• metabolic
  • Dietary fructose is associated with metabolic syndrome and an increase in kidney weight. (physiology.org)
  • Promising avenues for treatment, such as the potential of low-level light therapy to increase the rate of oxygen consumption in the brain and enhance cortical metabolic capacity, and the possibility that some antihypertensive drug classes reduce the risk and progression of AD more than others, are discussed. (iospress.nl)
  • In recent years, studies have reported an association between metabolic changes and various pathophysiological mechanisms in the central nervous system (CNS) in patients with metabolic diseases. (frontiersin.org)
  • Thus, we reviewed recent findings relating to degeneration of dopaminergic neurons during metabolic diseases. (frontiersin.org)
  • According to a recent survey, the prevalence of metabolic diseases increases by approximately 46.7% among people older than 60 years compared to younger individuals ( Sepúlveda and Murray, 2014 ). (frontiersin.org)
  • Here, we review recent studies and provide new insight on the link between metabolic diseases and the degeneration of dopaminergic neurons, which consequently leads to PD. (frontiersin.org)
  • markedly
  • Vascular risk factors to Alzheimer's disease offer the possibility of markedly reducing incident dementia by early identification and appropriate medical management of these likely precursors of cognitive deterioration and dementia," says Guest Editor Jack C. de la Torre, MD, PhD, of the University of Texas, Austin. (iospress.nl)
  • biology
  • 2-9 Therefore, recent advances in studies of Ang II receptors could prove the existence of a variety of new players and targets in addition to the traditional "Ang II world" and provide a new insight into cardiovascular biology. (ahajournals.org)
  • fracture
  • Thus, the elderly are prone to disease, are more likely to suffer a fracture due to progressive osteoporosis, demonstrate a decrease of sensory functions of vision and hearing, more frequently heart attacks and strokes and malignant diseases. (erank.tv)
  • Based on this point, fundamental computational and experimental studies on fracture phenomena of amyloid fibrils may provide mechanical insights [ 10 , 16 ]. (hindawi.com)
  • concentration
  • At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, concentration, and motor coordination. (wikipedia.org)
  • Estrogen
  • Estrogen, through estrogen receptor-α, increased Nox-derived ROS and redox-sensitive growth in hPASMCs, with greater effects in PAH-hPASMCs versus control hPASMCs. (ahajournals.org)
  • Exact reasons for this sex-related difference remain unclear although increasing evidence suggests that metabolites of 17β-estradiol (estrogen) may play a role. (ahajournals.org)
  • Ablation of the estrogen binding site in the PEMT promoter region may increase risk of hepatic steatosis from choline deficiency. (wikipedia.org)
  • disorders
  • The survival of many serious genetic disorders in our long evolutionary history has led researchers to reassess the role of antagonistic pleiotropy in disease. (wikipedia.org)
  • In a recent article, Carter and Nguyen identify several genetic disorders, arguing that far from being a rare phenomenon, antagonistic pleiotropy might be a fundamental mechanism for the survival of these non-optimal alleles. (wikipedia.org)
  • roles
  • Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane structure, bile secretion, and very-low-density lipoprotein (VLDL) secretion. (wikipedia.org)
  • hyperpolarization
  • 1 2 3 4 5 6 This Brief Review will first provide a short description of the functional characteristics of the 4 main types of vascular K + channels and the likely physiological importance of these channels, as well as the phenomenon of K + channel-mediated, endothelium-dependent vascular hyperpolarization. (ahajournals.org)
  • An increase in extracellular K+ has been shown to activate an ouabain-sensitive electrogenic Na+-K+-ATPase followed by hyperpolarization and smooth muscle cell relaxation. (wikipedia.org)
  • Subsequently, it was suggested that EDHF is a sulfur signal that results in activation of K channels via sulfhydration of a cysteine residue (formation of a cysteine persulfide) (https://doi.org/10.1161/CIRCRESAHA.111.240242) C-type natriuretic peptide (CNP) has been shown to exert a variety of cardiovascular effects including vasodilation and hyperpolarization of arteries through the opening of KCa+-channels. (wikipedia.org)
  • An alternative explanation for the EDHF phenomenon is that direct intercellular communication via gap junctions allows passive spread of agonist-induced endothelial hyperpolarization through the vessel wall. (wikipedia.org)
  • processes
  • These are cell atrophy, impaired metabolism (increased catabolism), reduction of the defense capacity of the organism, reducing healing processes and regeneration, degeneration of the nervous system. (erank.tv)
  • From the onset of reproductive maturity, throughout the organism's life, the efficiency of various physiological processes progressively declines [ 3 , 4 ]. (mdpi.com)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • endurance
  • Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. (wikipedia.org)
  • Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output. (wikipedia.org)
  • widely
  • The majority of well-known Ang II actions are mediated via AT 1 receptor stimulation, and angiotensin converting enzyme inhibitors (ACEI) and AT 1 receptor blockers (ARBs) have been widely used as antihypertensive drugs, with the expectation of cardiovascular protective effects. (ahajournals.org)
  • CNP is widely distributed in the cardiovascular system and it has been found at high concentrations, in particular in endothelial cells. (wikipedia.org)
  • effects
  • In the present study, we investigated the mechanical characteristics of transthyretin amyloid protein (TTR), which have been implicated in cardiovascular disease, and specifically considered the contribution of end-terminal capping effects. (hindawi.com)
  • Our current knowledge of the effects of disease on vascular K + channel function almost exclusively relies on interpretation of data obtained by using pharmacological modulators of K + channels. (ahajournals.org)
  • Hence, our current knowledge of the effects of disease on vascular K + channel expression is somewhat indirect and almost exclusively relies on interpretation of functional or electrophysiological data (eg, recordings of vessel tone or diameter, vascular muscle cell E m , or whole-cell or single-channel currents in isolated myocytes under voltage-clamp conditions) obtained in the presence of pharmacological modulators of K + channels. (ahajournals.org)
  • peripheral
  • Sleep is a vital phenomenon related to immunomodulation at the central and peripheral level. (hindawi.com)
  • In the present review we discuss the role of inflammatory mediators that increase during sleep loss and their association with general disturbances in peripheral endothelium and epithelium and how those inflammatory mediators may alter the blood-brain barrier. (hindawi.com)
  • Here, we will review (1) the inflammatory mediators that increase during periods of sleep loss and their association with general disturbances in peripheral endothelium and epithelium and (2) how those inflammatory mediators might alter the blood-brain barrier during sleep loss. (hindawi.com)
  • occurs
  • This increased pressure inhibits venous return to the heart and thus less atrial expansion and activation of baroreceptors occurs. (wikipedia.org)
  • dilation
  • Pompe disease is associated with BA dilation, elongation and elevated bifurcation height of the BA which might result in cerebrovascular complications. (springer.com)
  • patients
  • The diameter, length and volume of the BA were significantly increased in LOPD patients compared to controls. (springer.com)
  • Twenty LOPD patients with genetically and biochemically confirmed diagnosis of Pompe disease (age 53.7 ± 14.6 years, range 19 to 81) were studied. (springer.com)
  • role
  • The biological changes that occur with increasing age play a key role in the quality of physical - motor performance. (erank.tv)
  • skeletal muscle
  • Lysosomal α-glucosidase deficiency (Pompe disease) not only leads to glycogen accumulation in skeletal muscle, but also in the cerebral arteries. (springer.com)
  • It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. (wikipedia.org)
  • arteries
  • This finding raises concerns about whether or not long‐term benefits of anti‐TGF β therapeutics improve the durability of medically reopened arteries. (physiology.org)
  • hypoxia
  • It is important to differentiate between physiological adaptations to mild hypoxia and re-oxygenation episodes (i.e., the IHT protocol) and frequent nocturnal suffocation awakenings produced by sleep apnea, which might result in various pathologies. (wikipedia.org)
  • major
  • Many of the major types of degenerative disease are associated with denatured and misfolded amyloid proteins [ 1 - 3 ]. (hindawi.com)
  • Hence
  • Hence, protection of cardiomyocytes and their increased survival is a putative target for cardioprotection [ 3 ]. (hindawi.com)
  • health
  • This work was primarily supported by a Marriott Foundation Cardiovascular Fellowship (CME), National Institutes of Health R01 DK082507 (CME), as well as Georgetown University Department of Medicine internal funding. (physiology.org)
  • Polyphenol intake has been associated with reduced incidences of cardiovascular disease and better overall health. (hindawi.com)
  • These types of stressors tend to have a more negative effect on health because they are sustained and thus require the body's physiological response to occur daily. (wikipedia.org)
  • Maharishi Vedic Approach to Health uses a model for understanding health and disease that is fundamentally different from that of modern medicine. (wikipedia.org)
  • The TM technique is the main modality which proponents say improves mental health and promotes "collective health" in MVAH. (wikipedia.org)