Differentiation receptors antigen t cell alpha beta. Medical search. Frequent questions

We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
Triggering of the T3-Ti receptor complex induces a rapid increase in free cytoplasmic Ca2+ and gives rise to specific antigen-induced proliferation through an autocrine pathway involving endogenous interleukin-2 production, release and subsequent binding to interleukin-2 receptors. (ox.ac.uk)
The Ras-p110γ interaction was necessary for efficient β-selection-promoted proliferation but was dispensable for the survival or differentiation of thymocytes. (ox.ac.uk)
Additionally, it has also been reported that IL-5 can stimulate the proliferation and/or differentiation of basophils and B cells. (rndsystems.com)
This molecule inhibits the proliferation of IL-5-dependent cell lines and blocks human umbilical cord blood eosinophil differentiation. (rndsystems.com)
Mast cells can influence B cell survival, proliferation and differentiation into CD138(+) cells. (unipg.it)
TBR2 plays a role in brain development and is required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. (thermofisher.com)
May play a role in the control of granulocytic lineage proliferation or differentiation. (affbiotech.com)
In response to mito- pendence between the key mecha- gens, cell proliferation is triggered by nistic characteristics. (who.int)
H - Ras cell proliferation are also linked with haematopoietic cel s. (who.int)

As is the case with many other cytokines, the functional high-affinity receptor for IL-5 is a complex consisting of a ligand binding subunit ( alpha chain) and a second subunit ( beta chain) that can modulate the ligand binding affinity of the receptor complex. (rndsystems.com)
The beta chain does not bind any of the cytokines in question but is indispensable for the cytokine-mediated signaling. (rndsystems.com)
In our previous study, the defective T cell function in LL patients was restored to a proliferating state with the release of TH1 type cytokines using mycobacterial antigen(s) with two immunomodulators (Murabutide (MDP-BE) and T cell epitope of Trat protein of Escherichia coli) by presenting the antigen in particulate form in vitro to PBMC derived from leprosy patients. (bvsalud.org)
Among TH2 cytokines, interleukin (IL)-4 and IL-13 are responsible for class-switching in B cells which resolves in production of allergen-specific IgE antibodies that bind to specific receptor on mast cells. (unipg.it)
B cell differentiation into IgE-producing cells requires two signals provided by TH2 cells and IL-4, however IL-4, IL-1 and IL-10 as well as several hormones are critical for the development of TH2 cells, while cytokines, such as interferon (IFN)-alpha, IFN-gamma, IL-12 and transforming growth factor (TGF)-beta play a negative role. (unipg.it)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
T helper (Th) 2 cells, which recruit and accumulate in the lungs and produce a range of different effector cytokines. (cdc.gov)
However, more recent studies have revealed the potential collaboration of other helper T cells and their cytokines in this process. (cdc.gov)
The aim of this review is to summarize the current knowledge about the possible roles of newly identified helper T cells derived cytokines (IL-9, 17, 22, 25 and IL-33) in asthma. (cdc.gov)

Recent studies using cloned antigen-specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 kDa Ti heterodimer and the invariant 20 and 25 kDa T3 molecules. (ox.ac.uk)
Subsets of γδ TCR-bearing T cells, intestinal intraepithelial lymphocytes, and dendritic cells express CD8a without CD8b. (bdbiosciences.com)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
In addition, this modality does not eliminate all B lineage cells and thus may not be appropriate for all pathologic conditions involving B lymphocytes. (nationaljewish.org)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)

secreted version: antibodies) and T cell receptor (TCR), respectively. (nature.com)
Cells may be prepared, stained with antibodies and washed twice with wash buffer per established protocols for immunofluorescent staining prior to acquisition on a flow cytometer. (bdbiosciences.com)
Current technologies for treatment of many lymphomas, leukemias, transplant rejection and some autoimmune disorders include monoclonal antibodies (mAb) that target and deplete B cell populations. (nationaljewish.org)
Furthermore they established that anti-CD79a/b antibodies (intact, or mutants incompetent to bind IgG receptors and activate the complement cascade) block the development of disease and ameliorate ongoing target organ injury in MRL/LPR mouse model of Rheumatoid Arthritis, NOD mice for Type 1 Diabetes and EAE mouse model for MS. (nationaljewish.org)
Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. (thermofisher.com)
CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. (biolegend.com)

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. (nih.gov)
Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. (nih.gov)
The fluorochrome-labeled 359-81-11 antibody is useful for intracellular immunofluorescent staining and flow cytometric analysis to identify LT-α -producing cells within mixed cell populations. (biolegend.com)
Description: The RPA-T8 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). (thermofisher.com)
Applications Tested: This RPA-T8 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
These results suggest that T cells interact in a complex network, perhaps as complex as the regulatory interactions between antibody molecules and B cells. (ox.ac.uk)
Mouse splenocytes either (A) stimulated to induce Th1 cells or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB554P ). (rndsystems.com)
Mouse splenocytes either (A) stimulated for 4 hours with Cell Activation Cocktail 500x ( 5476 ) or (B) unstimulated were stained with Rat Anti-Mouse IFN-gamma Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # IC485N) and Rat Anti-Mouse CD4 PE-conjugated Monoclonal Antibody ( FAB554P ). (rndsystems.com)
The 53-5.8 monoclonal antibody specifically binds to the β chain of the CD8 differentiation antigen (Ly-3.2 or Lyt-3.2) of most mouse strains, having weak reactivity with Ly-3.1 strains (e.g. (bdbiosciences.com)
The mouse monoclonal antibody CB38 (NL07) recognizes an extracellular epitope of CD36 (GPIIIb), a 85-113 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. (exbio.cz)
CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. (exbio.cz)
Alessio M, Ghigo D, Garbarino G, Geuna M, Malavasi F: Analysis of the human CD36 leucocyte differentiation antigen by means of the monoclonal antibody NL07. (exbio.cz)
Alessio M, Roggero S, Bussolino F, Saitta M, Malavasi F: Characterization of the murine monoclonal antibody NL07 specific for the human thrombospondin receptor (CD36 molecule). (exbio.cz)
Further experiments will involve the characterization of the effectiveness of Curly 14 for modulating immune disease, understanding Curly 14 binding affinity, determination of the antibody binding site and the ability to destabilize and/or desensitize B cells in huSCID and human CD79 knockin mouse models. (nationaljewish.org)
Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. (nationaljewish.org)
A broad antibody response was detected that included immunoglobulin G (IgG) and IgA subtypes with demonstrable Fc-mediated effector function targeting multiple viral antigens. (cdc.gov)

CD79b molecule, immunoglobulin-associated beta, also known as CD79B (Cluster of Differentiation 79B), is a human gene. (wikipedia.org)
As a consequence CD79 is an ideal candidate molecule for B cell-targeted therapy. (nationaljewish.org)
The alpha1 domain is involved in binding to the beta chain and is essential for the stability of the MHC class II molecule. (tutorialspoint.com)
The interactions between the alpha and beta chains are critical for the stability of the MHC class II molecule. (tutorialspoint.com)
The MHC class II molecule is stabilized by disulfide bonds between the alpha and beta chains, as well as interactions with the TMDs. (tutorialspoint.com)
Once the MHC class II molecule has been transported to the cell surface, the invariant chain is cleaved and removed by proteases, allowing peptides to bind to the peptide-binding groove. (tutorialspoint.com)
The peptides that bind to the MHC class II molecule are derived from extracellular proteins that have been internalized by the cell via endocytosis or phagocytosis. (tutorialspoint.com)

In leprosy, cell-mediated immunity (CMI) is more significant than humoral response to eliminate intracellular pathogen. (bvsalud.org)
To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004 ) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005 ). (rndsystems.com)
Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. (exbio.cz)
CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. (microbiologyresearch.org)
Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). (thermofisher.com)
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. (affbiotech.com)
Intracellular antigens (eg, viruses) can be processed and presented to CD8 cytotoxic T cells by any nucleated cell because all nucleated cells express class I MHC molecules. (msdmanuals.com)

Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. (wikipedia.org)
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. (ximbio.com)
Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)
CD1A is a transmembrane glycoprotein that is structurally related to the major histocompatibility complex (MHC) proteins and forms heterodimers with beta-2-microglobulin. (nih.gov)
The Major Histocompatibility Complex (MHC) is a group of genes that encode for cell-surface proteins involved in antigen presentation to the immune system. (tutorialspoint.com)
These molecules present peptides derived from extracellular proteins to CD4+ T cells, which recognize the peptide-MHC complex through their T cell receptors (TCRs). (tutorialspoint.com)
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. (lookformedical.com)
The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits. (lookformedical.com)
There he worked with Dr. Max D. Cooper (Howard Hughes Medical Institute, National Academy of Sciences) and his research focused on cell surface proteins expressed by preB cells that regulate B cell maturation and homing. (ubc.ca)
In addition, he identified a number of novel hematopoietic stem cell surface proteins and began analyzing their function. (ubc.ca)
His laboratory has followed two primary interests: 1) the transcription factor networks that regulate fate determination in various cells that make blood, and 2) the cell surface proteins expressed by hematopoietic stem cells that and allow them to communicate with their microenvironment. (ubc.ca)
In this regard, his lab has identified a novel family of hematopoietic cell surface proteins, called the CD34 family, and shown that these are essential for a number of developmentally important processes. (ubc.ca)

Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
Dendritic cells (DCs), which are the most important antigen-presenting cells (APCs) that send signals to the T cells, mainly participate in the pathogenesis of many diseases with immunoregulatory mechanisms, such as AR. (frontiersin.org)
MHC class II molecules are found primarily on antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells. (tutorialspoint.com)
Although some antigens (Ags) can stimulate the immune response directly, T cell-dependent acquired immune responses typically require antigen-presenting cells (APCs) to present antigen-derived peptides within major histocompatibility complex (MHC) molecules. (msdmanuals.com)
Extracellular antigens (eg, from many bacteria) that are phagocytosed or endocytosed can be processed into peptides and complexed with surface class II MHC molecules on professional APCs, which specialize in presenting antigens to CD4 helper T (Th) cells. (msdmanuals.com)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. (nih.gov)

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). (wikipedia.org)
The ontogeny, structure and function of the human T lymphocyte receptor for antigen and major histocompatibility complex. (ox.ac.uk)
Cells in the lymphocyte gate were used for analysis. (thermofisher.com)
The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)

CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells. (thermofisher.com)
Human IL-5 is a potent eosinophil differentiation and activation factor in vivo and in vitro . (rndsystems.com)
For efficient initiation of CD4+, T cell response requires T cell receptor (TCR) activation and costimulation provided by molecules on antigen-presenting cells (APC) and their counter receptors on T cells. (bvsalud.org)
It plays a key function in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, up‑regulation of antigen presentation molecules, and immunoglobulin class switching in B cells. (rndsystems.com)
Hypoxia stimulates cancer cells to acquire a more malignant phenotype via activation of hypoxia-inducible factor 1 (HIF-1). (cancerindex.org)
TP53‑deficiency in cancer cells is associated with robust stromal activation. (spandidos-publications.com)
The mutational inactivation of the TP53 gene in tumor cells has been reported to affect not only tumor cells but also the surrounding cells in the tumor microenvironment and to promote tumor-stromal activation and subsequent tumor growth ( 11 , 12 ). (spandidos-publications.com)
Such activation is known to affect cell migration and outgrowth of axons and dendrites in vivo. (embl-heidelberg.de)
Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. (nationaljewish.org)
This interaction leads to the activation and differentiation of CD4+ T cells, which subsequently activate other immune cells such as B cells, CD8+ T cells, and natural killer cells. (tutorialspoint.com)
Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen sections 4,6,7 and formalin-fixed paraffin-embedded sections 11 , immunoprecipitation 1 , activation of T cells 2,3,5 , Western blotting 9 , and spatial biology (IBEX) 16,17 . (biolegend.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)

Both alpha and beta chains share significant homology to immunoglobulin variable light chains. (wikidoc.org)
The extracellular domain of the alpha chain is composed of two immunoglobulin (Ig)-like domains, called alpha1 and alpha2 domains. (tutorialspoint.com)
The extracellular domain of the beta chain is composed of one immunoglobulin-like domain, called the beta1 domain, and one MHC class II-specific domain called the "β2 domain. (tutorialspoint.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules. (uams.edu)
In addition to peptide antigens bound to highly polymorphic MHC molecules, T cells have also evolved to recognize bacterial lipids when bound to non-polymorphic CD1 molecules. (bvsalud.org)
The peptides are then presented to CD4+ T cells, which recognize the peptide-MHC complex and initiate an immune response. (tutorialspoint.com)

This gene encodes the Ig-beta protein of the B-cell antigen component. (wikipedia.org)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Human and mouse IL-5 R alpha are both members of the hematopoietin receptor superfamily characterized by the presence of the WSXWS, and a four cysteine residue motif in the extracellular domain of the transmembrane protein. (rndsystems.com)
In addition to the cDNA clone encoding the full-length transmembrane protein, cDNA clones that arise from alternative splicing and that encode soluble secreted forms of IL-5 R alpha have been isolated from mouse as well as human cells. (rndsystems.com)
Here, we derived a T-cell clone from a leprosy lesion that expressed TCR BV6 and the conserved CDR3 sequence L-S-G. This T-cell clone produced a T helper type 1 cytokine pattern, directly lysed M. leprae-pulsed antigen-presenting cells by the granule exocytosis pathway, and expressed the antimicrobial protein granulysin. (bvsalud.org)
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. (cancerindex.org)
The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). (cancerindex.org)
CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. (exbio.cz)
Thus, recently activated T cells that had migrated to the SI, colon and liver expressed high levels of CCR9, G protein coupled receptor (GPR) 15 and CXC-type motif chemokine receptor (CXCR) 3 respectively, suggesting a directed migration process to specific tissues orchestrated during T cell differentiation. (rwth-aachen.de)
CD1A functions as an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (nih.gov)
Cluster of Differentiation 79 (CD79) is a transmembrane protein found exclusively in B cells that is the transducer component of B-cell receptor (BCR), generating a signal following recognition of antigen by the BCR. (nationaljewish.org)
Beta 1,6-glucan, a protein bound polysaccharide, has been identified as the active constituent. (alohamedicinalseu.com)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
In the immune system, Eomes controls the differentiation of effector and memory CD8+ T cells, as well as natural killer (NK) cells. (thermofisher.com)
Maitake is thought to exert its effects through its ability to activate various effector cells, such as macrophages, natural killer cells, and T cells, as well as interleukin-1 and superoxide anions (2) (3) (4) (13) . (alohamedicinalseu.com)

The alpha and beta subunits of Ti bear no precursor-product relationship to one another and are encoded by separate germline V, D, J and C segments which rearrange during intrathymic differentiation to form an active gene set. (ox.ac.uk)
IFN-gamma dimers bind to IFN-gamma RI (alpha subunits) which then interact with IFN-gamma RII (beta subunits) to form the functional receptor complex of two alpha and two beta subunits. (rndsystems.com)
Dr. Cambier and his laboratory discovered that in certain circumstances, subunits of the B cell antigen receptor (BCR) become dissociated rendering the receptor incompetent to transduce activating signals. (nationaljewish.org)
Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits. (lookformedical.com)
One of the subunits of alpha-crystallins. (lookformedical.com)

In the case of IL-5, the beta subunit is shared with the high affinity receptor complexes for IL-3 and GM-CSF. (rndsystems.com)
IgE is an important marker for allergy and plays a central role in the induction of allergic diseases through its binding of the high affinity receptor on mast cells. (unipg.it)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)

The alpha subunit is the CD11C ANTIGEN, a surface antigen expressed on some myeloid cells. (bvsalud.org)

The gene is preferentially expressed by immature dendritic cells and memory T cells. (cancerindex.org)
This gene encodes the CD8 alpha chain isoforms. (wikidoc.org)
Patients who have common variable immunodeficiency and autoimmune conditions appear to have very low numbers of isotype-switched memory B cells in peripheral blood and are more likely to have a mutation in the gene that encodes TACI ( TNFRST13B ). (medscape.com)
He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
Through gene knockout studies he has shown that these molecules act as a type of molecular "Teflon" to make cells more mobile and invasive and also facilitate chemotaxis. (ubc.ca)

whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. (thermofisher.com)
This observation prompted us to study the expression of the costimulatory molecules (CD80, CD86, CD28, CD152), other accessory molecules (TCR alphabeta/gammadelta) and T cell lineage molecules (CD4+ and CD8+) during constitutive and activated state of peripheral blood mononuclear cells (PBMC) derived from normal and leprosy individuals using different formulations of Mycobacterium leprae total cell wall antigen (MLCWA), Trat and MDP-BE using flow cytometric analysis. (bvsalud.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
MHC class II molecules are heterodimers consisting of two chains: alpha and beta. (tutorialspoint.com)
This ensures that only properly folded MHC class II molecules are transported to the cell surface. (tutorialspoint.com)
MHC class II molecules are essential for the presentation of exogenous antigens to CD4+ T cells. (tutorialspoint.com)
He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)
Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)

Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. (ximbio.com)
Mechanisms of peripheral tolerance include inactivation of autoantigen-recognizing T and B cells by the induction of apoptosis, anergy or conversion into immunosuppressive regulatory cells. (frontiersin.org)

We found SI DCs to be most efficient in metabolising vitamin A derivatives which enhances their capacity to induce the retinoic acid (RA) dependent gut-homing factors CC type motif chemokine receptor (CCR) 9 and integrin alpha 4 beta 7 (Intα4β7) on newly activated T cells. (rwth-aachen.de)

CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. (thermofisher.com)
Kapinsky M, Torzewski M, Büchler C, Duong CQ, Rothe G, Schmitz G: Enzymatically degraded LDL preferentially binds to CD14(high) CD16(+) monocytes and induces foam cell formation mediated only in part by the class B scavenger-receptor CD36. (exbio.cz)

GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Mice with a conditional deletion of FURIN in their myeloid cells (LysMCre- fur (fl/fl) ) were healthy and showed unchanged proportions of neutrophils and macrophages. (oncotarget.com)
Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)

Lymphotoxin-α (LT-α), also known as tumor necrosis factor-beta (TNF-β), is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. (biolegend.com)
MHC class I-restricted T cells, including most T suppressor/cytotoxic cells) expresses almost exclusively the CD8 αβ heterodimer (the α' chain is absent). (bdbiosciences.com)

A naturally-occurring soluble form of the IL-5 R alpha has been detected in biological fluids of autoimmune-prone mice and mice bearing chronic B cell leukemia (BCL 1 ). (rndsystems.com)
Fully functional HLA B27-restricted CD4+ as well as CD8+ T cell responses in TCR transgenic mice. (ox.ac.uk)
B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. (nationaljewish.org)
As an immune stimulant aitake stimulates the activity of certain immune cells in laboratory studies and in mice. (alohamedicinalseu.com)
In a study done in mice, oral maitake extract promoted maturation of hematopoietic cells to functionally active myeloid cells and enhanced peripheral blood leukocyte recovery following chemotoxic bone marrow injury (17) . (alohamedicinalseu.com)
In addition, maitake extract may modulate antigen presentation as evidenced by protection of mice against tumor implantation following transfer of dendritic cells from tumor-bearing mice that were treated with maitake extract (15) . (alohamedicinalseu.com)

This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (cancerindex.org)

A novel polysaccharide, MZF, was shown to induce dendritic cell maturation and enhanced antitumor response (20) . (alohamedicinalseu.com)

One such subset, germline-encoded, mycolyl lipid-reactive (GEM) T cells, recognizes mycobacterial cell wall lipids and expresses a conserved TCR-É chain that is shared among genetically unrelated individuals. (bvsalud.org)
Further, these results reveal the feasibility of developing a simple, field deployable molecular diagnostic based on mycobacterial lipid antigen-specific TCR sequences that are readily detectable in human tissues and blood independent of genetic background. (bvsalud.org)

Cell Mol Immunol. (uams.edu)

T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. (uams.edu)

The TMDs of both chains are anchored in the plasma membrane of the cell. (tutorialspoint.com)
The TMDs of both chains are anchored in the plasma membrane of the cell and form a "hairpin" structure, which stabilizes the peptide-binding groove. (tutorialspoint.com)

T cell receptors (TCRs) encode the history of antigenic challenge within an individual and have the potential to serve as molecular markers of infection. (bvsalud.org)

This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)

Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. (nih.gov)
CD49e is the integrin alpha 5 chain. (ximbio.com)

Surprisingly, HLA B27 supported CD4+ as well as CD8+ T cell responses in vivo and in vitro. (ox.ac.uk)
The transgenic T cells were also able to enhance clearance of recombinant vaccinia virus containing influenza nucleoprotein in vivo. (ox.ac.uk)
We believe that this model provides a novel system for the study of unusual T cell behavior in vivo. (ox.ac.uk)
Third, IL-2 therapies aiming at expanding immunosuppressive regulatory T cells in vivo . (frontiersin.org)
We established a photoconversion-based experimental model of in vivo T cell tracking and use it to demonstrate that oral administration of cognate antigen leads to T cell migration to distinct organs, dependent on the inductive LN compartment. (rwth-aachen.de)
Receptor desensitization and therapeutic efficacy has been demonstrated in vitro and in vivo. (nationaljewish.org)

Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)

To address this, we examined if DCs of SI, colon and liver are able to pick up orally delivered antigen, migrate to draining lymph nodes (LNs) and activate T cells to become Treg. (rwth-aachen.de)
Dendritic cells are present in the skin (as Langerhans cells), lymph nodes, and tissues throughout the body. (msdmanuals.com)

The multiple effects of IL-5 are mediated by binding of the cytokine to specific cell surface receptors expressed on target cells. (rndsystems.com)
Further, HLA B27-restricted CD4+ T cells were capable of differentiation into a range of Th1 and Th2 T cell subsets with normal patterns of cytokine expression. (ox.ac.uk)

Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. (affbiotech.com)

It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
In addition, suppressor immune cells such as FOXP3 + regulatory T cells (Tregs) exert dominant immune suppression to control autoreactive T and B cells. (frontiersin.org)
Dendritic cells (DCs) are the main antigen presenting cells and therefore indispensable in both priming of protective immunity and maintaining immune tolerance to harmless antigen by inducing FoxP3+ regulatory T cells (Treg). (rwth-aachen.de)
In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). (bio-techne.com)

Adaptive immune repertoires are composed by the ensemble of B and T-cell receptors within an individual, reflecting both past and current immune responses. (nature.com)
Recent advances in single-cell sequencing enable recovery of the complete adaptive immune receptor sequences in addition to transcriptional information. (nature.com)
They play a critical role in initiating and regulating adaptive immune responses by presenting exogenous antigens to CD4+ T cells. (tutorialspoint.com)

Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
During tumor development, stromal cells are co-opted to the tumor milieu and provide favorable conditions for the tumor. (cancerindex.org)
In addition, xenografts of HCT116 cells with APJ‑suppressed fibroblasts showed accelerated tumor growth. (spandidos-publications.com)
The tumor microenvironment consists of various cell types and fibroblasts in the tumor tissue, called cancer-associated fibroblasts (CAFs), which play pivotal role in tumor progression ( 7 , 8 ). (spandidos-publications.com)
CAFs with tumor-promoting effects were usually activated and exhibited myofibroblast-like properties such as the upregulation of alpha-smooth muscle actin (α-SMA) ( 9 ). (spandidos-publications.com)
Surprisingly, most of the genes that were found to be informative for patients' metastasis were related to the immune system but not to common tumor cell characteristics such as angiogenesis, adhesion or invasion. (biomedcentral.com)
However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)

An increased surface expression of CD80, CD86 and CD28 but decreased CD152 expression was observed when PBMC of normal, BT/TT (tuberculoid) and BL/LL (lepromatous) patients were stimulated in vitro with MLCWA+MDP-BE+Trat peptide using liposomal mode of antigen delivery, while opposite results were obtained with the antigen alone. (bvsalud.org)
CD36 is expressed by most resting marginal zone B cells but not by follicular and B1 B cells, and it is rapidly induced on follicular B cells in vitro upon TLR and CD40 stimulation. (exbio.cz)

and in fibroblasts as extracellular matrix receptor 6 (ECMVI). (ximbio.com)

Here, we recovered transcriptome and immune repertoire information for polyclonal T follicular helper cells following lymphocytic choriomeningitis virus (LCMV) infection, CD8+ T cells with binding specificity restricted to two distinct LCMV peptides, and B and T cells isolated from the nervous system in the context of experimental autoimmune encephalomyelitis. (nature.com)
They play a critical role in presenting peptides to CD4+ T cells, which are necessary for mounting an effective immune response against pathogens. (tutorialspoint.com)

Therefore, we developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. (nature.com)
Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0038-42) and 0.25 µg of Mouse IgG1 K Isotype Control eFluor® 450 (Product # 48-4714-82) (left) or Anti-Human CD8a eFluor® 450 (right). (thermofisher.com)
The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)
Peripheral tolerance evolved to counteract autoantigen-recognizing T or B cells that escape central tolerance. (frontiersin.org)
FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance. (oncotarget.com)
The anti-diabetic effect of alpha-glucan may be due to its effects on insulin receptors by increasing insulin sensitivity and ameliorating insulin resistance of peripheral target tissues (12) . (alohamedicinalseu.com)

cDNA clones for the alpha chain (IL-5 R alpha ) of both the mouse and human high affinity IL-5 receptor complexes have been isolated. (rndsystems.com)

The implications of these findings for understanding of human T cell growth and its regulation in disease states are discussed. (ox.ac.uk)
The existence of CD4+ MHC class I-restricted T cells has significant implications for immune regulation in autoimmunity and, in particular, in HLA B27-associated arthritis. (ox.ac.uk)
The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found 16 significant regulated pathways in imDCs and 10 significant regulated pathways in mDCs, including the phagosome, cell adhesion signaling pathway, and inflammatory mediator regulation of TRP channels pathway. (frontiersin.org)
Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)
The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)

Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells. (nih.gov)
IgE synthesis by B cells is regulated by CD40 ligand, IL-4 and interferon-gamma, therefore inhibition of B cell antigen-specific IgE may prevent the cleavage of CD23 from B cells, having a therapeutic impact which also includes the removal of circulating free IgE, omalizumab, corticosteroids, mast cell stabilizers, leukotriene receptor antagonist, and others. (unipg.it)
Maitake also enhanced interferon activity against bladder cancer cells (18) and alleviated inflammation associated with inflammatory bowel disease (19) . (alohamedicinalseu.com)

CCR5 a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. (affbiotech.com)

Laboratory studies and small uncontrolled studies in humans show that maitake extracts slow the growth of tumors and stimulate certain immune cells. (alohamedicinalseu.com)

IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. (rndsystems.com)
Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
Immune cells of the gut come into contact with luminal antigen through the epithelial layer, while the liver is exposed to oral antigen via portal vein blood. (rwth-aachen.de)
To perpetuate an overall tolerogenic status, two types of immune cells are of particular importance. (rwth-aachen.de)
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease. (harvard.edu)

MicroRNA 5703 enriched in exosomes derived from HCT116 sh p53 cells inhibited APJ expression, and inhibition of miR‑5703 diminished APJ suppression in fibroblasts caused by cancer cells. (spandidos-publications.com)
These anti-CD79 mAbs show therapeutic potential to induce reversible inhibition of BCR signaling and B cell function. (nationaljewish.org)

There his work focused on transcriptional control of hematopoietic stem cell maturation and cell fate. (ubc.ca)

Moreover, γδ T cells can directly kill target cells without the involvement of dendritic cells (DCs) and perform dual functional roles in antitumor and anti-infective immunity. (nature.com)
Gut and liver build a functional entity, the so-called gut-liver axis, and act in concert to provide immunity and maintain tolerance to the gut microbiota as well as food derived antigens. (rwth-aachen.de)

Anatomy43

Organisms13

Diseases1

Chemicals and Drugs117

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes54

Disciplines and Occupations1

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Health Care1

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Signal Transduction2

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Gene5

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Monocytes2

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Macrophages2

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Immunol1

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