• transgenic
  • Furthermore, oral administration of CEppt to an aggressive AD transgenic mice model led to marked decrease in 56 kDa Aβ oligomers, reduction of plaques and improvement in cognitive behavior. (pubfacts.com)
  • We orally administered the flavonoid tannic acid (TA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human APP and presenilin-1 transgenes) and evaluated cognitive function and AD-like pathology. (pubfacts.com)
  • In the current study, we examined the effects of L-NBP on learning and memory in a triple-transgenic AD mouse model (3xTg-AD) that develops both plaques and tangles with aging, as well as cognitive deficits. (pubfacts.com)
  • multiple sclerosis
  • This review aims to provide an update on the most recent evidence of therapeutically-relevant neuro-immuneinteractions following NPC transplants in animal models of multiple sclerosis, cerebral stroke and traumas of the spinal cord, and consideration of the forthcoming challenges related to the early translation of some of these exciting experimental outcomes into clinical medicines. (wingsforlife.com)
  • mice
  • Whereas mice and rats are often not susceptible to human pathogens, replicate them at low levels or require rodent-adapted pathogen strains, the cotton rat has proven susceptible to a wide variety of human pathogens and to be a model system to simulate a number of important parameters of human disease. (osu.edu)
  • Specifically, 56 kDa oligomeric species were shown to be correlated with impaired cognitive function in AD model mice. (pubfacts.com)
  • More recently a dodecameric form of Aβ with a 56 kDa molecular weight, denoted Aβ*56, was shown to cause memory impairment in AD model mice. (pubfacts.com)
  • Fleming operates its own Animal House, which can house up to 20,000 mice and has its own complete mouse histopathology unit. (wikipedia.org)
  • The Animal House has a capacity to house more than 20,000 mice and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
  • cellular
  • Here we focus on recent advances of the evidence-linked neuroprotective activity of bioactive ingredients of herbal origin in cellular and animal models of PD research. (hindawi.com)
  • Compounds are screened in cellular or animal disease models to identify compounds that cause a desirable change in phenotype. (wikipedia.org)
  • Screening in model organism offers the advantage of interrogating test agents, or alterations in targets of interest, in the context of fully integrated, assembled, biological systems, providing insights that could otherwise not be obtained in cellular systems. (wikipedia.org)
  • Some have argued that cellular based systems are unable to adequately model human disease processes that involve many different cell types across many different organ systems and that this type of complexity can only be emulated in model organisms. (wikipedia.org)
  • Severity
  • The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy Kindling (sedative-hypnotic withdrawal) Epileptogenesis Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). (wikipedia.org)
  • brains
  • Amyloid precursor protein (APP) proteolysis is essential for production of amyloid-β (Aβ) peptides that form β-amyloid plaques in brains of Alzheimer disease (AD) patients. (pubfacts.com)
  • Strain
  • Commercial suppliers for this inbred strain are in the USA Harlan Inc., Ace Animals and Virion Systems, and in Europe Charles River. (osu.edu)
  • nervous
  • It induces hepatotoxicity and Zamia staggers, a fatal nervous disease affecting cattle resulting from browsing on the leaves or fruit of cycads. (wikipedia.org)
  • researchers
  • The Boyd Group, a British group comprising animal researchers, philosophers, primatologists, and animal advocates, has recommended a global prohibition on the use of great apes. (wikipedia.org)
  • Species
  • When administered to an AD fly model, CEppt rectified their reduced longevity, fully recovered their locomotion defects and totally abolished tetrameric species of Aβ in their brain. (pubfacts.com)
  • One of the uses of this ontology is to integrate data from different biological databases, and other species-specific ontologies such as the Foundational Model of Anatomy. (wikipedia.org)
  • occurs
  • The Lytico-bodig disease, also known as lateral sclerosis-parkinsonism-dementia, is a neurodegenerative disease of unknown origin that occurs exclusively in the Chamorro people of the island of Guam that has characteristics of both amyotrophic lateral sclerosis (ALS) and parkinsonism. (wikipedia.org)
  • structures
  • Uberon is a comparative anatomy ontology representing a variety of structures found in animals, such as lungs, muscles, bones, feathers and fins. (wikipedia.org)
  • Center
  • The Disease BioPortal is operated and maintained by the Center for Animal Disease Modeling and Surveillance (CADMS) at the University of California, Davis and is supported through a consortium of national and international institutions, agencies, and organizations. (ucdavis.edu)
  • hypothesis
  • More recently it has become popular to develop a hypothesis that a certain biological target is disease modifying, and then screen for compounds that modulate the activity of this purified target. (wikipedia.org)
  • approaches
  • Animal based approaches to phenotypic screening are not as amenable to screening libraries containing thousands of small molecules. (wikipedia.org)
  • Experiments
  • In December 2005, Austria outlawed experiments on any apes, unless it is conducted in the interests of the individual animal. (wikipedia.org)
  • effects
  • L-3-n-butylphthalide (L-NBP), an extract from seeds of Apium graveolens Linn (Chinese celery), has been demonstrated to have neuroprotective effects on ischemic, vascular dementia, and amyloid-beta (Abeta)-infused animal models. (pubfacts.com)
  • Phenotypic screening in animal-based systems utilize model organisms to evaluate the effects of a test agent in fully assembled biological systems. (wikipedia.org)
  • Do animal models of anxiety predict anxiolytic-like effects of antidepressants? (wikipedia.org)
  • toxic
  • The origin and biological role of these toxins is unknown, as there does not appear to be a statistically significant correlation between the concentration of toxic material and the types of herbivory observed in animals consuming the plants. (wikipedia.org)
  • disorders
  • Spinal and bulbar muscular atrophy may share mechanistic features with other disorders caused by polyglutamine expansion, such as Huntington's disease. (wikipedia.org)