carrying red blood cells change shape and clog the finest parts of the circulatory system (page 57). (bartleby.com)
Clinical disease and mortality result from anemia caused by antierythrocytic factors produced by the parasite, high numbers of the large gametocytes blocking pulmonary capillaries, or parasites invading the endothelium of vessels in tissues (brain, heart, etc) where they form megaloschizonts that occlude vessels and result in multifocal necrosis. (merckvetmanual.com)

Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)

Splenomegaly, weight loss, and parotid swelling rarely appear. (logicalimages.com)

Classically, lysosomal storage diseases encompassed only enzyme deficiencies of the lysosomal hydrolases. (medscape.com)
More than 50 lysosomal storage diseases have been described, some of which are discussed in this article. (medscape.com)
Thus far, ERT has been largely unsuccessful in improving central nervous system manifestations of the lysosomal storage diseases, putatively due to difficulty in penetrating the blood-brain barrier. (medscape.com)
This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)
The availability of both ERT and hematopoietic stem cell transplantation has prompted ongoing consideration of newborn screening efforts to diagnose lysosomal storage diseases. (medscape.com)

Cold agglutinin disease has also been detected in patients with polycythemia vera. (ispub.com)
Polycythemia vera (PV) is a rare blood disease in which the bone marrow makes too many red blood cells. (cdc.gov)

however, an infectious disease workup revealed no evidence of either a bacterial or viral infection. (cancernetwork.com)

TET2-knockout mice predominantly develop chronic myelomonocytic leukemia (CMML), but they can also develop other myeloproliferative as well as lymphoproliferative diseases, reflecting the prevalence of TET2 mutations in these varied hematologic malignancies. (aacrjournals.org)
is occurred with e re-emergence of diseases that were once under control the concomitant presence of high rates of morbidity and and the identi cation of new microorganisms and their mortality from chronic non-communicable diseases, and the dissemination has highlighted infectious diseases among the incidence and prevalence of infectious diseases, with high morbidities that a ect human beings. (bvsalud.org)

Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. (frontiersin.org)
This is a case of Gaucher disease (A). Mycobacterium avium complex (MAC) infection (B) and Whipple disease (D) are included in the differential diagnosis due to similar morphologic picture of clustering histiocytes with so-called "wrinkled paper-like" cytoplasm. (uab.edu)
Cat-scratch disease is a benign and self-limited bacterial infection of Bartonella henselae . (logicalimages.com)
Administration of doxycycline, amoxicillin-clavulanate, erythromycin, or fluoroquinolones can limit bacteremia but does not cure infection in all cats and has not been shown to lessen the risk of cat scratch disease. (vin.com)

It is advisable to take inside the car, in a visible place, a report including the data on the disease, and the treatment, in case road assistance should be required for the occurrence of complications while driving or in the event of an accident. (fundacionmapfre.org)

In this setting, splenomegaly is thought to reflect work hypertrophy that results from the removal of abnormal blood cells from the circulation (either cells with intrinsic defects or cells coated with antibody) or, in some cases, that results from extramedullary hematopoiesis (ie, myeloproliferative disease). (medscape.com)

Early atherosclerotic and thrombotic disease occurring with stroke, myocardial infarction and peripheral vascular disease are characteristic. (fundacionmapfre.org)

2005). In addition, about half of patients with the closely related blood diseases, essential thrombocythemia (ET) and primary myelofibrosis (PMF), also carry the JAK21 m utation (Baxter et al. (cdc.gov)

Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)

Objective The rate of platelet count reduction appears to differ among different liver diseases. (go.jp)

Tickborne rickettsial diseases in humans often share similar clinical features yet are epidemiologically and etiologically distinct. (cdc.gov)
Ticks can transmit diseases to humans and animals anywhere from a few minutes to a few days once attached to its host. (cooperpest.com)

Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)
Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study. (cerezyme.com)

Splenomegaly, which was observed in 80% of the ferrets with lymphoma in this study, is a nonspecific finding, and is a common finding in ferrets with numerous other illnesses (Ferguson, D.C. 1985). (vin.com)
The differential diagnosis of lymphoma includes neoplastic and inflammatory diseases that involve lymphatic organs and the histological examination is definitive for the final diagnostic. (vin.com)

Gaucher disease. (uab.edu)
Gaucher Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Weinreb N, Taylor J, Cox T, Yee J, vom Dahl S. A benchmark analysis of the achievement of therapeutic goals for Type 1 Gaucher disease patients treated with imiglucerase. (cerezyme.com)
Gaucher disease type 1 patients from the ICGG Gaucher Registry sustain initial clinical improvements during twenty years of imiglucerase treatment. (cerezyme.com)
Starzyk K, Richards S, Yee J, Smith SE, Kingma W. The long-term international safety experience of imiglucerase therapy for Gaucher disease. (cerezyme.com)

The only proven effective treatment for the disease is hematopoietic stem cell transplantation. (frontiersin.org)

The ability to drive will depend on the stage of the disease, for the multiple organ involvement frequently occurring. (fundacionmapfre.org)

Rare Disease PHGKB is an online, continuously updated, searchable database of published scientific literature, CDC and NIH resources, and other information that address the public health impact and translation of genomic and other precision health discoveries into improved health outcomes related to rare diseases. (cdc.gov)

A total of 37 specialist nurses participated in the rst stage, and in the second stage there were 65 individuals admitted to the infectious disease clinics of two university hospitals. (bvsalud.org)

Anatomy4

Organisms3

Diseases32

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes4

Disciplines and Occupations1

Hepatomegaly3

Spleen10

Lymphadenopathy7

Symptoms6

Massive splenomegaly3

Idiopathic3

Splenic4

Cirrhosis1

Congestive1

Malaria5

Fever2

Abnormalities3

Acute10

Findings5

Centers for Diseas4

Lymphoid hyperplasia2

Disorders8

Infections5

Hepatic1

Pancytopenia1

Hypersplenism1

Pediatric2

Include3

Fatty Liver4

Thrombopoietin levels1

Syndrome7

Anemia3

Hepatitis1

Rarely1

Lysosomal storage5

Polycythemia2

Workup1

Prevalence2

Infection4

Complications1

Myeloproliferative1

Peripheral1

Primary-myelofibrosis1

Lymphomas1

Liver diseases1

Humans2

Manifestations2

Lymphoma2

Gaucher Disease5

Hematopoietic stem cell trans1

Organ1

Rare-diseases1

Infectious disease1