• lymphocytes
  • Understanding Natural Killer (NK) cell anatomical distribution is key to dissect the role of these unconventional lymphocytes in physiological and disease conditions. (frontiersin.org)
  • Several studies have demonstrated the key role of adaptive CD4+ T lymphocytes in gluten‐dependent enteropathy, although it has been clear that the intraepithelial CD8+ T lymphocytes of innate immunity, highly infiltrating CD mucosa, are pivotal in the induction of intestinal mucosa alteration and malfunction. (els.net)
  • calprotectin
  • Although faecal calprotectin correlates significantly with disease activity in people with confirmed IBD, faecal calprotectin can be false-positive if the laboratory uses low calprotectin cut-off levels. (wikipedia.org)
  • Calprotectin becomes available in the intestinal lumen via leukocyte shedding, active secretion, cell disturbance, and cell death. (wikipedia.org)
  • atrophy
  • Cytotoxic CD8+ T cells, of both innate and adaptive branches, are involved in the intestinal villous atrophy. (els.net)
  • Cystic
  • Cystic fibrosis, is a hereditary disease that affects the entire body, causing progressive disability and early death. (wikipedia.org)
  • immune
  • Our results therefore characterize zonulin as a previously undescribed ligand that engages a key signalosome involved in the pathogenesis of human immune-mediated diseases that can be targeted for therapeutic interventions. (nih.gov)
  • IBD is a multifactorial disease that is nonetheless driven in part by an exaggerated immune response to gut microbiota that causes defects in epithelial barrier function. (wikipedia.org)
  • faecal
  • The aetiology of this disease is unknown but one hypothesis is that a luminal toxic agent may trigger the onset of CC. 1 Järnerot et al showed that faecal stream diversion leads to clinical and histopathological remission, although relapse occurred shortly after bowel reconstruction. (bmj.com)
  • receptors
  • Antibodies to signaling molecules and receptors in Alzheimer's disease are associated with psychomotor slowing, depression, and poor visuospatial function. (uio.no)
  • malabsorption
  • His research during this period included the description and elucidation of a new hereditary disorder of leucine metabolism called isovaleric acidemia, the definition of enzymatic defects in absorptive disorders, delineations of biochemical mechanism of nutrient absorption, malabsorption, and protein synthesis, derangements of metabolism and immunologic aspects of hepatic gastrointestinal diseases. (wikipedia.org)
  • pathogenic
  • E. coli and related bacteria constitute about 0.1% of gut flora, and fecal-oral transmission is the major route through which pathogenic strains of the bacterium cause disease. (wikipedia.org)
  • severe
  • In spite of Crohn's and UC being very different diseases, both may present with any of the following symptoms: abdominal pain, vomiting, diarrhea, rectal bleeding, severe internal cramps/muscle spasms in the region of the pelvis and weight loss. (wikipedia.org)
  • clinical
  • Significance of serological markers in the disease course of ulcerative colitis in a prospective clinical cohort of patients. (amedeo.com)
  • Clinical applications to alter detoxification pathway activity and improve patient outcomes are considered, drawing on the growing understanding of the relationship between detoxification functions and different disease states, genetic polymorphisms, and drug-nutrient interactions. (hindawi.com)
  • a high degree of clinical suspicion is often required to establish the diagnosis, as the disease is extremely rare. (wikipedia.org)
  • organism
  • The goals of treatment for intestinal amoebiasis are two-fold: to treat the invasive disease (using tissue agents) and to eradicate intestinal carriage of the organism (using luminal agents). (oncologynurseadvisor.com)
  • Luminal agents used to eradicate intestinal carriage of the organism include Paromomycin, Diiodohydroxyquin (iodoquinol) and diloxanide furoate. (oncologynurseadvisor.com)
  • He published a paper in 1854 entitled, "Microscopical observations and pathological deductions on cholera" in which he described the organism and its relation to the disease. (wikipedia.org)
  • tissue
  • However, quantitative and qualitative changes of NK cells that can be associated with disease conditions cannot be properly evaluated without a precise knowledge of NK cell tissue distribution at steady state. (frontiersin.org)
  • Complications
  • Correction: Corticosteroid Use and Complications in a US Inflammatory Bowel Disease Cohort. (amedeo.com)
  • Long-standing and untreated disease may lead to other complications, such as ulcerative jejunitis (ulcer formation of the small bowel) and stricturing (narrowing as a result of scarring with obstruction of the bowel). (wikipedia.org)
  • diagnosis
  • Collagenous colitis has become a more frequent diagnosis but the aetiology of this disease is still unknown. (bmj.com)