SituGastric carcinomaBreastDCISHyperplasiaGlandsIntraductalTumorHistologicalLymphomaGlandularCancerInvasive carcinoma cellsBasal cell carcPleomorphicMetastatic carcinomaMammaryColloidCDH1NoninvasivePapillaryMammographyMacroscopicallySignetPrognosisDistinguishVariantsDiseasesPoorlyHistologicTumourNuclearStomach
Situ11
- Ductal carcinoma in situ (DCIS) is noninvasive breast cancer that is limited to the inside of the ducts of the breast. (medscape.com)
- Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
- Lobular carcinoma in situ (LCIS) is a noninvasive proliferative lesion of the breast that arises from the terminal ductal lobular units . (amboss.com)
- Exceptions are ILC arising in florid lobular carcinoma in situ (F-LCIS) or pleomorphic lobular carcinoma in situ (P-LCIS), both of which show central necrosis and calcifications within glands (see Chapter 18 ). (basicmedicalkey.com)
- Increased use of screening mammography has resulted in a dramatic increase in the detection of ductal carcinoma in situ (DCIS). (medscape.com)
- Lobular carcinoma in situ - Preventive mastectomy is sometimes considered for a woman with lobular carcinoma in situ, a condition that increases the risk of developing breast cancer in either breast. (womenshealthcarecommunity.com)
- These results suggest that PAX2 immunoreactivity may be useful to (1) distinguish mesonephric hyperplasia from minimal deviation adenocarcinoma, (2) to distinguish lobular endocervical glandular hyperplasia from minimal deviation adenocarcinoma, and (3) to distinguish endocervical tubal metaplasia or cervical endometriosis from endocervical adenocarcinoma in situ. (nih.gov)
- carcinoma in situ in the stomach (a state of severe cellular atypia or dysplasia, without invasion across the basement membrane of the glands). (poznayka.org)
- Noninvasive breast cancer may be intralobular (lobular carcinoma in situ), and intraduct (ductal carcinoma in situ). (quartermainesterms.com)
- The percentage of breast cancer cases diagnosed in situ (excluding lobular carcinoma in situ) increased from 1.3% in 1981 to 11.9% in 2000. (cdc.gov)
- breast cancer in situ (BCIS) (excluding lobular carcinoma in situ [13-15]) is the earliest stage of localized breast cancer and is diagnosed almost exclusively by mammography ( 16 ). (cdc.gov)
Gastric carcinoma11
- 2001) Loss of E-cadherin is the fundamental defect in diffuse-type gastric carcinoma and infiltrating lobular carcinoma of the breast . (breast-cancer.ca)
- Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
- Gastric carcinoma comprises more than 90% of all gastric malignant tumors. (poznayka.org)
- Gastric carcinoma is most commonly located in the region of gastric canal (prepyloric region), less common localization are the body, cardia and fundus. (poznayka.org)
- 1. Early gastric carcinoma, when carcinoma confined only mucosal layers. (poznayka.org)
- 2. Advanced gastric carcinoma, when it penetrates the muscular layer or beyond. (poznayka.org)
- 1. Pyloric (50%) gastric carcinoma. (poznayka.org)
- Early gastric carcinoma is the term used to describe cancer limited to the mucosa and submucosa. (poznayka.org)
- Macroscopically, the lesions of early gastric carcinoma may have 3 patterns-superficial, polypoid and ulcer-associated. (poznayka.org)
- Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
- When the carcinoma crosses the basement membrane into the muscular propria or beyond, it is referred to as advanced gastric carcinoma. (poznayka.org)
Breast32
- Breast cancers usually are epithelial tumors of ductal or lobular origin. (medscape.com)
- Women with low-grade DCIS are at higher risk of developing invasive breast cancer than women without DCIS, but are less likely to have a recurrence of the breast carcinoma or to develop new cancers than women with higher-grade DCIS. (medscape.com)
- P. D. Pharoah, P. Guilford and C. Caldas, "Incidence of Gastric Cancer and Breast Cancer in CDH1 (E-Cadherin) Mutation Carriers from Hereditary Diffuse Gastric Cancer Families," Gastroenterology, Vol. 121, No. 6, 2001, pp. 1348-1353. (scirp.org)
- 1993) Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast . (breast-cancer.ca)
- 1995) The significance of signet ring cells in infiltrating lobular carcinoma of the breast . (breast-cancer.ca)
- 2003) Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma . (breast-cancer.ca)
- 1993) Differential loss of E- cadherin expression in infiltrating ductal and lobular breast carcinomas . (breast-cancer.ca)
- 1982) The importance of MUC1 cellular localization in patients with breast carcinoma: an immunohistologic study of 71 patients and review of the literature . (breast-cancer.ca)
- Tot T. (200) The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract . (breast-cancer.ca)
- ILC occurs almost throughout the entire age range of breast carcinoma in adult women (28-86 years). (basicmedicalkey.com)
- A population-based study of women with invasive breast carcinoma diagnosed from 1987 to 1999 revealed that the incidence rate of lobular carcinoma increased during this period ( 8 ). (basicmedicalkey.com)
- In a minority of cases, the only physical evidence of the neoplasm is vague thickening or diffuse nodularity of the breast. (basicmedicalkey.com)
- The main differential diagnosis is the bladder involvement by lymphoma-plasmocytoma or metastasis from lobular breast cancer or diffuse gastric cancer. (biomedcentral.com)
- We report the case of a 67 year-old-woman who presented with gastrointestinal symptoms which revealed to be the clinical manifestations of peritoneal and retroperitoneal metastatic spread of an invasive lobular breast cancer diagnosed 15 years before. (biomedcentral.com)
- To the best of our knowledge, the case presented is the third one reported in literature showing a wide peritoneal and extraperitoneal diffusion of an invasive lobular breast cancer. (biomedcentral.com)
- Invasive lobular breast cancer (ILC) takes origin in the milk-producing glands of the breast and is the most common histological breast cancer after the ductal carcinoma (DC), accounting for 8-14% of cases [ 1 ]. (biomedcentral.com)
- A 67-year-old woman underwent right modified radical mastectomy and axillary lymph node dissection for carcinoma of the breast 15 years ago. (biomedcentral.com)
- Dr. Goel has experience treating conditions like Breast Lump, Breast Cancer and Breast Carcinoma among other conditions at varying frequencies. (sharecare.com)
- or diffuse plus indeterminate breast microcalcifications or dense breast tissue that hinders diagnosis put women at higher risk to develop breast cancer. (womenshealthcarecommunity.com)
- Diffuse and indeterminate breast microcalcifications or dense breasts - Rarely, preventive mastectomy may be considered for a woman who has diffuse and indeterminate breast microcalcifications (tiny deposits of calcium in the breast) or for a woman whose breast tissue is very dense. (womenshealthcarecommunity.com)
- Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. (betalifesci.com)
- Breast cancer is represented macroscopically nodular and diffuse forms, along with cancer in the nipple and also the nipple from the field (Paget's disease from the breast). (quartermainesterms.com)
- Breast cancer is represented macroscopically nodular and diffuse forms, in addition to cancer with the nipple as well as the nipple with the field (Paget's disease of the breast). (quartermainesterms.com)
- Mutations in the CDH1 gene are a frequent cause of hereditary diffuse gastric cancer syndrome (HDGC), which is associated with both gastric and lobular breast cancers at an early age. (nostomachforcancer.org)
- Breast disorders occurring in pediatric patients range from congenital conditions to neonatal infections and from benign disorders such as fibroadenoma in females and gynecomastia in males to breast carcinoma and rhabdomyosarcoma . (medscape.com)
- Anatomopathological and immunohistochemical study revealed a preliminary diagnosis of breast carcinoma metastasis. (bvsalud.org)
- Although the patient had no medical history of breast cancer, due to this result, she was referred to a mastologist, who investigated her breast nodules for the possible primary focus of the carcinoma. (bvsalud.org)
- New anatomopathological and immunohistochemical exams confirmed the diagnosis of breast carcinoma metastasis. (bvsalud.org)
- breast carcinoma, sweat gland carcinoma, skin cancer. (bvsalud.org)
- Apocrine skin carcinoma has characteristics similar to those of cutaneous breast carcinoma metastases when it presents a tubule-lobular, or cordonal differentiation. (bvsalud.org)
- The anatomopathological report indicated breast carcinoma metastasis and the pathologist recommended a further immunohistochemical investigation to determine the neoplastic site of origin. (bvsalud.org)
- Affected women are also at high risk of developing cancer of the milk-producing glands (lobular breast cancer). (msdmanuals.com)
DCIS1
- LCIS has a lower risk of subsequent invasive carcinoma compared to DCIS . (amboss.com)
Hyperplasia3
- Mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis): three cases. (scielo.br)
- PAX2 was expressed in normal endocervical glands (including tunnel clusters and Nabothian cysts) (86 of 86), lobular endocervical glandular hyperplasia (5 of 5), tubal/tuboendometrioid metaplasia (8 of 8), and cervical endometriosis (13 of 14). (nih.gov)
- The reasons for this were as follows: papillary lesion (two), fibroepithelial lesion (two), atypical intraductal epithelial proliferation (two), stromal mucin (two), atypical lobular hyperplasia (one), and an unusual vascular lesion (one). (bmj.com)
Glands3
- The classic type of invasive lobular carcinoma (ILC) either infiltrates mammary stroma in linear cords or in a concentric pattern around uninvolved native glands. (basicmedicalkey.com)
- The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
- This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (bvsalud.org)
Intraductal3
Tumor5
- There are no details about the gross examination in the literature, but sessile and protruding isolated or multiple tumor masses, as well as diffuse infiltration of the bladder has been described. (biomedcentral.com)
- PAX2 encodes a transcription factor necessary in the development of the Wolffian duct system, and the protein is expressed in several tumors of mesonephric origin, including renal cell carcinoma, Wilm tumor, and nephrogenic adenoma. (nih.gov)
- carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
- Diffuse prostate cancer is included to get a considerable distance, the contours from the tumor are marked bad. (quartermainesterms.com)
- The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (bvsalud.org)
Histological1
- Histological examination of the tumour revealed a 4 cm invasive lobular carcinoma of histological grade 2. (biomedcentral.com)
Lymphoma1
- The radiographic findings of mesothelioma are nonspecific and are observed in other diseases, including metastatic carcinoma, lymphoma, and benign asbestos disease. (medscape.com)
Glandular1
- Skip areas," that is, poorly delimited foci of invasive carcinoma separated by unremarkable mammary glandular and stromal tissue without desmoplastic reaction, impart the impression of multifocality. (basicmedicalkey.com)
Cancer9
- Hereditary diffuse gastric cancer is a rare, autosomal dominant hereditary cancer syndrome associated with germline mutations in CDH 1 in which 60% - 80% of affected individuals develop advanced diffuse gastric cancer, many as young adults. (scirp.org)
- J. Odegaard and I. Schrijver, "Molecular Pathology of Hereditary Diffuse Gastric Cancer," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 554-561. (scirp.org)
- Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
- This type of cancer include, especially, infiltrating ductal and lobular carcinoma, which in turn has got the structure of scirrhus, as well as Paget's disease. (quartermainesterms.com)
- No Stomach For Cancer commits $289,000 to Hereditary Diffuse Gastric Cancer (HDGC) research through 2023. (nostomachforcancer.org)
- E-cadherin germline mutations are causative events of Hereditary Diffuse Gastric Cancer (HDGC). (nostomachforcancer.org)
- Affected individuals are usually diagnosed at advanced stages of the disease, with diffuse gastric cancer frequently spreading beneath intact gastric mucosa. (nostomachforcancer.org)
- Although gastric (stomach) cancer is uncommon in the United States, diffuse-type gastric cancer is increasing in incidence among young and female patients. (nostomachforcancer.org)
- Hereditary diffuse gastric cancer is a rare inherited disorder that increases a person's risk of developing stomach cancer. (msdmanuals.com)
Invasive carcinoma cells2
- The noncohesive individual invasive carcinoma cells are small with round-to-ovoid nuclei and minimal occasionally vacuolated cytoplasm. (basicmedicalkey.com)
- Notably, early-stage HDGC in E-cadherin mutant carriers is characterized by multiple foci of invasive carcinoma cells invading the superficial lamina propria. (nostomachforcancer.org)
Basal cell carc1
- After an incisional biopsy, her sample was firstly sent for anatomopathological study in a first pathology laboratory, chosen by the dermatologist, with the diagnostic hypothesis of basal cell carcinoma. (bvsalud.org)
Pleomorphic1
- 2000) Pleomorphic lobular carcinoma: Morphology, Immunohistochemistry and molecular analysis . (breast-cancer.ca)
Metastatic carcinoma1
- 27 ) found that magnetic resonance imaging ( MRI ) was more effective than mammography in a significant proportion of cases for determining the extent of a primary ILC, but the presence of metastatic carcinoma in axillary lymph nodes was not detected in four cases examined. (basicmedicalkey.com)
Colloid1
- 4. Colloid (mucoid) carcinoma. (poznayka.org)
CDH11
- NIH Grant Announcement: CDH1 loss of heterozygosity in the gastric epithelium is necessary but not sufficient for early diffuse-type gastric carcinogenesis. (nostomachforcancer.org)
Noninvasive1
- Unidimensional transient elastography (TE) is a noninvasive technique, which has been increasingly used in the assessment of diffuse liver diseases. (wjgnet.com)
Papillary1
- Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
Mammography2
- A lower frequency of calcifications detected by mammography has been reported in ILC than in ductal carcinomas ( 14 , 15 , 16 ). (basicmedicalkey.com)
- In the screening setting, ILC is found more often clinically during intervals between examinations than by mammography (so-called " interval carcinomas ") ( 17 ). (basicmedicalkey.com)
Macroscopically1
- Macroscopically, ulcerative carcinomas are poorly-differentiated adenocarcinomas, which invade deeply into the stomach wall. (poznayka.org)
Signet1
- 2. Signet-ring cell carcinoma, scirrhous carcinoma, solid carcinoma (poorly-differentiated). (poznayka.org)
Prognosis2
- E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas. (betalifesci.com)
- These carcinomas are typically unresponsive to adjuvant therapy and are associated with high relapse rates, resulting in a very poor prognosis. (nostomachforcancer.org)
Distinguish1
- It is common to distinguish between diffuse and focal distributions. (biomedcentral.com)
Variants1
- The WHO publication of 2016 recognizes 10 variants of urothelial carcinoma (UC), significant from the diagnostic, prognostic, and/or therapeutic perspective (Table 1 ). (biomedcentral.com)
Diseases1
- Acute restrictive diseases: diffuse alveolar damage (respiratory distress syndrome of adult and infant). (unibo.it)
Poorly1
- This rare and very aggressive form is called plasmacytoid urothelial carcinoma (PUC), also known as poorly cohesive or diffuse carcinoma. (biomedcentral.com)
Histologic1
- When the diagnosis is restricted to the histologic and cytologic features of an invasive carcinoma, as described in the preceding paragraph, less than 5% of carcinomas qualify for the diagnosis of the classic type of ILC ( 1 , 2 , 3 ). (basicmedicalkey.com)
Tumour1
- Anni 2017-2019","EN":"Tumour site comparison. (registrotumoriveneto.it)
Nuclear1
- In addition, the myoepithelial cells exhibited diffuse nuclear immunoreactivity for p63. (scielo.br)
Stomach1
- The involvement may be localized to pyloric antrum, or diffuse affecting whole of the stomach from the cardia to pylorus. (poznayka.org)