• dysfunction
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • nitric
  • Although Nitric Oxide (NO) is recognized as the primary factor at level of arteries, increased evidence for the role of another endothelium-derived vasodilator known as endothelium-derived hyperpolarizing factor (EDHF) has accumulated in the last years. (wikipedia.org)
  • disorders
  • The survival of many serious genetic disorders in our long evolutionary history has led researchers to reassess the role of antagonistic pleiotropy in disease. (wikipedia.org)
  • In a recent article, Carter and Nguyen identify several genetic disorders, arguing that far from being a rare phenomenon, antagonistic pleiotropy might be a fundamental mechanism for the survival of these non-optimal alleles. (wikipedia.org)
  • markedly
  • Vascular risk factors to Alzheimer's disease offer the possibility of markedly reducing incident dementia by early identification and appropriate medical management of these likely precursors of cognitive deterioration and dementia," says Guest Editor Jack C. de la Torre, MD, PhD, of the University of Texas, Austin. (iospress.nl)
  • biology
  • 2-9 Therefore, recent advances in studies of Ang II receptors could prove the existence of a variety of new players and targets in addition to the traditional "Ang II world" and provide a new insight into cardiovascular biology. (ahajournals.org)
  • roles
  • Furthermore, PC made via PEMT plays a wide range of physiological roles, utilized in choline synthesis, hepatocyte membrane structure, bile secretion, and very-low-density lipoprotein (VLDL) secretion. (wikipedia.org)
  • The physiological roles and properties of K + channels in arterial smooth muscle have recently been comprehensively reviewed. (ahajournals.org)
  • adaptation
  • Intermittent hypoxic training (IHT), also known as intermittent hypoxic therapy, is a non-invasive, drug-free technique aimed at improving human performance and well-being by way of adaptation to reduced oxygen. (wikipedia.org)
  • It was from these studies that he outlined the phenomenon of human physiological adaptation to environmental changes as a predictable event, a novel idea in a time when such things as blood pressure and resting heart rate were considered immutable. (wikipedia.org)
  • hyperpolarization
  • 1 2 3 4 5 6 This Brief Review will first provide a short description of the functional characteristics of the 4 main types of vascular K + channels and the likely physiological importance of these channels, as well as the phenomenon of K + channel-mediated, endothelium-dependent vascular hyperpolarization. (ahajournals.org)
  • An increase in extracellular K+ has been shown to activate an ouabain-sensitive electrogenic Na+-K+-ATPase followed by hyperpolarization and smooth muscle cell relaxation. (wikipedia.org)
  • Subsequently, it was suggested that EDHF is a sulfur signal that results in activation of K channels via sulfhydration of a cysteine residue (formation of a cysteine persulfide) (https://doi.org/10.1161/CIRCRESAHA.111.240242) C-type natriuretic peptide (CNP) has been shown to exert a variety of cardiovascular effects including vasodilation and hyperpolarization of arteries through the opening of KCa+-channels. (wikipedia.org)
  • processes
  • These are cell atrophy, impaired metabolism (increased catabolism), reduction of the defense capacity of the organism, reducing healing processes and regeneration, degeneration of the nervous system. (erank.tv)
  • From the onset of reproductive maturity, throughout the organism's life, the efficiency of various physiological processes progressively declines [ 3 , 4 ]. (mdpi.com)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • exposure
  • Likewise, molecular epidemiological observations between aging, telomere shortening and risk of cardiovascular diseases have prompted novel research of relationships between particle exposure and telomere attrition in cell cultures and animal models. (nanoeh2017.dk)
  • In this context, the effects attributed to particle exposure can be interpreted as a phenomenon related to accelerated aging. (nanoeh2017.dk)
  • endurance
  • Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. (wikipedia.org)
  • Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output. (wikipedia.org)
  • effects
  • The majority of well-known Ang II actions are mediated via AT 1 receptor stimulation, and angiotensin converting enzyme inhibitors (ACEI) and AT 1 receptor blockers (ARBs) have been widely used as antihypertensive drugs, with the expectation of cardiovascular protective effects. (ahajournals.org)
  • Our current knowledge of the effects of disease on vascular K + channel function almost exclusively relies on interpretation of data obtained by using pharmacological modulators of K + channels. (ahajournals.org)
  • Hence, our current knowledge of the effects of disease on vascular K + channel expression is somewhat indirect and almost exclusively relies on interpretation of functional or electrophysiological data (eg, recordings of vessel tone or diameter, vascular muscle cell E m , or whole-cell or single-channel currents in isolated myocytes under voltage-clamp conditions) obtained in the presence of pharmacological modulators of K + channels. (ahajournals.org)
  • Estrogen, through estrogen receptor-α, increased Nox-derived ROS and redox-sensitive growth in hPASMCs, with greater effects in PAH-hPASMCs versus control hPASMCs. (ahajournals.org)
  • Unfortunately, the success rate of pharmacologic intervention for depression is a mere 50% or less and these medications are fraught with potential side effects, including a proclivity to increase suicidal ideation with some anti-depressant drugs (Prescrire Int. 2011). (lifeextension.com)
  • The ACE2/Ang-(1-7)/Mas axis has been shown to counteract many of the physiological effects of the Angiotensin II (Ang II) Type 1 Receptor (AT1R), including vasoconstrictor and proliferative actions. (ufl.edu)
  • The experiment yielded important data on the physiological, social and psychological effects of long-term close-quarters isolation. (wikipedia.org)
  • At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, concentration, and motor coordination. (wikipedia.org)
  • heart
  • Increased vagal tone (and thus vagal action) is associated with a diminished and more variable heart rate. (wikipedia.org)
  • It is characterized by an increased heart rate during inhalation and a diminished heart rate during exhalation. (wikipedia.org)
  • Subsequently, heart rate increases. (wikipedia.org)
  • This increased pressure inhibits venous return to the heart and thus less atrial expansion and activation of baroreceptors occurs. (wikipedia.org)
  • Thus, the elderly are prone to disease, are more likely to suffer a fracture due to progressive osteoporosis, demonstrate a decrease of sensory functions of vision and hearing, more frequently heart attacks and strokes and malignant diseases. (erank.tv)
  • Class Ia drugs increase the time one action potential lasts in the heart. (wikipedia.org)
  • In particular, he hypothesized that dietary saturated fat causes cardiovascular heart disease and should be avoided. (wikipedia.org)
  • protective
  • Based on previous studies indicating the presence of ACE2 and Mas in the brain as well as a protective role for ACE2/Ang-(1-7)/Mas axis during cardiovascular disease, we have developed the general hypothesis that activation of the brain ACE2/Ang-(1-7)/Mas axis will have cerebroprotective action during ischemic stroke. (ufl.edu)
  • risk factors
  • BA length, diameter and volume, and cerebral lesions were analysed by MRI/TOF-MR angiography or CT/CT angiography in 20 LOPD patients and 40 controls matching in age, sex- and cardiovascular risk factors. (springer.com)
  • To triangulate the evidence concerning dairy products, we examined the associations of whole cow's milk consumption with cardiovascular risk factors in a non-Western setting with a different pattern of milk consumption and cardiovascular diseases from Western populations. (jove.com)
  • We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country. (jove.com)
  • To date, trials that target major cardiovascular risk factors in the prevention of AD remain inconclusive but have become an important focus of international research as described by contributors of this special volume in their overviews. (iospress.nl)
  • dilation
  • Pompe disease is associated with BA dilation, elongation and elevated bifurcation height of the BA which might result in cerebrovascular complications. (springer.com)
  • synthesis
  • In vitro studies have shown that paracrine dialogs between human adipocytes and inflammatory cells present in adipose tissue (ie, macrophage, lymphocytes, and others) promote an increased synthesis of numerous biomolecules, 4 leading to a low-grade inflammatory microenvironment. (ahajournals.org)
  • skeletal muscle
  • Lysosomal α-glucosidase deficiency (Pompe disease) not only leads to glycogen accumulation in skeletal muscle, but also in the cerebral arteries. (springer.com)
  • It is essential for cardiovascular function, and development and function of skeletal muscle, the retina, and the central nervous system. (wikipedia.org)
  • moderately
  • This measurement was qualitatively interpretable in 264 consecutive patients with a large range of age, a normal or moderately increased body mass index (BMI), and no a priori coronary disease. (ahajournals.org)
  • biological
  • The biological changes that occur with increasing age play a key role in the quality of physical - motor performance. (erank.tv)
  • He also designed an improved Kjeldahl apparatus which improved upon Krogh's earlier design and allowed for more rapid determination of nitrogen content in biological samples. (wikipedia.org)
  • arteries
  • This finding raises concerns about whether or not long‐term benefits of anti‐TGF β therapeutics improve the durability of medically reopened arteries. (physiology.org)
  • hypoxia
  • It is important to differentiate between physiological adaptations to mild hypoxia and re-oxygenation episodes (i.e., the IHT protocol) and frequent nocturnal suffocation awakenings produced by sleep apnea, which might result in various pathologies. (wikipedia.org)
  • decreases
  • During exhalation, the diaphragm relaxes, moving upward and decreases the size of the chest cavity, causing a subsequent increase in intra-thoracic pressure. (wikipedia.org)
  • blood
  • Comprehensive characterization and quantification of blood flow is essential for understanding the function of the cardiovascular system under normal and diseased conditions. (wisc.edu)
  • patients
  • The diameter, length and volume of the BA were significantly increased in LOPD patients compared to controls. (springer.com)
  • Twenty LOPD patients with genetically and biochemically confirmed diagnosis of Pompe disease (age 53.7 ± 14.6 years, range 19 to 81) were studied. (springer.com)