• The effects of myostatin on adipogenic differentiation are poorly understood, and the underlying mechanisms are unknown. (elsevierpure.com)
  • Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
  • This work will develop new cell lines for cultivated seafood production, provide insights into the relative merits of embryonic and adult stem cells as starting materials, and improve our ability to control the myogenic and adipogenic differentiation processes. (gfi.org)
  • In addition, several miRNAs reported to have osteogenic and adipogenic differentiation potentials are also identified in these exosomes. (exosome-rna.com)
  • In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
  • Using interleukin (IL)-33 receptor knockout mice and in vitro experiments, we show that basophils establish a lung-specific function imprinted by IL-33 and granulocyte-macrophage colony-stimulating factor (GM-CSF), characterized by unique signaling of cytokines and growth factors important for stromal, epithelial, and myeloid cell fates. (nih.gov)
  • The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies on the biochemistry and function of cells in situ are especially encouraged . (wiley.com)
  • Dr. Goswami, principal scientist at the Indian Council of Agricultural Research, is studying in vitro differentiation of carp embryonic, myogenic, and adipogenic stem cells in collaboration with the Ovissipour Lab at Virginia Tech. (gfi.org)
  • Antibody inhibitors and siRNA were used to manipulate the expression profiles of LX-2 cells that were incubated under normal culture conditions or after treatment with TGF-Β, a known ligand for the αv integrins and a pro-fibrotic cytokine, to mimic a pro-fibrotic environment in vitro. (harvard.edu)
  • We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)
  • Acting principally through the latter, it inhibits basal and CRH-stimulated ACTH secretion from the AtT20 mouse corticotroph cell line and ACTH release from a proportion of human corticotroph adenomas both in vitro and in vivo. (endocrine-abstracts.org)
  • Discuss how we can use stem cells combined with biomaterials for in vitro and in vivo applications. (manchester.ac.uk)
  • The successful generation of beta cells in vitro and regeneration of pancreatic beta cells in vivo will require a thorough understanding of the molecular networks that direct the normal development and function of these cells. (lu.se)
  • For example, patients with partial DGS rarely lack T-cell function as measured by in vitro T-cell proliferation to nonspecific mitogens. (medscape.com)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • Support the growth and differentiation of human pluripotent stem cells by using Vitronectin XF™, a defined and xeno-free cell culture matrix. (stemcell.com)
  • We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
  • Notch regulates blastema proliferation and prevents differentiation during adult zebrafish fin regeneration. (uni-potsdam.de)
  • ErbB3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. (rndsystems.com)
  • Use Vitronectin XF™ with mTeSR™1 , mTeSR™ Plus , TeSR™-E8™ , or TeSR™-AOF medium to provide a defined culture system for the maintenance of human embryonic stem (ES) cells and human induced pluripotent stem (iPS) cells under feeder-free conditions. (stemcell.com)
  • Clinical use of human embryonic stem (hES) cells is already being explored in a several phase1 safety trials. (selectbiosciences.com)
  • The unit will demonstrate various types of stem cells: adult, embryonic, induced pluripotent and their specialised culture methods. (manchester.ac.uk)
  • Goal The objective of our research is to understand the molecular and cellular mechanisms that control beta cell maturation and function in the embryonic and adult pancreas. (lu.se)
  • I've also worked with differentiation from embryonic stem cells into interneurons. (lu.se)
  • Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
  • We determined the effects of human recombinant myostatin protein on adipogenesis of bone marrow-derived human mesenchymal stem cells (hMSCs) and adipose tissue-derived preadipocytes. (elsevierpure.com)
  • The conclusion is that myostatin inhibited adipogenesis in human bone marrow-derived mesenchymal stem cells and preadipocytes. (elsevierpure.com)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • Osteoblast mainly originates from mesenchymal stem cells (MSCs), and it is involved in bone formation, remodeling, and reconstruction via the formation of a bone matrix and regulation of bone resorption ( 6 ). (frontiersin.org)
  • Researchers from the West Virginia University School of Medicine demonstrate that osteoblasts-derived (Os-Exo) and adipocytes-derived (Ad-Exo) exosomes contain instructive factors that regulate the lineage specification of human mesenchymal stem cells (hMSCs). (exosome-rna.com)
  • The magnitude, direction and timing of contractile force depend on the organization of the cellular actomyosin meshworks and how these networks are connected between cells at the level of the tissue. (nature.com)
  • Using single-cell RNA sequencing (RNA-seq), we characterize the cellular composition of the lung during development and identify vast dynamics in cell composition and their molecular characteristics. (nih.gov)
  • Together, our study demonstrates how whole-tissue signaling interaction map on the single-cell level can broaden our understanding of cellular networks in health and disease. (nih.gov)
  • For both progenitor cell types, differentiation in the presence of myostatin caused a dose-dependent reduction of lipid accumulation and diminished incorporation of exogenous fatty acid into cellular lipids. (elsevierpure.com)
  • Cell Biochemistry & Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease . (wiley.com)
  • Through the study of temporal and spatial regulation of important genes and pathways in our model systems, we will develop a more comprehensive picture of the molecular mechanisms orchestrating egg development and gain a deeper understanding of how basic cellular functions such as proliferation, differentiation, and growth are regulated in development. (fsu.edu)
  • In this study, I have tried to address the role of the nucleolus in cellular differentiation. (nii.ac.jp)
  • These results suggest that the downregulation of rRNA transcription accelerates cellular differentiation at least in hematopoietic cells. (nii.ac.jp)
  • The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
  • Further I am seeking to gain better insight in the developmental origin of endocardial cells and the molecules that drive cellular differentiation during cardiovascular development and regeneration. (uni-potsdam.de)
  • This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
  • For decades scientists have been trying to reproduce cell culture environment for the closest mimicry of the natural cellular "embedding" within a living organism. (selectbiosciences.com)
  • The cell cycle and cellular differentiation in bacteria. (lu.se)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
  • Upon maturation, the cell sheets were harvested by lowering the temperature. (researchgate.net)
  • The nomenclature for T lymphocytes is based on the role of the thymus in the differentiation and maturation of T lymphocytes. (medscape.com)
  • As a result, the pathologic cells of LCH have been hypothesized to represent Langerhans cells in a state of arrested maturation. (medscape.com)
  • The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
  • The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
  • There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
  • The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
  • Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
  • In the mosaic Drosophila wing imaginal discs, mahj-/- or lgl-/- cells adjacent to wild-type cells undergo apoptosis, whereas mahj-/- or lgl-/- cells that are not adjacent to wild-type cells do not. (fsu.edu)
  • The nonautonomous apoptosis in these mutant cells is suppressed by inhibition of the JNK pathway. (fsu.edu)
  • Furthermore, overexpression of Mahj in lgl-/- mutant cells suppresses JNK activation and blocks apoptosis of lgl-/- mutant cells in the wild-type wing-disc epithelium. (fsu.edu)
  • G) Quantification of apoptotic cells in the mahj1 mosaic wing discs showing non-cell-autonomous apoptosis in mahj−/− cells. (fsu.edu)
  • They play an important role in many different vital cell processes including migration, proliferation, differentiation, and apoptosis. (harvard.edu)
  • Accordingly, in various biological contexts, EVs are reported to engage in immune modulation, senescence, and cell proliferation and differentiation. (wjgnet.com)
  • Andreas Bruzelius defended his Ph.D. thesis 'Generating GABAergic interneurons through reprogramming and differentiation strategies' on Friday, 20 October 2023. (lu.se)
  • The proposed studies seek to fill this knowledge gap by investigating the hypothesis that arsenic impairs muscle progenitor cell function and differentiation to promote declines in muscle quality and composition, as well as disrupt communication of healthy muscle metabolism with systemic organs. (nih.gov)
  • The internalized ventral cells give rise to the mesoderm that differentiates into muscle and other internal cell types such as the fat body, macrophages or lymph glands. (nature.com)
  • SIV antigen has been demonstrated by immunohistochemical methods in lymph node sinus histiocytes, macrophages, and giant cells (14) as well as in macrophage-derived cells in brain tissue from diseased monkeys (8). (cdc.gov)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • For example, researchers were able to overexpress transporter genes in hamster ovary cells to increase monoclonal antibody yield. (wikipedia.org)
  • Therapeutic T cell engineering: altering T cells to target cancer-related antigens for treatment Monoclonal antibody production: improving monoclonal antibody production using engineered cells In vivo cell factories: engineering cells to produce therapeutics within the patient's body Directed stem cell differentiation: using external factors to direct stem cell differentiation Cameron, Douglas C. (wikipedia.org)
  • Our findings unravel a new pathway orchestrating CD4 + T-cell differentiation and demonstrate that NAD + may serve as a powerful therapeutic agent for the treatment of autoimmune and other diseases. (nature.com)
  • In the Drosophila thorax, opposing gradients of Dachsous and Four-jointed expression, which are constituents of the Fat/Dachsous/Four-jointed planar cell polarity pathway, result in the polarized localization of the myosin Dachs 9 . (nature.com)
  • These effects were mediated, in part, by activation of Smad3 and cross-communication of the TGFβ/Smad signal to Wnt/β-catenin/TCF4 pathway, leading to down-regulation of PPARγ. (elsevierpure.com)
  • Notch1 signaling is a critical cell-cell communication pathway responsible for regulating differentiation, cell fate determination, and epithelial-mesenchymal transition (EMT). (endocrine-abstracts.org)
  • We present a rate equation model for the TGF-b pathway in endothelial cells together with novel measurements. (lu.se)
  • This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)
  • Much of the recent research on stem cell therapies and treatments falls under the aforementioned cell engineering methods. (wikipedia.org)
  • One example of directed stem cell engineering includes partially differentiating stem cells into myocytes to enable production of pro-myogenic factors for the treatment of sarcopenia or muscle disuse atrophy. (wikipedia.org)
  • Tracing Stem Cell Differentiation with Single-Cell Resolution. (routledge.com)
  • Lineage specification is an essential process in stem cell fate, tissue homeostasis and development. (exosome-rna.com)
  • The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
  • Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)
  • Stem cell-based regenerative medicine shows much promise. (selectbiosciences.com)
  • We will discuss our recent findings in the use of novel chemistry and physical energy, including radioelectric conveyed fields, to optimize stem cell expression of pluripotentiality. (selectbiosciences.com)
  • Recognise the differences between stem cell types. (manchester.ac.uk)
  • Be able to apply the correct (stem) cell type for a particular application. (manchester.ac.uk)
  • Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons. (antibodiesinc.com)
  • Conventional clinical management for absent T-cell function consists of immune reconstitution using stem cell or bone marrow transplantation. (medscape.com)
  • Stem Cell Res Ther. (lu.se)
  • In summary, the three major areas of research in my lab are independent yet connected-proper differentiation of follicle cells is key to the establishment of oocyte polarity, and cell competition involves intercellular communication and regulation of cell proliferation. (fsu.edu)
  • Extracellular vesicles (EVs) are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication tools. (wjgnet.com)
  • The complexity of the intercellular communication network obscures analysis and understanding of its function. (weizmann.ac.il)
  • Our research focuses on the study of simple building blocks of the immune intercellular communication network, combining experimental approaches and mathematical modeling. (weizmann.ac.il)
  • This is the simplest module of the intercellular cytokine communication network, and is abundantly found throughout the network. (weizmann.ac.il)
  • The finding of mutations in GJB3, GJB4, and GJA1 suggests that the clinical manifestations of EKVP are caused by impaired gap junctional intercellular communication or hemichannel function owing to a dominant effect of mutant gap junction proteins. (medscape.com)
  • CD4 + T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD + ) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ + IL-10 + T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. (nature.com)
  • In contrast, regulatory T cells (Tregs) play a cardinal role in protecting against autoimmune diseases, inflammation and tissue damage 13 through secretion of IL-10 (ref. 14 ) and other mechanisms. (nature.com)
  • Studies have shown that Th1 IFN-γ-producing cells that co-produce IL-10 have immunosuppressive properties and can protect from tissue damage 21 , 22 . (nature.com)
  • How cells determine the direction in which they apply force is of critical importance to cell and tissue shape changes. (nature.com)
  • Previous work has shown that gradients or asymmetries in biochemical signals at the cell and tissue level can serve as instructive cues to pattern force generation. (nature.com)
  • How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)
  • In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)
  • Cell engineering often makes use of DNA technology to achieve these modifications as well as closely related tissue engineering methods. (wikipedia.org)
  • Cell engineering can be characterized as an intermediary level in the increasingly specific disciplines of biological engineering which includes organ engineering, tissue engineering, protein engineering, and genetic engineering. (wikipedia.org)
  • Among these, the neoplastic tumor-suppressor genes (nTSGs) have been shown to fulfill two significant functions requisite for organ size control: first, establishing apicobasal cell polarity as a principle of epithelial tissue organization and appropriate timing of terminal differentiation and, second, exerting cell-proliferation control as a primary factor in tissue growth. (fsu.edu)
  • Little has been studied regarding EVs derived from human pluripotent stem cells (hPSC-EVs), even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative ability. (wjgnet.com)
  • Endocrinology, by definition, focuses on homeostatic, and cell‑to‑cell and tissue‑to‑tissue communication mechanisms. (spandidos-publications.com)
  • Exosomes, via their cargo or surface composition, are signals/mediators of systemic homeostasis and stress for specific cell-to-cell or tissue-to-tissue communication ( 5 ). (spandidos-publications.com)
  • 43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
  • Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. (researchgate.net)
  • Findings from this study reveal that thermo-responsive elastomer, together with mechanical conditioning, can potentially be applied to prepare high-quality cell sheets for bone tissue engineering. (researchgate.net)
  • Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
  • In total, 1-10% of nucleated cells in adipose tissue are ADSCs, whereas only 0.0001-0.01% of nucleated cells in bone marrow are stem cells ( 5 ). (spandidos-publications.com)
  • Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids. (antibodiesinc.com)
  • Exosomes are small lipid bilayer-surrounded extracellular vesicles released from cells into the extracellular space or biological fluids ( 1 , 2 ). (spandidos-publications.com)
  • In addition to impairing normal brain development, a lack of functional ARX protein disrupts cell differentiation during the formation of the testes, leading to abnormal genitalia. (medlineplus.gov)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
  • Therefore, a central goal of diabetes research is to regenerate beta cells or produce large numbers of functional beta cells for transplantation. (lu.se)
  • Additionally, some gene sequences overlapped with transposons, suggesting replication and functional differentiation of carotenoid-related genes during carrot evolution. (bvsalud.org)
  • Systems Biology Approach to Study Heterogeneity and Cell Communication Networks in the Tumour Microenvironment. (routledge.com)
  • Dr. Goswami has a strong background in molecular biology and experience in the development and characterization of fish cell lines. (gfi.org)
  • 2012). In an additional work, performed in collaboration with Yuval Hart and Uri Alon from the department of molecular cell biology, we show that IL-2 pleiotropic activity can result in homeostasis of cell numbers, where the final cell concentration is independent of initial concentration over a large range (Hart et. (weizmann.ac.il)
  • Combining cell biology and electrophysiology, his work has the potential to create personalized disease models for future research. (lu.se)
  • The absence of significant MSC-mediated inhibitory effects on myeloid DC differentiation was confirmed by additional experiments in GM-CSF/IL-4-supplemented BM cultures. (nih.gov)
  • Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
  • Kinetic and differentiation analyses indicate that both osteoblast and adipocyte exosomes augment ECM-mediated differentiation of hMSCs into the respective lineage. (exosome-rna.com)
  • The combination of osteoblast/adipocyte ECM and exosomes turned-on the lineage specific gene expressions at earlier time points of differentiation compared to the respective ECM or exosomes administered individually. (exosome-rna.com)
  • An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
  • We identified 715 upregulated DEGs and 603 downregulated DEGs between MC3T3-E1 cells with and without osteoblast induction by analyzing the raw data of the GSE46400 dataset. (frontiersin.org)
  • The RT-qPCR also determined declined expressions of miR-204-5p and miR-24-3p concomitant with elevated expressions of miR-211-5p, miR-3470b, miR-466b-3p, and miR-466c-3p in the MC3T3-E1 cells, with osteoblast induction compared with undifferentiated MC3T3-E1 cells. (frontiersin.org)
  • The impairment of proliferation, differentiation, and mineralization in osteoblast is the main pathophysiological mechanism of osteoporosis, which has been proven by previous studies ( 4 , 5 ). (frontiersin.org)
  • Runx2 belongs to the Run family and is an essential upstream transcription factor during osteoblast differentiation. (frontiersin.org)
  • Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
  • MS is an inflammatory-mediated demyelinating disease that has been associated with production of interferon (IFN)-γ and interleukin (IL)-17, two cytokines that are produced by Th1 and Th17 cells, respectively 12 . (nature.com)
  • This decision is influenced by the spectrum of cytokines that the cells sense. (weizmann.ac.il)
  • The differentiating cells also actively alter these signals by producing relevant cytokines, thus influencing the differentiation process through extracellular feedbacks. (weizmann.ac.il)
  • While differentiation is usually studied under polarizing conditions, applying only one signal at a time, cells in vivo are expected to sense a more complex environment, in which they may be simultaneously exposed to combinations of cytokines. (weizmann.ac.il)
  • We explore differentiation under mixed input conditions by exposing cells to varied combinations of cytokines, experimentally mapping the "decision space" of the differentiation process at the single cell level. (weizmann.ac.il)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • Despite their crucial role as a link between innate and adaptive immunity, little is known about the modulation of pDC differentiation by other bone marrow (BM) cells. (nih.gov)
  • The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)
  • After implantation into the critical-sized calvarial defects of mice, the mechanically conditioned cell sheets significantly promoted new bone formation. (researchgate.net)
  • The expressions of candidate miRNAs and mRNAs were determined by real-time quantitative PCR(RT-qPCR) in MC3T3-E1 cells. (frontiersin.org)
  • Forces that shape cells and tissues can be produced by the contraction of actin filament (F-actin) meshworks by the molecular motor Myosin II (myosin). (nature.com)
  • This threshold has been exceeded tens of times, perhaps because much of the requisite molecular machinery to facilitate cell-cell coordination is a shared primitive feature of living organisms, but also because some definitions of multicellularity encompass everything from simple bacterial colonies to badgers. (creation.com)
  • Its Molecular Mechanisms the process of cell specialization throughout development is termed differentiation. (alliedacademies.org)
  • Closely tied with the field of biotechnology, this subject of cell engineering employs recombinant DNA methods to induce cells to construct a desired product such as a protein, antibody, or enzyme. (wikipedia.org)
  • In the pancreas and testes, the ARX protein helps to regulate the process by which cells mature to carry out specific functions (differentiation). (medlineplus.gov)
  • In response to the inhibition of rRNA transcription, nucleolar protein MYBBP1A was translocated from the nucleolus to the nucleoplasm and interacted with c-Myc, which is one of the master regulator of hematopoietic differentiation. (nii.ac.jp)
  • Fluorescent proteins enable a wide range of applications where they have functioned as cell lineage tracers, reporters of gene expression, or as a measure of protein-protein interactions. (antibodiesinc.com)
  • A possible method for changing natural cell production includes boosting or repressing genes that are involved in the metabolism of the product. (wikipedia.org)
  • Another approach could involve incorporating biologically foreign genes into an existing cell line. (wikipedia.org)
  • For example, E.Coli, which synthesizes ethanol, can be modified using genes from Zymomonas mobilis to make ethanol fermentation the primary cell fermentation product. (wikipedia.org)
  • Recently, genetic analyses in Drosophila have revealed various genes that regulate the competitive behavior of cells. (fsu.edu)
  • Mutations in the CD3 + T-cell complex are associated with autoimmune cytopenias, autoimmune enteropathy, and recurrent sinopulmonary infections. (medscape.com)
  • I became especially interested in the implication of endocardial/ endothelial cells in regenerating organs and its interaction with surrounding tissues. (uni-potsdam.de)
  • endothelial cells. (lu.se)
  • Finally, much progress has been made in engineering cells to produce antigens for the purpose of creating vaccines. (wikipedia.org)
  • This study reported that Nam reduced CD4 + T cell infiltration and demyelination 24 , but failed to identify the protective mechanisms of action. (nature.com)
  • She participates in multidisciplinary projects to decipher cell mechanisms rewiring in cancer. (routledge.com)
  • Impact Understanding the mechanisms underlying beta cell development and function will be a prerequisite for cell replacement therapy in diabetes. (lu.se)
  • This inhibition was cell contact-dependent and soluble factor-independent, as indicated by trans-well experiments. (nih.gov)
  • Measured by its ability to block anti-ErbB2 mediated inhibition of SK‑BR‑3 human breast cancer cell proliferation. (novusbio.com)
  • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis. (uib.no)
  • T-cell disorders in which autoimmunity and polyendocrinopathy predominate have recently been elucidated, and more will certainly be discovered as pathways for T-cell signal transduction are better understood. (medscape.com)
  • Qualitative Dynamical Modelling of T-Helper Cell Differentiation and Reprogramming. (routledge.com)
  • Reprogramming of differentiated cells can be efficiently induced in oocytes. (selectbiosciences.com)
  • I've worked specifically with generating interneurons in the lab, using reprogramming and differentiation strategies. (lu.se)
  • Within the focus of bioengineering, various cell modification methods are utilized to alter inherent properties of cells such as growth density, growth rate, growth yield, temperature resistance, freezing tolerance, chemical sensitivity, and vulnerability to pathogens. (wikipedia.org)
  • The first use of the term in a biological context was in 1971 in a paper which describes methods to graft reproductive caps between algae cells. (wikipedia.org)
  • Together, our in vivo and in silico data provide a framework for understanding how cells orient force generation, establishing a role for geometrical and mechanical patterning of force production in tissues. (nature.com)
  • The advantages also include production of one cell type isolated from complexity of leaf tissues, accessibility for chemical manipulations and microscope observations, high potential and synchrony of TE differentiation, preservation of vessel element patterning in similarity to zinnia hypocotyls in vivo. (europa.eu)
  • Most clinical trials which utilize ADSCs for OA treatment have been based on the autologous cells from the stromal vascular fraction, as have most of the in vivo studies ( 6 , 7 ). (spandidos-publications.com)
  • MiR-211-5p upregulation by its mimic increased Arhgap11a expression in MC3T3-E1 cells. (frontiersin.org)
  • Satellite cells and skeletal muscle regeneration . (inrs.ca)
  • MYBBP1A attenuated transcriptional activity of c-Myc and promoted megakaryocytic differentiation. (nii.ac.jp)
  • Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
  • Lung development and function arises from the interactions between diverse cell types and lineages. (nih.gov)
  • Cell Biochemistry and Function currently does not publish research in specific areas that are better served by specialist journals. (wiley.com)
  • Cell Biochemistry & Function also discourages submission of research based exclusively on analysis of publically available transcriptomic and proteomic datasets, although the acceptability of specific manuscripts in this particular area can be discussed with the Editor-in-Chief. (wiley.com)
  • Loss of Mahj function induces cell competition in Drosophila wing disc epithelium. (fsu.edu)
  • The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
  • TEs are dead hollow cells with a function supported by the neighbouring living cells. (europa.eu)
  • Background: Type 2 DM is a disease caused by both insulin resistance and an insulin secretory defect.Reports suggest that vitamin D supplementation improves insulin resistance and pancreatic beta-cell function, however, there is paucity of data on vitamin D and glycaemia among type 2 diabetes mellitus in Nigeria.Objective: To determine the effect of vitamin D supplementation on insulin resistance and pancreatic beta-cell function i. (endocrine-abstracts.org)
  • The structure and function of prokaryotic cells. (lu.se)
  • Other well-known partial deficiencies in T-cell function include the chromosomal breakage syndromes (CBSs), B-cell and T-cell combined disorders (eg, ataxia telangiectasia [AT]) and Wiskott-Aldrich Syndrome (WAS), which are discussed in separate articles. (medscape.com)
  • When T-cell function is absent in T-cell disorders, the disorder can be lethal. (medscape.com)
  • Integrins are cell adhesion molecules that reside on the surface of cells as transmembrane proteins made of an alpha and beta subunit. (harvard.edu)
  • Marked hyperkeratosis is present, probably because of an increased proliferation and disturbed differentiation of keratinocytes. (medscape.com)
  • Stem cells are unique in that they may differentiate into various other types of cells which may then be altered to produce novel therapeutics or provide a foundation for further cell engineering efforts. (wikipedia.org)
  • Zinnia cell culture is a unique model system, which at the administration of certain ratio of cytokinins and auxins can be induced to trans-differentiate into vessel elements. (europa.eu)
  • because the embryo develops, some cells differentiate, whereas others, referred to as stem cells stay pluripotent, which suggests that they will bring about to a particular set of cell sorts referred to as a lineage. (alliedacademies.org)
  • Upon activation, naïve CD4+ T-cells can differentiate into one out of few possible lineages, each invoking a specific immune response. (weizmann.ac.il)
  • In the present study, the potential of using exosomes isolated from adipose‑derived stem cells (ADSCs) as a therapeutic tool for reducing chronic inflammation and promoting chondrogenesis was investigated using patient‑derived primary cells. (spandidos-publications.com)
  • Extracellular feedback occurs when a cell expresses receptors to a cytokine that it secretes. (weizmann.ac.il)
  • More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)
  • Transcription factor AP2 controls cnidarian germ cell induction. (uib.no)
  • I also found that hematopoietic differentiation was sufficiently induced by specific suppression of rRNA transcription using actinomycin D or siRNA for TIF-IA. (nii.ac.jp)
  • A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes in each cell. (medlineplus.gov)
  • In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. (medlineplus.gov)
  • In females, who have two copies of the X chromosome, one altered copy of the gene in each cell can lead to less severe brain malformations or may cause no symptoms at all. (medlineplus.gov)
  • Don Ayer, PhD, is a leader in the study of gene regulation and its role in normal and cancer cell growth. (utah.edu)
  • One way we did this was by converting adult fibroblasts, or skin cells, into interneurons. (lu.se)
  • During Drosophila gastrulation, actomyosin contraction in ventral cells generates a long, narrow epithelial furrow, termed the ventral furrow, in which actomyosin fibres and tension are directed along the length of the furrow. (nature.com)
  • Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)
  • Plasmacytoid dendritic cells (pDCs) are rare central regulators of antiviral immunity and unsurpassed producers of interferon-α (IFN-α). (nih.gov)
  • In 1868, Paul Langerhans discovered the epidermal dendritic cells that now bear his name. (medscape.com)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Analyzing 818 ligand-receptor interaction pairs within and between cell lineages, we identify broadly interacting cells, including AT2, innate lymphocytes (ILCs), and basophils. (nih.gov)
  • They originate from the blebbing of dying cells ( 1 , 7 , 8 ). (spandidos-publications.com)
  • Xylem vessels consist of a number of stacked tracheary elements (TEs) that originate through re-differentiation of root and shoot pro-cambium and cambium cells. (europa.eu)
  • The experiments consist of kinetic (time- kinetic data is typically not sufficient to constrain the course) measurements after TGF-b stimulation under differ- parameter values to a single optimal solution, and multiple ent conditions: untreated cells and three cases in which parameter sets can explain the available data. (lu.se)
  • The increased risk for reactive airway disease and thyroiditis in patients with DGS and the high incidence of autoimmune hemolytic anemia in patients with WAS are examples of defective T-cell/B-cell interactions that result in self-reactivity. (medscape.com)