StreptograminsAntibioticAntibioticsAminoglycosidesLincomycinMacrolides and lincosamidesStreptograminMacrolidePenicillinsAntibacterialResistanceBacteriaBacteriostaticIsolatesRetinoidProtein synthesisPathwayClinicalSoft tissueResultsMacrolide-Lincosamide-StreptograminClindamycin or other lincosamidesAntibacterialBacterialRibosomalSynthesisStaphylococciCommonlySimilar
Streptogramins3
- Resistant strains were characterized by expression of methyltransferases which dimethylate residues within the 23S subunit of ribosomal RNA, preventing binding of macrolides, lincosamides and streptogramins B. The gene family responsible for encoding of these methyltransferases is referred to as the "erm" family, or erythromycin ribosome methylase family of genes. (wikipedia.org)
- Lincosamides, Oxazolidinones, and Streptogramins Lincosamides ( clindamycin), oxazolidinones ( linezolid, tedizolid), and streptogramins ( dalfopristin [streptogramin A] and quinupristin [streptogramin B]) are structurally different but are. (merckmanuals.com)
- B. by mutation , and results in a cross resistance to macrolides, lincosamides and streptogramins (an MLS-resistant phenotype). (zxc.wiki)
Antibiotic7
- Clindamycin Clindamycin is a lincosamide antibiotic that is primarily bacteriostatic. (msdmanuals.com)
- Clindamyacin is a lincosamide antibiotic. (dentistryiq.com)
- For example, most Enterococcus faecalis is naturally resistant to the antibiotic class of lincosamides. (nationalchickencouncil.org)
- ZIANA ® Gel is a lincosamide antibiotic and retinoid combination product indicated for the topical treatment of acne vulgaris in patients 12 years or older. (nih.gov)
- ZIANA Gel, a combination of a lincosamide antibiotic and a retinoid, contains clindamycin phosphate 1.2% and tretinoin 0.025%, formulated as a topical gel. (nih.gov)
- Clindamycin is a lincosamide antibiotic, which means that it helps to remove an anaerobic bacterial infection by disrupting the synthesis of proteins that the bacteria need in order to continue to survive and grow. (vetinfo.com)
- We show that CplR contributes to intrinsic pleuromutilin, lincosamide and streptogramin A resistance in Clostridioides, and demonstrate that C. difficile CplR (CDIF630_02847) synergises with the transposon-encoded 23S ribosomal RNA methyltransferase Erm to grant high levels of antibiotic resistance to the C. difficile 630 clinical isolate. (lu.se)
Antibiotics6
- While several hundred synthetic and semi-synthetic derivatives of lincosamides have been prepared, only lincomycin A and clindamycin are used in clinical practice due to issues with toxicity and low biological activity in other lincosamide antibiotics. (wikipedia.org)
- Quinupristin and Dalfopristin Quinupristin and dalfopristin are streptogramin antibiotics, which, like macrolides and lincosamides, inhibit the synthesis of bacterial proteins. (msdmanuals.com)
- Macrolides are prescribed for intolerance to antibiotics of the penicillin series or cephalosporins, and in the presence of allergy to macrolides, lincosamides are indicated. (abchealthonline.com)
- It is part of a group of antibiotics called lincosamides. (villagecountryinn.com)
- Behr C, Ramirez-Hincapie S, Cameron HJ, Strauss V, Walk T, Herold M, Beekmann K, Rietjens IMCM, van Ravenzwaay B (2018): Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces. (basf.com)
- There are many different types of these enzymes which have different activities against antibiotics from many different classes of antibiotics including aminoglycosides, tetracyclines, phenicols and lincosamides. (futurelearn.com)
Aminoglycosides1
- Antimicrobial classes that had the largest increase in sales (kg) in 2021 were the penicillins, aminoglycosides and lincosamides. (canada.ca)
Lincomycin3
- Hydrolysis of lincosamides, specifically lincomycin, splits the molecule into its building blocks of the sugar and proline moieties. (wikipedia.org)
- Lincosamides: Such as Clindamycin and Lincomycin. (seagullindia.com)
- lincosamides: Lincomycin, Clindamycin. (abchealthonline.com)
Macrolides and lincosamides1
- Gram-negative bacteria harbor genes encoding for molecular pumps which can contribute to resistance of hydrophobic compounds like macrolides and lincosamides. (wikipedia.org)
Streptogramin4
- In a mechanism similar to macrolides and streptogramin B, lincosamides bind close to the peptidyl transferase center on the 23S portion of the 50S subunit of bacterial ribosomes. (wikipedia.org)
- Staphylococci express efflux pumps with specificity for 14 and 15 member ring macrolides and streptogramin B, but not lincosamide molecules. (wikipedia.org)
- Eighteen isolates exhibited macrolide-lincosamide-streptogramin B resistance (MLSB): 6 were MLSBi and 12 were MLSBc. (who.int)
- Metagenomic sequencing detected 43 ARGs in feces and all lots harbored ARGs from aminoglycoside, beta-lactam, macrolide-lincosamide-streptogramin (MLS), and tetracycline classes. (usda.gov)
Macrolide1
- Linear Regression Equations To Predict β-Lactam, Macrolide, Lincosamide, and Fluoroquinolone MICs from Molecular Antimicrobial Resistance Determinants in Streptococcus pneumoniae. (mun.ca)
Penicillins1
- Top classes of antimicrobials sold by manufacturers and importers were tetracyclines, penicillins, macrolides, bacitracins and lincosamides. (canada.ca)
Antibacterial1
- Clindamycin phosphate and benzoyl peroxide gel is a combination of clindamycin phosphate (a lincosamide antibacterial) and benzoyl peroxide indicated for the topical treatment of acne vulgaris in patients 12 years of age and older. (nih.gov)
Resistance1
- Out of the many families of multidrug resistance pumps, lincosamides are most commonly shunted through pumps belonging to the resistance-nodulation-cell division superfamily. (wikipedia.org)
Bacteria3
- Lincosamides are used against Gram-positive bacteria since they are unable to pass through the porins of Gram-negative bacteria. (wikipedia.org)
- They have some features in common - for example they inhibit protein synthesis in bacteria (with macrolides, lincosamides, and chloramphenicol acting at a similar site), and have some similar pharmacokinetic features. (veteriankey.com)
- Lincosamides prevent bacteria from reproducing. (adam.com)
Bacteriostatic1
- Lincosamides prevent bacterial replication in a bacteriostatic mechanism by interfering with the synthesis of proteins. (wikipedia.org)
Isolates1
- Clinical isolates of S. aureus harboring genes which encode for lincosamide nucleotransferases have been reported. (wikipedia.org)
Retinoid1
- Lincosamide + retinoid. (empr.com)
Protein synthesis1
- Lincosamides do not interfere with protein synthesis in human cells (or those of other eukaryotes) due to structural differences between prokaryotic and eukaryotic ribosomes. (wikipedia.org)
Pathway1
- Biosynthesis of lincosamides occurs through a biphasic pathway, in which propylproline and methylthiolincosamide are independently synthesized immediately before condensation of the two precursor molecules. (wikipedia.org)
Clinical1
- Soon after the emergence of clinical lincosamide use in 1953, strains of resistant staphylococci were isolated in several countries including France, Japan and the United States. (wikipedia.org)
Soft tissue1
- Clindamycin is a lincosamide for the treatment of serious skin and soft tissue staphylococcal infections. (medscape.com)
Results1
- Intramuscular administration of lincosamides results in strong absorption, with peak plasma levels being reached in 1-2 hours. (wikipedia.org)
Macrolide-Lincosamide-Streptogramin2
- Modukuru GK, Surya PMS, Kakumanu VR, Yarava S. Phenotypic characterization of Macrolide-Lincosamide-Streptogramin B resistance in Staphylococcus aureus . (microbiologyjournal.org)
- Eighteen isolates exhibited macrolide-lincosamide-streptogramin B resistance (MLSB): 6 were MLSBi and 12 were MLSBc. (who.int)
Clindamycin or other lincosamides1
- Do not administer Clindesse to individuals with a history of hypersensitivity to clindamycin or other lincosamides. (nih.gov)
Antibacterial2
- Lincosamide antibacterial active against many gram-positive bacteria (staphylococci, streptococci, clostridium) and some anaerobes (Bacteroides fragilis) and parasites (plasmodium, toxoplasma). (e-lactancia.org)
- Daré's first FDA-approved product, XACIATO (clindamycin phosphate) vaginal gel, 2% is a lincosamide antibacterial indicated for the treatment of bacterial vaginosis in female patients 12 years of age and older, which is under a global license agreement with Organon. (drug-dev.com)
Bacterial3
- Lincosamides prevent bacterial replication in a bacteriostatic mechanism by interfering with the synthesis of proteins. (wikipedia.org)
- In a mechanism similar to macrolides and streptogramin B, lincosamides bind close to the peptidyl transferase center on the 23S portion of the 50S subunit of bacterial ribosomes. (wikipedia.org)
- This group comprises macrolide, lincosamide and streptogramin antibacterials inhibiting bacterial protein synthesis through binding to the 50-S part of the ribosomes. (whocc.no)
Ribosomal1
- Because of their similar mode of action, amphenicols, lincosamides, pleuromutilins and macrolides should not be used concomitantly as they would compete against each other to bind on the 50S ribosomal subunit. (umn.edu)
Synthesis1
- Lincosamides do not interfere with protein synthesis in human cells (or those of other eukaryotes) due to structural differences between prokaryotic and eukaryotic ribosomes. (wikipedia.org)
Staphylococci2
- Soon after the emergence of clinical lincosamide use in 1953, strains of resistant staphylococci were isolated in several countries including France, Japan and the United States. (wikipedia.org)
- Staphylococci express efflux pumps with specificity for 14 and 15 member ring macrolides and streptogramin B, but not lincosamide molecules. (wikipedia.org)
Commonly1
- Out of the many families of multidrug resistance pumps, lincosamides are most commonly shunted through pumps belonging to the resistance-nodulation-cell division superfamily. (wikipedia.org)
Similar1
- Macrolides have a similar mode of action to lincosamides and pleuromutilins. (umn.edu)