Differences mutant proteins. Medical search. Frequent questions

We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
N-linked glycosylation is the most prevalent posttranslational modification of plasma membrane and secretory proteins and participates in many important biological roles such as protein folding, intracellular targeting, immune response, cell adhesion, and protease resistance. (jneurosci.org)
In fundamental cell biological processes such as signal transduction, enzymatic activity or intracellular fusion during vesicular transport, a large number of proteins are recruited to and released from the cytoplasmic surface of intracellular membranes (Casey et al. (biologists.com)
IV) chain causes retention of the protein to the endoplasmic reticulum lumen, which causes endoplasmic reticulum stress (ERS) and subsequent exertion of deleterious intracellular effects through the activation of ERS. (omicsdi.org)
The observed differences in activation of ERS by the COL4A5 mutant fibroblasts may contribute to the intracellular molecular mechanisms that describe the correlation between genotype and clinical features in XLAS. (omicsdi.org)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
HCM is inherited as an autosomal dominant trait and, in about 40% of patients, the causal mutation is identified in genes encoding sarcomere proteins. (mdpi.com)
Among these effects, growth-defective 60S mutants increased synthesis of proteins involved in proteasome-mediated degradation, whereas 40S mutants accumulated mature 60S subunits and increased translation of ribosome biogenesis genes. (broadinstitute.org)
The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
Mitochondria contain DNA in a single circular chromosome containing 37 genes that code for 13 proteins, various RNAs, and several regulating. (msdmanuals.com)
Proteins active in mitochondrial structure and function originate both from mitochondrial genes and also from nuclear genes. (msdmanuals.com)

Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP Sw ), resulting in high β-amyloid (Aβ) levels in the brain. (jneurosci.org)
For instance, familial AD is linked to mutations in the amyloid precursor protein (APP), presenilin 1, and presenilin 2, all of which lead to increased levels of Aβ. (jneurosci.org)
Poor sleep quality in adulthood is a risk factor for Alzheimer's, as our brains, when at rest, naturally cleanse themselves of amyloid beta proteins that are thought to form harmful tangles in Alzheimer's. (virginia.edu)
In summary, we present an autopsy case of concurrent Ig-λ and TTR deposition as revealed by IHC and LC-MS/MS. When Congo red staining and IHC results are indeterminate due to the deposition of multiple amyloid proteins, LMD-LC-MS/MS is useful for determining the precursor protein. (bvsalud.org)

The cytosolic, intermembrane space, compartment has a higher aqueous:protein content of around 3.8 μL/mg protein relative to that occurring in mitochondrial matrix where such levels typically are near 0.8 μL/mg protein. (wikipedia.org)
Protein synthesis makes use of mitochondrial DNA, RNA, and tRNA. (wikipedia.org)
Molecules enter and exit the mitochondrial matrix through transport proteins and ion transporters. (wikipedia.org)
Outer mitochondrial membrane permeabilization and cytochrome c release are typically achieved by pro-apoptotic Bcl-2 proteins, such as Bax and Bak. (nature.com)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. (harvard.edu)
The fragment encoding HAI-tagged EYFP was fused with the C-terminus of glycerol-phosphate dehydrogenase, an integral protein of the inner mitochondrial membrane. (harvard.edu)

Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)
d - i Type IV collagen protein and mRNA expression in the lung. (biomedcentral.com)

Because gene expression defects resulting from ribosome deficiency have not yet been experimentally defined, we systematically probed mRNA, translation, and protein signatures that were either unlinked from or linked to cellular growth rate in RP-deficient yeast cells. (broadinstitute.org)
To examine the effects of distinct PRPH2 point mutations on mRNA splicing and protein expression in vivo , we designed PRPH2 minigenes containing the three coding exons and relevant intronic regions of human PRPH2. (cipsm.de)
These mechanisms include aberrant mRNA splicing, protein mislocalization, and protein degradation. (cipsm.de)
It specifically targets X-box-binding protein 1 (XBP1) mRNA, from which a 26 nt intron is spliced. (helsinki.fi)
This allows a complete translation of spliced XBP1 mRNA into a functional protein that acts as a transcription factor. (helsinki.fi)

which contains the electron transport chain that is found on the cristae of the inner membrane and consists of four protein complexes and ATP synthase. (wikipedia.org)
All of the enzymes for the citric acid cycle are in the matrix (e.g. citrate synthase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, fumarase, and malate dehydrogenase) except for succinate dehydrogenase which is on the inner membrane and is part of protein complex II in the electron transport chain. (wikipedia.org)
Of these proteins affected by virB, products of the two major outer membrane proteins (OMPs), Omp25 and Omp31, were expressed at decreased levels, implying that T4SS might affect the membrane properties of Brucella. (a-inhibitor.com)
2007). Virulence regulation systems, exemplified by VjbR and BvrR/BvrS, regulate the expression of membrane proteins. (a-inhibitor.com)
The membrane integrity was tested by comparing the sensitivity of these proteins to polymyxin B and several stresses. (a-inhibitor.com)
These data indicated that a drastic modification in the OM of the virB mutant occurred and that T4SS plays important roles in membrane integrity. (a-inhibitor.com)
Endoplasmic reticulum (ER) stress is caused by the accumulation of unfolded proteins in the ER, which leads to the activation of unfolded protein response (UPR) through three transmembrane protein sensors located in the ER membrane. (helsinki.fi)
If the membrane-anchor is missing or defective, Fp and Ip subunits accumulate as soluble proteins in the cytoplasm. (lu.se)
Notably, certain B. subtilis mutants with mutated Fp lack covalently bound flavin and do not assemble the SQR polypeptides in the membrane [3]. (lu.se)

Here we report biallelic variants in CACNA2D1, encoding the α2δ-1 protein, in two unrelated individuals showing a developmental and epileptic encephalopathy (DEE). (stanford.edu)
We evaluated consequences of 12 intragenic variants by protein modelling and molecular dynamic studies. (springer.com)
Careful phenotyping is essential in interpreting consequences of RAD21 variants, and protein modeling and dynamics can be helpful in determining pathogenicity. (springer.com)
Truncating RAD21 variants are shown above, and missense mutations and in-frame deletions are shown below the protein representation. (springer.com)
Variants for which protein modelling is available, are marked in bold. (springer.com)
ClinVar variants which are reported in the ClinVar database and could be investigated for pathogeneity with protein modelling (see supplementary Table S6). (springer.com)
By NMR, differences in the structural configuration of the three CopG variants were not observed. (uam.es)
We prospectively enrolled seven children hospitalized with MIS-C and measured SARS-CoV-2 binding IgG antibodies to spike protein variants longitudinally pre- and post-Pfizer-BioNTech BNT162b2 primary series COVID-19 vaccination. (cdc.gov)

Mutant ISO Surge is ideal for post-workout recovery, as it helps to stimulate muscle protein synthesis and prevent muscle breakdown. (ultimatesupsg.com)
These distinct signatures of protein synthesis suggest intriguing and currently mysterious differences in the cellular consequences of deficiency for small and large ribosomal subunits. (broadinstitute.org)
Protein synthesis, folding. (msdmanuals.com)

The formation of extracellular plaques is common to all lines of transgenic mice overexpressing high levels of mutant APP. (jneurosci.org)
[ 7 ] More recent data from striatal neuronal cultures transfected with mutant huntingtin and transgenic mice carrying the spinocerebellar ataxia-1 (SCA-1) gene (another CAG repeat disorder) suggest that NIIs may not be necessary or sufficient to cause neuronal cell death, but translocation into the nucleus is sufficient to cause neuronal cell death. (medscape.com)

Despite anatomical differences, the lungs of both species are functional equivalents, so the chick can serve as an effective experimental surrogate for the formation of the BGB in mammals (Fig. 1a ). (biomedcentral.com)
We thus wondered if this residue could account for some of the functional differences between SGLT1 and SGLT3. (fiu.edu)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)

Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)

The aim of this review is to describe the differences in the phenotypic expression and clinical outcomes of Sarc+ and Sarc− HCM and to briefly discuss the current knowledge about HCM caused by rare non-sarcomeric mutations. (mdpi.com)
Strikingly, three out of five cone disease-causing PRPH2 mutations profoundly enhanced correct splicing of PRPH2, which correlated with strong upregulation of mutant PRPH2 protein expression in cones. (cipsm.de)
By contrast, the pathology of rod-specific PRPH2 mutations is rather characterized by PRPH2 downregulation and impaired protein localization. (cipsm.de)
RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)
Several mutations in the N terminus of the G-protein-coupled receptor rhodopsin disrupt NXS/T consensus sequences for N-linked glycosylation (located at N2 and N15) and cause sector retinitis pigmentosa in which the inferior retina preferentially degenerates. (jneurosci.org)
Mutations affecting glycosylation of the heptahelical G-protein-coupled receptor rhodopsin are associated with retinitis pigmentosa (RP), a disease characterized by progressive degeneration of photoreceptors. (jneurosci.org)
The gene had two mutations, resulting in a severely shortened protein that affected the function of the hair-like sensors, leading to hearing loss. (hearingreview.com)
The current study looked at the difference in disease progression in patients with differing mutations. (genengnews.com)

Cytochrome c release, caspase-3 activation, and apoptotic chromatin condensation were unchanged in all mutant fibroblasts. (nature.com)
however, significant activation of ERS in COL4A5 mutant fibroblasts was observed. (omicsdi.org)

The genetic basis of HD is the expansion of a cysteine-adenosine-guanine (CAG) repeat encoding a polyglutamine tract in the N-terminus of the protein product called huntingtin. (medscape.com)
N-terminal fragments of mutant huntingtin accumulate and form inclusions in the cell nucleus in the brains of patients with HD, as well as in various animal and cell models of HD. (medscape.com)

In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
Expression analysis of mutant XY gonads at the same stage also reveals a dramatic reduction in Sox9 and, crucially, Sry at the transcript and protein levels. (plos.org)
In addition, we show that only the correctly spliced isoform results in detectable protein expression. (cipsm.de)
By contrast, four out of six PRPH2 mutants associated with rod disorders gave rise to a reduced PRPH2 protein expression via different mechanisms. (cipsm.de)
Interestingly, expression of similar bovine rhodopsin mutants did not cause rod cell death, possibly attributable to greater stability of bovine rhodopsin. (jneurosci.org)
Together with the other pathways, the UPR leads to a decrease in the protein folding load by causing a reduction in the general level of protein translation, and by inducing the expression of protein folding machinery. (helsinki.fi)

The altered residues in these mutants are located in the dimer-dimer interaction surface observed in the SE-CopG tetramer co-crystals. (uam.es)
To examine the role of water penetration, we have measured the 17O and 2H magnetic relaxation dis- persions (MRD) for the V66E and V66K mutants of staphylococcal nuclease, where glutamic acid and lysine residues are buried in predominantly apolar environments. (lu.se)

Davon ausgenommen bleibt delta lmo0559, welche keine sRNA Mutante sonder die Deletion eines vermuteten Proteins ist. (uni-giessen.de)

CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domain recognition complex (TRC) pathway, which mediates post-translational ER-targeting and insertion of tail-anchored (TA) proteins, including SNAREs required for retrograde transport. (elifesciences.org)

Both studies suggest that defects in rhodopsin glycosylation are associated with impairment of protein folding or stability. (jneurosci.org)
ralative stability of mutant protein with respect to wild type protein. (ambermd.org)
CONCLUSIONS: Overall, this work (i) identifies variations in biofilm formation capacity among pathogenically different GAS strains, (ii) identifies GAS surface properties that may aid in biofilm stability and, (iii) establishes that the Scl1 surface protein is an important determinant of GAS biofilm, which is sufficient to enable biofilm formation in the heterologous host Lactococcus. (cdc.gov)

Mutant ISO Surge is a whey protein isolate powder that contains 25 grams of protein per serving, along with 5 grams of BCAAs and 4.6 grams of glutamine. (ultimatesupsg.com)
Mutant ISO Surge is made with high-quality whey protein isolate and hydrolysate, which are quickly digested and absorbed by the body. (ultimatesupsg.com)
Mutant ISO Surge is one of the best whey protein isolate products on the market, and you can buy it from Ultimate Sup, the most prestigious fitness nutrition brand in Singapore. (ultimatesupsg.com)
Mutant ISO Surge is a whey protein isolate and hydrolysate product that is designed to provide pure and fast-acting protein to your muscles. (ultimatesupsg.com)
Whey protein isolate is a form of whey protein that has been further processed to remove most of the lactose and fat, resulting in a product that contains about 90% protein. (ultimatesupsg.com)
Whey protein hydrolysate is a form of whey protein that has been partially broken down into smaller peptides, making it easier to digest and absorb. (ultimatesupsg.com)
Mutant ISO Surge combines these two forms of whey protein to deliver a high-quality product that can help you build muscle, recover faster, and improve your performance. (ultimatesupsg.com)
Mutant ISO Surge is made with high-quality ingredients, such as New Zealand whey protein isolate, whey protein hydrolysate, natural and artificial flavors, sea salt, sucralose, and stevia. (ultimatesupsg.com)
The Protein Mutant Whey consists of microfiltered whey protein isolates and concentrates, lipids, immunoglobulins, and amino acids, making it a powerful blend for sports nutrition. (revain.org)
In its formula, the main place is occupied by microfiltered whey protein isolates and concentrates, lipids, immunoglobulins, amino acids. (revain.org)

Briefly, they contain the human APP 695 with the double mutation K670N and M671L (Swedish mutation) and are driven by the prion protein promoter. (jneurosci.org)
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)

ALS mice that either expressed 1 or 2 mutant SEMA3A alleles demonstrated no difference in ALS-induced decline in motor behavior. (nih.gov)
Interestingly, we did observe a sex difference in motor neuron sprouting behavior after BotoxA-induced paralysis in WT mice which we speculate may be an important factor in the sex dimorphic differences seen in ALS. (nih.gov)
Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
While targeting microglia could be beneficial for other reasons in treating Alzheimer's, the scientists ultimately ruled out the hypothesis, determining that microglia did not make a difference in how quickly mice adapted. (virginia.edu)
The presence of these tangles also did not make a difference in how the mice adapted. (virginia.edu)
In mutant mice, nephropathy commenced from focal GBM irregularity by EM at 6 weeks of age, prior to exclusive crescents at 13 weeks of age. (omicsdi.org)

Cell-based and in vitro assays show that Retro-2 blocks delivery of newly-synthesized TA-proteins to the ER-targeting factor ASNA1 (TRC40). (elifesciences.org)
Plasma protein absorption assays and flow cytometry analysis revealed that pronounced binding of human fibrinogen is a common phenotype of human S. equi subsp. (lu.se)

3 Pro-apoptotic proteins, such as cytochrome c and second mitochondria-derived activator of caspase (SMAC), are released from mitochondria into the cytosol where they participate in the activation of execution caspases. (nature.com)

While much study has been devoted to genetic "triggers" of CNS neurodegeneration-notably mutant Htt in Huntington's disease (HD)-such inherited triggers are typically expressed from early fetal development and are fundamentally inaccessible to timely clinical intervention. (hdsa.org)

Importantly, all Scl1-negative mutants examined showed significantly decreased ability to form biofilm in vitro. (cdc.gov)

Regardless of their effect on rod viability, all of the mutants primarily localized to the outer segment and Golgi and showed little or no endoplasmic reticulum accumulation. (jneurosci.org)

A virB inactivation mutant BMΔvirB (BM with a promoter of the virB operon deleted) and complementary strains BM-IVGT (BMΔvirB containing complementary plasmid pBBR1-IVGT) were constructed previously (Wang et al. (a-inhibitor.com)
Differences in architecture and cell-surface morphology were observed in biofilms formed by the M1- and M41-wild-type strains, accompanied by varying amounts of deposited extracellular matrix and differences in cell-to-cell junctions within each biofilm. (cdc.gov)
zooepidemicus strains in association with differences in M-like protein-mediated binding of host plasma proteins. (lu.se)
zooepidemicus strains that the M-like protein SzM is crucial for the binding of fibrinogen to the bacterial surface and for survival in equine and human blood. (lu.se)

At the ultra-structural level, we specifically show that these mutant defects map to a very specific cog in the transduction machinery," says Gleason. (hearingreview.com)

Because a uniform dielectric ionizable group in a protein relative to the pKa value of the continuum model is a very crude description of the highly same group in a small reference molecule in dilute aqueous heterogeneous protein interior, the dielectric coefficient, eP, solution. (lu.se)

Hence, the novel surrogate myristoyl moiety not only failed to increase NOS2 activity when introduced in a wild-type sequence environment, but was also unable to rescue the inactive phenotype of the Cys3Ser mutant. (biologists.com)

Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)
SOD1 is an enzyme that neutralizes potentially dangerous molecules, but ALS-causing mutant enzymes gain an unknown toxic function. (genengnews.com)

An ASNA1 point mutant identified using CRISPR-mediated mutagenesis abolishes both the cytoprotective effect of Retro-2 against ricin and its inhibitory effect on ASNA1-mediated ER-targeting. (elifesciences.org)

Ratios were taken for each mutant strain at each temperature against the equivalent wild-type sample, and the median protein ratio calculated. (matrixscience.com)
In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no mortality. (imperial.ac.uk)
protein differences between a virB mutant and its parental strain using comparative proteomic analysis (Wang et al. (a-inhibitor.com)
To further test the effect of T4SS on the OM, in the present study, OMPs of a wild-type and a virB 4-Aminobutyrate aminotransferase mutant strain were isolated and compared. (a-inhibitor.com)

In order to explain the biochemical differences, we analysed the GTPase reaction mechanism with a linear free energy relationships approach. (rcsb.org)

The trimolter-B exhibited less distinct differences in FL content than the trimolter-A. These patterns of haemolymph proteins in the allatectomy-induced trimolters were similar to those of the recessive trimolter mutant rt. (elsevierpure.com)

We also investigated the effects of BotoxA-induced paralysis on the sprouting capacity of NMJs in the K108N-SEMA3A mutant mouse, and observed no change in the differential neuronal plasticity found at NMJs on fast-fatigable or slow muscle fibers due to the presence of the SEMA3A mutant protein. (nih.gov)

The sensors correspond to three branches of the UPR, namely protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 (IRE1) branches. (helsinki.fi)

Because the same amount of protein was loaded for each sample, we'd expect the average protein ratio for each sample to be unchanged - that is a value of 1 when the ratio to wild type is calculated - so we enabled normalization using the median ratio. (matrixscience.com)
However, EMSAs revealed a diminished affinity for DNA and altered cooperative properties in both mutants compared to the wild-type protein. (uam.es)
In the absence of palmitoylation, introduction of a surrogate myristoylation site resulted in a mutant NOS2 with only 25% activity compared with the wild-type enzyme. (biologists.com)

The mutant rhodopsins were rendered less toxic in their dark inactive states, because RD was abolished or significantly reduced when transgenic tadpoles expressing T4K, T17M, and N2S/N15S were protected from light exposure. (jneurosci.org)
Here we compare CRM197 with the alternative diphtheria non-toxic variant DT-K51E/E148K, an inactive mutant that can be produced in the periplasm of Escherichia coli. (ox.ac.uk)

Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)

Overall, our data indicate that DT-K51E/E148K is a readily produced protein that now allows the added flexibility of E. coli production in vaccine development and that can be effectively used as protein carrier for a meningococcal conjugate vaccine. (ox.ac.uk)
However, the E. coli cells did not show increased succinate dehydrogenase activity nor did the operon complement a sdhCDAB defective E. coli mutant [7]. (lu.se)
The slight difference in electrophoretic mobility of normal Fp and that produced in E. coli could be due to the absence of covalently FAD but could have another explanation because this difference was not observed for some mutant Fp without covalently bound FAD [3]. (lu.se)

CopG represses Pcr promoter, which directs the transcription of its own gen (copG) and that of the initiator protein for plasmid replication (repB). (uam.es)

Furthermore, the Scl1 protein expressed on the surface of a heterologous host, Lactococcus lactis, was sufficient to induce biofilm formation by this organism. (cdc.gov)

It is shown here for p21ras, a well studied example of GTP hydrolysing proteins, that the GTP-hydrolysis rate is significantly faster if Mg2+ is replaced by Mn2+, both in the presence or absence of its GTPase-activating protein Ras-GAP. (rcsb.org)

The protein induction of autophagy was analyzed by RT-qPCR, western blot, immunofluorescence, and electron microscopy. (frontiersin.org)
Electron micrographs of two hair cell bundles in the zebra fish ear show the difference between those born with (left) and without (right) the protein Tmie. (hearingreview.com)

Mutant ISO Surge is also affordable, easy to mix, and suitable for all fitness levels. (ultimatesupsg.com)
In humans, ribosomopathies are diseases associated with cell-type-specific pathologies and reduced ribosomal protein (RP) levels. (broadinstitute.org)
Hereditary angioedema (HAE) is an autosomal dominant disease caused by low levels of the plasma protein C1 inhibitor (C1-INH). (medscape.com)

The ionizable amino acid side chains of proteins are usually located at the surface. (lu.se)
All or other nearby charged groups, the pKa shift of a buried pH-dependent properties of proteins are ultimately governed residue is dominated by the large electrostatic self-energy by the electrostatic interactions of ionizable side chains. (lu.se)
Most ionizable side chains reside at the protein surface, parent physical significance. (lu.se)

The ABCB11 gene provides instructions for making a protein called the bile salt export pump (BSEP). (medlineplus.gov)
MUTANT is known for its innovative and cutting-edge products, such as MUTANT MASS, MUTANT PUMP, MUTANT BCAA, and MUTANT TEST. (ultimatesupsg.com)

In this study, we demonstrate that surface-associated streptococcal collagen-like protein-1 (Scl1) plays an important role in GAS biofilm formation. (cdc.gov)

By using polyacrylamide gel electrophoresis, these trimolters were analysed for the banding patterns of haemolymph proteins at their final (fourth) instar. (elsevierpure.com)
Because of the limited separation resolution of two-dimensional polyacrylamide gel electrophoresis (2-DE), only a small part of the proteins could be isolated and identified. (a-inhibitor.com)

Biophysical characterization of DT-K51E/E148K suggested high similarity with CRM197, with main differences in their alpha-helical content, and a suitable purity for conjugation and vaccine preparation. (ox.ac.uk)

Author Manuscript and RNA repair protein AlkB-derived enzyme mixture was first used to remove methylations at the Watson-Crick face. (cdc.gov)

Evaluation of the non-toxic mutant of the diphtheria toxin K51E/E148K as carrier protein for meningococcal vaccines. (ox.ac.uk)

Within the RNaseA superfamily there is a group of highly cationic proteins secreted by innate immune cells with anti-infective and immune-regulatory properties. (frontiersin.org)

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