Diseases gene expression regulation neoplastic. Medical search. Frequent questions

Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene. (wikipedia.org)

At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. (wikipedia.org)
The PAX genes give instructions for making proteins that attach themselves to certain areas of DNA. (wikipedia.org)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. (uchicago.edu)

A mutation in the PAX8 gene could prevent or disrupt normal development. (wikipedia.org)
At least one mutation in the BRAF gene has been identified in some people with Erdheim-Chester disease. (medlineplus.gov)
The BRAF gene mutation that causes this condition is somatic, meaning that it occurs during a person's lifetime and is present only in certain cells. (medlineplus.gov)
This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation and may allow histiocytes to grow and divide uncontrollably, leading to the abnormal accumulation of histiocytes that occurs in Erdheim-Chester disease. (medlineplus.gov)
The V600E mutation (described above) in the BRAF gene has also been found to cause giant congenital melanocytic nevus. (medlineplus.gov)
This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell proliferation. (medlineplus.gov)
The BRAF gene mutations change single amino acids in the BRAF protein: One mutation replaces the amino acid threonine with the amino acid proline at position 241 (written as Thr241Pro or T241P) and the other mutation replaces the amino acid leucine with the amino acid phenylalanine at position 245 (written as Leu245Phe or L245F). (medlineplus.gov)

3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)

Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1-regulated genes. (ox.ac.uk)
JQ1 treatment resulted in significant changes in expression of genes that play important roles in glioblastoma such as c-Myc, p21(CIP1/WAF1), hTERT, Bcl-2, and Bcl-xL. (ox.ac.uk)

Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology. (ox.ac.uk)
As director of the UCLA Medical Center's Diagnostic Molecular Pathology Laboratory, Grody can offer his trainees exposure to the latest clinical applications of molecular biology in the diagnosis of a wide range of genetic, neoplastic and infectious diseases as well as DNA fingerprinting. (uclahealth.org)
This proposed CAP-ACP Virtual Education Series is an introduction to Molecular Genetic Pathology and covers core principles and applications in neoplastic disease. (cap-acp.com)
The material is intended for practicing pathologists and pathology residents across Canada and is pertinent to all pathology specialties that interact with neoplastic disease. (cap-acp.com)
Explain the roles and mechanisms of genomic variation in inherited and somatic disease and recognize how they inform the principles and best practices of pathology. (cap-acp.com)

For comparative purposes, we distributed the genes according to Gene Ontology processes and identified expressed genes involved in transcription, signal transduction, immune response, cell proliferation, cell growth and apoptosis, which were affected by Tax. (biomedcentral.com)
Interestingly, there was a notable fold change difference between up-regulated genes involved in transcription, signal transduction and cell proliferation induced by TaxS240P or TaxD247G. (biomedcentral.com)

MiRNAs participate in controlling cancer cell metabolism by regulating the expression of genes whose protein products either directly regulate metabolic machinery or indirectly modulate the expression of metabolic enzymes, serving as master regulators. (edu.au)
It is shown that reactive oxygen species metabolism and oxidative stress responsive genes are deregulated. (nature.com)

In addition, the lower GRHL2 expression group showed a significantly lower overall survival rate in acute leukemia patients than that of patients with a higher GRHL2 expression group. (hindawi.com)
Some studies have suggested that the renal PAX genes act as pro-survival factors and allow tumor cells to resist apoptosis. (wikipedia.org)
The androgen receptor (AR) is required for prostate cancer (PCa) survival and progression, and ablation of AR activity is the first line of therapeutic intervention for disseminated disease. (ox.ac.uk)
Illustrating the impact of these unmasked AR-driven pathways, dihydroceramide desaturase 1 was identified as an AR-regulated gene in mitotically active cells that promoted pro-metastatic phenotypes, and in advanced PCa proved to be highly associated with development of metastases, recurrence after therapeutic intervention and reduced overall survival. (ox.ac.uk)
Here, we showed that XAF1 low expression correlates with poor survival and disease status. (nus.edu.sg)
5 4 In addition to increased disease-related morbidity, MF results in early death with the median survival of affected patients being approximately 6 years. (haematologica.org)
The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). (biorxiv.org)
The survival of patients with CRC is directly associated with the pathological stage (pTNM) of the disease which is determined after microscope analysis of the sample obtained by biopsy or surgical resection of the tumor 2 , 3 . (biorxiv.org)
AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. (geneticsmr.com)

Methylated DNA can prevent transcription factors from binding to it, resulting in low or no gene expression, which is an important alteration in the early initiation and development of malignant neoplastic diseases [ 7 ]. (hindawi.com)

We propose that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt activity and HIF-1-regulated gene expression. (ox.ac.uk)
Despite the dependence of PCa on AR activity throughout the course of disease, delineation of the AR-dependent transcriptional network that governs disease progression remains elusive, and the function of AR in mitotically active cells is not well understood. (ox.ac.uk)
At present, the role of autophagy in cutaneous melanoma (CM) is still controversial, since it appears to be tumor-suppressive at early stages of malignant transformation and cancer-promoting during disease progression. (bvsalud.org)

Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. (cancerindex.org)

Using the recently described MeLiM miniature pig model of heritable cutaneous malignant melanoma, we studied the expression of two ECM glycoproteins, the tenascin-C (TN-C) and tenascin-X (TN-X), in normal skin and melanoma. (nih.gov)
Additional gene mutations in cells within the nevus after birth can lead to melanoma in people with giant congenital melanocytic nevus. (medlineplus.gov)

In addition, he is heavily involved in basic molecular genetics research involving regulation of gene expression of arginase and related enzymes in hereditary arginase deficiency and various cancers, population molecular genetic screening, and genomic approaches to hereditary disease pathogenesis. (news.am)
Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. (geneticsmr.com)

We used quantitative real-time polymerase chain reaction (qRT-PCR) for detecting the aberrant expression level of GRHL2 in 60 patients with acute leukemia and 60 normal controls. (hindawi.com)
Finally, we identified aberrant methylation in multiple genes also targeted by recurring DNA copy number alterations in ALL, suggesting that these genes are inactivated far more frequently than suggested by structural genomic analyses alone. (lu.se)
Children with ADAR1 mutations develop fatal Aicardi-Goutières syndrome characterized by aberrant interferon expression. (cancerindex.org)
On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)

We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray analysis of DNA copy number alterations and gene expression, and genome-wide cytosine methylation profiling using the HpaII tiny fragment enrichment by ligation-mediated PCR (HELP) assay. (lu.se)

We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
In addition to classical gene regulatory networks noted above, we have recently identified a central role for additional biologic mechanisms, namely gene regulation by chromatin regulators and by noncoding RNAs. (stanford.edu)

A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. (lookformedical.com)
10] Interestingly, this analysis found no differences in expression of proliferation markers between these subsets of CD207+ cells, consistent with the hypothesis that LCH may be a disease of abnormal cellular accumulation. (medscape.com)
Considering the important role of activator protein-1 (AP-1) in regulating multiple genes involved in the cell proliferation and inflammation and the induction of neoplastic transformation, we aimed to evaluate the potency of TiO2 NPs (≤ 20 nm) on the activation of AP-1 signaling pathway and the generation of reactive oxygen species (ROS) in a mouse epidermal cell line, JB6 cells. (cdc.gov)

Bioinformatics analysis also revealed the 85 most frequently altered neighboring genes of SERPINB5, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed 20 GO terms and 3 KEGG pathways with statistical significance. (duke.edu)

research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)
Expression of PAX8 is increased in neoplastic renal tissues, Wilms tumors, ovarian cancer and Müllerian carcinomas. (wikipedia.org)
Re-activation of PAX8 (or Pax2) expression has been reported in pediatric Wilms Tumors, almost all subtypes of renal cell carcinoma, nephrogenic adenomas, ovarian cancer cells, bladder, prostate, and endometrial carcinomas. (wikipedia.org)
However, we identify changes shared by these samples with their corresponding primary tumors and prostate-cancer alterations reported in the literature, evidence that these cells, like those in advanced disease, are disseminated tumor cells (DTCs). (fhcrc.org)
In retrospect, the fact that cancer was viewed as a genetic disease for so long was likely an artifact of focus and technology: Chromosomal changes began to be detectable before we understood epigenetics at a molecular level, and the early focus on familial cancer and rapidly induced viral tumors favored the discovery of mutational carcinogenesis, which has largely colored our views over the past three decades ( 3, 4 ). (aacrjournals.org)
Both the ontogeny and the regulated expression of the arginase isozymes are being studied in a variety of developmental and adult systems and in certain malignant tumors in which their expression is induced. (uclahealth.org)

It has been debated whether LCH is a reactive or neoplastic process, although the latter is now more commonly accepted. (medscape.com)
It has been debated whether LCH is a reactive or neoplastic process. (medscape.com)

Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia. (hindawi.com)

MASPIN had a statistically negative correlation with NSCLC prognosis, functioning as an oncoprotein by hypomethylation and influencing specific pathways involving the 85 genes identified herein. (duke.edu)
Our present research is aimed at studying the abnormal expression of GRHL2 and the association of methylation in patients with acute leukemia and its relationship with prognosis. (hindawi.com)
We analyzed the significant correlation between the expression level of GRHL2 with clinicopathological features and patients' prognosis in acute leukemia using the corresponding statistical methods. (hindawi.com)
Furthermore, ET A R/β-arr1/YAP gene signature correlates with a worst prognosis in HG-SOC. (mcmaster.ca)
Neuroblastomas with poor prognosis are often characterized by 1p36 deletion, containing the kinesin gene KIF1B. (nus.edu.sg)
Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. (biorxiv.org)

Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)

It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
We also identified an epigenetic signature common to all cases, with correlation to gene expression in 65% of these genes, suggesting that a core set of epigenetically deregulated genes is central to the initiation or maintenance of lymphoid transformation. (lu.se)
The mechanism of epigenetic regulation involves the CpG site methylation of promoter regions and the modification of DNA and histones by altering chromatin structure ( 9 - 11 ). (spandidos-publications.com)
It took a while to recognize that these same processes are intimately involved in the pathophysiology of disease states, but research into epigenetic deregulation is now as commonplace as research into genetic etiology in various medical conditions. (aacrjournals.org)
It is easy to understand how cancer can be an epigenetic disease. (aacrjournals.org)
Different regulatory mechanisms can control miRNA expression at the genetic or epigenetic level, thus affecting the biogenetic machinery via recruitment of specific transcription factors. (edu.au)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. (cancerindex.org)
This gene encodes subunit 1 of the splicing factor 3b protein complex. (cancer-genetics.org)

These differences were found in genes involved in cell cycle regulation, apoptosis, cell signaling, metastasis, and myeloid differentiation. (medscape.com)
The Drg-1 gene suppresses tumor metastasis in prostate cancer. (wakehealth.edu)

Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

Together, these results demonstrate subtype- and disease-specific alterations in cytosine methylation in ALL that influence transcriptional activity, and are likely to exert a key role in leukemogenesis. (lu.se)
The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, DNA hypomethylation of the COX‑2 promoter region located from ‑1,522 to ‑829 bp might contribute to transcriptional regulation of COX‑2 expression and induce a pro‑inflammatory response in KIC. (spandidos-publications.com)
Several known tumor suppressor genes like TP53 and WT1 have been identified as transcriptional targets in human astrocytoma cells. (wikipedia.org)

Estimation of DNA methylation level in endometrial neoplastic tissues compared to normal endometrial samples was the aim of this study. (cnrs.fr)
RESULTS: The median DNA methylation level was significantly higher in neoplastic tissues than in normal endometrium. (cnrs.fr)
article{, title = {[Estimation of DNA methylation level in nonendometrial uterus malignancies]}, author = { A. Popiela and M. S. Gabrys and J. Rabczynski and M. Panszczyk and G. Keith and W. Baranowski}, year = {2002}, date = {2002-01-01}, journal = {Ginekol Pol}, volume = {73}, number = {11}, pages = {962-5}, abstract = {OBJECTIVES: Rebuilding of genome structure leads to many pathological states including neoplastic malignancies. (cnrs.fr)
Authors describe an analysis of DNA methylation level in nonendometrial neoplastic uterine tissues compared to DNA methylation level in normal endometrium. (cnrs.fr)

CV004 trade name] may also be used in the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with body weight of at least 40 kg) who require supplemental oxygen therapy. (who.int)

2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

The synergistic effects of increased ROS production, accumulated DNA damage and impaired DNA repair could participate in, and partly explain, the massive loss of neurons observed in Alzheimer's disease since both oxidative stress and DNA damage can trigger apoptosis. (cnr.it)
These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)

These mutations can affect different functions of the protein including DNA binding, gene activation, protein stability, and cooperation with the co-activator p300. (wikipedia.org)
Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. (wikipedia.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
We then screened the residual HSCs and detected some of these mutations including mutations in the NPM1, TET2, and SMC1A genes. (ox.ac.uk)
Collectively, mutations in U2AF1 induce expression of therapeutically targetable 'active' IRAK4 isoforms and provide a genetic link to activation of chronic innate immune signalling in MDS and AML. (cancer-genetics.org)
Mutations in the BRAF gene are the most common cause of cardiofaciocutaneous syndrome. (medlineplus.gov)
At least two mutations in the BRAF gene have been found to cause Noonan syndrome with multiple lentigines (formerly called LEOPARD syndrome). (medlineplus.gov)

Down regulation of the PAX gene expression inhibits cell growth and induces apoptosis. (wikipedia.org)

Then we investigated the demethylating effect of arsenic trioxide and 5-azacitidine on the mRNA and protein expression levels of GRHL2 in cell lines of acute leukemia. (hindawi.com)
We found a lower level of GRHL2 expression not only in acute leukemia patients but also in cell lines when compared with normal controls. (hindawi.com)
At the same time, the expression level of GRHL2 in patients with acute leukemia was significantly correlated with leukocyte count, platelet count, and cytogenetic risk grouping. (hindawi.com)
Univariate and multivariate analyses revealed that the expression of GRHL2 is an independent risk factor in acute leukemia patients. (hindawi.com)
On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

Expressions were investigated for selected kinases in the extracellular signal-regulated kinase/mitogen activated protein kinase (ERK/MAPK), the phosphoinositide 3-kinase/Akt, and the Wnt/-catenin pathways as well as for selected phosphatases and several entities associated with prostaglandin E2 (PGE(2)) signaling. (ku.dk)

Using qPCR and Western blot technique, we investigated mRNA and protein expressions. (ku.dk)

Whereas pig normal skin displayed a discrete TN-C signal at the dermo-epidermal junction, around blood vessels and hair bulbs, the swine tumour showed enhanced expression of TN-C in these areas and around stromal and tumour cells. (nih.gov)
Furthermore, responses were associated with T-helper type 1 (TH1) gene expression, CTLA4 expression and the absence of fractalkine (CX3CL1) in baseline tumour specimens. (nih.gov)

Disseminated epithelial cells can be isolated from the bone marrow of a far greater fraction of prostate-cancer patients than the fraction of patients who progress to metastatic disease. (fhcrc.org)
Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites. (lookformedical.com)
He is the director of the Molecular Diagnostic Laboratories and the Clinical Genomics Center within the UCLA Health, one of the first such facilities in the country to offer DNA-based tests for diagnosis of a wide variety of genetic, infectious, and neoplastic diseases, as well as bone marrow engraftment, patient specimen identification and paternity testing by DNA fingerprinting, and clinical genomic DNA sequencing for undiagnosed disorders. (news.am)

The PAX gene family has an important role in the formation of tissues and organs during embryonic development and maintaining the normal function of some cells after birth. (wikipedia.org)
CONCLUSIONS: Authors conclude that neoplastic endometrial tissues show high DNA methylation rate compared to normal or hyperplastic endometrium. (cnrs.fr)

A 2010 study comparing gene expression of cells expressing CD207 (a marker of Langerhans cells) in LCH lesions with epidermal CD207+ control cells identified differential expression of more than 2000 genes between these 2 subsets. (medscape.com)

deletion results in loss of XAF1 expression, suggesting that XAF1 is indeed a downstream target of KIF1B? (nus.edu.sg)

Utilizing modern molecular biologic techniques such as the polymerase chain reaction, gene cloning and gene transfer, Dr. Wayne Grody's laboratory is involved in the elucidation, diagnosis and ultimately the treatment of single-gene defects at the molecular level. (uclahealth.org)

We found fewer and less striking genomic alterations in the 48 pools of disseminated cells from patients with organ-confined disease. (fhcrc.org)
Analyzing AR activity as a function of cell cycle revealed an unexpected and highly expanded repertoire of AR-regulated gene networks in actively cycling cells. (ox.ac.uk)
Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
[ 3 ] Taken together, these findings have led some to speculate that LCH is not a specific disease of epidermal Langerhans cells, but rather one of mononuclear phagocyte dysregulation. (medscape.com)
Cells have built in machinery to turn off and on gene expression permanently. (aacrjournals.org)
Inhibition of IRAK4-L abrogates leukaemic growth, particularly in AML cells with higher expression of the IRAK4-L isoform. (cancer-genetics.org)
The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. (geneticsmr.com)
The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)
Our results suggest that although trisomy 8 cells are in a pro-apoptotic state, they are checked by the enhanced expression of anti-apoptotic signals which provide them with their proliferative advantage. (who.int)

Scholars@Duke publication: The roles of MASPIN expression and subcellular localization in non-small cell lung cancer. (duke.edu)
However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene expression by regulating Akt activation of HIF-1 activity. (ox.ac.uk)
This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. (wikipedia.org)
We show multiple regions of copy-number change, including alterations common in prostate cancer, such as 8p loss, 8q gain, and gain encompassing the androgen-receptor gene on Xq, in the disseminated cell pools from 11 metastatic patients. (fhcrc.org)
We also demonstrate that DTCs from patients with advanced and localized disease share several abnormalities, including losses containing cell-adhesion genes and alterations reported to associate with progressive disease. (fhcrc.org)
Cell Death & Disease , 9 (11). (ncsu.edu)
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
The BRAF gene provides instructions for making a protein that helps transmit chemical signals from outside the cell to the cell's nucleus. (medlineplus.gov)

More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)

Alternatives for gene replacement therapy have been explored by re-directing the transfected genes to different subcellular compartments. (uclahealth.org)

Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. (geneticsmr.com)

Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
The results of the present study revealed that ketamine treatment induced NF‑κB p65 translocation to nuclei and activated COX‑2 expression and prostaglandin (PGE)2 production in bladder tissue, whereas COX‑2 inhibitor suppressed the inflammatory effect. (spandidos-publications.com)
Using human arginase deficiency, a defect in the urea cycle, as a model system, Grody and his colleagues are exploring, in close collaboration with the laboratory of Dr. Stephen Cederbaum, the molecular structure and tissue-specific regulation of the arginase genes in health and disease. (uclahealth.org)
BackgroundInvestigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. (ku.dk)

In the nucleus, ET-1 through β-arr1 orchestrates the tethering of YAP and mutp53 to YAP/mutp53 target gene promoters, including EDN1 that ensures persistent signals. (mcmaster.ca)
During my postdoctoral years, I was drawn to understanding the fundamental signaling cascades that transmit information from growth factor receptors at the plasma membrane all the way to the nucleus where gene expression is controlled. (mpnfoundation.org)

Colonic mucosal contents of PGE(2) and PGE(2) metabolites were determined by use of ELISA.ResultsWe found up-regulation of ERK1, ERK2, Akt1, Akt2, PLA2G4A, prostanoid receptor EP3 and phosphatase scaffold subunit PPP2R1B mRNA expression in normal appearing colonic mucosa of CRN patients compared to controls.ConclusionPresent study supports that even normal appearing mucosa of CRN patients differs from that of non-CRN patients at a molecular level. (ku.dk)

This led to a natural convergence of my interests in signaling with those in neoplastic disease. (mpnfoundation.org)

p16INK4a overexpression is the standard in determining HPV-driven carcinogenesis, but disease prevalence impacts on its positive predictive value. (bvsalud.org)

The study in the validation cohort of the significant methylated sites from the discovery cohort found that hypermethylation of five genes was significantly associated with shorter RFS in stage I NSCLC: HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9. (edgehill.ac.uk)

Here a global analysis of exon usage in AML samples revealed distinct molecular subsets containing alternative spliced isoforms of inflammatory and immune genes. (cancer-genetics.org)
The molecular consequence of translocation is overexpression of the protein cyclin D1 (coded by the PRAD1 gene located close to the breakpoint). (medscape.com)

Moreover, alignment of cytokine mRNA expression from the cortex of these rats with a computational model of neuronglia interaction found that the moderate-severe TBI produced by the stainless-steel projectile strongly associated with the neuroinflammatory state, while the mild TBI existed in a state between normal and inflammatory neuronglia interactions. (cdc.gov)

As a master regulator, it is possible that it regulates expression of genes other than thyroid-specific. (wikipedia.org)

Epigenetics indicates the alterations of gene expression levels mediated by nongene sequence changes. (hindawi.com)
These shared alterations might confer the capability to disseminate or establish secondary disease. (fhcrc.org)

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