• vivo
  • Improved non-invasive magnetic resonance (MR) characterisation of in vivo models of focal ischaemic insults such as transient ischaemic attack (TIA) and perinatal arterial ischaemic stroke (AIS) may assist diagnosis, outcome prediction and treatment design. (springer.com)
  • fMRS is based on the same principles as in vivo magnetic resonance spectroscopy (MRS). However, while conventional MRS records a single spectrum of metabolites from a region of interest, a key interest of fMRS is to detect multiple spectra and study metabolite concentration dynamics during brain function. (wikipedia.org)
  • brain
  • Transcranial magnetic stimulation (TMS): This procedure maps brain function. (clinicaltrials.gov)
  • A wire coil is held on the scalp, and a brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the brain. (clinicaltrials.gov)
  • All of these techniques are similar to conventional MRI, and like the conventional method they use a strong magnetic field and radio waves to measure structural and chemical changes in brain tissue. (clinicaltrials.gov)
  • The aim of this study was to investigate the presence of significant changes in magnetization transfer ratio (MTR) values, which could reflect an increase in free water within the brain of patients with liver cirrhosis, and to correlate these findings with minimal hepatic encephalopathy and proton MR spectroscopy ((1)H-MRS) abnormalities. (semanticscholar.org)
  • The data generated by fMRS usually shows spectra of resonances, instead of a brain image, as with MRI. (wikipedia.org)
  • Multi-voxel spectroscopy usually is performed when the specific volume of interest is not known or it is important to study metabolite dynamics in a larger brain region. (wikipedia.org)
  • we observed different diffusion patterns parallel and perpendicular to the midline of the brain, which was repeatable, and depended only on the direction of diffusion encoding gradient relative to the brain, regardless of which physical gradient was used. (wikipedia.org)
  • and by Turner had shown that oxygen depletion led to significant drops in MRI signal changes in large veins and the brain cortex itself, respectively, via a magnetic susceptibility mechanism analogous to that used by Belliveau with exogenous tracers, but in this case using deoxygenated blood itself as the contrast agent. (wikipedia.org)
  • The first dynamic video images of human brain activity appeared first at a meeting of the Society for Magnetic Resonance in Medicine in August 1991 in San Francisco in a plenary session by colleague Tom Brady, and was subsequently published in 1992 in the Proceedings of the National Academy of Sciences. (wikipedia.org)
  • tissue
  • In spite of a chronically reduced ADC, typically associated with ischaemia-induced energy failure, a 31 P MRS-detectable reduction in the phosphocreatine (PCr) to gamma adenosine triphosphate (γATP) ratio was not observed at any time point in either age group, suggesting dissociation of tissue water diffusion and metabolic changes within the ET-1-induced lesion. (springer.com)
  • van der Graaf M, Schipper RG, Oosterhof GO, Schalken JA, Verhofstad AA, Heerschap A. Proton MR spectroscopy of prostatic tissue focused on the detection of spermine, a possible biomarker of malignant behavior in prostate cancer. (springer.com)
  • Spectroscopy can detect molecular components in tissue, whereas the Magnetization Transfer Ratio (MTR) allows the measurement of water-macromolecule interactions. (clinicaltrials.gov)
  • This is possible because water diffusion properties in tissues, as measured by DT-MRI, are affected by tissue constituents, such as macromolecules, membranes, organelles, as well as by tissue microstructure, architecture and organization. (clinicaltrials.gov)
  • Gradient
  • An NMR spectrometer typically consists of a spinning sample-holder inside a very strong magnet, a radio-frequency emitter and a receiver with a probe (an antenna assembly) that goes inside the magnet to surround the sample, optionally gradient coils for diffusion measurements and electronics to control the system. (wikipedia.org)
  • spectroscopic
  • His researches were primarily in the fields of thermodynamics and he worked on the chemical application of Mossbauer spectroscopy and the beta and gamma spectroscopic studies isotopes in the closed shell region. (wikipedia.org)
  • coefficients
  • The analysis of the NMR-derived diffusion coefficients and T 1 relaxation times shows that in the presence of DM-β-CD, NFOH decreases its mobility in solution, indicating that this antichagasic compound interacts with the cyclodextrin cavity. (springer.com)
  • investigate
  • Most frequently, NMR spectroscopy is used by chemists and biochemists to investigate the properties of organic molecules, although it is applicable to any kind of sample that contains nuclei possessing spin. (wikipedia.org)
  • atoms
  • This type of spectroscopy determines the physical and chemical properties of atoms or the molecules in which they are contained. (wikipedia.org)
  • The presence or absence of imino proton resonances, or of coupling between 15N atoms across a hydrogen bond, indicates the presence or absence of basepairing. (wikipedia.org)
  • chemical
  • His association with scientific organizations include memberships in Indian Chemical Society, American Physical Society, American Association for the Advancement of Science, Magnetic Resonance Spectroscopy Association of India and the International Diffusion Research Association and the fellowship of Sigma Xi. (wikipedia.org)
  • field
  • During the scan, the subject lies on a table in a narrow cylinder containing a magnetic field, wearing ear plugs to muffle loud noises that occur with electrical switching of the magnetic fields. (clinicaltrials.gov)
  • To balance the need for temporal resolution and sufficient SNR, fMRS requires a high magnetic field strength (1.5 T and above). (wikipedia.org)
  • Modern NMR spectrometers have a very strong, large and expensive liquid helium-cooled superconducting magnet, because resolution directly depends on magnetic field strength. (wikipedia.org)
  • When placed in a magnetic field, NMR active nuclei (such as 1H or 13C) absorb electromagnetic radiation at a frequency characteristic of the isotope. (wikipedia.org)
  • The resonant frequency, energy of the absorption, and the intensity of the signal are proportional to the strength of the magnetic field. (wikipedia.org)
  • known
  • It is useful for molecules of up to 100 nucleotides, and as of 2003, nearly half of all known RNA structures had been determined by NMR spectroscopy. (wikipedia.org)
  • Group
  • Multi-voxel spectroscopy provides information about group of voxels and data can be presented in 2D or 3D images, but it requires longer acquisition times and therefore temporal resolution is decreased. (wikipedia.org)
  • The Purcell group at Harvard University and the Bloch group at Stanford University independently developed NMR spectroscopy in the late 1940s and early 1950s. (wikipedia.org)
  • study
  • Consistent with his joint appointment in the Massachusetts Eye and Ear Infirmary, he and his colleagues were able to demonstrate that MRI could be used to study diffusion and flow in the living eye. (wikipedia.org)
  • structures
  • The sequential walking methodology is not possible for non-double helical nucleic acid structures, nor for the Z-DNA form, making assignment of resonances more difficult. (wikipedia.org)
  • complex
  • He also did researches on intermetallic diffusion and kinetics of high-temperature oxidation of metals and alloys and thermodynamics of the formation of complex ions in aqueous solutions. (wikipedia.org)