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  • autonomic
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • Tolerance to the autonomic effects of increased blood pressure and heart rate, and increased urine output, develops with chronic use (i.e., these symptoms become less pronounced or do not occur following consistent use). (wikipedia.org)
  • biology
  • 2-9 Therefore, recent advances in studies of Ang II receptors could prove the existence of a variety of new players and targets in addition to the traditional "Ang II world" and provide a new insight into cardiovascular biology. (ahajournals.org)
  • fracture
  • Thus, the elderly are prone to disease, are more likely to suffer a fracture due to progressive osteoporosis, demonstrate a decrease of sensory functions of vision and hearing, more frequently heart attacks and strokes and malignant diseases. (erank.tv)
  • Based on this point, fundamental computational and experimental studies on fracture phenomena of amyloid fibrils may provide mechanical insights [ 10 , 16 ]. (hindawi.com)
  • Regulation
  • While molecular biological studies are revealing a large diversity in the subtypes of K + channels that are normally expressed in vascular muscle, 7 it is noteworthy that there is still very little information available at the molecular level regarding regulation of K + channel expression and function in vascular disease. (ahajournals.org)
  • roles
  • Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane structure, bile secretion, and very-low-density lipoprotein (VLDL) secretion. (wikipedia.org)
  • adaptation
  • Intermittent hypoxic training (IHT), also known as intermittent hypoxic therapy, is a non-invasive, drug-free technique aimed at improving human performance and well-being by way of adaptation to reduced oxygen. (wikipedia.org)
  • It was from these studies that he outlined the phenomenon of human physiological adaptation to environmental changes as a predictable event, a novel idea in a time when such things as blood pressure and resting heart rate were considered immutable. (wikipedia.org)
  • incidence
  • It has been suggested that higher antioxidant potential can protect the organism against undesirable reactive oxygen species activity and thus prevent disease incidence [ 1 , 2 ]. (hindawi.com)
  • The incidence of SAD increases along with the distance from the equator. (lifeextension.com)
  • It may improve weight gain during therapy and reduce the incidence of cerebral palsy as well as reduce language and cognitive delay. (wikipedia.org)
  • hyperpolarization
  • 1 2 3 4 5 6 This Brief Review will first provide a short description of the functional characteristics of the 4 main types of vascular K + channels and the likely physiological importance of these channels, as well as the phenomenon of K + channel-mediated, endothelium-dependent vascular hyperpolarization. (ahajournals.org)
  • An increase in extracellular K+ has been shown to activate an ouabain-sensitive electrogenic Na+-K+-ATPase followed by hyperpolarization and smooth muscle cell relaxation. (wikipedia.org)
  • Subsequently, it was suggested that EDHF is a sulfur signal that results in activation of K channels via sulfhydration of a cysteine residue (formation of a cysteine persulfide) (https://doi.org/10.1161/CIRCRESAHA.111.240242) C-type natriuretic peptide (CNP) has been shown to exert a variety of cardiovascular effects including vasodilation and hyperpolarization of arteries through the opening of KCa+-channels. (wikipedia.org)
  • An alternative explanation for the EDHF phenomenon is that direct intercellular communication via gap junctions allows passive spread of agonist-induced endothelial hyperpolarization through the vessel wall. (wikipedia.org)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • processes
  • These are cell atrophy, impaired metabolism (increased catabolism), reduction of the defense capacity of the organism, reducing healing processes and regeneration, degeneration of the nervous system. (erank.tv)
  • Thus, urinary proteome changes in the elderly appear to reflect the physiological processes of aging and are particularly clearly represented in the circulatory and immune systems. (springer.com)
  • endurance
  • Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. (wikipedia.org)
  • Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output. (wikipedia.org)
  • prevention
  • Hence, taurine supplementation is possibly beneficial for the prevention of these diseases. (wikipedia.org)
  • The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. (wikipedia.org)
  • heart
  • Increased vagal tone (and thus vagal action) is associated with a diminished and more variable heart rate. (wikipedia.org)
  • It is characterized by an increased heart rate during inhalation and a diminished heart rate during exhalation. (wikipedia.org)
  • Subsequently, heart rate increases. (wikipedia.org)
  • This increased pressure inhibits venous return to the heart and thus less atrial expansion and activation of baroreceptors occurs. (wikipedia.org)
  • 2012 ). Thus, diagnoses and research in which heart disease and cancer are the focus are ineffectual for half of the patients older than 80 years, and physiological aging raises many unanswered questions, particularly with regard to changing metabolic patterns. (springer.com)
  • Class Ia drugs increase the time one action potential lasts in the heart. (wikipedia.org)
  • In particular, he hypothesized that dietary saturated fat causes cardiovascular heart disease and should be avoided. (wikipedia.org)
  • deprivation
  • Bodosi and colleagues have shown, on the other hand, that 5 h sleep deprivation does not affect leptin concentrations but increases ghrelin concentrations [ 8 ]. (hindawi.com)
  • Caffeine can delay or prevent sleep, and improves task performance during sleep deprivation. (wikipedia.org)
  • dilation
  • Pompe disease is associated with BA dilation, elongation and elevated bifurcation height of the BA which might result in cerebrovascular complications. (springer.com)
  • effects
  • The majority of well-known Ang II actions are mediated via AT 1 receptor stimulation, and angiotensin converting enzyme inhibitors (ACEI) and AT 1 receptor blockers (ARBs) have been widely used as antihypertensive drugs, with the expectation of cardiovascular protective effects. (ahajournals.org)
  • In the present study, we investigated the mechanical characteristics of transthyretin amyloid protein (TTR), which have been implicated in cardiovascular disease, and specifically considered the contribution of end-terminal capping effects. (hindawi.com)
  • Sleep is considered to be a restorative process with beneficial effects on many bodily systems, including the digestive system, the immune system, and the cardiovascular system. (hindawi.com)
  • Unfortunately, the success rate of pharmacologic intervention for depression is a mere 50% or less and these medications are fraught with potential side effects, including a proclivity to increase suicidal ideation with some anti-depressant drugs (Prescrire Int. 2011). (lifeextension.com)
  • Our current knowledge of the effects of disease on vascular K + channel function almost exclusively relies on interpretation of data obtained by using pharmacological modulators of K + channels. (ahajournals.org)
  • Hence, our current knowledge of the effects of disease on vascular K + channel expression is somewhat indirect and almost exclusively relies on interpretation of functional or electrophysiological data (eg, recordings of vessel tone or diameter, vascular muscle cell E m , or whole-cell or single-channel currents in isolated myocytes under voltage-clamp conditions) obtained in the presence of pharmacological modulators of K + channels. (ahajournals.org)
  • anaerobic
  • When used for performance enhancement in sports settings IHT improves mitochondrial status, leading to improvements in aerobic and anaerobic performance. (wikipedia.org)
  • renal
  • Urine proteome analysis is a rapidly developing analytical tool that is aimed at establishing new, non-invasive "fluid biopsy" diagnostic methods for renal and urinary tract diseases (Tyan et al. (springer.com)
  • skeletal muscle
  • Lysosomal α-glucosidase deficiency (Pompe disease) not only leads to glycogen accumulation in skeletal muscle, but also in the cerebral arteries. (springer.com)
  • It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. (wikipedia.org)
  • health
  • This work was primarily supported by a Marriott Foundation Cardiovascular Fellowship (CME), National Institutes of Health R01 DK082507 (CME), as well as Georgetown University Department of Medicine internal funding. (physiology.org)
  • Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health. (hindawi.com)
  • 2007 ). Although this methodology is still in its infancy, knowledge on urine proteomes in health and disease is growing rapidly due to advancements in instrumentation, data analysis techniques, and the relative ease of acquiring clinically relevant samples. (springer.com)
  • These types of stressors tend to have a more negative effect on health because they are sustained and thus require the body's physiological response to occur daily. (wikipedia.org)
  • Maharishi Vedic Approach to Health uses a model for understanding health and disease that is fundamentally different from that of modern medicine. (wikipedia.org)
  • The TM technique is the main modality which proponents say improves mental health and promotes "collective health" in MVAH. (wikipedia.org)
  • biological
  • The biological changes that occur with increasing age play a key role in the quality of physical - motor performance. (erank.tv)
  • Physiological or biological stress is an organism's response to a stressor such as an environmental condition. (wikipedia.org)
  • He also designed an improved Kjeldahl apparatus which improved upon Krogh's earlier design and allowed for more rapid determination of nitrogen content in biological samples. (wikipedia.org)
  • arteries
  • This finding raises concerns about whether or not long‐term benefits of anti‐TGF β therapeutics improve the durability of medically reopened arteries. (physiology.org)
  • hypoxia
  • It is important to differentiate between physiological adaptations to mild hypoxia and re-oxygenation episodes (i.e., the IHT protocol) and frequent nocturnal suffocation awakenings produced by sleep apnea, which might result in various pathologies. (wikipedia.org)
  • Hence
  • Hence, protection of cardiomyocytes and their increased survival is a putative target for cardioprotection [ 3 ]. (hindawi.com)
  • changes
  • Regular PA at moderate intensity may induce favorable changes in antioxidant defense system, especially by an increase of individual enzymatic antioxidants activity [ 11 , 12 ]. (hindawi.com)
  • Physiological changes can include changes in sympathetic activation or HPA activity, and immunological function. (wikipedia.org)
  • Thus
  • The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract, thus it improves the surfactant properties of the cholic acid conjugate. (wikipedia.org)
  • proteins
  • These amyloid proteins are generated from misfolded and denatured amyloid monomers under physiological conditions. (hindawi.com)
  • Many of the major types of degenerative disease are associated with denatured and misfolded amyloid proteins [ 1 - 3 ]. (hindawi.com)