• Results from a large, multicenter clinical trial show that patients with AIDS treated for cytomegalovirus (CMV) retinitis, a serious eye infection, with the antiviral drug foscarnet, lived longer than those who received the standard treatment for CMV retinitis, ganciclovir. (nih.gov)
  • Cytomegalovirus (CMV) infection is usually asymptomatic in healthy individuals and manifests as a life and sight threatening disease commonly amongst immunocompromised and HIV infected individuals. (pediatriconcall.com)
  • 1) According to a study conducted in 2010, primary CMV infection in infants can cause both systemic diseases or affect single organs. (pediatriconcall.com)
  • Pateints with severe CMV diseases have been treated with a loading dose of IV Ganciclovir followed by oral Valganciclovir in various in a study conducted in 2007 (8).A case of a preterm infant with congenital CMV infection who was treated with oral Valganciclovir and showed a good response has been reported (10). (pediatriconcall.com)
  • Congenital toxoplasma and cytomegalovirus (CMV) infection are the most common etiologies in this age group. (medscape.com)
  • Although CMV is the most common congenital infection in the developed world, affecting approximately 1% of all infants born in the United States, only 10% of all infants born in the United States with congenital CMV infection have symptomatic disease at birth, including chorioretinitis. (medscape.com)
  • CMV retinitis may affect one eye at first, but usually progresses to both eyes and becomes worse as the patient's ability to fight infection decreases. (westvalleyoptometry.com)
  • Tell your doctor if you have or have ever had kidney disease or if you have a dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration or recently have had diarrhea, vomiting, fever, infection, excessive sweating, or have been unable to drink enough fluids. (medlineplus.gov)
  • Foscarnet injection is used alone or with ganciclovir (Cytovene) to treat cytomegalovirus (CMV) retinitis (an eye infection that can cause blindness) in people who have human immunodeficiency virus (HIV) infection. (medlineplus.gov)
  • Cytomegalovirus infection is a common herpesvirus infection with a wide range of symptoms: from no symptoms to fever and fatigue (resembling infectious mononucleosis) to severe symptoms involving the eyes, brain, or other internal organs. (msdmanuals.com)
  • Infection with cytomegalovirus (CMV) is very common. (msdmanuals.com)
  • Cytomegalovirus (CMV) Infection in Newborns Cytomegalovirus is a common virus that usually causes few or no problems but can cause serious illness in infants who are infected before birth or around the time of birth. (msdmanuals.com)
  • In 1994, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) recognized that, although strategies were available to reduce the frequency of opportunistic infections in patients who have human immunodeficiency virus (HIV) infection, information regarding prevention of both exposure and disease often was published in journals not regularly reviewed by health-care providers. (cdc.gov)
  • Polyradiculopathy typically results from cytomegalovirus (CMV) infection. (medscape.com)
  • The most common manifestation of neurological CMV disease in HIV infection is retinitis followed by encephalitis, myelitis, multifocal polyneuropathy, and polyradiculopathy. (medscape.com)
  • It is used to treat a viral eye infection called cytomegalovirus (CMV) retinitis for people with acquired immunodeficiency syndrome (AIDS). (medbroadcast.com)
  • Cytomegalovirus (CMV) is a beta variant of the Herpes Simplex Virus (HSV), a highly prevalent opportunistic pathogen with over 50% of adults infected worldwide by age [ 1. De Matos SB, Meyer R, de Mendonça Lima FW. Cytomegalovirus infection after renal transplantation: Occurrence, clinical features, and the cutoff for antigenemia in a university hospital in Brazil. Infect Chemother. 2017; 49: 255-261. [ CrossRef ] ">1 ]. (lidsen.com)
  • A herpesvirus infection caused by Cytomegalovirus. (embl.de)
  • She was diagnosed with human immunodeficiency virus infection and cytomegalovirus retinitis, treated with intravitreal injections of ganciclovir. (springeropen.com)
  • The primary focus of CMV management post transplantation is prevention of CMV disease (although not necessarily CMV infection). (cancertherapyadvisor.com)
  • However, during severe immunosuppression, CMV reactivation or primary infection can result in life-threatening disease. (creativebiolabs.net)
  • Sevirumab has been evaluated in the clinic for the prevention of CMV infection following allogeneic hematopoietic stem cell transplantation and as adjuvant therapy for CMV retinitis in HIV-infected individuals. (creativebiolabs.net)
  • CMV disease can lead to serious infections in the body, including an infection in the eye , called CMV retinitis , that can cause blindness. (webmd.com)
  • It helps prevent the spread of infection to other areas of the body.Valganciclovir is also used to treat CMV retinitis in people with advanced HIV disease (AIDS). (webmd.com)
  • Nursing Central , nursing.unboundmedicine.com/nursingcentral/view/Diseases-and-Disorders/73569/9.2/Cytomegalovirus_Infection. (unboundmedicine.com)
  • Risk of CMV infection post transplant Cytomegalovirus (CMV) is a γ-herpes virus and is one of the most common infections encountered post-transplant. (pediagenosis.com)
  • HHV-2, also known as HSV-2, causes genital herpes and occasionally causes oral disease that is clinically similar to that of HHV-1 infection. (medscape.com)
  • HHV-3, also known as varicella-zoster virus (VZV), causes the primary infection chickenpox and the secondary reactivation disease herpes zoster. (medscape.com)
  • HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
  • HHV-5, also known as cytomegalovirus (CMV), causes a primary infection of the salivary glands and other tissues, and it is believed to have a chronic form. (medscape.com)
  • The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
  • 9. Kabata Y, Takahashi G, Tsuneoka H. Cytomegalovirus retinitis treated with valganciclovir in Wegener's granulomatosis. (koreamed.org)
  • The normal treatment plan for CMV pneumonia is using IV Ganciclovir and immunoglobulins but Valganciclovir can also be administered orally. (pediatriconcall.com)
  • Studies have shown that Valganciclovir at a dose of 900 mg orally results in blood levels of gancicolvir obtained when a standard dose of 5mg/kg intravenous is administered and is also known to have similar efficacy to intravenous Ganciclovir as induction therapy in HIV associated CMV retinitis (7). (pediatriconcall.com)
  • The efficacy of valganiciclovir for prophylactic use in pediatric liver transplant patients was first proved by a a retrospective study carried out in 2004 (8).Valganciclovir has been approved by the FDA only for use of prevention of CMV disease in pediatric patients between the ages 4 months and 16 years with kidney and heart transplants (9). (pediatriconcall.com)
  • The infant however was treated first with IV Ganciclovir followed by oral Valganciclovir which succeeded in decreasing the viral load successfully (10). (pediatriconcall.com)
  • Prior clinical research has also focused on intravitreal therapeutics for rapid remission induction of ARN and CMV retinitis and maintenance therapy with oral antiviral agents with high vitreous penetration (i.e. valacyclovir and valganciclovir). (emory.edu)
  • Studies utilizing ganciclovir and valganciclovir demonstrate improved hearing and Bailey Developmental scores. (lww.com)
  • She was treated with intravenous ganciclovir for 2 weeks, intravitreal ganciclovir (twice weekly) for 1 week, and also daily oral valganciclovir as maintenance therapy for 6 months resulted in resolving of retinitis patches and improving her best-visual acuity from hand motions to 20/100. (springeropen.com)
  • However, is known, that valganciclovir, existing, as a mixture of R and S diasteriomers, is the active ingredient in Valcyte, which is used as an antiviral medication given to patients who have a high chance of developing cytomegalovirus (CMV) disease after receiving a heart, kidney, or kidney-pancreas transplant. (ncats.io)
  • The current therapy for CMV disease is treatment with either ganciclovir or valganciclovir, which are associated with significant toxicity and not approved for use in pregnant women or for congenitally damaged infants. (creativebiolabs.net)
  • This medication helps control CMV retinitis and decrease the risk of blindness.Valganciclovir is not a cure for CMV disease. (webmd.com)
  • Do not take ganciclovir instead of valganciclovir on your own without consulting your doctor or pharmacist. (webmd.com)
  • The effects and the dosages of ganciclovir and valganciclovir are not equal. (webmd.com)
  • Valganciclovir turns into the drug ganciclovir inside your body. (webmd.com)
  • Patients with low viral titres or with reactivation rather than primary disease can be treated with high-dose oral valganciclovir. (pediagenosis.com)
  • Valganciclovir is a pro-drug which is converted in the liver to ganciclovir. (pediagenosis.com)
  • Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, 15-40% of those with AIDS. (wikipedia.org)
  • Leukemia AIDS Immunosuppressive chemotherapy Human cytomegalovirus (HCMV or CMV) is a DNA virus in the family Herpesviridae known for producing large cells with nuclear and cytoplasmic inclusions, CMV infects around 40% of the population worldwide. (wikipedia.org)
  • CMV retinitis is a potentially blinding disease of the retina that affects about 20 percent of people with AIDS. (nih.gov)
  • It was conducted in collaboration with the AIDS Clinical Trials Group sponsored by the National Institute of Allergy and Infectious Diseases at NIH. (nih.gov)
  • According to Douglas Jabs, M.D., associate professor of ophthalmology at The Johns Hopkins School of Medicine and chairman of the study, "These results suggest that, for many patients with AIDS and CMV retinitis, foscarnet may be a better initial treatment than ganciclovir. (nih.gov)
  • After the development of CMV retinitis, patients with AIDS have a life expectancy of about eight months. (nih.gov)
  • In the past, this incompatibility has forced AIDS patients with CMV retinitis to choose between taking ganciclovir to try to save their vision or opting to take AZT in the hope of prolonging their lives. (nih.gov)
  • However, he cautioned that the results of this study are only applicable to people with AIDS who have CMV retinitis. (nih.gov)
  • Carl Kupfer, M.D., director of the National Eye Institute, said, "The findings from this study underscore the importance of conducting randomized, controlled trials that compare treatments for the ocular complications of AIDS, and the importance of collaboration between ophthalmologists and infectious disease specialists. (nih.gov)
  • Optimal management of cytomegalovirus retinitis in patients with AIDS. (koreamed.org)
  • 7. Langner-Wegscheider BJ, ten Dam-van Loon N, Mura M. . Intravitreal ganciclovir in the management of non-AIDS-related human cytomegalovirus retinitis. (koreamed.org)
  • The objectives of the study were to examine the clinical significance of cytomegalovirus (CMV) culture results and drug susceptibilities in CMV isolates from patients with AIDS-related CMV retinitis. (johnshopkins.edu)
  • Jabs, DA & Jacobson, M 1997, ' Cytomegalovirus (CMV) culture results, drug resistance, and clinical outcome in patients with AIDS and CMV retinitis treated with foscarnet or ganciclovir ', Journal of Infectious Diseases , vol. 176, no. 1, pp. 50-58. (johnshopkins.edu)
  • HHV-8 is etiologically associated with all forms of Kaposi sarcoma (KS) including classic, endemic, transplant-related, and AIDS-related, as well as rare neoplastic disorders (primary effusion lymphoma [PEL] and solid organ variants) and the lymphoproliferative disorder known as multicentric Castleman's disease (MCD). (hiv.gov)
  • CMV or cytomegalovirus retinitis is a vision threatening virus that causes inflammation of the retina, primarily in individuals with a compromised immune system, such as those with AIDS (Acquired Immunodeficiency Syndrome). (firsteyecareirving.com)
  • This has been shown to be highly effective in reducing the incidence of CMV retinitis in AIDS patients and reducing the damage for those that are affected. (firsteyecareirving.com)
  • For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients. (druglib.com)
  • CYTOVENE-IV is indicated for the treatment of CMV retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). (ncats.io)
  • Cytomegalovirus retinitis remains the most common cause of visual loss in AIDs patients. (springeropen.com)
  • We report a case of cytomegalovirus retinitis and AIDs who developed an unusual presentation of IRU after the initiation of HAART. (springeropen.com)
  • Cytomegalovirus retinitis remains the most common cause of visual loss in AIDs patients either pre or post HAART era [ 4 , 5 ]. (springeropen.com)
  • A further phase II study, sponsored by the National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group (ACTG), has been halted as the use of higher doses of sevirumab were indicated. (creativebiolabs.net)
  • The study, which was evaluating sevirumab as an adjunctive treatment to ganciclovir or foscarnet in AIDS patients with newly diagnosed CMV retinitis, had enrolled approximately half of the anticipated 167 patients. (creativebiolabs.net)
  • Cidofovir is indicated only for the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS). (medilib.ir)
  • To evaluate the safety and efficacy of foscarnet induction treatment of cytomegalovirus (CMV) retinitis in AIDS patients who have previously suffered severe dose-limiting ganciclovir-related myelosuppression, who are ineligible for ganciclovir treatment due to myelosuppression or who have clearly failed to have a therapeutic response to ganciclovir therapy. (inclinicaltrials.com)
  • Cytomegalovirus (CMV) Retinitis~clinical at eMedicine. (wikipedia.org)
  • The Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial, a randomized, multicenter clinical trial, is supported by the National Eye Institute, a component of the National Institutes of Health. (nih.gov)
  • 8. Ausayakhun S, Keenan JD, Ausayakhun S. . Clinical features of newly diagnosed cytomegalovirus retinitis in northern Thailand. (koreamed.org)
  • Results of virologic assays of blood appear to be associated with clinical outcome of CMV retinitis. (johnshopkins.edu)
  • Beyond the neonatal period, chorioretinitis can be diagnosed in diverse clinical conditions and can reflect newly acquired diseases or reactivation. (medscape.com)
  • Within infectious uveitis, his research has focused on the clinical and scientific implications underlying eye disease in Ebola virus survivors. (emory.edu)
  • Aims The aim of this observational study was to report the distribution of glycoprotein B (gB) genotypes in the eyes of cytomegalovirus (CMV) positive patients with Posner-Schlossman syndrome (PSS), and to investigate their clinical characteristics and outcomes. (bmj.com)
  • The resulting USPHS/IDSA guidelines were published in 1995 in the MMWR, Clinical Infectious Diseases, and the Annals of Internal Medicine, with an accompanying editorial in the Journal of the American Medical Association (1-4). (cdc.gov)
  • A9 - Torlontano G, FIORITONI G, Pontano O, Iacone A, Bonanni G: Normal granulocyte transfusion therapy in the management of acute leukemias.Current Studies on Standardization Problems in Clinical Patholology, Haematology and Radiotherapy in Hodgkin's Disease.Eds: G. Astaldi, C. Biagini. (giuseppefioritoni.it)
  • Current Studies on Standardizzation problems in Clinical Pathology, Haematology and Radiotherapy in Hodgkin's Disease. (giuseppefioritoni.it)
  • The quantitative relationship between the in vitro susceptibility of human cytomegalovirus (CMV) or herpes simplex virus 1 and 2 (HSV-1 and HSV-2) to FOSCAVIR and clinical response to therapy has not been established and virus sensitivity testing has not been standardized. (nih.gov)
  • Although median time to progression of CMV retinitis was increased in patients treated with FOSCAVIR, reductions in positive blood or urine cultures have not been shown to correlate with clinical efficacy in individual patients. (nih.gov)
  • Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
  • ganciclovir, foscarnet, and cidofovir use for treatment of CMV disease). (hiv.gov)
  • Treatment includes antiviral medications such as ganciclovir, foscarnet or cidofovir, which can be administered orally, via injection through a vein or directly into the eye or through a time-release implant the releases the medication at intervals. (firsteyecareirving.com)
  • Resistant disease can be treated with second and third line agents such as foscarnet or cidofovir. (cancertherapyadvisor.com)
  • Other agents used include foscarnet, cidofovir and intravenous CMV immune globulin, although these are usually reserved for patients with refractory or ganciclovir resistant disease. (pediagenosis.com)
  • CMV retinitis usually causes symptoms, but not always. (westvalleyoptometry.com)
  • Consider stopping treatment for CMV disease after resolution of symptoms AND two consecutive, CMV viral load tests that confirm that CMV is not detected (below the local laboratory threshold for detection) [2D]. (bts.org.uk)
  • Symptoms of CMV retinitis often appear relatively suddenly. (firsteyecareirving.com)
  • Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (medscape.com)
  • Some patients with cytomegalovirus retinitis who experienced immune recovery as a consequence of HAART develop worsening of visual symptoms from immune recovery uveitis (IRU). (springeropen.com)
  • Based on work in infectious viral uveitis, they have most recently studied Ebola virus disease (EVD) associated uveitis in the United States and West Africa as a result of the recent outbreak of unprecedented magnitude. (emory.edu)
  • More commonly associated with systemic disease or underlying ocular syndrome than nongranulomatous uveitis. (entokey.com)
  • Those areas infected by cytomegalovirus have cells evolve to necrosis, though inflammation within the retina is not great. (wikipedia.org)
  • Rhegmatogenous retinal detachments can occur following the development of holes in areas of healed retinitis (retina may be atrophic). (wikipedia.org)
  • Multiple large areas of retinitis with intraretinal hemorrhage involving the inferotemporal retina were noted. (springeropen.com)
  • The difference in mortality between patients treated with foscarnet and those treated with ganciclovir cannot be fully explained by the differential use of zidovudine (AZT) or other anti-retroviral drugs by patients in these treatment groups. (nih.gov)
  • Nor could the difference in survival between study patients treated with foscarnet and those who received ganciclovir be explained by variations in disease severity between the two patient groups at the time they entered the study, or to other chance factors. (nih.gov)
  • It may cause respiratory problems, damage to the central nervous system, bleeding ulcers in the digestive system, and CMV retinitis, which can lead to blindness. (mywestmedconnect.com)
  • However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. (druglib.com)
  • Depending on the virulence of the organism, as well as the age and comorbidities of the patient, viral pneumonia can vary from a mild, self-limited illness to a life-threatening disease. (medscape.com)
  • See Cutaneous Manifestations of HIV Disease and Cutaneous Manifestations of Hepatitis C for information on these viral infections. (medscape.com)
  • Increased IOP may suggest a viral etiology or secondary glaucoma from chronic disease. (entokey.com)
  • In HIV-infected men who have sex with men, Pneumocystis carinii pneumonia (PCP), toxoplasmic encephalitis, fungal infections, and disseminated Mycobacterium avium complex (MAC) disease have decreased in incidence (9). (cdc.gov)
  • Below is the selection of side effect reports (a.k.a. adverse event reports) related to Foscarnet where reactions include encephalitis cytomegalovirus. (druglib.com)
  • Foscarnet controls CMV retinitis and HSV infections of the skin and mucus membranes but does not cure these infections. (medlineplus.gov)
  • Most attention was focused on recent data related to chemoprophylaxis against disseminated MAC disease, cytomegalovirus (CMV), and fungal infections and to immunization against Streptococcus pneumoniae. (cdc.gov)
  • The condition is usually caused by infections Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. (lecturio.com)
  • Some of these infections Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. (lecturio.com)
  • Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat? (lww.com)
  • Congenital cytomegalovirus infections are among the most common of the newborn in the developed world. (lww.com)
  • Over the past 2 decades, therapies have been recommended by the American Academy of Pediatrics Red Book Committee for the management of neonatal herpes simplex virus (HSV) and congenital cytomegalovirus (CMV) infections. (lww.com)
  • Systemic diseases such as sarcoidosis Sarcoidosis Sarcoidosis is a multisystem inflammatory disease that causes noncaseating granulomas. (lecturio.com)
  • A 68-year-old woman without any history of systemic diseases referred to the emergency ward of Farabi eye hospital with a two-week history of decreased vision in her left eye. (springeropen.com)
  • Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)
  • U.S. Centers for Disease Control and Prevention. (wikipedia.org)
  • The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
  • Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
  • Specific treatment for CMV - intravenous ganciclovir is the treatment of choice for patients with life-threatening disease. (pediagenosis.com)
  • 14 Supporting the latter hypothesis, observational studies indicate that patients receiving ganciclovir or foscarnet (but not acyclovir) develop KS at a reduced rate. (hiv.gov)
  • Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. (druglib.com)
  • The Herpetic Eye Disease Study (HEDS), one of the largest multicenter randomized control trials studying ocular HSV to date, found that 400 mg of acyclovir twice daily reduced the rate of all types of ocular HSV recurrence to 19% compared to 32% in the placebo group. (dovepress.com)
  • In immunocompromised individuals, symptomatic disease usually manifests as a mononucleosis syndrome. (medscape.com)
  • People whose immune systems are compromised, on the other hand, are usually treated with the antiviral drug ganciclovir, which can sometimes cause nausea, a lowered testosterone level, and a decrease in the white blood cells called neutrophils. (mywestmedconnect.com)
  • CYTOVENE-IV is also indicated for the prevention of CMV disease in transplant recipients at risk for CMV disease. (ncats.io)
  • Journal of Infectious Diseases , 176 (1), 50-58. (johnshopkins.edu)
  • In addition, with increasing air travel and globalization, several emerging infectious diseases have been recognized as causing ocular disease, including retinitis, chorioretinitis, retinal vasculitis, and optic nerve involvement. (medscape.com)
  • National Center for Infectious Diseases. (cdc.gov)
  • The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). (bjid.org.br)
  • It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents. (bjid.org.br)
  • 6 Stromal HSK only represents two percent of the initial HSV ocular presentations but causes 20-61% of recurrent disease. (dovepress.com)
  • Cytomegalovirus retinitis can recur in the same or contralateral eye of immunocompetent patients, especially without prophylactic medication. (springeropen.com)
  • Cytomegalovirus retinitis (CMVR) is a sight-threatening condition usually affecting immunosuppressed individuals but few cases of CMVR have been reported in immunocompetent patients [ 1 ]. (springeropen.com)
  • In the absence of prophylaxis, the CMV disease is seen most commonly 6-12 weeks after transplantation or after augmentation of immunosuppression for rescue therapy of rejection. (cancertherapyadvisor.com)
  • Based on the PCR results, 16 cases (69.6%) had Varicella zoster virus, 3 cases (13%) had Cytomegalovirus, 1 patient (4.3%) had Herpes simplex virus associated ARN, and 1 case (4.3%) had negative PCR. (biomedcentral.com)
  • Systemic anti-cytomegalovirus medication was limited because of financial issue. (springeropen.com)
  • Drug-resistant CMV was found, over comparable follow-up periods on assigned treatment, in 4 of 8 ganciclovir-assigned patients with persistent viremia and 0 of 5 foscarnet-assigned patients with persistent viremia. (johnshopkins.edu)
  • Thus, the virus may become resistant to ganciclovir if it mutates to produce a non-functional enzyme. (pediagenosis.com)
  • RATIONALE: Fludarabine may be an effective treatment for graft-versus-host disease caused by bone marrow transplantation. (inclinicaltrials.com)
  • PURPOSE: Phase I/II trial to study the effectiveness of fludarabine in treating patients who have chronic graft-versus-host disease that has not responded to steroid therapy. (inclinicaltrials.com)
  • Cytomegalovirus can cause serious illness in infants who are infected before birth. (msdmanuals.com)
  • Thus, it is acute in nature and frequently presents with the telltale sign of disease, namely, a vesicular rash, although this may fail to develop in many infants. (lww.com)
  • Is congenital CMV disease common in infants? (mywestmedconnect.com)
  • Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)
  • [ 8 ] However, oral manifestations at follow-up once disease is controlled may not be a marker for recurring intestinal disease. (medscape.com)
  • Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
  • Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (medscape.com)
  • However, when the immune system is suppressed because of disease (HIV), organ or bone marrow transplant, or chemotherapy, the CMV virus can cause damage and disease to the eye and the rest of the body. (westvalleyoptometry.com)
  • Cytomegalovirus end-organ-disease (CMV EOD) is still a major cause of debilitating illness in people living with HIV, especially in developing countries. (bjid.org.br)
  • It can also be used to prevent CMV disease for people who have received a solid organ transplant and are at risk of the condition. (medbroadcast.com)
  • CMV can be contracted from the general community, transmitted via solid organ transplantation, or may be a reactivation of latent disease. (cancertherapyadvisor.com)
  • It is used to prevent disease caused by a virus called cytomegalovirus ( CMV ) in people who have received organ transplants . (webmd.com)
  • Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)
  • Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)
  • Effective treatment of CMV disease requires a high degree of suspicion and appropriate diagnostic tests. (lidsen.com)
  • In people with a weakened immune system, disease often results from reactivation of the dormant virus. (msdmanuals.com)