• Parkinson's
  • Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease," PLoS ONE , vol. 4, no. 9, Article ID e7247, 2009. (hindawi.com)
  • Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons," American Journal of Pathology , vol. 154, no. 5, pp. 1423-1429, 1999. (hindawi.com)
  • E. C. Hirsch and S. Hunot, "Neuroinflammation in Parkinson's disease: a target for neuroprotection? (hindawi.com)
  • S. Karunakaran and V. Ravindranath, "Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF- κ B in MPTP-treated mice: implication in Parkinson's disease," Journal of Neurochemistry , vol. 109, no. 6, pp. 1791-1799, 2009. (hindawi.com)
  • Researchers at UCLA have developed a molecular compound that improves balance and coordination in mice with early stage Parkinson's disease. (ucla.edu)
  • Parkinson's disease is a nervous system disorder that affects movement. (ucla.edu)
  • CLR01 previously showed a strong therapeutic effect in a zebrafish model of Parkinson's. (ucla.edu)
  • This work was supported by multiple funding agencies, including the National Institutes of Health, RJG Foundation, the Michael J. Fox Foundation, Team Parkinson/Parkinson Alliance, the American Parkinson's Disease Association, and gifts to the Center for the Study of Parkinson's Disease at UCLA. (ucla.edu)
  • Parkinson's disease (PD) is a multifactorial disorder, which is neuropathologically identified by age-dependent neurodegeneration of dopaminergic neurons in the substantia nigra. (hindawi.com)
  • Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. (epfl.ch)
  • MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. (wikipedia.org)
  • Within three days he began exhibiting symptoms of Parkinson's disease. (wikipedia.org)
  • 1984) found that injections of MPTP in squirrel monkeys resulted in Parkinsonism, symptoms of which were subsequently reduced by levodopa, a precursor for the neurotransmitter dopamine, currently the drug-of-choice in treatment of Parkinson's disease. (wikipedia.org)
  • The symptoms and brain structures of MPTP-induced Parkinson's disease are fairly indistinguishable to the point that MPTP may be used to simulate the disease in order to study Parkinson's disease physiology and possible treatments within the laboratory. (wikipedia.org)
  • Knowledge of MPTP and its use in reliably recreating Parkinson's disease symptoms in experimental models has inspired scientists to investigate the possibilities of surgically replacing neuron loss through fetal tissue implants, subthalamic electrical stimulation and stem cell research, all of which have demonstrated initial, provisional successes. (wikipedia.org)
  • multiple sclerosis
  • This review aims to provide an update on the most recent evidence of therapeutically-relevant neuro-immuneinteractions following NPC transplants in animal models of multiple sclerosis, cerebral stroke and traumas of the spinal cord, and consideration of the forthcoming challenges related to the early translation of some of these exciting experimental outcomes into clinical medicines. (wingsforlife.com)
  • Alzheimer's
  • To receive news and publication updates for International Journal of Alzheimer's Disease, enter your email address in the box below. (hindawi.com)
  • Nanowerk News ) On Wednesday Revalesio Corporation presented new data at the Alzheimer's Association International Conference that identifies the specific cellular pathways by which Revalesio's lead investigational product, RNS60, impacts Alzheimer's Disease. (nanowerk.com)
  • Defining RNS60's activity against these genes is an important link between the significant therapeutic activity demonstrated by RNS60 in mouse and cellular models where RNS60 prevented beta-amyloid induced cell death and tau-neurofibrillary tangles the most common hallmarks of Alzheimer's disease. (nanowerk.com)
  • These plasticity associated genes and associated pathways have long been targets for drug developers, but Revalesio's approach through its charge-stabilized nanostructure technology provides a new paradigm for treating Alzheimer's disease. (nanowerk.com)
  • organism
  • Screening in model organism offers the advantage of interrogating test agents, or alterations in targets of interest, in the context of fully integrated, assembled, biological systems, providing insights that could otherwise not be obtained in cellular systems. (wikipedia.org)
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • progression
  • Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. (springer.com)
  • Development of suitable experimental models is critical in identifying risk factors for disease, elucidating fundamental molecular mechanisms in disease progression, and providing guidance as to whether or not a particular treatment is safe and effective for humans. (springer.com)
  • human
  • Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. (wingsforlife.com)
  • Stem cell technology is a promising branch of regenerative medicine that is aimed at developing new approaches for the treatment of severely debilitating human diseases, including those affecting the central nervous system (CNS). (wingsforlife.com)
  • The significant impact in vivo of experimental NPC therapies in animal models of inflammatory CNS diseases has raised great expectations that these stem cells, or the manipulation of the mechanisms behind their therapeutic impact, could soon be translated to human studies. (wingsforlife.com)
  • Not only does a rodent's small brain often preclude the use of advanced neuroimaging techniques, it is also not clear how intracerebral application of trophic factors, transplant therapies, and gene therapies in small animals might translate to the much larger human brain. (medindia.net)
  • Importantly, the brains of large animals can be studied using sensitive measures that should be highly translatable to the human condition, including MRI and PET imaging, EEG, and electrophysiology, as well as behavioral tests looking at motor and cognitive function," says Professor Jenny Morton, PhD, of the Department of Physiology, Development and Neuroscience at the University of Cambridge. (medindia.net)
  • The relevance to human biology of NHP models in Huntington's disease hold great potential value for preclinical research and development, but we need to fully consider the substantial issues of cost, long-term housing of affected animals, access of the models to HD investigators, and ethical concerns with modeling in these species," says Dr Howland. (medindia.net)
  • Animal models are used by scientists to replicate human diseases in another living animal, allowing them to study the biology of the disease and test potential treatments. (understandinganimalresearch.org.uk)
  • In conjunction, these models reflect the diversity and utility of tools used to study human disease. (springer.com)
  • The mission of the 7th Aquatic Animal Mod-els of Human Disease Conference is to provide scientists using aquatic animal models a unique opportunity to exchange scientific information, identify research tools and opportunities, address environmental health issues, and encourage the utility of aquatic models for the study of human disease. (xenbase.org)
  • This venue will encourage development of an appreciation of aquatic animal models and their contributions to understanding human disease. (xenbase.org)
  • We hope to see you at the 7th Aquatic Animal Models of Human Disease Conference as it returns to Texas. (xenbase.org)
  • Genesis, the Journal of Genetics and Development will sponsor a $500 travel award for the best abstract on Xenopus research submitted by a junior researcher to the 7th Aquatic Animal Models of Human Disease Conference. (xenbase.org)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Although kindling is a widely used model, its applicability to human epilepsy is controversial. (wikipedia.org)
  • However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does occur. (wikipedia.org)
  • Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
  • The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy Kindling (sedative-hypnotic withdrawal) Epileptogenesis Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • Ontology
  • Uberon is a comparative anatomy ontology representing a variety of structures found in animals, such as lungs, muscles, bones, feathers and fins. (wikipedia.org)
  • One of the uses of this ontology is to integrate data from different biological databases, and other species-specific ontologies such as the Foundational Model of Anatomy. (wikipedia.org)
  • mice
  • Fleming operates its own Animal House, which can house up to 20,000 mice and has its own complete mouse histopathology unit. (wikipedia.org)
  • The Animal House has a capacity to house more than 20,000 mice and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
  • In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • Regarding experiments on mice in particular, some researchers have complained that "years and billions of dollars have been wasted following false leads" as a result of a preoccupation with the use of these animals in studies. (wikipedia.org)
  • Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. (wikipedia.org)
  • ocular
  • Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study. (springer.com)
  • therapeutic
  • In Animal Models for Retinal Diseases , recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. (springer.com)
  • The initial idea that stem cell transplants work in vivo via the replacement of endogenous cells lost or damaged owing to disease has been challenged by accumulating evidence of their therapeutic plasticity. (wingsforlife.com)
  • Strategies directed against the huntingtin gene in the brain are an important part of CHDI's therapeutic portfolio", says David Howland, PhD, Director of Model Systems at CHDI. (medindia.net)
  • Development of symptomatic treatments has been partly successful for PD research, but there remain a number of inadequacies in therapeutic strategies for the disease. (hindawi.com)
  • These viral models provide valuable insights into Parkinson disease mechanisms, help to identify therapeutic targets and may contribute to the development of therapeutic approaches. (epfl.ch)
  • In whole animal-based approaches, phenotypic screening is best exemplified where a substance is evaluated for potential therapeutic benefit across many different types of animal models representing different disease states. (wikipedia.org)
  • autoimmune
  • Autoimmune bullous diseases (AIBDs) are characterized by blisters and erosions on the skin and/or mucous membranes, which are caused by autoantibodies directed to structural proteins of the epidermis and the epidermal basement membrane zone. (wiley.com)
  • Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. (wikipedia.org)
  • vivo
  • Altogen Labs maintains a GLP-compliant laboratory performing preclinical research and biotechnology studies, pharmacology and toxicology assays, and in vivo experiments including: cancer xenograft models, pharmacokinetics, pharmacodynamics, and toxicology testing. (wikipedia.org)
  • In drug discovery, Altogen Labs offers include the following in vivo efficacy tests: teratoma formation and analysis, cancer disease animal models, and animal xenograft models. (wikipedia.org)
  • research
  • We cover all aspects of animal research with snapshots of biomedical advances from scientific journals, staff blogs and video links. (understandinganimalresearch.org.uk)
  • CAMARADES is currently leading the way in advancing education about systematic reviews in animal research. (wikipedia.org)
  • Prof. Macleod is on the Methodology Advisory Board of the charity SABRE Research UK which raises awareness of the need for systematic reviews of existing animal studies. (wikipedia.org)
  • Diabetes & Vascular Disease Research. (wikipedia.org)
  • Fleming's Animal house (certified with ISO 9001) provides husbandry of animals and services to the biomedical research community since 2001. (wikipedia.org)
  • Some of the most publicized attacks on animal research facilities by animal rights groups have occurred because of primate research. (wikipedia.org)
  • They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. (wikipedia.org)
  • In 2006-07, Syrian hamsters accounted for 19% of the total animal research participants in the United States. (wikipedia.org)
  • treatments
  • Further understanding of the pathogenicity of autoreactive CD4 + T cells may lead to disease-specific treatments. (wiley.com)
  • experiments
  • In December 2005, Austria outlawed experiments on any apes, unless it is conducted in the interests of the individual animal. (wikipedia.org)
  • commonly
  • Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. (wikipedia.org)
  • species
  • This meeting is unique in that our program is not limited to a sin-gle disease, discipline, or species, and thereby will provide a breadth and diversity of topics not seen in more narrowly focused conferences. (xenbase.org)
  • approaches
  • Animal based approaches to phenotypic screening are not as amenable to screening libraries containing thousands of small molecules. (wikipedia.org)
  • nervous
  • It induces hepatotoxicity and Zamia staggers, a fatal nervous disease affecting cattle resulting from browsing on the leaves or fruit of cycads. (wikipedia.org)
  • researchers
  • In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents, and medical students. (springer.com)
  • The Boyd Group, a British group comprising animal researchers, philosophers, primatologists, and animal advocates, has recommended a global prohibition on the use of great apes. (wikipedia.org)
  • occurs
  • The Lytico-bodig disease, also known as lateral sclerosis-parkinsonism-dementia, is a neurodegenerative disease of unknown origin that occurs exclusively in the Chamorro people of the island of Guam that has characteristics of both amyotrophic lateral sclerosis (ALS) and parkinsonism. (wikipedia.org)
  • hypothesis
  • More recently it has become popular to develop a hypothesis that a certain biological target is disease modifying, and then screen for compounds that modulate the activity of this purified target. (wikipedia.org)