• doses
  • In high doses, digoxin increases sympathetic outflow from the central nervous system (CNS). (nih.gov)
  • Comparisons of the systemic availability and equivalent doses for preparations of digoxin are shown in Table 1. (nih.gov)
  • contains 40
  • Each vial of DigiFab , which will bind approximately 0.5 mg digoxin, contains 40 mg of digoxin immune Fab, 75 mg (approx) of mannitol USP, and 2 mg (approx) sodium acetate USP as a buffering agent. (wikipedia.org)
  • immune fab
  • The patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. (wikipedia.org)
  • mortality
  • There is tentative evidence that digoxin may increase the risk of death, though another meta-analysis in 2015 reported no change in mortality. (wikipedia.org)
  • nausea
  • While IV therapy may be better tolerated (less nausea), digoxin has a very long distribution half-life into the cardiac tissue, which will delay its onset of action by a number of hours. (wikipedia.org)
  • fragments
  • Unfortunately, fab fragments interfere with both fluorescence excitation transfer immunoassays and radioimmunoassays for digoxin. (wikipedia.org)
  • arrhythmias
  • Magnesium suppresses digoxin-induced ventricular arrhythmias while phenytoin and lidocaine suppresses digoxin-induced ventricular automaticity and delay afterdepolarizations without depressing AV conduction. (wikipedia.org)
  • increase
  • Digoxin was associated with a 41 percent increase in deaths from any cause, after controlling for other factors. (wibw.com)
  • Price increase was reported to range from US $380 to US $750 during 2013 for digoxin-Fab. (wikipedia.org)
  • drug interaction
  • In a 15-year study reported in the Clinical Pharmacology and Therapeutics Journal in October 2009, which observed use of these macrolide antibiotics with digoxin, drug interaction and toxicity (identified by hospital admission) were greatly associated with clarithromycin use. (livestrong.com)