• transgenic
  • Furthermore, oral administration of CEppt to an aggressive AD transgenic mice model led to marked decrease in 56 kDa Aβ oligomers, reduction of plaques and improvement in cognitive behavior. (pubfacts.com)
  • We orally administered the flavonoid tannic acid (TA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human APP and presenilin-1 transgenes) and evaluated cognitive function and AD-like pathology. (pubfacts.com)
  • In the current study, we examined the effects of L-NBP on learning and memory in a triple-transgenic AD mouse model (3xTg-AD) that develops both plaques and tangles with aging, as well as cognitive deficits. (pubfacts.com)
  • Transgenic animal production consists of injecting each construct into 300-350 eggs, typically representing three days' work. (wikipedia.org)
  • The number of transgenic animals typically varies from two to eight. (wikipedia.org)
  • multiple sclerosis
  • This review aims to provide an update on the most recent evidence of therapeutically-relevant neuro-immuneinteractions following NPC transplants in animal models of multiple sclerosis, cerebral stroke and traumas of the spinal cord, and consideration of the forthcoming challenges related to the early translation of some of these exciting experimental outcomes into clinical medicines. (wingsforlife.com)
  • mice
  • Whereas mice and rats are often not susceptible to human pathogens, replicate them at low levels or require rodent-adapted pathogen strains, the cotton rat has proven susceptible to a wide variety of human pathogens and to be a model system to simulate a number of important parameters of human disease. (osu.edu)
  • Specifically, 56 kDa oligomeric species were shown to be correlated with impaired cognitive function in AD model mice. (pubfacts.com)
  • More recently a dodecameric form of Aβ with a 56 kDa molecular weight, denoted Aβ*56, was shown to cause memory impairment in AD model mice. (pubfacts.com)
  • Fleming operates its own Animal House, which can house up to 20,000 mice and has its own complete mouse histopathology unit. (wikipedia.org)
  • The Animal House has a capacity to house more than 20,000 mice and is currently the largest Mouse Unit in Greece in terms of number and variety of mice. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • In 1902 Lucien Cuénot published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • Rodents are commonly used in animal testing, particularly mice and rats, but also guinea pigs, hamsters, gerbils and others. (wikipedia.org)
  • While mice, rats and other rodents are by far the most widely used animals in biomedical research, recent studies have highlighted their limitations. (wikipedia.org)
  • Regarding experiments on mice in particular, some researchers have complained that "years and billions of dollars have been wasted following false leads" as a result of a preoccupation with the use of these animals in studies. (wikipedia.org)
  • Many laboratory animals, including mice and rats, are chronically stressed which can also negatively affect research outcomes and the ability to accurately extrapolate findings to humans. (wikipedia.org)
  • human
  • Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials. (wingsforlife.com)
  • Stem cell technology is a promising branch of regenerative medicine that is aimed at developing new approaches for the treatment of severely debilitating human diseases, including those affecting the central nervous system (CNS). (wingsforlife.com)
  • Animal models are used by scientists to replicate human diseases in another living animal, allowing them to study the biology of the disease and test potential treatments. (understandinganimalresearch.org.uk)
  • This was shown in human Muse cells infused into animal models with fulminant hepatitis, partial hepatectomy, muscle degeneration, skin injury, stroke and spinal cord injury. (wikipedia.org)
  • Although kindling is a widely used model, its applicability to human epilepsy is controversial. (wikipedia.org)
  • However, in both human epilepsy and in some animal models, evidence suggests that a process like that found in kindling does occur. (wikipedia.org)
  • Further research by Goddard on the characteristics of the kindling phenomenon led to his conclusion that kindling can be used to model human epileptogenesis, learning and memory. (wikipedia.org)
  • The publication of these results opened a completely new niche for epilepsy research and has stimulated a significant amount of studies on the subject of kindling and its relevance to human epilepsy Kindling (sedative-hypnotic withdrawal) Epileptogenesis Racine Stages (a method by which seizure severity is quantified in animal models of epilepsy) Bertram E (2007). (wikipedia.org)
  • The directive stresses the use of the 3R principle (replacement, refinement, reduction) and animal welfare when conducting animal testing on non-human primates. (wikipedia.org)
  • organism
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • viral
  • To date, viral PD models comprise α-synuclein and LRRK-2-based overexpression models, as well as models that mimic parkin loss of function by overexpression of the parkin substrates Pael-R, CDCrel-1, p38/JTV or synphilin-1. (epfl.ch)
  • The following animal models of viral infections have either been established or are under development at the BRL. (gmu.edu)
  • treatments
  • Further understanding of the pathogenicity of autoreactive CD4 + T cells may lead to disease-specific treatments. (wiley.com)
  • brains
  • Amyloid precursor protein (APP) proteolysis is essential for production of amyloid-β (Aβ) peptides that form β-amyloid plaques in brains of Alzheimer disease (AD) patients. (pubfacts.com)
  • commonly
  • Kindling is a commonly used model for the development of seizures and epilepsy in which the duration and behavioral involvement of induced seizures increases after seizures are induced repeatedly. (wikipedia.org)
  • Strain
  • Commercial suppliers for this inbred strain are in the USA Harlan Inc., Ace Animals and Virion Systems, and in Europe Charles River. (osu.edu)
  • nervous
  • It induces hepatotoxicity and Zamia staggers, a fatal nervous disease affecting cattle resulting from browsing on the leaves or fruit of cycads. (wikipedia.org)
  • researchers
  • The Boyd Group, a British group comprising animal researchers, philosophers, primatologists, and animal advocates, has recommended a global prohibition on the use of great apes. (wikipedia.org)
  • Species
  • When administered to an AD fly model, CEppt rectified their reduced longevity, fully recovered their locomotion defects and totally abolished tetrameric species of Aβ in their brain. (pubfacts.com)
  • One of the uses of this ontology is to integrate data from different biological databases, and other species-specific ontologies such as the Foundational Model of Anatomy. (wikipedia.org)
  • occurs
  • The Lytico-bodig disease, also known as lateral sclerosis-parkinsonism-dementia, is a neurodegenerative disease of unknown origin that occurs exclusively in the Chamorro people of the island of Guam that has characteristics of both amyotrophic lateral sclerosis (ALS) and parkinsonism. (wikipedia.org)
  • structures
  • Uberon is a comparative anatomy ontology representing a variety of structures found in animals, such as lungs, muscles, bones, feathers and fins. (wikipedia.org)
  • Center
  • The Disease BioPortal is operated and maintained by the Center for Animal Disease Modeling and Surveillance (CADMS) at the University of California, Davis and is supported through a consortium of national and international institutions, agencies, and organizations. (ucdavis.edu)
  • hypothesis
  • More recently it has become popular to develop a hypothesis that a certain biological target is disease modifying, and then screen for compounds that modulate the activity of this purified target. (wikipedia.org)
  • approaches
  • Animal based approaches to phenotypic screening are not as amenable to screening libraries containing thousands of small molecules. (wikipedia.org)
  • biological
  • Phenotypic screening in animal-based systems utilize model organisms to evaluate the effects of a test agent in fully assembled biological systems. (wikipedia.org)
  • The origin and biological role of these toxins is unknown, as there does not appear to be a statistically significant correlation between the concentration of toxic material and the types of herbivory observed in animals consuming the plants. (wikipedia.org)
  • Experiments
  • In December 2005, Austria outlawed experiments on any apes, unless it is conducted in the interests of the individual animal. (wikipedia.org)