• factors
  • Proliferation of the cancer cell at the metastatic site Formation of a micrometastasis inside the secondary site Progressive colonization, forming a life-threatening metastasis The potential of a tumor cell to metastasize depends on its microenvironment, or "niche" interactions with local factors promoting tumor-cell growth, survival, angiogenesis, invasion and metastasis. (wikipedia.org)
  • Classification aspects must be carefully tested and validated, such that confounding effects are minimized, making them either true prognostic factors, which estimate disease outcomes such as disease-free or overall survival in the absence of therapy, or true predictive factors, which estimate the likelihood of response or lack of response to a specific treatment. (wikipedia.org)