AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Motor NeuronsMotor Neuron DiseaseNeuronsSurvival of Motor Neuron 1 ProteinNeurons, AfferentMotor CortexSurvival of Motor Neuron 2 ProteinEvoked Potentials, MotorAmyotrophic Lateral SclerosisSpinal CordMuscular Atrophy, SpinalMotor ActivityAxonsSMN Complex ProteinsAction PotentialsNerve Tissue ProteinsMolecular Motor ProteinsElectric StimulationNerve DegenerationSynapsesNeuromuscular DiseasesGanglia, InvertebrateElectrophysiologyInterneuronsSynaptic TransmissionMovementCholinergic NeuronsCells, CulturedAplysiaMice, TransgenicDopaminergic NeuronsSuperoxide DismutaseElectromyographyAnterior Horn CellsNeuromuscular JunctionDendritesSensory Receptor CellsBulbar Palsy, ProgressiveGanglia, SpinalNeural InhibitionGABAergic NeuronsPatch-Clamp TechniquesImmunohistochemistryModels, NeurologicalBrainCerebral CortexAnimals, NewbornDisease Models, AnimalTime FactorsFacial NerveMembrane PotentialsMotor Skills DisordersAnimals, Genetically ModifiedHippocampusgamma-Aminobutyric AcidBrain StemAxonal TransportNeuropeptidesMutationNeural ConductionCholine O-AcetyltransferaseGangliaGrasshoppersNeurons, EfferentNerve NetNeurofilament ProteinsLocomotionCentral Nervous SystemReaction TimeGreen Fluorescent ProteinsBehavior, AnimalMedulla OblongataExcitatory Postsynaptic PotentialsNeuronal PlasticityEvoked PotentialsCell CountMice, Inbred C57BLMuscle, SkeletalGene Expression Regulation, DevelopmentalOlfactory Receptor NeuronsGlutamic AcidPsychomotor PerformanceCatsAfferent PathwaysDopamineLeechesCyclic AMP Response Element-Binding ProteinChick EmbryoRats, Sprague-DawleyMusclesNeurogliaRhombencephalonParalysisAnalysis of VariancePyramidal CellsSpinal Muscular Atrophies of ChildhoodRats, WistarCell DifferentiationCerebellumAstrocytes
Amyotrophic Lateral SLoss of motor neuronsUpper and lower motorMNDsDegenerationHuntington'sWeaknessCerebral cortexMuscle atrophy and fasciculationsDiagnosisSpinal musculaMusclesAssessmentAlzheimer'sSMN1GeneNeurodegenerative disordersDysfunctionProgressive bulbaNerveDisordersPatientsSymptomsTreatmentsFrontotemporalAffectsHumansProgressesSporadicPhenotypeSelectivelyCorticospinalCenters for DiseasAssociationAbnormalBucket challengeSignalsRarerRapidly progressiveGroupDeteriorationGeneticAxonsSurvivalResearchBrainFatal diseaseGenesProgression
Amyotrophic Lateral S19
Loss of motor neurons2
Upper and lower motor2
  • ALS, PBP, PLS) Motor neuron diseases are on a spectrum in terms of upper and lower motor neuron involvement. (wikipedia.org)
  • Clinically, ALS is characterised by co-existence of upper and lower motor neuron signs encompassing multiple body regions, with evidence of progressive deterioration. (acnr.co.uk)
MNDs6
  • Motor neuron diseases or motor neurone diseases (MNDs) are a group of rare neurodegenerative disorders that selectively affect motor neurons, the cells which control voluntary muscles of the body. (wikipedia.org)
  • Motor neuron degenerative diseases (MNDs) are a large family of neurological disorders. (sflorg.com)
  • In the latest research, the team used cutting-edge genetic sequencing techniques to investigate the genome of three families with individuals affected by hereditary spastic paraplegia - a large group of MNDs in which the motor neurons in the upper part of the spinal cord miscommunicate with muscle fibers, leading to symptoms including muscle stiffness, weakness and wasting. (sflorg.com)
  • Upper MNDs (eg, primary lateral sclerosis) affect neurons of the motor cortex, which extend to the brain stem (corticobulbar tracts) or spinal cord (corticospinal tracts). (msdmanuals.com)
  • Lower MNDs affect the anterior horn cells or cranial nerve motor nuclei or their efferent axons to the skeletal muscles. (msdmanuals.com)
  • ALS is one of a group of conditions known as motor neuron diseases (MNDs). (cdc.gov)
Degeneration5
  • It is characterized by pyramidal cell loss in the frontal and temporal lobes and degeneration of motor neurons in the hypoglossal nucleus and spinal motor neurons. (medscape.com)
  • Data now suggest that delocalization, accumulation, and ubiquitination of TDP-43 in the cytoplasm of motor neurons are early dysfunctions in the cascade of the events leading to motor neuron degeneration in ALS. (medscape.com)
  • MND is characterised by the degeneration of primarily motor neurones, leading to muscle weakness. (nih.gov)
  • The disorder induces muscle weakness and atrophy throughout the body caused by the degeneration of the upper and lower motor neurons. (evotec.com)
  • Acanthocytosis has also been associated with the rare hypobetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) syndrome, a disease of childhood akin to Hallervorden-Spatz disease and a defect in the gene for pantothenate kinase. (medscape.com)
Huntington's3
  • Background: Early non-motor features including anxiety, depression and altered social cognition are present in Huntington's disease (HD). (lu.se)
  • These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia. (news-medical.net)
  • Brainstem findings in Huntington's disease. (bvsalud.org)
Weakness10
  • While each motor neuron disease affects patients differently, they all cause movement-related symptoms, mainly muscle weakness. (wikipedia.org)
  • Various patterns of muscle weakness occur in different motor neuron diseases. (wikipedia.org)
  • there are three main weakness patterns that are seen in motor neuron diseases, which are: Asymmetric distal weakness without sensory loss (e.g. (wikipedia.org)
  • Progressive dementia with symptoms of executive dysfunction, personality change, and motor weakness leads to severe morbidity. (medscape.com)
  • Signs and symptoms reflect frontal and temporal lobe dysfunction with lower motor neuron-type weakness, muscle atrophy, and fasciculations. (medscape.com)
  • The presentation of the disease varies and can be as muscle weakness, wasting, cramps and stiffness of arms and/or legs, problems with speech and/or swallowing or, more rarely, with breathing problems. (nih.gov)
  • Whichever area the disease starts, as the disease progresses the pattern of signs and symptoms becomes similar, with increasing muscle weakness in the person's arms and legs, problems swallowing and communicating and weakness of the muscles used for breathing, which ultimately leads to death. (nih.gov)
  • It covers monitoring of disease progression, management of symptoms (in particular muscle weakness, excess secretions, breathing and nutrition problems), ongoing support and services, mobility, emotional and psychological changes, and preparation for end of life. (nih.gov)
  • 2 Lower motor neuron signs are clinically characterised by fasciculations, muscle wasting and weakness, while UMN signs include slowness of movement, increased tone, hyper-reflexia and extensor plantar responses. (acnr.co.uk)
  • Bulbar-onset disease may be evident in 20-25% of patients, characterised by progressive dysarthria, dysphagia, hoarseness, tongue wasting, weakness and fasciculations as well as emotional lability. (acnr.co.uk)
Cerebral cortex3
  • Since they are embedded among hundreds of other types of neurons in the cerebral cortex, it has been difficult to study CSMN, and little has been known about cellular and molecular factors that control their growth and development. (sci-info-pages.com)
  • 2001. Subchronic dermal application of N,N-diethyl m-toluamide (DEET) and permethrin to adult rats, alone or in combination, causes diffuse neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and purkinje neuron loss in the cerebellum. (cdc.gov)
  • In contrast to Huntington disease (HD), the major inherited choreiform disorder of adults, the cerebral cortex and corpus callosum are relatively spared. (medscape.com)
Muscle atrophy and fasciculations1
  • Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal reflexes. (wikipedia.org)
Diagnosis7
  • Differential diagnosis can be challenging due to the number of overlapping symptoms, shared between several motor neuron diseases. (wikipedia.org)
  • Early diagnosis, without delay after investigation, may be helpful as it allows for the provision of medication and aids, as well as for communication about the disease and advance care planning to be undertaken appropriately. (nih.gov)
  • This diagnosis was changed to probable Pick’s disease. (ucl.ac.uk)
  • OBJECTIVES--To describe the frequency and characteristics of those patients initially registered with the Scottish Motor Neuron Disease Register (SMNDR) but who subsequently had a diagnosis other than MND made (false positives), to analyse the features which led to a revised diagnosis, and to draw conclusions which might improve routine neurological practice. (bmj.com)
  • The diagnosis of motor neuron disease must be made by a specialist. (sunlife.ca)
  • Each year in the U.S., 5,000 patients receive a diagnosis of ALS, an incurable neurodegenerative disease that will likely kill them within two to five years. (news-medical.net)
  • Around 5,000 people in the UK have MND at any one time, with half of people with the disease dying within 14 months of diagnosis. (iambreathing.com)
Spinal muscula3
  • SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. (broadinstitute.org)
  • Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. (broadinstitute.org)
  • Columbia researchers have discovered how a genetic defect leads to spinal muscular atrophy (SMA), a critical piece of information about the disease that neurologists have been seeking for decades. (news-medical.net)
Muscles10
  • Researchers have found that the insulin-like growth factor 1 (IGF-1) dramatically increases the in vitro growth of corticospinal motor neuron (CSMN) axons - projections that carry nerve impulses to the spinal motor neurons that connect to muscles. (sci-info-pages.com)
  • 16 Extra-ocular and sphincter muscles are preserved until advanced stages of the disease, 17 and sensory nerves are not typically affected. (acnr.co.uk)
  • Motor neuron disease (MND) is a group of diseases in which the nerve cells in the brain and spinal cord controlling the muscles that enable us to move, speak, breathe and swallow slowly degenerate and die. (vetscite.org)
  • Individuals affected by the disorder may ultimately lose the ability to initiate and control all voluntary movement, although bladder and bowel sphincters and the muscles responsible for eye movement are usually, but not always, spared until the terminal stages of the disease. (evotec.com)
  • It can affect any adult at any time and attacks the motor neurones that send messages from the brain to the muscles, leaving people unable to walk, talk or feed themselves. (iambreathing.com)
  • The term motor neurone disease describes a group of related diseases, affecting the motor nerves or neurones in the brain and spinal cord which pass messages to the muscles telling them what to do. (iambreathing.com)
  • A new theory is making rounds regarding Motor Neuron Disease, which is known to alter muscles in a major way. (tmrblog.com)
  • Motor neurons transmit signals from the brain and spinal cord that tell skeletal muscles to tense (contract), which allows the body to move. (medlineplus.gov)
  • Dendrites and axons are required for the transmission of impulses between neurons and from neurons to muscles. (medlineplus.gov)
  • Motor neurons send signals to the muscles. (cdc.gov)
Assessment1
  • The novel approach presented in this paper can supplement conventional two-source validation for accuracy assessment of decomposed motor units from experimental signals, which is essential for development of surface EMG decomposition methods. (embs.org)
Alzheimer's4
  • In June 1990, he spent a week there undergoing tests and in the following October we were told that he probably had Alzheimer's disease and there was nothing that could be done. (ucl.ac.uk)
  • Many of these "genetic suspects" have been identified in other brain-related disease, including Alzheimer's disease, Parkinson's disease and autism. (vetscite.org)
  • Nearly one million people in the United States are living with Parkinson's disease, making it the second-most common neurodegenerative disease after Alzheimer's. (news-medical.net)
  • Mortality from presenile dementia (PSD), Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease (MND) was examined for 27 states in the National Occupational Mortality Surveillance (NOMS) system for the period 1982 through 1991. (cdc.gov)
SMN11
  • The SMN1 gene provides instructions for making the survival motor neuron (SMN) protein. (medlineplus.gov)
Gene7
  • A new gene therapy could revolutionize the treatment of diseases like sickle cell anaemia. (weforum.org)
  • The researchers believe these gene variants are "promising candidates" for playing a role in the development of motor neuron disease. (vetscite.org)
  • Now, the team has identified a further new gene - named TMEM63C - which causes a degenerative disease that affects the upper motor neuron cells in the nervous system. (sflorg.com)
  • This new gene finding is consistent with our hypothesis that the correct maintenance of specific lipid processing pathways is crucial for the way brain cells function, and that abnormalities in these pathways are a common linking theme in motor neuron degenerative diseases," said study co-author Professor Andrew Crosby from the University of Exeter. (sflorg.com)
  • These investigations showed that changes in the TMEM63C gene were the cause of the disease. (sflorg.com)
  • From a mitochondrial cell biologist point of view, identification of TMEM63C as a new motor neuron degenerative disease gene and its importance to different organelle functions reinforce the idea that the capacity of different cellular compartments to communicate together, by exchanging lipids for example, is critical to ensure cellular homeostasis required to prevent disease," said Prudent. (sflorg.com)
  • Importantly, individuals with the mutant HD gene suffer from psychiatric symptoms and metabolic dysfunction many years before onset of typical motor symptoms. (lu.se)
Neurodegenerative disorders1
  • Motor neuron disease (MND) encompasses a group of rapidly progressive and universally fatal neurodegenerative disorders of the human motor system, first described in the mid-19th century by the French Neurologist Jean Martin Charcot. (acnr.co.uk)
Dysfunction2
  • MND, as the name suggests, is a pure motor disorder without any significant evidence of sensory symptoms, extraocular movement disturbances, bladder and bowel dysfunction, or cognitive impairment. (medscape.com)
  • Objective -To confirm whether the plasma glucose concentration curve obtained during oral glucose tolerance tests (OGTTs) in horses with equine motor neuron disease (EMND) is decreased, compared with that obtained in clinically normal horses, and determine whether that decrease is a result of defective glucose metabolism or intestinal glucose transport dysfunction. (avma.org)
Progressive bulba1
  • 2 In addition, the varied clinical presentations of MND also include (i) progressive muscle atrophy (PMA, ~ 10% of MND cases), a clinically pure lower motor neuron (LMN) phenotype, (ii) primary lateral sclerosis (PLS, 1-3% of MND cases), a clinically pure upper motor neuron (UMN) phenotype and (iii) progressive bulbar palsy (PBP, 1-2% of MND cases), an isolated bulbar phenotype with relative preservation of spinal motor neurons. (acnr.co.uk)
Nerve5
  • In bulbar palsies, only the cranial nerve motor nuclei in the brain stem (bulbar nuclei) are affected. (msdmanuals.com)
  • This protein is one of a group of proteins called the SMN complex, which is important for the maintenance of specialized nerve cells called motor neurons. (medlineplus.gov)
  • ALS is a disease that affects the nerve cells in both the upper and lower parts of the body. (cdc.gov)
  • This disease causes the nerve cells to stop working and die. (cdc.gov)
  • What are motor neuron (nerve cell) diseases? (cdc.gov)
Disorders3
  • Currently, there are no approved treatments for the majority of motor neuron disorders, and care is mostly symptomatic. (wikipedia.org)
  • In addition to providing insight into the development and circuit formation of this critical population of neurons, these results might lead to the future ability to treat motor neuron disorders and spinal cord injuries. (sci-info-pages.com)
  • Motor neurone disease (MND) is a group of progressive neurological disorders that destroy the motor neurons - cells that control voluntary muscle activity including speaking, walking, breathing, swallowing and general movement of the body. (irishlife.ie)
Patients8
  • About 95% of ALS patients have abnormalities in the nucleus-cytoplasmic localization in spinal motor neurons of TDP43. (wikipedia.org)
  • In TDP-43 depleted human neural stem cell-derived motor neurons, as well as in sporadic ALS patients' spinal cord specimens there is significant double-strand break accumulation and reduced levels of NHEJ. (wikipedia.org)
  • Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
  • Referral was based primarily on symptoms, and was influenced by the number of MND patients under review, level of disability, rate of disease progression and availability of a NIV service. (nih.gov)
  • The majority of ALS patients present with limb-onset disease (65-75%), 10 spreading along the neuraxis to affect contiguous motor neurons. (acnr.co.uk)
  • This breakthrough will be extremely valuable in identifying patients for clinical trials and will assist in finding new treatments for this devastating disease. (entertainmentlive.co)
  • We reviewed the clinical manifestations and outcome of 20 cases of neurobrocellosis out of 1375 patients with brucellosis admitted to the infectious diseases ward of a tertiary hospital in Hamedan, Islamic Republic of Iran. (who.int)
  • In endemic areas, the disease should be ruled out in all patients who develop unexplained neurological symptoms. (who.int)
Symptoms4
  • Symptoms of motor neuron diseases can be first seen at birth or can come on slowly later in life. (wikipedia.org)
  • Signs and symptoms depend on the specific disease, but motor neuron diseases typically manifest as a group of movement-related symptoms. (wikipedia.org)
  • influence of symptoms, respiratory function, rate of disease progression, level of disability and bulbar involvement on referral for NIV. (nih.gov)
  • Nomenclature and symptoms vary according to the part of the motor system most affected. (msdmanuals.com)
Treatments6
  • The research may lead to treatments for motor neuron disease and spinal cord injury. (sci-info-pages.com)
  • More than 300 million people worldwide live with rare diseases, for which there are no preventative measures, no cures, and no effective treatments. (weforum.org)
  • Understanding precisely how lipid processing is altered in motor neuron degenerative diseases is essential to be able to develop more effective diagnostic tools and treatments for a large group of diseases that have a huge impact on people's lives," said study co-author Dr Emma Baple from the University of Exeter. (sflorg.com)
  • Research at The University of Queensland could eventually help develop viable treatments - and ultimately a cure - for motor neuron disease (MND). (news-medical.net)
  • The team's findings move the Trinity researchers one step closer to building better and more effective treatments for different sub-categories of the disease. (entertainmentlive.co)
  • Ongoing work will identify key molecular pathways and the critical neuronal circuitries affected early in the HD hypothalamus in order to develop disease modifying treatments. (lu.se)
Frontotemporal1
Affects1
Humans1
Progresses2
  • As the condition progresses, the motor neuron cells become damaged and may eventually die. (sflorg.com)
  • The Trinity researchers have now shown that these patterns of brain network disruptions in MND cluster into 4 distinct subtypes that are predictive of how the disease progresses. (entertainmentlive.co)
Sporadic4
  • Motor neuron diseases with both UMN and LMN findings include both familial and sporadic ALS. (wikipedia.org)
  • This is an advance in knowledge about the role genetics is likely to play in sporadic forms of motor neuron disease," says the University of Sydney's Associate Professor Roger Pamphlett, a co-author of the new study. (vetscite.org)
  • Sporadic' motor neuron disease accounts for about 90 per cent of cases. (vetscite.org)
  • The findings indicate that the genetic changes underlying many cases of sporadic motor neuron disease could stem from one of two sources," Associate Professor Pamphlett says. (vetscite.org)
Phenotype3
  • However, selective deletion of mHTT from OXT neurons alone was not sufficient to alter the metabolic and psychiatric phenotype of the BACHD mice at this early time point. (lu.se)
  • Conclusions: Our results indicate that mHTT expression can exert cell-autonomous toxic effects on OXT neurons without affecting the non-motor phenotype at early time points in mice. (lu.se)
  • in the presence of chronic lithium, such increased NPCs differentiate towards a neuron-like rather than a glial phenotype. (fupress.net)
Selectively3
  • Methods: To express mHTT only in OXT neurons, we used a novel flex-switch adeno-associated viral vector design to selectively express either mHTT or wild-type HTT in the. (lu.se)
  • Methods: To express mHTT only in OXT neurons, we used a novel flex-switch adeno-associated viral vector design to selectively express either mHTT or wild-type HTT in the paraventricular nucleus of the hypothalamus using OXT-Cre-recombinase mice. (lu.se)
  • We also performed a mirror experiment to selectively delete mHTT in OXT neurons using the BACHD mouse model. (lu.se)
Corticospinal1
  • Jeffrey Macklis, director of the MGH-Harvard Medical School Center for Nervous System Repair, said: "Our findings that IGF-1 specifically enhances both the speed and extent of axon outgrowth of corticospinal motor neurons are the first direct evidence of growth factor control over the differentiation of these neurons. (sci-info-pages.com)
Centers for Diseas4
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Good afternoon, I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • Before we begin, the following presentation contains some content made by external presenters and not by the Centers for Disease Control and Prevention, or the Department of Health and Human Services. (cdc.gov)
Association5
  • I am running the Plymouth Half Marathon for Motor Neurone Disease Association because of the excellent work the Plymouth branch does. (justgiving.com)
  • We are raising money for Motor Neurone Disease Association because It's a charity close to our hearts. (justgiving.com)
  • We have been privileged to work with the Motor Neurone Disease Association - including talking to people who have the condition and their families - to ensure we do justice to people's real-life experiences. (radiotimes.com)
  • They'll take your donation and pass it onto Motor Neurone Disease Association. (giveasyoulive.com)
  • Your donations will help the great work Motor Neurone Disease Association do. (giveasyoulive.com)
Abnormal2
  • About 5-10% of people with MND have a family history of the disease and several abnormal genes have been identified. (nih.gov)
  • A new genetic discovery adds weight to a theory that motor neuron degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells. (sflorg.com)
Bucket challenge1
  • On Friday, the motor neuron research group took on the ALS Ice Bucket Challenge to help raise awareness for this rapidly progressive neurodegenerative disease. (evotec.com)
Signals1
  • Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. (news-medical.net)
Rarer1
  • Since that year, rarer autosomal dominant disease forms with variable penetrance with or without chromosome 9 abnormalities have also been described. (medscape.com)
Rapidly progressive1
Group3
  • Scientists have reported a breakthrough in their development of a group of neurons which govern motor activity. (sci-info-pages.com)
  • It is a group of conditions in the motor neurone type that is quite large. (tmrblog.com)
  • The research group studies the underlying pathogenic mechanisms of the neurodegenerative and neuropsychiatric Huntington disease (HD) with the ultimate aim to develop novel effective therapies. (lu.se)
Deterioration1
Genetic3
  • In an effort to identify genetic variants that may play a role in the disease, the researchers sequenced the protein-coding genes of 44 MND-affected individuals and their parents. (vetscite.org)
  • Background Apart from increasing age and a few specific genetic polymorphisms, the aetiology of Motor Neurone Disease is largely unknown. (bmj.com)
  • Neil Platt was among the small proportion (5-10%) of people with MND who have a family history of the disease, caused by genetic mistakes that can be passed from one generation to the next. (iambreathing.com)
Axons1
Survival1
  • A lack of mature mRNA, and subsequently the proteins needed for normal cell functioning, has damaging effects on motor neuron development and survival. (medlineplus.gov)
Research2
  • The world class electrical signal analysis research developed within Trinity College has discovered different patterns of brain network disruption reflect the underlying disease process. (entertainmentlive.co)
  • The purpose of this research is to get a better picture of who gets ALS or other motor neuron diseases. (cdc.gov)
Brain1
  • Unfortunately, it remains typical for those suffering with mental illness and brain disease. (ucl.ac.uk)
Fatal disease1
  • Currently two to three thousand Australians are living with this fatal disease. (vetscite.org)
Genes1
  • More than 80 mutated genes have been identified in HSPs, making this one of the most genetically heterogenous inherited diseases. (the-scientist.com)
Progression3
  • Every person with MND has an individual progression of the disease. (nih.gov)
  • While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures. (news-medical.net)
  • These effects of lithium are concomitant with slowed disease progression and are reminiscent of the neurogenetic effects described in the sub-ependymal ventricular zone of the hippocampus. (fupress.net)