• patients
  • However, before we can think about applying this approach to patients, we need to know more about any off-target effects of these gap junction inhibitors and better understand the long-term ramifications of temporarily blocking liver-specific gap junction channels. (massgeneral.org)
  • Jaundice and other symptoms highly suggestive of liver injury, such as itching, nausea, abdominal discomfort and lethargy, were present in the majority of patients. (redorbit.com)
  • However, such differences were not observed in the alcohol-altered liver membrane antibody-positive and alcohol-altered liver membrane antibody-negative cirrhotic patients. (wiley.com)
  • Liver biochemistry, insulin resistance (using the insulin resistance homeostasis model assessment method for insulin resistance, HOMA-IR) and body mass index were assessed and liver biopsies were performed on patients older than 45 years with persistently abnormal liver function and/ or hepatomegaly. (scielo.org.za)
  • research
  • Research into alcohol-related liver disease has been highlighted as a priority by the NIHR , which jointly funded the James Lind Alliance (JLA) PSP with the British Society of Gastroenterology (BSG) . (nihr.ac.uk)
  • improve
  • Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety. (massgeneral.org)
  • role
  • In the heart, gap junctions are known to propagate the electrical activity required for contraction, but their role in the liver is poorly defined. (massgeneral.org)
  • team
  • Recent work by the MGH team and others has shown that assemblies of intercellular gap junctions spread immune signals from injured liver cells to surrounding undamaged cells, amplifying overall inflammation and injury. (massgeneral.org)