Different gene expression regulation developmental. Medical search. Frequent questions

Recent work has shown that these proteins are also involved in hormonal regulation of breast cancer cells. (ucsc.edu)
Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
Development of bacterial and mammalian vectors for the expression of eukaryotic proteins. (academictree.org)
The MBD5 gene provides instructions for a protein that likely regulates the activity (expression) of genes, controlling the production of proteins that are involved in neurological functions such as learning, memory, and behavior. (medlineplus.gov)
It is likely that any changes in MBD5 protein levels impair its regulation of gene expression, leading to the uncontrolled production of certain proteins. (medlineplus.gov)

Cardiovascular screening and genetics in competitive athletes, disease gene discovery in cardiomyopathy and rare disease. (stanford.edu)
We can now understand mental illness as an expression of underlying brain circuit disruptions, shaped by experience and genetics. (stanford.edu)
Developmental genetics and tumour genetics. (lu.se)

Human evolutionary developmental biology or informally human evo-devo is the human-specific subset of evolutionary developmental biology. (wikipedia.org)
Evolutionary developmental biology is the study of the evolution of developmental processes across different organisms. (wikipedia.org)
Evolutionary developmental biology is primarily concerned with the ways in which evolution affects development, and seeks to unravel the causes of evolutionary innovations. (wikipedia.org)
Brian Hall traces the roots of evolutionary developmental biology in his 2012 paper on its past present and future. (wikipedia.org)
Many of the human evolutionary developmental biology studies have been modeled after primate studies and consider the two together in a comparative model. (wikipedia.org)
Some of the work on human evolutionary developmental biology has centered around the neotenous features that present in humans, but are not shared across the primate spectrum. (wikipedia.org)
Cancer research at UC Santa Cruz includes faculty in a wide range of departments, including Applied Math and Statistics, Biomolecular Engineering, Chemistry and Biochemistry, Electrical Engineering, Microbiology and Environmental Toxicology, and Molecular, Cell, and Developmental Biology. (ucsc.edu)
Detlef Weigel received his PhD in 1988 from the Max Planck Institute for Developmental Biology. (elifesciences.org)
Since 2002, he has been director of the Department of Molecular Biology at the Max Planck Institute for Developmental Biology. (elifesciences.org)
He serves on the Editorial Boards of Annual Review of Cell and Developmental Biology and Genome Biology. (elifesciences.org)
She is currently a Senior Investigator leading the Chromosome Structure and Epigenetics Mechanism Unit within the Laboratory of Receptor Biology and Gene Expression at the Center for Cancer Research of the NCI/NIH in Bethesda. (elifesciences.org)
Developmental Biology , 255 (2), 303-12. (ed.ac.uk)
We ask fundamental questions in chromatin biology and seek to understand how these multifaceted regulations are dysregulated in human cancers. (childrensnational.org)
Gene regulation in developmental biology and the cell cycle. (lu.se)

However, the developmental timing of these effects, which provide insight into the cellular and molecular pathways through which early experience alters later behavior, had not been explored. (elsevierpure.com)
A molecular explanation for this may be that several of the engulfment genes expressed by macrophages, including the ABC1 transporter (believed to be part of the phagocytic machinery conserved from Caenorhabditis elegans to mouse), are not upregulated by these 'stand-in' phagocytes. (bris.ac.uk)
A complex interaction between the cleavage and polyadenylation molecular complex and cis -elements determine the polyadenylation site, which may result in the choice of non-canonical sites, resulting in alternative polyadenylation events, involved in the regulation of more than 80% of the genes expressed in plants. (frontiersin.org)
Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
Gene technology: basic and applied molecular genetic methods. (lu.se)

Selenoproteins contain the rare amino acid selenocysteine (Sec). Mutations in SECISBP2 in humans lead to reduced selenoprotein expression thereby affecting thyroid hormone-dependent growth and differentiation processes. (nih.gov)
Her lab focuses on mutations that cause changes in gene expression by affecting a process called alternative splicing of RNA. (ucsc.edu)
One in eight women in the United States will develop breast cancer in her lifetime, yet only about 15 percent of these cancers have been linked to inherited gene mutations. (ucsc.edu)
This paper reports that loss of function of the Drosophila gene cabeza (the Drosophila equivalent of the human FUS gene, mutations in which can cause a familial form of the motor neurodegenerative disease amyotrophic lateral sclerosis or ALS) induces muscle developmental defects. (europa.eu)
Less frequently, MAND is caused by mutations that affect only the MBD5 gene. (medlineplus.gov)
Because mutations in the MBD5 gene and changes on chromosome 2 that involve this gene both cause MAND, researchers believe that MBD5 gene changes underlie most of the signs and symptoms of the condition. (medlineplus.gov)
MBD5 gene mutations and deletions prevent one copy of the MBD5 gene in each cell from producing any functional protein, which reduces the total amount of this protein in cells. (medlineplus.gov)
Resistance to antimicrobial drugs of convenience, the examples will be taken mainly from in bacteria can result from mutations in housekeeping the work carried out in the author's laboratory, although structural or regulatory genes. (cdc.gov)
SCID results from mutations in any of more than 15 known genes. (medscape.com)

To examine the expression pattern in different species, we cloned the zebrafish homolog of Vg1 RBP by using a highly homologous EST clone to screen an embryonic cDNA library. (zfin.org)
Although Vg1 RBP RNA is detected in all blastomeres of the early embryo, the expression pattern in the one day old zebrafish embryo is almost identical to that of the equivalent stage Xenopus embryo. (zfin.org)
To better characterize the Hh response in the zebrafish neural tube, we cloned the zebrafish Class II Hh target genes nkx2.9 and nkx6.2. (zfin.org)
We then analyzed the expression of a number of Class I and Class II Hh responsive genes in wild type, Hh mutant, and Hh over-expressing zebrafish embryos. (zfin.org)
This comprehensive expression study provides an important tool for the characterization of Hh signaling in zebrafish and provides a sensitive assay for determining the degree to which newly identified zebrafish mutants affect Hh signaling. (zfin.org)
In zebrafish, the oscillatory transcriptional repressor genes her1 and her7 are crucial for genesis of the oscillations, which are thought to arise from negative autoregulation of these genes. (zfin.org)

Collectively, our results suggest a mutually exclusive role for Ring1B and Suv39h1 in regulating distinct chromatin states at key developmental genes and propose a novel mechanism by which lineage specification can be reinforced during early development. (cnrs.fr)
In epigenetics, he is studying gene expression regulation mechanisms through chromatin interaction, and RNA silencing pathways in the developmental stages of germ-line cells. (wpi.edu)
Current Research and Scholarly Interests The Wang lab takes an interdisciplinary approach to studying fundamental mechanisms controlling gene expression in mammalian cells, and how epigenetic mechanisms such as DNA methylation, chromatin modifications, and RNA influence chromatin dynamics to affect gene regulation. (stanford.edu)
Dr. Yu's research group studies regulations of gene expression at the chromatin level. (childrensnational.org)
As chromatin is a highly compartmentalized structure, the temporo-spatial regulations of chromatin-associated factors are crucial for their collective functions in shaping the epigenome. (childrensnational.org)

Further, gene length analysis of the differentially expressed genes showed that the loss of Elp1 mainly impacts the expression of long genes and that by gradually restoring Elongator their expression is progressively rescued. (figshare.com)
We observe sex-biased isoform switching consistently across development, but mostly in genes that are already differentially expressed. (lu.se)

Given the substantial inter-individual variation seen in metabolism, regulation of nutrients, protein synthesis, and detoxification of xenobiotics. (biomedcentral.com)
2019 ) Regulation of Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism. (academictree.org)
This technique, for example, was used successfully to study the have to protect themselves from the products of their own extent of variations in penicillinase genes that generate secondary metabolism. (cdc.gov)

These defects are mediated by increased expression of a protein called Xrp1, which is involved in gene expression regulation. (europa.eu)
We show that dysregulation of appropriate expression of components of the fibroblast growth factor (FGF) pathway contributes to muscle developmental defects in cabeza mutant Drosophila. (europa.eu)
The segregation and near-exclusion of mutant cells from the nasal epithelium mirrored the behaviour of mutant cells in other developmental contexts, particularly the lens, suggesting that common primary defects may be responsible for diverse Pax6-related phenotypes. (ed.ac.uk)
These changes were correlated with dramatic development defects in leaves, roots, and flowers, showing that microRNA-mediated regulation of ARF17 is essential for normal plant development. (sciencedaily.com)
Arabidopsis ago1 mutants lacking the AGO1 protein have numerous severe developmental defects, supporting the notion that regulation by microRNAs is critical for normal plant growth. (sciencedaily.com)

Our work to generate a phenotypic mouse model for FD headed to the discovery that homozygous deletion of the mouse Elp1 gene leads to embryonic lethality prior to mid-gestation. (figshare.com)
Given that FD is caused by a reduction, not loss, of ELP1, we generated two new mouse models by introducing different copy numbers of the human FD ELP1 transgene into the Elp1 knockout mouse (Elp1-/-) and observed that human ELP1 expression rescues embryonic development in a dose dependent manner. (figshare.com)
Despite the massive reduction of Dio1 and Sepp1 mRNAs, significantly more corresponding protein was detected in primary hepatocytes lacking Secisbp2 than in cells lacking tRNA[Ser]Sec. Regarding selenoprotein expression, compensatory nuclear factor, erythroid-derived, like 2 (Nrf2)-dependent gene expression, or embryonic development, phenotypes were always milder in Secisbp2-deficient than in tRNA[Ser]Sec-deficient mice. (nih.gov)
We are proposing that this is a basic, early embryonic switch that can cause the initiation of cascades of gene expression that are responsible for at least some early, diversification of cell phenotypes. (duke.edu)
not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)

Peña, CJ , Neugut, YD & Champagne, FA 2013, ' Developmental timing of the effects of maternal care on gene expression and epigenetic regulation of hormone receptor levels in female rats ', Endocrinology , vol. 154, no. 11, pp. 4340-4351. (elsevierpure.com)
More examples on epigenetic regulation of ADME genes have been reviewed by Kacevska et al. (biomedcentral.com)

Hence, developmentally regulated, lineage-specific transcription of the lck gene is mediated by distinct promoter sequences that appear to be capable of functioning independently. (rupress.org)
This stably repressed state is linked with a loss of gene priming for transcription through the exclusion of PRC1 (Ring1B) and RNA polymerase II complexes at bivalent, lineage-inappropriate genes upon trophoblast lineage commitment. (cnrs.fr)
By analyzing the methylomes and transcriptomes of 14 fetal and 181 adult livers, we identified 657 differentially methylated genes with adult-specific expression, these genes were enriched for transcription factor binding sites of HNF1A and HNF4A. (biomedcentral.com)
One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the expression of a number of other genes involved in auxin responses. (sciencedaily.com)
Sonic Hedgehog (Shh) signaling helps pattern the vertebrate neural tube, in part by regulating the dorsal/ventral expression of a number of homeodomain containing transcription factors. (zfin.org)

Reduced DNA methylation and histone 3 lysine 9 trimethylation and increased histone 3 lysine 4 tri-methylation at the ERα gene promoter (Esr1) were detected at PN21 in high LG female offspring. (elsevierpure.com)
Of the 526 unique eQTL associated genes, 293 correlated significantly not only with genetic variation but also with methylation levels. (biomedcentral.com)
We observed that meQTL were more stable between tissues than eQTL and a very strong tissue-specificity for the identified associations between CpG methylation and gene expression. (biomedcentral.com)
It is essential to have a better understanding on inter-individual variation of gene expression, methylation and genetic effects specific to liver, and on different conditions, e.g. developmental stages. (biomedcentral.com)
The epigenetic code is determined by several mechanisms that affect gene expression, the most well-known of which is DNA methylation (See Figure 1). (cdc.gov)
This happens because BPA decreases DNA methylation so that more offspring have unmethylated Agouti genes. (cdc.gov)
When pregnant mice are exposed to BPA along with a vitamin B cocktail (including B12 and folic acid) which increase methylation of the Agouti gene, the offspring are no longer predominantly yellow and obese. (cdc.gov)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (jefferson.edu)
We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks show sex-biased functional interactions in early developmental stages. (lu.se)
Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (sciencedaily.com)
By tailbud stages, Vg1 RBP expression is present in the branchial arches, otic vesicle, pronephros, and along the neural tube. (zfin.org)

We then conducted a comprehensive transcriptome analysis in mouse embryos to identify genes and pathways whose expression correlates with the amount of ELP1. (figshare.com)
The assembled transcriptome is estimated to have the complete sequence information for ~86% of the genes found in the Chia genome. (oregonstate.edu)
Through APA, a single gene containing multiple PAS can generate a considerable number of transcript isoforms, thereby producing a highly diversified transcriptome ( Tian and Manley, 2013 ). (frontiersin.org)
discrete on/off states for individual genes in these states), and time-resolved transcriptome data, a comprehensive model of spontaneous and perturbed gene expression dynamics was developed. (fu-berlin.de)

We compare the dynamics of differential expression, isoform switching and functional interactions in the sexual development of the model parasitoid wasp Nasonia vitripennis, a system that permits genome wide analysis of sex bias from early embryos to adults. (lu.se)

MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)

Gene Expression Regulation, Developmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Expression of ZNF558 is controlled by the size of a variable number tandem repeat that is longer in chimpanzees compared to humans, and variable in the human population. (lu.se)
Therefore, it is all the more surprising pathogenic for humans have evolved toward antimi- that genes commonly found on plasmids in the latter bac- crobial drug resistance. (cdc.gov)

Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage. (figshare.com)
Familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy, is caused by a mutation in the Elongator complex protein 1 (ELP1) gene that lead to a tissue-specific reduction of ELP1 protein. (figshare.com)
Xrp1 is a DNA-binding protein that is involved in gene expression regulation. (europa.eu)
The complex then cleaves the mRNA into smaller pieces, thereby preventing translation of the protein it encodes, and thus inhibiting or "silencing" gene expression. (sciencedaily.com)
Expression and estrogen sensitivity of target genes and nuclear receptor coregulators were altered at mRNA and protein levels in adult uterus, prostate and brain. (researchgate.net)
We have analyzed the expression and intracellular distribution, during oogenesis and embryogenesis, of Vg1 RBP, a protein implicated in the intracellular localization of Vg1 mRNA to the vegetal cortex of Xenopus oocytes. (zfin.org)
We therefore tested the effects of pre‐natal betamethasone on testicular morphology and apoptotic protein immune expression during pre‐ and post‐natal development. (mcmaster.ca)
The human forebrain has expanded in size and complexity compared to chimpanzees despite limited changes in protein-coding genes, suggesting that gene expression regulation is an important driver of brain evolution. (lu.se)
An increase or decrease in MBD5 protein disrupts gene expression that is normally well-controlled by this protein, which is likely why duplications and deletions involving the MBD5 gene lead to the same signs and symptoms. (medlineplus.gov)

mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
which remain susceptible to most antimicrobial drugs ing structural or regulatory genes or from acquiring foreign even though they can acquire plasmids from both entero- genetic information. (cdc.gov)

In particular, such mechanisms can influence the expression of hepatic ADME genes. (biomedcentral.com)

As previously reported, transgenic mice bearing functional proximal promoter sequence juxtaposed with the SV40 large T antigen gene invariably develop lymphoid tumors confined to the thymus. (rupress.org)
In the current work, transgenic mice bearing a 2.6-kb fragment of the human distal promoter fused to the SV40 large T antigen gene express large T antigen in thymocytes and in peripheral lymphoid cells, and develop tumors of both the thymus and the peripheral lymphoid organs. (rupress.org)
In three separate lines of transgenic mice, expression in fetal livers was high, and this level persisted into adulthood. (princeton.edu)
Furthermore, we could show that expression of the acetylcholine receptor in skeletal muscles of these mice is affected. (europa.eu)

In the course of our studies concerning the evolution of Hox gene regulation, we produced a transgenic mouse model expressing fish Hox genes, which displayed a reduced number of thoraco-lumbar vertebrae and concurrent sacral homeotic transformations. (nih.gov)
Using a transgenic mouse model in which an ALS-like mutation was introduced in the mouse Fus gene, we could show that ALS pathology starts at the neuromuscular juction (the transition between motor nerves and skeletal muscle cells), long before motor neuron cell bodies in the spinal cord degenerate. (europa.eu)

Research conducted by three independent groups and reported in The Plant Cell shows that fundamental developmental processes controlled by the plant hormone auxin are regulated by microRNAs in the model plant Arabidopsis thaliana. (sciencedaily.com)
Insights into the developmental processes during which the brain forms from the neuroepithelium may provide a deeper understanding how the brain works. (uni-muenchen.de)

1. Catinozzi M, Mallik M, Frickenhaus M, Been M, Sijlmans C, Kulshrestha D, Alexopoulos I, Weitkunat M, Schnorrer F, Storkebaum E. The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling. (europa.eu)
2022 ) Corrigendum to "GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis" [Dev. (academictree.org)

We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks. (lu.se)

In hepatocyte-specific conditional mouse models, Secisbp2 gene inactivation is less detrimental than tRNA[Ser]Sec inactivation. (nih.gov)

Further, ventral-most Class II gene expression was completely lost in all Hh pathway mutants analyzed, indicating high levels of Hh signaling are blocked in all of these mutants. (zfin.org)
In contrast, more dorsally expressed genes were variably affected in different Hh pathway mutants, indicating mid-levels of Hh signaling are differentially affected. (zfin.org)

Polyadenylation is essential for the stability of the transcript, preventing the mRNA from being the target of posttranscriptional gene silencing (PTGS) via RNA-dependent RNA polymerase 6 (RDR6) in plants ( Luo and Chen, 2007 ). (frontiersin.org)

Sexual dimorphism requires regulation of gene expression in developing organisms. (lu.se)
Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)

and the regulation of the expression of enzyme-coding genes associated with important metabolic pathways. (oregonstate.edu)

We also suggest that this mechanism may be playing a significant role in the repression of genes in undifferentiated stem cells. (duke.edu)

These data suggest that there is differential expression of the SRIF gene in different regions of the brain and in the stomach during development. (northwestern.edu)
These developmental differences are caused by differential expression of genes and isoforms. (lu.se)
In contrast, sex-bias in pupae and adults is driven by the differential expression of genes. (lu.se)

When SRIF mRNA levels from each stage of development were quantified and normalized by the amount of poly (A) + RNA present at that stage of development, a unique pattern of SRIF gene expression was seen in each region. (northwestern.edu)
The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (sciencedaily.com)
Dr. Bellini and her colleagues found that the mutant plants over-accumulate ARF17 mRNA within the hypocotyl, pointing to ARF17 as a major regulator of adventitious rooting and microRNA-mediated regulation as a major regulator of ARF17. (sciencedaily.com)
The 3' regulatory regions have a great diversity of cis -regulatory elements directly involved in polyadenylation, stability, transport and mRNA translation, essential to achieve the desired levels of gene expression. (frontiersin.org)
Vg1 RBP mRNA expression is also detected in what appears to be neural crest cells undergoing delamination and lateral migration. (zfin.org)

Principles for regulation of gene expression through intercellular signalling. (lu.se)

They concluded that even though much of the developmental results are similar insofar as brain size, the trajectories by which they arrived are not shared. (wikipedia.org)

The Rho family of small GTPases is known for its many cell biological functions such as regulation of the cytoskeleton, gene expression, cell migration, adhesion, cell polarity and the cell cycle. (uni-muenchen.de)

Our analyses generated a comprehensive resource of factors involved in the regulation of hepatic gene expression, and allowed us to estimate the proportion of variation in gene expression that could be attributed to genetic and epigenetic variation, both crucial to understanding differences in drug response and the etiology of liver diseases. (biomedcentral.com)
However, these natural principles are often dysregulated in human diseases such as congenital developmental syndromes and various types of cancer. (childrensnational.org)
The turning on of this gene leads not only to changes in coat color but to predisposition to all kinds of metabolic diseases including obesity and diabetes. (cdc.gov)

abstract = "Developmental regulation of somatostatin (SRIF) gene expression was studied in five regions of rat brain and in rat stomach. (northwestern.edu)

This is a review of research that supports a hypothesis regarding early restriction of gene expression in the vertebrate embryo. (duke.edu)
A gene expression oscillator called the segmentation clock controls somite segmentation in the vertebrate embryo. (zfin.org)

Finally, through evaluation of co-expression modules, we identified gene sets with unique expression patterns that depended on ELP1 expression. (figshare.com)
Gene expression patterns : GEP. (zfin.org)
Transient patterns of gene regulation were identified from model predictions. (fu-berlin.de)

This is due to the assemblage of a rar-corepressor-histone deacetylase complex on retinoic acid response elements (RAREs) in regulatory regions of a subset of genes. (duke.edu)
Dehydrogenases and a subset of cytochrome p450 genes (cyp26a1, cyp26b1, and cyp26c1) play the major role in providing the retinoic acid and limiting its access. (duke.edu)

This chapter discusses the relative merits of the basic approaches to assay tissue-specific gene expression. (princeton.edu)

We found that ELP1 is essential for the expression of genes responsible for nervous system development. (figshare.com)
with these three reports, we are beginning to understand the consequences of this regulation for the development of the plant. (sciencedaily.com)
Chia () Gene Expression Atlas Elucidates Dynamic Spatio-Temporal Changes Associated With Plant Growth and Development. (oregonstate.edu)
In addition, selective and precise allocation of retinoic acid during early development through the interaction of Phase I enzymes throws the switch 'ON' in a predictable, developmental manner. (duke.edu)
ZNF558 plays a role in mitochondrial homeostasis, and loss-of-function experiments in cerebral organoids suggests that ZNF558 influences developmental timing during early human brain development. (lu.se)

The gene and cell approaches are more likely to be curative, but they are still under investigation. (medscape.com)

Such exposures can have a profound and long lasting impact on gene expression across generations. (cdc.gov)
Environmental exposures can influence whether or not this gene is turned on or off. (cdc.gov)

Since F-actin stabilizes adherens junctions, RhoA's regulation of actin levels might indeed be at the origin "double-cortex" phenotype. (uni-muenchen.de)

To this end, preventive screening for genetic disorders, including developmental disabilities, is an essential component in uncovering possible disorders early, thus enabling timely medical intervention. (who.int)

The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). (lu.se)

One should distinguish "natural" antimicrobial drugs ated with chromosome replication, plasmid conjugation (e.g., kanamycin), which are produced by microorganisms with replicative transfer, and gene migration with replica- from the environment, from semisynthetic (e.g., amikacin) tive transposition (1). (cdc.gov)
PERSPECTIVES antimicrobial drugs in animal feed also leads to the selec- tion of a pool of resistance genes that can be transferred to commensal bacteria in the human digestive tract and thus ultimately to human pathogens, even when selective pres- sure is absent (10). (cdc.gov)

Anatomy11

Organisms11

Diseases3

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes91

Disciplines and Occupations3

Information Science8

Health Care3

Proteins7

Genetics3

Biology14

Molecular5

Mutations9

Zebrafish6

Chromatin5

Differentially expressed2

Metabolism3

Defects5

Embryonic5

Epigenetic regulation2

Transcription5

Methylation7

Stages4

Transcriptome4

Dynamics1

Eukaryotic1

MeSH1

Humans2

Protein9

Regulatory genes2

Mechanisms1

Mice4

Transgenic2

Processes2

Drosophila2

Embryos1

Inactivation1

Pathway2

Silencing1

Organisms2

Pathways1

Stem Cells1

Differential expression3

MRNA5

Intercellular1

Trajectories1

Biological1

Diseases3

Abstract1

Vertebrate embryo2

Patterns3

Subset2

Tissue-specific gene expression1

Development5

Cell1

Exposures2

Phenotype1

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Interactions1

Antimicrobial2