• congestive heart f
  • Because other therapies have shown a mortality benefit in congestive heart failure, maximizing other therapies (e.g., beta blockers) first is recommended before using digoxin. (wikipedia.org)
  • The Prospective Randomized study Of Ventricular failure and the Efficacy of Digoxin (PROVED) trial assessed the effect of digoxin withdrawal in patients with mild to moderate congestive heart failure and sinus rhythm, and the Randomized Assessment of Digoxin on Inhibitors of Angiotensin-Converting Enzyme (RADIANCE) study had the same design and patient characteristics with the exception of patients being on concomitant ACEi therapy. (oncologynurseadvisor.com)
  • The results published in 1997 revealed that after 3 years of follow up, when digoxin was added to an ACEi-based protocol for symptomatic congestive heart failure and sinus rhythm with left ventricular ejection fraction below 45%, there was no statistically significant mortality differences between treatment and control group but hospitalization for worsening heart failure and all-cause hospitalizations were significantly diminished in the digoxin group. (oncologynurseadvisor.com)
  • serum
  • A serum digoxin concentration of 0.5-0.9 ng/mL among those with heart failure is associated with reduced heart failure deaths and hospitalizations. (wikipedia.org)
  • It is prepared by isolating the immunoglobulin fraction of the ovine serum, digesting it with papain and isolating the digoxin-specific Fab fragments by affinity chromatography. (wikipedia.org)
  • This is followed by a much more gradual decline in the serum concentration of the drug, which is dependent on the elimination of digoxin from the body. (nih.gov)
  • The digoxin receptor sites are located in the peripheral compartment, and the high degree of tissue binding means that equilibrium drug concentrations in cardiac tissue are 15-30 times those in serum. (southend.nhs.uk)
  • McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. (memorialhospitaljax.com)
  • potassium
  • If arrhythmias prove troublesome, or malignant hyperkalaemia occurs (inexorably rising potassium level due to paralysis of the cell membrane-bound, ATPase-dependent Na/K pumps), the specific antidote is antidigoxin (antibody fragments against digoxin, trade names Digibind and Digifab). (wikipedia.org)
  • High amounts of the electrolyte potassium (K+) in the blood (hyperkalemia) is characteristic of digoxin toxicity. (wikipedia.org)
  • A patent to use digoxin immunoglobulins C07k16/44 as a regulator of the preeclamptic/eclamptic patient's sodium/potassium ATPase activity was approved in 2003 to Charles David Adair under application number WO2004011028A1. (wikipedia.org)
  • Digoxin inhibits sodium-potassium ATPase, an enzyme that regulates the quantity of sodium and potassium inside cells. (nih.gov)
  • Licorice root can lower potassium levels in the body, which can be dangerous for an individual taking digoxin. (memorialhospitaljax.com)
  • doses
  • The half-life is about 36 hours for patients with normal renal function, digoxin is given once daily, usually in 125-μg or 250-μg doses. (wikipedia.org)
  • In high doses, digoxin increases sympathetic outflow from the central nervous system (CNS). (nih.gov)
  • Comparisons of the systemic availability and equivalent doses for preparations of digoxin are shown in Table 1. (nih.gov)
  • antibody
  • Treatment of severe toxicity is with digoxin-specific antibody fragments. (wikipedia.org)
  • The patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. (wikipedia.org)
  • ventricular
  • In digoxin toxicity, the finding of frequent premature ventricular beats (PVCs) is the most common and the earliest dysrhythmia. (wikipedia.org)
  • Magnesium suppresses digoxin-induced ventricular arrhythmias while phenytoin and lidocaine suppresses digoxin-induced ventricular automaticity and delay afterdepolarizations without depressing AV conduction. (wikipedia.org)
  • Digoxin is useful in the control of SVT, especially for slowing the ventricular rate in AF and in associated CCF. (southend.nhs.uk)
  • Digitek
  • Veterinarians who use the human drug Digitek (digoxin tablets, USP, all strengths) to treat their patients should be aware that a Class I recall has been issued because of the possibility the tablet strength may be doubled. (avma.org)
  • nausea
  • While IV therapy may be better tolerated (less nausea), digoxin has a very long distribution half-life into the cardiac tissue, which will delay its onset of action by a number of hours. (wikipedia.org)
  • fatigue nausea vomiting anorexia bradycardia headache weakness blurred vision yellow or green vision ECG changes AV block SA block diarrhea thrombocytopenia electrolyte imbalances with acute digoxin toxicity Arrythmias Cardiorespiratory failure Digoxin may be prescribed for a child to treat heart defects. (wikipedia.org)
  • Spurious use of digoxin as a weight loss drug has been reported, presumably driven by its side effect of anorexia and nausea. (oncologynurseadvisor.com)
  • inhibits
  • Digoxin inhibits the Na + ,K + ATP (sodium pump) and its main properties are the ability to increase the force and velocity of myocardial contraction. (southend.nhs.uk)
  • fragments
  • Unfortunately, fab fragments interfere with both fluorescence excitation transfer immunoassays and radioimmunoassays for digoxin. (wikipedia.org)
  • renal
  • Quinidine, verapamil, and amiodarone increase plasma levels of digoxin (by displacing tissue binding sites and depressing renal digoxin clearance), so plasma digoxin must be monitored carefully when coadministered. (wikipedia.org)
  • There is wide ranging clinical response for a given digoxin concentration and routine monitoring in patients on long- term therapy has little relevance unless renal function is changing or interacting drugs (e.g. quinidine or verapamil) are added or withdrawn. (southend.nhs.uk)
  • Digoxin elimination is predominately renal and half-life is prolonged in patients with impaired renal function. (southend.nhs.uk)
  • irregular
  • Milnacipran ( Savella ), used to treat fibromyalgia, can increase the risk of dizziness and fainting and irregular heart rhythms in conjunction with digoxin. (peoplespharmacy.com)
  • Digoxin is considered the most widely used cardiac medicine for heart failure and irregular heart rhythm problems (ASHP 2001). (livestrong.com)
  • symptomatic
  • Digoxin is no longer the first choice for heart failure, but can still be useful in people who remain symptomatic despite proper diuretic and ACE inhibitor treatment. (wikipedia.org)
  • drug
  • Digoxin is a drug used to treat heart failure and abnormal heart rhythms. (labtestsonline.org)
  • Digoxin levels must be monitored because the drug has a narrow safety range. (labtestsonline.org)
  • A digoxin test is used to monitor the concentration of the drug in the blood. (labtestsonline.org)
  • Digoxin is an old drug, perhaps ancient by some standards. (oncologynurseadvisor.com)
  • Comparatively little is written and published about digoxin today, arguably an indication of interest in the drug. (oncologynurseadvisor.com)
  • We need to remember that although digoxin has been used for over two centuries, it was approved by the FDA in the late 1999s under its strict guidelines for new drug approval based on its safety and efficacy data from multiple randomized clinical trials. (redorbit.com)
  • So, we are not talking about a new or unsafe drug when we talk about digoxin. (redorbit.com)
  • In a 15-year study reported in the Clinical Pharmacology and Therapeutics Journal in October 2009, which observed use of these macrolide antibiotics with digoxin, drug interaction and toxicity (identified by hospital admission) were greatly associated with clarithromycin use. (livestrong.com)
  • Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration on the basis of prospective, randomized study and clinical trials. (wikipedia.org)
  • drugs
  • The two drugs differ in that digoxin has an additional hydroxyl group at the C-3 position on the B-ring (adjacent to the pentane). (wikipedia.org)
  • hospitalization
  • For example, in the SOLVD study of enalapril done in the late 1980s and published in 1991 about 67% of participants were concomitantly on digoxin compared to 27% in Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF) and 22% in Systolic Heart Failure Treatment (SHIFT), which were recently completed. (oncologynurseadvisor.com)
  • Clinical
  • The proportion of patients on digoxin in large scale clinical trials done between 1980 and 2010 to evaluate angiotensin-converting enzyme inhibitors, beta-blockers, angiotensin receptor blocking agents, aldosterone antagonists, as well as pacemaker resynchronization and defibrillators has dropped rather dramatically. (oncologynurseadvisor.com)
  • Evidence of this is contained in many well done, controlled, small, short-term follow-up clinical trials, as well as two larger, nonmorbidity endpoint "digoxin withdrawal" studies. (oncologynurseadvisor.com)
  • Heart failure is the only other condition for which digoxin is used, so many of the patients who continued digoxin in the AF clinical trial also had heart failure," said Ali Ahmed, M.D., professor in the divisions of Gerontology, Geriatrics, & Palliative Care and Cardiovascular Disease within the School of Medicine at the University of Alabama at Birmingham (UAB), and the new study's senior author. (redorbit.com)
  • increase
  • citation needed] Digoxin has fallen out of favor in people with heart failure because it may increase the risk of death. (wikipedia.org)
  • Price increase was reported to range from US $380 to US $750 during 2013 for digoxin-Fab. (wikipedia.org)
  • 14 These substances also might alter (either increase or decrease) the effectiveness of digoxin. (memorialhospitaljax.com)
  • Digoxin was associated with a 41 percent increase in deaths from any cause, after controlling for other factors. (wibw.com)
  • Patients who took digoxin also had a 35 percent increase in deaths from cardiovascular causes, and a 61 percent increase in deaths from arrhythmias, or problems with heart rate. (wibw.com)