• antigen
  • Thus, this new potent method of antigen presentation, using autoantigen-transfected EBVL, has permitted the first unequivocal identification of TSHR T cells in GD thyroid, with distinct Th0/Th2 characteristics, unlike previously cloned TPO-responsive cells which have Th1 characteristics. (ox.ac.uk)
  • The IFA method has gained perfection by introducing the so called diagnostic mosaics, consisting of various tissue sections (primate and/or mammalian in origin), of Hep-2 cells, of microbeads (biochips) coated with specific purified antigen(s) and/or of transfected HEK cells expressing the target autoantigens. (ke-i.org)
  • It is most common in patients of northern European/northern Indian ancestry, and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 along with coeliac disease and gluten sensitivity. (wikipedia.org)
  • novel
  • Disease susceptibility to this novel mouse model varies among strains, where C3H/HeJ (H2-k) and C3H/HeN (H2-k) are susceptible while DBA/1 (H2-q) and C57BL/6 (H2-b) are resistant. (frontiersin.org)
  • antibodies
  • Depletion of B cells using anti-CD20 monoclonal antibodies prevented C3H/HeN mice from development of the pSS-like disease. (frontiersin.org)
  • Higher titres of anti-dsDNA antibodies are more suggestive of SLE and lower titres can be found in people without the disease. (wikipedia.org)
  • Therefore, presence of anti-dsDNA antibodies are suggestive of SLE, however an absence of the antibodies does not rule out the disease. (wikipedia.org)
  • Increases in titres of the antibodies can coincide with, or even precede an increase of disease activity. (wikipedia.org)
  • Addison's Disease
  • 80% are due to an autoimmune disease called Addison's disease or autoimmune adrenalitis. (wikipedia.org)
  • Addison's disease can present with tanning of the skin that may be patchy or even all over the body. (wikipedia.org)
  • Addison's disease arises from problems with the adrenal gland such that not enough of the steroid hormone cortisol and possibly aldosterone are produced, most often due to damage by the body's own immune system in the developed world and tuberculosis in the developing world. (wikipedia.org)
  • Addison's disease is generally diagnosed by blood tests, urine tests, and medical imaging. (wikipedia.org)
  • Addison's disease affects about 0.9 to 1.4 per 10,000 people in the developed world. (wikipedia.org)
  • The adjective "addisonian" is used to describe features of the condition, as well as people with Addison's disease. (wikipedia.org)
  • The symptoms of Addison's disease develop gradually and may become established before they are recognized. (wikipedia.org)
  • This may be the result of either previously undiagnosed Addison's disease, a disease process suddenly affecting adrenal function (such as adrenal hemorrhage), or an intercurrent problem (e.g., infection, trauma) in someone known to have Addison's disease. (wikipedia.org)
  • Biomarkers
  • His focus is on the development of targeted and individualized therapies-based, for example, on therapeutic nanoparticles as drug carriers in combination with the development of specific disease biomarkers. (wikipedia.org)
  • Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease:a prospective cross-sectional comparative study. (bath.ac.uk)
  • immune response
  • However, anti-TSHR immune response is once activated, Th2-immune polarization has little effect on disease course, indicating this type of immune manipulation may be just preventive, not therapeutic. (nii.ac.jp)
  • If this process is defective, these autoantigens can be released into the circulation allowing an immune response. (wikipedia.org)
  • Previously
  • Considering these effects of viruses, the "X chromosome-nucleolus nexus" hypothesis, which proposed disruption of the inactive X by the nucleolus during stress, is now expanded here to propose subsequent disruption of the nucleolus by previously sequestered Alu elements, which can fragment the nucleolus, leading to generation of autoantigens. (frontiersin.org)
  • This could lead to eventual creation of autoantigens due to overexpression of genes and elements from both the previously active chromatin and the, now, reactivated chromatin. (frontiersin.org)
  • cells
  • However, the specificity of T cells that cause the disease is not known. (rupress.org)
  • Blebs on apoptotic cells contain nearly all the autoantigens found in SLE, and phagocytes bind these apoptotic cells and phagocytose them. (wikipedia.org)
  • Autoantigens present on the blebs of apoptotic cells are also prone to modification, which can increase their immunogenicity. (wikipedia.org)
  • present
  • These are adrenal dysgenesis (the gland has not formed adequately during development), impaired steroidogenesis (the gland is present but is biochemically unable to produce cortisol) or adrenal destruction (disease processes leading to glandular damage). (wikipedia.org)
  • mice
  • Murine experimental autoimmune gastritis is a CD4+ T cell-mediated organ-specific autoimmune disease induced by neonatal thymectomy of BALB/c mice. (rupress.org)
  • To examine the role of the H/K ATPase in this T cell-mediated disease, transgenic mice were generated that express the beta subunit of the H/K ATPase under the control of the major histocompatibility complex class II I-Ek alpha promoter. (rupress.org)