• A promising formulation approach that can effectively improve the dissolution profile and the bioavailability of poorly water-soluble drugs is the utilization of amorphous systems. (bvsalud.org)
  • Numerous formulation methods have been developed to enhance poorly water-soluble drugs through amorphization systems, including co-amorphous formulations, amorphous solid dispersions (ASDs), and the use of mesoporous silica as a carrier. (bvsalud.org)
  • Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
  • The use of solid dispersion technology to increase the bioavailability of poorly water-soluble drugs has always been limited by processing and scale-up difficulties. (pharmtech.com)
  • Serajuddin et al.10 demonstrated that PEG itself might not be a suitable carrier for the solid dispersion of poorly water-soluble drugs intended for direct filling into hard gelatin capsules. (pharmtech.com)
  • Since the emergence of Soluplus® (SOL) as a commercial graft copolymer, multiple publications have been issued on its promising potential as a solubilizing excipient that could promote the dissolution rate and bioavailability of several poorly water-soluble drugs. (pharmaexcipients.com)
  • These poorly-water soluble drugs show many problems in formulatingnthem in conventional dosage forms and the critical problem associated is its very low bioavailability.nThe development of new colloidal carrier called nanosponges has the potential to solve these problems. (isfcppharmaspire.com)
  • Several researchers have shown that the liquisolid technique is one of the most promising methods for enhancing the dissolution rate of poorly water-soluble drugs. (ijpsr.com)
  • Nanoparticles in contact with and to the body interact with the ligand bound to the drug. (chemistryexamhero.com)
  • Moreover, nanoparticles with higher micellar drug densities react with the drug on the ligand through the interaction with cytoplasmic proteins. (chemistryexamhero.com)
  • Several publications have been discussed concerning the possibilities of nanosafety technique in drug delivery carriers, demonstrating the efficient and significant use of nanoparticles. (chemistryexamhero.com)
  • Usually the paper about the safety of the nanoparticles has to be cited or articles published, especially the ones named as publication concerning nanomaterials in the field of electrochemical drug delivery are lacking for the use of nanomaterials, so the paper does not intend for the actual selection of authors to cite, so the decision is being difficult. (chemistryexamhero.com)
  • In the present work, a three-layer magnetic nanocomposite containing ceria nanoparticles was synthesized as Fe3O4@SiO2@CeO2 by precipitation method and after characterization was used as a photocatalyst for the degradation of malachite green dye from industrial wastewater under visible light. (magiran.com)
  • The thesis entitled "The Role of Liposomal Hybrids and Gold Nanoparticles in the Efficacious Transport of Nucleic Acids and Small Molecular Drugs for Cancer Nanomedicine" elucidates the preparation of various liposomal formulations of cationic monomeric and gemini lipids where hydrophobic domains were consisted of tocopherol, cholesterol and pseudoglyceryl backbone for the cellular transport of nucleic acids. (iisc.ac.in)
  • This thesis also elucidates the role of gold nanoparticles stabilized with natural pH sensitive molecules for efficacious drug delivery applications. (iisc.ac.in)
  • Additionally, the role of such pH sensitive gold nanoparticles in association with liposomes for the co-delivery of drug and gene has been discussed. (iisc.ac.in)
  • and characterized by UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning electron microscopy (SEM) and Energy Dispersive X(EDX).Characterization by the above said instrument analysis confirmed the presence, size and stability of silver nanoparticles. (iajpr.com)
  • Drug delivery systems are being studied to surmount these obstacles, including polymeric constructs and nanoparticles that consti-tute the focus of this article. (ibecbarcelona.eu)
  • Then, recent techniques adopted in the production of hybrid nanoparticles are discussed, highlighting limitations still present that hold back the industrial implementation. (gruppotpp.it)
  • The physicochemical problems of chemotherapy drugs are the primary challenge that now causes a drug's low effectiveness. (bvsalud.org)
  • In this article, after a brief review of the physicochemical properties and pharmacokinetic profiles of curcumin, recent advances in curcumin oral delivery systems are discussed. (researchgate.net)
  • Moreover, to date, no comprehensive reviews have discussed the preparation strategies of systems incorporating SOL and the physicochemical properties of SOL-based fast-dissolving preparations. (pharmaexcipients.com)
  • Pristine NPs have shown a huge similarity to nanofibers in terms of their specific physicochemical characterizations. (chemistryexamhero.com)
  • Carrier-linked prodrugs are for drugs with major drawbacks, which are linked to a nontoxic carrier or promoiety through covalent linkage to change or get rid of their undesirable physicochemical properties. (ijpsonline.com)
  • Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. (isfcppharmaspire.com)
  • Likewise, the resulting formulations are supposed to improve drugs' physical stability and solubility in biological fluids. (pharmaexcipients.com)
  • The reason beyond this is that drugs with poor solubility in water have poor pharmacokinetic properties and limited availability to the target site [2]. (pharmaexcipients.com)
  • Therefore, active principals classified by the Biopharmaceutics Classification System (BCS) as class-II and class-IV drugs suffer from inadequate bioavailability because they lack appropriate water solubility. (pharmaexcipients.com)
  • Nevertheless, several SOL-based formulations are promising for boosting drug solubility and have been developed based on the SD technique [13]. (pharmaexcipients.com)
  • The virtual 2020 Global Drug Bioavailability Enhancement Summit this past December showcased novel technologies and platforms aimed at addressing bioavailability and solubility challenges. (drug-dev.com)
  • The driver for novel strategies to resolve solubility issues, with a target of improving bioavailability, often stems from a requirement to get more information about the key relationships using less API, in a reduced time frame," says Andrew Parker, PhD, Director Open Innovation, Small Molecules, Oral and Speciality Drug Delivery, Catalent. (drug-dev.com)
  • This annual Drug Development & Delivery report introduces readers to some novel approaches to improving bioavailability and solubility that have one commonality: they treat each molecule as unique. (drug-dev.com)
  • Where drug solubility is inade-quate to generate the necessary driv-ing force for drug release, it creates a typical 'no release, no bioavailability' situation, explains Dr. Lai. (drug-dev.com)
  • One ap-proach to overcome such a pH-dependent solubility issue in the case of an alkaline drug is to use an organic acid as the drug core or an acid layer prior to using it as the substrate for the drug layer, which is then followed by a rate-controlling membrane. (drug-dev.com)
  • When enhanced solubility is neces-sary, the binder polymer is strategically selected based on its ability to form a solid dispersion/solid solution with the drug, usually through a sol-vent system. (drug-dev.com)
  • Carrier would change a drug's physical attributes in order to increase its fat or water solubility or to allow site-directed delivery. (ijpsonline.com)
  • Specific site drug is the major problem faced among researchers due to drug poor solubility in water and pharmacokinetic issues. (isfcppharmaspire.com)
  • Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine. (omicsonline.org)
  • Two factors govern the total oral absorption of drug i.e. drug's solubility and permeability across intestine. (omicsonline.org)
  • Over past few years, various formulation techniques have been developed, to improve the solubility and dissolution of poorly soluble substances, with different degrees of success. (ijpsr.com)
  • Liquisolid Compacts of poorly soluble drugs containing a drug molecularly dispersed in a solubilizing vehicle show enhanced drug dissolution due to an increased surface area of drug, an increased aqueous solubility of the drug, and an improved wettability of the drug particle. (ijpsr.com)
  • 22. Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrinbased nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study. (isfcppharmaspire.com)
  • The rheological characterization as well as microbiological and stability testing will be covered. (gmp-compliance.org)
  • Furthermore, rheology plays a significant role in the determination of a formulation's flow properties (and for the characterization of semi-solid raw materials, like for example petrolatum, lanolin), during development, in-process-control (IPC), final end-product testing & release as well as in stability testing. (gmp-compliance.org)
  • This presentation will focus on some pharmaceutical development key issues including drug product performance and physical stability and how to use novel material technologies to mitigate the risks, illustrated by nano material and SDD product development case study examples. (ddfsummit.com)
  • Myriad drug delivery systems (DDS) have emerged to boost the absorption of certain drugs via amending their release profile and therefore enhancing the biodistribution of these drugs throughout the body and minimizing the adverse effects arising following administration [6,7]. (pharmaexcipients.com)
  • One use this link approach that has garnered interest is the use have a peek at these guys nanochannels as they enable delivery drug particles to the site of absorption, which can be important even without the use of drug material. (chemistryexamhero.com)
  • Due to the intrinsic effect of the vehicle and the influence of the formulation on the release of active ingredients (and the subsequent absorption), the final formulation (including packaging) should be defined early in the pharmaceutical development process. (gmp-compliance.org)
  • For usual absorption of drug it is soluble then it will reach intestinal wall in dissolved state and later absorbed in gut membranes combining all above transport mechanisms. (omicsonline.org)
  • Accordingly, this improved drug dissolution may result in higher drug absorption and thus, an improved oral bioavailability 5, 6 . (ijpsr.com)
  • At room temperature, solid plugs were formed inside the capsules where the dissolution of the drug from PEG-based solid dispersions was incomplete. (pharmtech.com)
  • The water-soluble carrier dissolved more rapidly than the drug, and drug-rich layers were formed over the surfaces of the dissolving plugs, preventing further dissolution of the drug from solid dispersions. (pharmtech.com)
  • Studies report that complete dissolution of the drug from solid dispersions can be achieved using surface- active or self-emulsifying carriers, but only a small number of such carriers are currently available for oral use. (pharmtech.com)
  • These traits can assist SOL in ameliorating the dissolution behavior and bioavailability of drugs loaded in self-nanoemulsifying drug delivery systems (SNEDDSs). (pharmaexcipients.com)
  • Various outstanding reviews have been issued about the technologies in the dissolution enhancement of drugs using certain DDSs, such as micelles, solid dispersions (SD), nanosuspensions, and nanoemulsions. (pharmaexcipients.com)
  • drug dissolution and angle of repose. (ijpsr.com)
  • Results showed that maximum drug dissolution was exhibited by systems with minimum drug concentration in liquid vehicle and optimum carrier to coating ratio. (ijpsr.com)
  • Optimized formulation displayed significantly enhanced dissolution profiles than that of marketed formulation. (ijpsr.com)
  • In conclusion, avicel could be replaced by neusilin for the formulation of low weight liquisolid tablets along with increased dissolution. (ijpsr.com)
  • There are multiple methods which have been used for past many years, to enhance the dissolution characteristics of water-insoluble drugs which include micronization, lyophilisation, soliddispersion. (ijpsr.com)
  • The repeat units are built up at undecaprenylphosphate lipid carriers that are anchored in the cytoplasmic membrane. (caister.com)
  • Specific glycosyltransferases sequentially transfer the sugar moieties of the nucleotide sugar xanthan precursors to the lipid carriers. (caister.com)
  • All the efficient co-liposomal formulations derived from each of these geminis and a helper lipid, dioleoyl phosphatidyl ethanolamine (DOPE) were well characterized using physical methods such as atomic force microscopy (AFM) and dynamic light scattering (DLS). (iisc.ac.in)
  • Over the past few decades, lipid-based drug delivery, in particular, has experienced significant growth. (fleming.events)
  • Formulation concepts (including the use of emulsifiers and colloidal carrier systems), GMP aspects and the industrial manufacture/ filling of semi-solid formulations are clearly illustrated. (gmp-compliance.org)
  • The optimized formulation F7 (15% drug concentration and 30 carrier coating ratio) was tested for X-ray powder diffractometry and FTIR. (ijpsr.com)
  • Our study's objectives were to explore and summarize the effects of targeting mediator on drug development using mesoporous silica with and without functionalized polymer. (bvsalud.org)
  • Recently, polymer-based DDSs have been designed to rapidly release drugs to improve their limited bioavailability. (pharmaexcipients.com)
  • This amphiphilic polymer can be used above the critical micelle concentration (CMC) to dissolve certain drugs via micelle formation. (pharmaexcipients.com)
  • These nanofoil fillers typically make up 30-60% of all drug delivery polymer formulations, but provide a similar anisotropic porosity to the core particle. (chemistryexamhero.com)
  • Comparative study was carried out using Pluronic as solid dispersion and beta cyclodextrin as inclusion complexation in different drug to polymer ratios through physical mix, kneading, solvent evaporation and spray drying technique. (omicsonline.org)
  • They prepared solid dispersions of sulfathiazole in carriers such as ascorbic acid, acetamide, nicotinamide, nicotinic acid, succinimide and urea by melting various drug -- carrier mixtures. (pharmtech.com)
  • Chatham9 reported the possibility of preparing PEG-based solid dispersions by filling drug-PEG melts into hard gelatin capsules. (pharmtech.com)
  • Numerous drug formulation strategies were embraced for SOL to yield highly bioavailable products, such as solid dispersions (SDs), nanosuspensions, nanomicelles, and nanoemulsions. (pharmaexcipients.com)
  • We discuss in this chapter about six tocopherol based cationic gemini lipids, which induce substantial gene knockdown without any obvious cytotoxicity. (iisc.ac.in)
  • On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. (mdpi.com)
  • Approaches for characterization of the systems are presented. (fleming.events)
  • This is a significant paradigm shift for pharmaceutical industry which aims to improve efficiency, quality and patient outcomes by utilizing digital solutions and data driven approaches in drug discovery, development, manufacturing, supply chain management and personalized medicine. (ddfsummit.com)
  • These APIs present challenges in formulation, particularly for oral dosage forms, despite their considerable therapeutic potential. (bvsalud.org)
  • Hence, search for new lead molecule/bioactive and rational delivery of the existing drug (for better therapeutic effect) to the site of action is the need of the hour. (hindawi.com)
  • Hydrogels are novel drug deliverers that can aid in the delivery of several kinds of drug molecules either therapeutic or diagnostic nature. (biomedres.us)
  • Co-formulating two or more drugs can be highly beneficial for therapeutic treatment of disease. (chi-peptalk.com)
  • Therapeutic treatments such as glucocorticoids (GCs), non-steroidal anti-inflammatory drugs (NSAIDs), biological agents like IL-1 receptor antagonists (IL-1Ra) and TNF-a blockers, and disease-modifying anti-rheumatic drugs (DMARDs), reduce pain and joint inflammation. (drugtargetreview.com)
  • In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. (molcells.org)
  • In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinicalgrade exosomes. (molcells.org)
  • In this review, we discuss the major challenges regarding therapeutic exosome manufacture and the perspectives for successfully developing clinical-grade exosomes. (molcells.org)
  • In this review, we will study in which generic medicines, Lifestyle modifications, establishing drug information centers, Preventing antibiotic resistance, Conducting smoking cessation and awareness programme's, Improving the percent of immunization further focusing on Clinical research and Pharmacovigilance thus pharmacist has a role from dispensing to total patient care which improves the therapeutic outcomes of patients. (iajpr.com)
  • However, there are several other nanoparticle formats which have demonstrated to be promising as delivery systems for RNA and other drugs. (fleming.events)
  • After characterization, the silver nanoparticle was tested at 100?g-ml, 200?g-ml, 300?g-ml and 400?g-ml concentrations to check the bactericidal activity against clinical isolates of five bacterial pathogens. (iajpr.com)
  • The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and safety. (biomedcentral.com)
  • Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
  • A great proportion of the orally administered drug dose remains unabsorbed, which limits its clinical applicability [1]. (pharmaexcipients.com)
  • The development of exosome treatment starts at the bench, and in order to be commercialized, it goes through the manufacturing, characterization, and formulation stages, production under Good Manufacturing Practice (GMP) conditions for clinical use, and close consultation with regulatory authorities. (molcells.org)
  • Physiologically based biopharmaceutics models (PBBM) have been playing an increased role in development decisions as related to formulation changes, spanning both clinical development aspects and drug product quality. (ddfsummit.com)
  • We also summarize the nanomedicines' current advantages and disadvantages in drug administration, from natural/synthetic sources to clinical applications. (biomedcentral.com)
  • In this chapter, we have covered various aspects of hyaluronic acid-modified delivery systems including strategies for synthesis, characterization, and biocompatibility. (intechopen.com)
  • difficulties during formulation and adverse effects and toxicity [ 2 - 4 ]. (ijpsonline.com)
  • The cell viability assays performed using optimized formulations demonstrated no significant toxicity towards any of the cell lines used in the study. (iisc.ac.in)
  • Drug residues in food refer to the presence of pharmaceutical compounds or their metabolites in products such as meat, fish, eggs, poultry and ready-to-eat foods, which are intended for human consumption. (bvsalud.org)
  • This review recapitulates the most recent literature showing the diversity of the current application of SOL in the different pharmaceutical formulations, highlighting the prospective, current drug delivery systems, and applied preparation strategies. (pharmaexcipients.com)
  • This important feature is significantly have been widely used in pharmaceutical and medical applications as synthetic material for bone tissue engineering, wound healing and drug delivery. (ijbnb.com)
  • Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. (gruppotpp.it)
  • This current review focuses on the overview of regulations, classifications and types of food, as well as the latest analytical methods that have been used in recent years (2020-2023) for the determination of drug residues in food so that appropriate methods and accurate results can be used. (bvsalud.org)
  • This article discusses current melting methods and describes the dropping method, a promising new hot melt technology. (pharmtech.com)
  • The present review discusses the history, description of hydrogels, basic properties, classification, different techniques or methods of hydrogel synthesis and the areas in which hydrogels find applications. (biomedres.us)
  • Current methods of contrast agent design and its use in drug delivery are empirical. (sarkarkausik.com)
  • Nanotechnology offers multiple benefits to overcome the constraints associated with conventional drug administration methods through site-specific and target-oriented conveyances. (biomedcentral.com)
  • We highlight key questions that serologic studies can help answer at different times, review strengths and limitations of different assay types and study designs, and discuss methods for rapid sharing and analysis of serologic data to determine global transmission of severe acute respiratory syndrome coronavirus 2. (cdc.gov)
  • Prodrugs are derivatives of drug molecules that are pharmacologically inactive but require either chemical or enzymatic transformation to release the active drug in vivo in order to exert a pharmacological effect. (ijpsonline.com)
  • Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles: preparation, characterization, and preliminary in vivo studies. (zju.edu.cn)
  • Now that lipidic drug delivery systems can be designed to be highly responsive in vivo , they have advanced beyond being simple, inert drug carriers. (fleming.events)
  • The genetic manipulation of microorganisms opens up an enormous potential for the biotechnological production of biopolymers with tailored properties suitable for high-value medical application such as tissue engineering and drug delivery. (caister.com)
  • They are also suitable carriers for immunological products such as vaccines and other biological products like plasmas and seras and valvular intestinal cells [11]. (biomedres.us)
  • The objective of this review is to provide the researchers with a compilation of which carriers would be suitable for prodrug synthesis and what would be their benefits. (ijpsonline.com)
  • However, what molecular properties, physical chemical, and PK properties of a drug, are suitable for which technology to enable success is not established. (ddfsummit.com)
  • Liquisolid systems are considered as acceptably flowing and compressible powdered forms of liquid medications that imply oily liquid drugs and solutions or suspensions of water-insoluble solid drugs carried in suitable non-volatile solvent systems. (ijpsr.com)
  • Prepared formulations were also evaluated for % drug permeation using non-everted rat intestinal sac method which showed that Pluronic was not involved in permeability enhancement of Cefixime. (omicsonline.org)
  • The system is having donar and receiver compartment for studying permeation of drug across the membrane. (omicsonline.org)
  • Interference among the three attenuated poliovirus serotypes was minimized with a 'balanced- formulation' vaccine, and serologic responses after IPV were optimized by adjusting the antigenic content of each inactivated poliovirus serotype. (who.int)
  • Inverse gas chromatography is a physical characterization analytical technique that is used in the analysis of the surfaces of solids. (wikipedia.org)
  • IGC is considered a materials characterization technique (of the solid) rather than an analytical technique (of a gas mixture). (wikipedia.org)
  • Effective monitoring and control of drug residues in food requires continuous advances in analytical techniques. (bvsalud.org)
  • Cambridge Healthtech Institute's 12th Annual Optimizing Biologics Formulation Development conference is an essential yearly gathering of analytical and formulation scientists from leading industry companies that provides an exchange of scientific developments and emerging technologies in an environment that encourages discussion with colleagues. (chi-peptalk.com)
  • For 2020, the meeting will address the formulation challenges of emerging modalities, new strategies for predictive analysis at this stage, exciting new analytical methodologies and accelerating and the best practices being employed to overcome formulation challenges. (chi-peptalk.com)
  • The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters. (mdpi.com)
  • The prodrug approach using various carriers has evolved as a significant tool in surmounting different obstacles in relation to drug formulation and targeting. (ijpsonline.com)
  • Although this is a significant step forward in achieving targeted drug delivery, the drug carrier must have to overcome various biological obstacles throughout the body to reach the specific target of interest. (biomedcentral.com)
  • Prodrug concept is justified because it enables the active drug to overcome the barrier that would impede it from reaching the site of action to exert the required pharmacological activity. (ijpsonline.com)
  • However, NPs must overcome or navigate several biological barriers of the human body to successfully deliver drugs at precise locations. (biomedcentral.com)
  • Engineering the drug carrier biointerface can help overcome the main biological barriers and optimize the drug delivery in a more personalized manner. (biomedcentral.com)
  • Though several studies have been carried out on various prodrugs, surprisingly very few reviews on different carriers, which can be used for prodrug synthesis were published to date. (ijpsonline.com)
  • In this review different types of carriers, which can be used for prodrug synthesis are summarized. (ijpsonline.com)
  • These residues can come from the use of drugs in the field of veterinary medicine, such as antibiotics, antiparasitic agents, growth promoters and other veterinary drugs given to livestock and aquaculture with the aim of providing them as prophylaxis, therapy and for promoting growth. (bvsalud.org)
  • Moreover, these molecules have the added advantage of being biocompatible and biodegradable, and may be conjugated with a variety of drugs and drug carriers for developing various formulations as anti-cancer therapies such as nanogels, self-assembled and metallic nanoparticulates. (intechopen.com)
  • 11 Herbals have tremendous potential, with wide structural diversity not commonly seen with synthetic drug molecules. (drugtargetreview.com)
  • This review provides a new development method that has been used to control veterinary drug residue limit in food. (bvsalud.org)
  • SD is regarded as a straightforward approach that was implemented with SOL in drug development. (pharmaexcipients.com)
  • The new laboratory space brings customizable, flexible systems that will expedite formulation and process development services," he says. (drug-dev.com)
  • As such, there has been look at more info interest in the development of nanomaterials that will enhance the physical properties of drug delivery carriers in the body. (chemistryexamhero.com)
  • The present review is expected to be useful for scientists working in the field of drug discovery and development. (ijpsonline.com)
  • To efficiently deliver against these diverse needs, development strategies that leverage established platforms while catering to unique needs of the emerging modalities will be discussed. (chi-peptalk.com)
  • Chitosan based nanocomposites have potential antimicrobial activity against different bacterial, viral and fungal pathogens it's valuable for biological application of drug development system. (ijbnb.com)
  • Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
  • In 1961, Sekiguchi and Obi6 formed eutectic mixtures of drugs with water-soluble carriers by melting their physical mixtures. (pharmtech.com)
  • The formulation of a high dose, poorly soluble drug is one of the limitations of the liquisolid technique. (ijpsr.com)
  • In one of the well-known chitosan loaded drug delivery system it disturbs adsorption of fat soluble substances. (ijbnb.com)
  • Next, the use of hyaluronic acid-modified systems as anti-cancer therapies is discussed. (intechopen.com)
  • Aras, O., Kazanci, M. - Production of collagen micro- and nanofibers for potential drug-carrier systems, Journal of Enzyme Inhibition and Medicinal Chemistry 30 (6) (2015) 1013-1016. (ac.vn)
  • To circumvent these barriers, alternative drug delivery strategies and systems should be explored. (researchgate.net)
  • 6. Lembo D, Cavalli R. Nanoparticulate delivery systems for antiviral drugs. (isfcppharmaspire.com)
  • Eutectic mixtures of the drug with carriers were used to minimize melting temperatures. (pharmtech.com)
  • To prepare a piroxicam-PEG 4000 solid dispersion, Fernandez et al.4 dissolved the drug in chloroform and then mixed the solution with a melt of PEG 4000 at 70 °C. (pharmtech.com)
  • During an IGC experiment a pulse or constant concentration of a known gas or vapor (probe molecule) is injected down the column at a fixed carrier gas flow rate. (wikipedia.org)
  • Measuring how the retention time changes as a function of probe molecule chemistry, probe molecule size, probe molecule concentration, column temperature, or carrier gas flow rate can elucidate a wide range of physico-chemical properties of the solid under investigation. (wikipedia.org)
  • In this study the formulation F1 with 15-% zeolite was found to be the best formulation with granule flow rate parameters of 13.6 g/s, stationary angle of 22.0°, compressibility of 16.6-%, detergent tablet hardness accounted to 0.81 kgf/cm 2 , crushed time of tablet detergent of 1.5 min, pH 6.7, and biodegradability value of 70.3-% in BOD 5 test. (degruyter.com)
  • Flow cytometric analysis showed that the optimized co-liposomal formulations could transfect anti-GFP siRNA efficiently in three different GFP expressing cell lines, viz. (iisc.ac.in)
  • This model was based upon the theory that the carrier and coating materials can retain only certain amounts of liquid while maintaining acceptable flow and compression properties 2-4 . (ijpsr.com)
  • Hear their presentations and discuss the latest research advances. (aspet.org)
  • This review discusses the significant heterogeneous biological delivery barriers and how biointerface engineering can promote drug carriers to prevail over hurdles and navigate in a more personalized manner, thus ushering in the era of Precision Medicine. (biomedcentral.com)
  • In most cases, oral drug delivery is most preferred as it is convenient, non-invasive, and easy to incorporate into a patient's lifestyle. (mdpi.com)
  • It has been reported that plasma Cur levels are quite low after oral administration of conventional formulations [7, 8,10]. (researchgate.net)
  • A pharmacokinetic study after oral administration of the Cur ester derivatives was performed in rats and compared to the administration of suspended or dissolved Cur formulation. (researchgate.net)
  • Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. (omicsonline.org)
  • The major challenge in the oral drug delivery of poorly permeable drug is their transport across intestine [ 1 , 2 ]. (omicsonline.org)
  • The presence of drug residues in food products has become a growing concern because of the adverse health risks and regulatory implications. (bvsalud.org)
  • However, below CMC, SOL is used for drug precipitation inhibition via restraining the drug nucleation and crystal growth and providing steric stabilization in a supersaturated state [10]. (pharmaexcipients.com)
  • Natural ingredients based products are getting popular, as a public concerned toward long term effect of synthetic material in cosmetic formulation increased. (iajpr.com)
  • All prepared liquisolid formulations were characterized for pre-and post- compression parameters. (ijpsr.com)
  • "Measurement of Hardness of Semisolids" (an updated title was proposed in PF 48(3) to better describe the content of the chapter: Measurement of Yield Stress) regarding the characterization of viscoelastic properties of semi-solid preparations. (gmp-compliance.org)
  • To the best of our knowledge, two literature reviews have discussed the application of SOL in preparing polymeric nanomicelles and SDs to produce more effective therapeutics [11,12]. (pharmaexcipients.com)
  • The researchers used small angle neutron scattering to study the microstructure of a new gel-like formulation that could be used as a buoyant gel dispersant for oil spill remediation. (lsu.edu)
  • Because of higher liquid load factor, Neusilin was selected as a carrier for further optimization study using 3 2 Factorial design. (ijpsr.com)
  • In this study, formulation and optimization of liquisolid tablets were done using Olmesartan medoxomil as a model drug. (ijpsr.com)
  • Few studies have been reviewed on sample extraction and preparation techniques as well as challenges and future directions for the determination of veterinary drug residues in food. (bvsalud.org)
  • Several SD strategies, such as hot-melt extrusion , nanoextrusion, supercritical fluid processing, electrospinning , spray-drying, and freeze-drying are superior to other techniques in producing more effective SOL-based formulations. (pharmaexcipients.com)
  • These strategies are widely pursued because of their favorable drug-loading characteristics, nature, and low excipients concentration. (pharmaexcipients.com)
  • Novel drug delivery strategies of important plant leads in the treatment of acne have also been discussed. (hindawi.com)