Directly basic helix loop helix transcription factors. Medical search. Frequent questions

Here, TcMYC2a was identified to contain a basic helix-loop-helix (bHLH)-leucine zipper domain, a bHLH-MYC_N domain, and a BIF/ACT-like domain. (frontiersin.org)
Phys transduce light signals via a sub-family of the basic Helix-Loop-Helix (bHLH) transcription factors called Phytochrome Interacting Factors (PIFs). (utexas.edu)
this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
We show that the basic helix-loop-helix (bHLH) transcription factor PIF7 (phytochrome-interacting factor 7), an interactor of PHYB, accumulates in its dephosphorylated form in shade, allowing it to bind auxin biosynthetic genes and increase their expression. (slu.se)
The basic helix-loop-helix (bHLH) transcription factors play important roles in many processes in plant growth, metabolism and responses to abiotic stresses. (biomedcentral.com)
The basic helix-loop-helix (bHLH) transcription factor family is the second largest family in plants. (biomedcentral.com)
The conserved bHLH domain consists of about 60 amino acids and has two functional segments, the basic region and the HLH region. (biomedcentral.com)
The HLH region is located at the C-terminus of the bHLH domain, which consists of two parental α -helixes, mainly composed of hydrophobic residues, connected by a relatively dispersed (length and primary sequence) loop region. (biomedcentral.com)
These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
Efficient DNA binding requires dimerization with another basic helix-loop-helix (bHLH) protein. (thermofisher.com)
These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
HIF-1 belongs to the PER-ARNT-SIM (PAS) subfamily of the basic helix-loop-helix (bHLH) family of transcription factors. (hifpathway.com)
Neurogenin (Ngn) 2 is a basic helix-loop-helix ( bHLH ) transcription factor that promotes direct differentiation of pluripotent stem cells to functional excitatory neurons. (alstembio.com)

Using a targeted systems biology approach, we identified new factors, HECATE proteins that promote photomorphogenesis by negatively regulating the function of PIF1. (utexas.edu)
The microphthalmia-associated transcription factor family (MiT family) proteins are evolutionarily conserved transcription factors that perform many essential biological functions. (molcells.org)
The control of nuclear localization via phosphorylation and dephosphorylation serves as the primary regulatory mechanism for MiT family proteins, and several kinases and phosphatases have been identified to directly determine the transcriptional activities of MiT proteins. (molcells.org)
The mTOR signaling complex 1 (mTORC1) helps maintaining protein synthesis through phosphorylation of at least two direct targets, eukaryotic initiation factor (eIF) 4E-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks) [ 3 ] that regulate the activity of EIF4F, a heterotrimeric complex required for the cap-dependent ribosome recruitment phase of translation initiation. (biomedcentral.com)
Sterol regulatory element-binding proteins (SREBPs) compose a family of transcriptional factors that regulate the expression of various genes required for the synthesis of phospholipids, fatty acids, and cholesterol. (novusbio.com)
Curiously, none of the other basic helix-loop-helix proteins affected PIS1 expression. (umass.edu)
Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. (thermofisher.com)
If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)

Transcription factors (TFs) are protein molecules with special structure and function of regulating gene expression, which plays many crucial roles in plant growth and development [ 1 ]. (biomedcentral.com)
Ino4p is a basic helix-loop-helix protein that requires a binding partner. (umass.edu)
First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
Markedly, we found that suppression of HIF-1α accumulation by celastrol correlated with strong dephosphorylation of mammalian target of rapamycin (mTOR) and its effectors, ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) and extracellular signal-regulated kinase (ERK), pathways known to regulate HIF-1α expression at the translational level. (spandidos-publications.com)

Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)

Here we showed that PIF1 directly and indirectly regulates key genes involved in chlorophyll biosynthesis to optimize the greening process in Arabidopsis. (utexas.edu)
It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
In addition, RT-qPCR experiments with the other main clock genes showed that pdp1 , antagonist of vrille in the modulatory feedback loop of the circadian clock, showed higher expression levels in the rice-strain than in the corn-strain. (biomedcentral.com)
Quantitative reverse transcription-polymerase chain reaction analyses showed that several key BR biosynthetic genes are significantly up-regulated in cog1-3D compared with those of the wild type. (cas.cz)
Chromatin immunoprecipitation and electrophoretic mobility shift assays indicated that COG1 binds to the promoter regions of PIF4 and PIF5, and PIF4 and PIF5 bind to the promoter regions of key BR biosynthetic genes, such as DWF4 and BR6ox2, to directly promote their expression. (cas.cz)
AhR regulates the transcription of diverse genes through binding to the xenobiotic-responsive element (XRE). (biomedcentral.com)
In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. (umass.edu)
Hundreds to thousands of genes are regulated, either directly or indirectly, by the AhR. (aopwiki.org)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)

Extra-macrochaetae sequesters these basic-region-helix-loop-helix transcription factors as heterodimers inefficient for binding to DNA. (biologists.com)

Together, our results indicate that the allochronic differentiation in the two strains of S. frugiperda is associated with differential transcription of vrille or a cis-acting gene close to vrille, which contributes to the evolution of prezygotic isolation in S. frugiperda . (biomedcentral.com)
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. (thermofisher.com)
A goal of this project is to test a fundamental hypothesis: that factors that promote slow muscle differentiation will ameliorate the effects of DMD. (seattlechildrens.org)
We take advantage of zebrafish models to address whether factors that regulate fiber-type differentiation enhance or suppress the zebrafish dmd muscle degeneration phenotype. (seattlechildrens.org)

Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. (sdbonline.org)
While a combination of transcription factors might be necessary to initiate a cascade of transcriptional programs in order to convert these cells into neurons, identifying the minimal number of factors needed for the conversion is essential to better define and easily manipulate the cell types generated in the dish. (researchsquare.com)
Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)

Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-rearranged AMLs. (ox.ac.uk)

These results demonstrated that COG1 regulates BR biosynthesis via up-regulating the transcription of PIF4 and PIF5. (cas.cz)
Ume6p, and several associated factors, were required for inositol-mediated induction and chromatin immunoprecipitation analysis showed that Ume6p directly regulates PIS1 expression. (umass.edu)

Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
Reverse transcription‑quantitative PCR was then used to validate the downstream targets. (spandidos-publications.com)

Therefore, wheat yield is a complex quantitative trait contributed by many morphological, physiological and biochemical components, all of which can be improved to increase the yield directly or indirectly. (biomedcentral.com)
They may also be directly, or indirectly, predictive of maternal responsiveness to her infant. (hifpathway.com)

Current evidence indicates that, through either of these pathways, HER2 signaling can regulate c-Myc, a multifunctional transcription factor involved in cell cycle progression (see [ 4 ] and references therein). (biomedcentral.com)
Hypoxia is an important micro-environmental factor in promoting tumor progression. (spandidos-publications.com)

Interactions between caveolin-3 and cardiac NCX influence NCX-regulation of cellular signaling factors and excitation of cardiac myocytes. (wikipedia.org)
Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology. (spandidos-publications.com)

study, we reported that inducible expression of a single basic helix-loop-helix transcription factor Neurogenin-2 (Ngn2) in human embryonic stem (ES) and induced pluripotent stem (iPS) cells generates a homogenous population of excitatory neurons that resemble those of cortical upper layer 2/3 neurons in the brain 3 . (researchsquare.com)
In a previous report, we have identified that a single transcription factor, Neurogenin-2 (Ngn2), is sufficient to generate functional and homogenous population of excitatory neurons from human ES and iPS cells 3 . (researchsquare.com)
Upon induction, Ngn2 is expressed and the iPS cells will be directly differentiated into excitatory neurons. (alstembio.com)

All these results revealed that TcMYC2a can regulate taxol biosynthesis either directly or via ERF regulators depending on JA signaling transduction. (frontiersin.org)
ADR1 and CAT8 were identified as positive regulators of RTG -dependent gene transcription. (microbialcell.com)
Our group has shown that Pbx and Meis homeodomain transcription factors are critical regulators of heart development in zebrafish. (seattlechildrens.org)

Forced expression of transcription factor cocktails, particularly those important for neuronal cell fate determination in the mouse embryonic development has been recently adopted in fibroblasts and human ES/iPS cells to generate multiple neuronal cell types in a dish 1-5, 10-16 . (researchsquare.com)

Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)

EBF3 bound directly to p21 cip1/waf1 promoter and regulated transcription from both p21 cip1/waf1 and p27 kip1 promoters in reporter assays. (aacrjournals.org)
For instance, a previous study by the authors validated that USF1 binds to the core promoter of APOBEC3G and increases its transcription level in hepatocytes ( 7 ). (spandidos-publications.com)
Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following recruitment of positive elongation factors. (sdbonline.org)
This Mcl-1 dependence is due to Bim expression and it directly results from oncogenic signaling, as depletion of the oncoprotein c-Myc, which occupies regions of the Bim promoter as evaluated in ChIP assays, decreases Bim levels and mitigates Mcl-1 dependence. (biomedcentral.com)

Transcription regulation of taxol biosynthesis. (frontiersin.org)

In hypoxia, several transcription factors are induced to respond to the decreased oxygen level. (spandidos-publications.com)
Among these transcription factors, hypoxia-inducible factor-1 (HIF-1) is one of the most important factors that play a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions. (spandidos-publications.com)

Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)

We are also working to identify new epigenetic factors that regulate muscle fiber type. (seattlechildrens.org)

Here, we report the crystal structure of B5 antigen-binding fragments (Fabs) in complex with recombinant OspC type A (OspC(A)). Each OspC monomer within the homodimer was bound by a single B5 Fab in a side-on orientation, with contact points along OspC's -helix 1 and -helix 6, as well as interactions with the loop between -helices 5 and 6. (cdc.gov)

Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p. (umass.edu)

The mesangial cells showed increased expression of profibrotic factors, including thrombospondin, Tgfb2 and Tgfb3, as well as the angiogenesis factor Vegf. (refine.bio)

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. (ox.ac.uk)
Thus, the elucidation of a new oncogenic pathway is required to precisely target lung cancer and to serve as a prognostic factor. (biomedcentral.com)

Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. (rupress.org)

SHARP1 is expressed solely in MLL-AF6 AML, and its expression is regulated directly by MLL-AF6/DOT1L. (ox.ac.uk)
Expression profiles following lilliputian and Suppressor of Triplolethal RNAi were nearly identical raising the possibility that they are obligatory co-factors. (sdbonline.org)
Yeast single and double mutants lacking RTG2 and/or certain factors regulating carbon source utilization, including MIG1 , HXK2 , ADR1 , CAT8 , and HAP4 , have been analyzed for their survival and CIT2 expression after acetic acid treatment. (microbialcell.com)
As a transcription factor whose expression is increased by DNA damage, p53 blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)

Out of the three isoforms present (SREBP-1a, SREBP-1c and SREBP-2), SREBP-2 has been implicated more directly in the synthesis of cholesterol during metabolism. (novusbio.com)

In mammals, the MiT family consists of MITF (microphthalmia-associated transcription factor or melanocyte-inducing transcription factor), TFEB (transcription factor EB), TFE3 (transcription factor E3), and TFEC (transcription factor EC). (molcells.org)

Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
Transcription factor-based reprogramming of various cell types has revolutionized the field of translational medicine. (researchsquare.com)
With protocols ranging from cortical neurons to medium spiny neuron-like cells, with a defined set of factors, one can generate neuronal cell type of choice with improved definition and fidelity. (researchsquare.com)
In the absence of ADR1 and CAT8 , AA-PCD evasion is acquired through activation of an alternative factor/pathway repressed by RTG2, suggesting that RTG2 may play a function in promoting necrotic cell death in repressing conditions when RTG pathway is inactive. (microbialcell.com)
The download Sarkozy, Israël et by which cell transcription nurses are from an ER molecule is also thus as identified. (erik-mill.de)

In Arabidopsis, phytochrome B (PHYB) is the major sensor of shade, but PHYB excitation has not been linked directly to a growth response. (slu.se)

One such entity is the so-called HER2 subtype, which is characterized by amplification and/or overexpression of this member of the human epidermal growth factor receptor (HER) family. (biomedcentral.com)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)

Proinsulin Like Growth Factor I (prolGF-I) and myostatin (Mstn) regulate muscle regeneration and mass when intravenously delivered. (bvsalud.org)

These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)

The cloning and characterization of these mutants will help identify the factors, such as the kinase and E3 ligase, responsible for the light-induced degradation of PIF1. (utexas.edu)

however, the impact of 2 doses on hospitalization risk, especially among persons infected with HIV, who are at higher risk for severe disease, is an important factor in evaluating vaccine effectiveness against mpox disease severity and Monkeypox virus infection. (cdc.gov)

COG1 encodes a Dof-type transcription factor found previously to act as a negative regulator of the phytochrome signaling pathway. (cas.cz)

Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells. (refine.bio)
In addition, patient-specific materials can be directly converted from either fibroblast stage or as iPS cells to carry out disease modeling studies. (researchsquare.com)

Exposure to a variety of growth factors has also been shown to increase HIF-1 activity in normoxic and hypoxic conditions. (spandidos-publications.com)

Anatomy5

Organisms3

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes21

Information Science3

BHLH13

Proteins8

Protein6

Leucine zipper2

Genes9

Heterodimers1

Differentiation4

Transcriptional3

Circadian clock1

Regulates2

Downstream2

Indirectly2

Progression2

Cellular3

Excitatory neurons3

Regulators3

Embryonic1

Complexes1

Promoter4

Biosynthesis1

Hypoxia2

Pathogenesis1

Epigenetic1

Interactions1

Regulation1

Vegf1

Oncogenic2

Targets1

Expression4

Initiation1

Metabolism1

Consists1

Cell5

Arabidopsis1

Human2

Regulate muscle1

Nuclear1

Mutants1

Important1

Regulator1

Cells2

Variety1