pointed out that Mage-D1 may participate in the proliferation of bone marrow mesenchymal stem cells (BMSCs) and the differentiation of odontoblasts through the NF-κB signalling pathway 21 . (researchsquare.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
There were no significant differences in dental pulpcell proliferation patterns related to the absence or presence of GDF-5 after seven days of culture. (ispub.com)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
These pathways are important for the growth and division (proliferation) and maturation (differentiation) of cells. (medlineplus.gov)
In particular, Sonic Hedgehog appears to be essential for the proliferation and differentiation of cells that ultimately give rise to cartilage and bone. (medlineplus.gov)
The finger like projection full of dental lamina undergoes extensive proliferation, starts to fatten up and look like a bud. (freezingblue.com)
1-5 Accumulated knowledge in the past decade has demonstrated the importance of tear components such as epidermal growth factor (EGF) and vitamin A in the regulation of proliferation, differentiation, and maturation of the ocular surface epithelium. (bmj.com)
Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. (mdpi.com)
Subsequent studies further confirmed that Mage-D1 inhibits the NF-κB signalling pathway by combining with IκB kinase β (IKKβ) 22 , which is a vital regulator of odontoblast differentiation. (researchsquare.com)
Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)
Periodontal ligament1
2002). It has also been reported that the GDF-5 gene is expressed in dental sac, periodontal ligament, dental pulp cells, and odontoblasts during tooth development (Morotome et al. (ispub.com)
Epithelium2
The mechanism of differentiation of the cementoblasts is controversial but circumstantial evidence suggests that an epithelium or epithelial component may cause dental sac cells to differentiate into cementoblasts, characterised by an increase in length. (wikipedia.org)
BACKGROUND: We recently published evidence to suggest that two populations of stem cells including very small embryonic-like stem cells (VSELs) and ovarian stem cells (OSCs) in ovary surface epithelium (OSE) undergo proliferation/differentiation, germ cell nests (GCN) formation, meiosis and eventually differentiate into oocytes that assemble as primordial follicles on regular basis during estrus cycle. (bvsalud.org)
Odontoblasts3
To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
The odontoblasts are differentiated from the dental papilla, which remains a soft connective tissue in the tooth interior also known as the dental pulp, even after development is complete. (ispub.com)
The cells in the dental pulp comprise a heterogeneous mixed population, made up of odontoblasts, fibroblasts, stem cells, and macrophages and other immunocompetent cells. (ispub.com)
Mineralization4
However, the mechanism of dental mineralization is still far from being revealed, which restricts the process of dental tissue engineering and tooth regeneration. (researchsquare.com)
Ectomesenchymal stem cells (EMSCs) derived from the cranial neural crest are significant in tooth development and dental mineralization. (researchsquare.com)
In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
Mesenchymal2
The development of teeth is initiated by epithelial-mesenchymal interactions, which form dental papilla cells and dental sac cells, subsequently forming pulp, dentin, cementum, periodontal ligament and proper alveolar bone, except enamel 1 - 4 . (researchsquare.com)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)
Dentin1
Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
Pulp4
Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Furthermore, dental pulp cells cultured in the presence of GDF-5 formed alizarin red-positive nodules after 10 days of culture. (ispub.com)
To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)
In dental pulp cells, however, the functions of GDF-5 are still unknown. (ispub.com)
Mesoderm1
Laterally, the mesoderm undergoes differentiation: para-axial (peripheral nervous system), intermediate (gonads and kidneys), and lateral, which further divides into splanchnic (gastrointestinal [GI] tract) and somatic (body wall). (medscape.com)
Yolk5
Following fertilization, cellular division generates a hollow sphere, bisected by a bilaminar plate composed of epiblast and hypoblast, which abut the amnion and yolk sac cavities respectively. (medscape.com)
With the formation of head and tail fold, part of the yolk sac becomes enclosed within the embryo, giving rise to formation of primitive gut. (homeopathy360.com)
As the distension of the amnion still continues, the ventral bulging, round the margin of the umbilical orifice, becomes more pronounced, the yolk-sac is forced farther and farther away from the embryo, the vitello-intestinal duct is elongated, and it is surrounded by a hollow tube. (co.ma)
the distal end is attached to the chorion, and in its neighbourhood lies the now relatively small vesicular yolk-sac (Fig. 62). (co.ma)
showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)
Cells1
ES cells transformed from ectopic PGCs through molecular dysregulation or de-differentiation may become the source of iGCT. (bvsalud.org)
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3.They lack tissue differentiation and vascular tissues. (rbsesolutions.com)
Regeneration1
These findings are expected to improve our knowledge of the role of GDF-5 in dental tissue development and to provide information that may be useful in the application of GDF-5 as a molecular manipulator in dental tissue regeneration. (ispub.com)
Growth1
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Populations1
To investigate whether morphological change mirrors the genetic differentiation observed in New York City P. leucopus populations, we conducted univariate and multivariate analyses on 4 external and 14 skull variables to compare urban, suburban and rural P. leucopus populations from in and around New York City. (bioone.org)
The success of rehabilitation with dental implants is directly related to the amount of bone tissue of the patient. (bvsalud.org)
Development1
describe the development of the dental lamina layer. (freezingblue.com)
Stages1
In the advanced stages of the disease, the pathogenic bacteria of dental plaque and their metabolic products may enter into the systemic circulation during mastication or mechanical procedures. (encyclopedia.pub)
Small1
Bursitis is a common condition affecting the small protective sacs around a joint. (regenerativemedicinenow.com)
Form2
What are the new layers that form during the bell stage as a result of extensive differentiation? (freezingblue.com)
Paired palatine processes meet at midline to form anterior 2/3 of hard palate, bounded by dental arch of maxilla 2. (slideshare.net)
Significant1
MRI scan showed mild central disc bulges at L23 and L34 without significant impingement on the dural sac. (doctorsmedicalopinion.com)