• Patients were more satisfied with the efficacy of topiramate than with that of placebo, whereas satisfaction with tolerability was similar in both treatment groups. (nih.gov)
  • Placebos are used in randomized clinical trials to test the efficacy of medical treatments, so they serve as epistemological tools to screen out the 'noise' of clinical research. (wikipedia.org)
  • Placebos in clinical trials should ideally be indistinguishable from so-called verum treatments under investigation, except for the latter's particular hypothesized remedial factor(s). [1] This is to prevent the recipient or others from knowing (with their consent) whether a treatment is active or inactive, as expectations about efficacy can influence results. (wikipedia.org)
  • In order to further verify the ameliorative effect of HLG on ALS patients, a double-blind, placebo-controlled clinical trial would be conducted, while the placebo control implementation is an effective guarantee for blindness and clinical efficacy. (hindawi.com)
  • Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer patients receiving non-platinum-based chemotherapy. (nature.com)
  • In this pooled analysis, 348 subjects from 3 randomized, double-blind, parallel-group, active- or placebo-controlled studies were used to compare the efficacy, safety, and tolerability of oral-loaded divalproex with standard-titration divalproex, lithium, olanzapine, or placebo. (psychiatrist.com)
  • There were no efficacy differences between divalproex loading and olanzapine. (psychiatrist.com)
  • Divalproex loading showed greater efficacy than placebo at all time points. (psychiatrist.com)
  • OBJECTIVE: A placebo controlled, double-blind trial (DBT) was conducted for Japanese patients with active rheumatoid arthritis (RA) despite treatment with low dose methotrexate (MTX) to evaluate the efficacy and safety of infliximab. (jrheum.org)
  • Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. (druglib.com)
  • This study provides a prospective, randomized, double-blinded, placebo-controlled clinical trial investigating the safety profile and the efficacy of NAC to prevent hearing loss in a military population after weapons training. (cdc.gov)
  • In some studies, the placebo relieves the disorder in a high percentage of patients, making it more difficult to show the active treatment's efficacy. (msdmanuals.com)
  • A limited number of studies comparing these agents suggest no major differences in efficacy. (medscape.com)
  • There were no statistically significant differences between groups with respect to racial distribution, age, gender, or severity of autism. (bmj.com)
  • This randomized, double-blind placebo-controlled clinical trial of 312 economy class passengers travelling from Australia to an overseas destination aimed to investigate if a standardised membrane filtered elderberry ( Sambucus nigra L.) extract has beneficial effects on physical, especially respiratory, and mental health. (mdpi.com)
  • Patients were randomly assigned to continue this dose or switch to placebo for a 26-week double-blind phase. (nih.gov)
  • The primary endpoint was the difference in number of days with migraine during the last 4 weeks of the double-blind phase compared with the last 4 weeks of the open-label phase. (nih.gov)
  • 514 entered the double-blind phase and were assigned to topiramate (n=255) or placebo (n=259). (nih.gov)
  • Inhaled beclomethasone dipropionate (BDP), 500 micrograms twice per day or placebo was administered for 4 mo in a double-blind parallel group study. (nih.gov)
  • Sixty euthymic subjects with DSM-IV bipolar disorder were enrolled in an 8-week, double-blind, placebo-controlled, randomized study of WSE (500 mg/d) as a procognitive agent added adjunctively to the medications being used as maintenance treatment for bipolar disorder. (psychiatrist.com)
  • Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double-blind, placebo-controlled randomized trial. (amrita.edu)
  • We designed a randomized, double-blind, placebo-controlled trial to evaluate the role of perioperative PGE1 infusion in LDLT. (amrita.edu)
  • Multicenter, randomized, double-blind, placebo-controlled trial conducted at 10 hospitals in Denmark, including 4 large university hospitals. (emra.org)
  • A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial. (iasp-pain.org)
  • Q-CABG is a phase II, prospectively registered, randomized, double-blind and placebo-controlled clinical trial. (frontiersin.org)
  • Eighteen privately-owned entire male dogs were enrolled in this double-blind, placebo-controlled, randomized clinical trial. (frontiersin.org)
  • To determine the ability of parents of children with autism to guess, under double blind conditions, whether their child had received secretin or placebo. (bmj.com)
  • We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis. (bmj.com)
  • A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis. (jrheum.org)
  • C. grimmi fishoil.Thedailysupplement forseveralyears,womenhavepainful Youngwomenwithdysmenorrhoea was15mL,takenasasingledosestart- menseswithoutdemonstrablepelvicab- werefol owedupinthissingle-centre, ingatthebeginningofthemenstrual normality[ 1 ].Symptomsmaydecrease double-blind, randomized, placebo- cycleandcontinuedfor3consecutive afterpregnancy[ 2 ].Amongfemaleado- controlled,6cyclecrossoverstudy.All months.Thedosageandthe3-month lescentsitisthemostcommongynae- theparticipantssignedconsentforms. (who.int)
  • For example, a patient may feel better after taking a placebo due to regression to the mean (i.e. a natural recovery or change in symptoms), but this can be ruled out by comparing the placebo group with a no treatment group (as all the placebo research does). (wikipedia.org)
  • A randomised placebo controlled superiority trial was performed. (bmj.com)
  • Use of preventive therapy for migraine is often recommended for only 6-9 months, but no randomised, placebo-controlled trials have investigated migraine frequency after the end of prophylaxis. (nih.gov)
  • A placebo (/pləˈsiːboʊ/ plə-SEE-boh) can be roughly defined as a sham medical treatment. (wikipedia.org)
  • Common placebos include inert tablets (like sugar pills), inert injections (like saline), sham surgery, and other procedures. (wikipedia.org)
  • The medical community has been aware of the placebo effect - the phenomenon in which a nontherapeutic treatment (like a sham pill) improves a patient's physical condition - for centuries. (wanttoknow.info)
  • To do this, a sham treatment (the placebo) is given, but the patient believes it is effective and expects a clinical improvement. (jneurosci.org)
  • The placebo effect, or response, is the outcome after the sham treatment. (jneurosci.org)
  • More recently, sham interventions (eg, mock electrical stimulation or simulated surgical procedures in clinical trials) have also been considered placebos. (msdmanuals.com)
  • 2×2 crossover randomised blinded study, comparing the effect of synthetic human secretin 2 U/kg to placebo (saline). (bmj.com)
  • Group 1 received saline placebo initially, followed six weeks later by human synthetic secretin (ChiRhoClin, Silver Spring, Maryland). (bmj.com)
  • Researchers in France conducted a randomized, placebo-controlled study called ANRS 120-Fosivir in HIV-positive people with osteoporosis. (catie.ca)
  • Ketamine was no more effective than placebo in reducing depressive symptoms in surgical patients with major depressive disorder (MDD), results of a new study, which contradict prior research, suggest. (medscape.com)
  • An influential 1955 study entitled The Powerful Placebo firmly established the idea that placebo effects were clinically important, and were a result of the brain's role in physical health. (wikipedia.org)
  • A 1997 reassessment found no evidence of any placebo effect in the source data, as the study had not accounted for regression to the mean. (wikipedia.org)
  • 112/146 patients (76.7%) taking ropinirole and 109/138 (79.0%) taking placebo completed the study. (bmj.com)
  • In this study, the established similarity evaluation methods based on the CQAs were convenient and reliable, which can be utilized to evaluate the similarity of TCM granule and their placebo at granule and solution status, and demonstrated to be well applied in placebo-controlled trials. (hindawi.com)
  • Methods The STEM-AMI Trial was a prospective, placebo-controlled, multicentre study. (bmj.com)
  • Therefore, it is important to emphasize that the study of the placebo effect is the study of the psychosocial context around the patient. (jneurosci.org)
  • The study of the placebo effect, at its core, is the study of how the context of beliefs and values shape brain processes related to perception and emotion and, ultimately, mental and physical health. (jneurosci.org)
  • The study of the placebo effect reflects a current neuroscientific thought that has as its central tenet the idea that "subjective" constructs such as expectation and value have identifiable physiological bases, and that these bases are powerful modulators of basic perceptual, motor, and internal homeostatic processes. (jneurosci.org)
  • The study of the placebo effect also has immediate clinical and ethical implications, because the use of inactive (placebo) conditions in clinical trials when effective treatments are available has created an ethical controversy. (jneurosci.org)
  • In the same study, if the placebo response was obtained after exposure to opioid drugs, it was naloxone reversible, whereas if it was obtained after exposure to non-opioid drugs, it was naloxone insensitive. (jneurosci.org)
  • These subjects then received ivabradine (15mg) or placebo one hour prior to capsaicin application in randomly allocated order in a crossover study. (iasp-pain.org)
  • Perioperative treatment to preserve nerve function did not significantly improve erectile function after surgery for prostate cancer, a randomized, placebo-controlled study showed. (medpagetoday.com)
  • In a study of more than 340 patients suffering from low back or neck pain, a team of Australian researchers found there was no difference in pain severity after six weeks between those who received opioids versus a placebo sugar pill. (wskg.org)
  • The BLOOM-DM study was a 1-year RCT in Type 2 diabetics taking metformin or SU, or both, comparing placebo with 10 mg lorcaserin daily (q.d.) versus lorcaserin 10 mg twice daily (b.i.d. (medscape.com)
  • Therefore, as one component of a multifaceted study of secretin in children with autism, 1 we asked parents simply to guess whether their child had received secretin or placebo, and to provide the basis for their guess. (bmj.com)
  • At the conclusion of the study, but prior to unblinding, we asked parents to guess which infusion they believed to have been placebo, and which to have been secretin, using any criteria they wished. (bmj.com)
  • This 5-arm study compared TDiclo with a placebo solution, the DMSO vehicle, oral diclofenac (ODiclo) and the combination of TDiclo+ODiclo for relieving the signs and symptoms of knee osteoarthritis. (druglib.com)
  • Of the 566 total study subjects, 277 received NAC while 289 were given placebo. (cdc.gov)
  • While the secondary outcomes and post-hoc analysis suggest that NAC treatment is superior to the placebo, the present study design failed to confirm this. (cdc.gov)
  • MADRS scores dropped by around half 1 day after treatment, indicating an improvement in depressive symptoms in both the group that received ketamine (mean decrease from 25 to 12.6 points) and the group that received placebo (mean decrease from 30 to 15.3 points). (medscape.com)
  • The ketamine group had a significantly shorter hospital stay (1.9 days) than the placebo group (4 days) ( P = .02). (medscape.com)
  • Quality of life, as assessed by the MIDAS questionnaire, fell in the placebo group but remained stable in the topiramate group. (nih.gov)
  • In a placebo-controlled clinical trial any change in the control group is known as the placebo response, and the difference between this and the result of no treatment is the placebo effect. (wikipedia.org)
  • None of the other cognitive tasks showed significant between-group differences. (psychiatrist.com)
  • At 8 weeks there was a significant decrease in elbow pain with activity in the glyceryl trinitrate 0.72 mg/24 h group compared with placebo (p = 0.04). (bmj.com)
  • In fact, the median score favored the placebo group (19 vs 14). (medpagetoday.com)
  • Patients who had new low back or neck pain for 12 weeks or fewer were recruited from more than 150 primary care clinics and emergency departments in Sydney, Australia, and randomly assigned to either the opioid group or the placebo group. (wskg.org)
  • At 1 year mean weight loss from baseline was 6.2% (±0.5%) in those on orlistat versus 4.3% (±0.5%) in the placebo group. (medscape.com)
  • Improved glycemic control, as evidenced by a significant reduction of 0.28% (±0.09%) in HbA 1c versus an increase of 0.18% (±0.11%) in the placebo group and reduced fasting glucose and a better lipid profile, were also noted in the orlistat group. (medscape.com)
  • However, a worsening of the sex hormone related problems (i.e., urinary marking, mounting, aggressiveness toward other dogs and/or escape) was only observed in the placebo group, in 56 or 66% of the dogs as measured by respectively the veterinarian and the owners. (frontiersin.org)
  • Sixty two children with autism (aged 43-103 months) were randomly allocated to two groups: group 1 received placebo, followed six weeks later by secretin, and group 2 received secretin followed by placebo. (bmj.com)
  • Subjects in Group 2 received human synthetic secretin first, followed six weeks thereafter by placebo. (bmj.com)
  • 205 mg decosahexaenoic acid) while Group B received placebo. (who.int)
  • The control treatment was placebo ointment, which consisted of a mixture of soft white and liquid paraffin with no known anti-infective properties. (bmj.com)
  • Participants in the ketamine and placebo groups also reported high rates of clinical response (60% and 50%, respectively) and remission (50% and 35%, respectively), again with no significant difference based on treatment with ketamine or placebo. (medscape.com)
  • The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor-patient relationship and bypasses informed consent. (wikipedia.org)
  • While it was once assumed that this deception was necessary for placebos to have any effect, there is some evidence that placebos may have subjective effects even when the patient is aware that the treatment is a placebo (known as "open-label" placebo). (wikipedia.org)
  • Some researchers now recommend comparing the experimental treatment with an existing treatment when possible, instead of a placebo. (wikipedia.org)
  • The idea of a placebo effect-a therapeutic outcome derived from an inert treatment-was discussed in 18th century psychology, but became more prominent in the 20th century. (wikipedia.org)
  • the placebo effect is the difference between that response and no treatment. (wikipedia.org)
  • placebo, n = 29), and the 2 groups were matched in terms of demographic, illness, and treatment characteristics. (psychiatrist.com)
  • Nearly twice as many people in the trial who knowingly received placebo pills reported experiencing adequate symptom relief, compared with the people who received no treatment. (wanttoknow.info)
  • But a new UNSW Sydney-led trial, the results of which are published today in The Journal of the American Medical Association (JAMA) , compared the results of the laser to results from a placebo treatment - and surprisingly, it found there was no difference between the two. (menopause.org.au)
  • The women were randomly split into two groups: half were given the laser treatment, while the other half were given a placebo treatment. (menopause.org.au)
  • No matter which way you look at it, there wasn't any difference between whether you had the actual laser or whether you had this placebo treatment," says Prof. Abbott. (menopause.org.au)
  • In that case, the differences in outcomes between the treatment unit (policies implemented during Morales's Presidency) and the control unit could be, in principle, attributed to the policies. (springer.com)
  • The most common adverse events in treatment-experienced adult subjects (greater than 8% incidence) which occurred at a higher frequency compared with placebo are upper respiratory tract infections, cough, pyrexia, rash, and dizziness. (drugs.com)
  • There was no significant difference in incidence of adverse events among the treatment groups. (jrheum.org)
  • and the shading used, it is easy to see that more people given the placebo experienced no improvement, while more people given the active treatment reported marked improvement. (r-project.org)
  • The treatment groups reported a significant difference after 3 months of supplementation with fish oil (visual analogue scale score 20.9 compared with 61.8 for the placebo ( P = 0.001). (who.int)
  • The lack of significant differences in overall hearing loss between the treatment and placebo groups may be due to a number of factors, including suboptimal dosing, premature post-exposure audiograms, or differences in risk between ears or subjects. (cdc.gov)
  • Many clinical trials compare an active treatment with a placebo. (msdmanuals.com)
  • However, when a placebo is given in medical practice, patients are not told they are receiving an inactive treatment. (msdmanuals.com)
  • Thirty-two participants (mean age, 22.8 years) undergoing fixed orthodontic appliance treatment after maxillary premolar extraction were randomly allocated in a parallel fashion to either receive (1) MW with an active component of chlorhexidine or (2) a placebo. (bvsalud.org)
  • Serum high sensitivity CRP levels at week 16 were significantly reduced with secukinumab 75 mg, 150 mg and 300 mg doses versus placebo. (bmj.com)
  • The randomized, placebo-controlled trial included 40 patients who had previously been diagnosed with MDD and who were scheduled for elective noncardiac, nonintracranial surgery. (medscape.com)
  • The placebo response may include improvements due to natural healing, declines due to natural disease progression, the tendency for people who were temporarily feeling either better or worse than usual to return to their average situations (regression toward the mean), and errors in the clinical trial records, which can make it appear that a change has happened when nothing has changed. (wikipedia.org)
  • launched the first open-label placebo, or so-called honest placebo, trial to date, starting with people who had [irritable bowel syndrome, or] IBS. (wanttoknow.info)
  • Intention-to-treat hierarchical analysis revealed no significant effects of the drug on primary trial outcome, defined as a difference in effects of placebo and ivabradine on the area of punctate hyperalgesia (ivabradine - placebo: mean=3.22 cm2, 95% CI: = -4.04, 10.48, p=0.37). (iasp-pain.org)
  • Methods and analysis The InterVitaminK trial is a randomised, double-blinded, placebo-controlled, trial. (lu.se)
  • Effect of chlorhexidine mouthwash on gingival health around orthodontic miniscrew implants: A pilot placebo-controlled randomized trial. (bvsalud.org)
  • In this 20-week, randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency received 2000 IU/d vitamin D 3 or placebo. (medscape.com)
  • In patients treated with BDP compared with placebo, there was a significant reduction in toluidine blue-staining mast cells (p = 0.028) and total (p = 0.005) and activated eosinophils (p = 0.05) in biopsies but no difference in eosinophils or eosinophil cationic protein in BAL. (nih.gov)
  • For example, a placebo can reduce pain by both opioid and non-opioid mechanisms ( Colloca and Benedetti, 2005 ) ( Fig. 1 ). (jneurosci.org)
  • In the first case, placebo analgesia is typically blocked by the opioid antagonist naloxone, whereas in the second case it is not, depending on the procedure that is applied to induce the placebo analgesic response. (jneurosci.org)
  • But what most people - patients and clinicians alike - don't know is that in more than half of the 47 trials used by the Food and Drug Administration to approve the six leading antidepressants on the market, the drugs failed to outperform sugar pills, and in the trials that were successful, the advantage of drugs over placebo was slight. (dpl-surveillance-equipment.com)
  • That, and not the power of suggestion, is why antidepressants barely outperform placebos, these scientists say. (dpl-surveillance-equipment.com)
  • Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. (drugs.com)
  • there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. (drugs.com)
  • Participants didn't know if they were receiving the medication or a placebo. (wskg.org)
  • Because participants acknowledge in advance that they may be given a placebo, there is no concern about deception. (msdmanuals.com)
  • Participants will be given 25000 IU of oral retinyl Palmitate (Vitamin A) or Placebo once daily for 12 weeks. (who.int)
  • However, exceptions do exist: one example is Parkinson's disease, where recent research has linked placebo interventions to improved motor functions. (wikipedia.org)
  • Thus, placebo effects may represent points of either strength or vulnerability for the expression and maintenance of various pathological states and their inherent therapeutic interventions. (jneurosci.org)
  • Placebos are inactive substances or interventions, most often used in controlled studies for comparison with potentially active drugs. (msdmanuals.com)
  • p=0.048) for (223)Ra versus placebo, respectively. (researchgate.net)
  • Disease activity score in 28 joints (DAS28)-C-reactive protein (CRP) was a secondary endpoint and clinically relevant decreases with secukinumab 75-300 mg were reported versus placebo. (bmj.com)
  • To evaluate the similarity of Huoling Shengji granule (HLG) and its placebo at both granules and solution status, the innovative methods that consist of intelligent sensory evaluation technologies and human sensory evaluation methods were developed based on critical quality attributes (CQAs) of granule. (hindawi.com)
  • Methods Patients (n=237) with inadequate response to methotrexate were randomly assigned to receive monthly subcutaneous injections of secukinumab 25 mg, 75 mg, 150 mg, 300 mg or placebo. (bmj.com)
  • METHODS: In the DBT, 147 patients were randomly assigned and treated with a placebo or 3 mg/kg or 10 mg/kg infliximab at Weeks 0, 2 and 6, combined with MTX. (jrheum.org)
  • Methods: Ninety-six New York apple harvest workers were randomly assigned to use the intervention hip belt or placebo belt for one week. (cdc.gov)
  • More important to Kaptchuk than understanding why honest placebos work is figuring out how the gain in scientific knowledge could translate into clinical practice. (wanttoknow.info)
  • 10 subjects/arm 80% power to detect a 1 SD difference. (natap.org)
  • All subjects received a 4.7 mg deslorelin implant by SC route and 1-3 capsules containing either cyproterone acetate 2 mg/kg ( N = 9) or a placebo ( N = 9), by oral route BID for 14 days, depending on the dog's weight. (frontiersin.org)
  • Both women knew that half the test subjects were getting placebos and that Schonfeld might be among them. (dpl-surveillance-equipment.com)
  • No significant difference was found in the second primary outcome, percentage of subjects experiencing an adverse event between placebo and NAC groups (26.7% and 27.4%, respectively, p = 0.4465). (cdc.gov)
  • There was no difference in bronchial responsiveness or lung function between groups. (nih.gov)
  • No significant differences were found in mortality and MACCE between G-CSF and placebo-treated groups. (bmj.com)
  • After 12 months, the research team compared outcomes - both self-reported changes as well as changes reported by an assessing doctor or independent pathologist - and found there wasn't any difference between the two groups. (menopause.org.au)
  • But these improvements happened to both the laser and placebo groups. (menopause.org.au)
  • Investigators also found no significant difference between groups at 3, 9, and 12 months. (medpagetoday.com)
  • As the ideal experiment, in which the systematic difference among two groups is clearly defined, is generally not available in social sciences, causal inference about the effects of events requires the development of different techniques. (springer.com)
  • Groups of animals (n=4) were treated (every 8 hours, 50mg/kg) for 14 consecutive days with 150mg/kg/day of favipiravir (red) or placebo (blue) beginning on day 4 post-infection. (cdc.gov)
  • There was no significant difference between both groups in terms of survivability (P = .585). (bvsalud.org)
  • No difference was observed between all groups during the different experimental periods in relation to biochemical composition. (bvsalud.org)
  • The term is sometimes used for an active drug that is given solely for its placebo effect on a disorder in which the drug is inactive (eg, an antibiotic for patients with viral illness). (msdmanuals.com)
  • Placebos can improve patient-reported outcomes such as pain and nausea but also objective outcomes such as motor functions and immune/endocrine parameters. (wikipedia.org)
  • That's because placebos do not appear to affect the actual diseases, or outcomes that are not dependent on a patient's perception. (wikipedia.org)
  • No differences have been detected in clinical outcome. (bmj.com)
  • While no significant differences were found for the primary outcome, rate of threshold shifts, the right ear threshold shift rate difference did approach significance (p = 0.0562). (cdc.gov)
  • Results for the secondary outcome, STS rate in the trigger hand ear, did show a significant difference (34.98% for placebo-treated, 27.14% for NAC-treated, p-value = 0.0288). (cdc.gov)
  • The placebo effect is a psychobiological phenomenon that can be attributable to different mechanisms, including expectation of clinical improvement and pavlovian conditioning. (jneurosci.org)
  • Recruited patients awaiting CABG surgery at the Montreal Heart Institute (n = 100) will be randomly assigned in a 1:1 ratio to receive either quercetin supplementation (500 mg twice daily) or placebo, starting 2 days before surgery and until the seventh postoperative day. (frontiersin.org)
  • However, it has been well documented that placebo effects can obscure those of active conditions, even for treatments that were eventually demonstrated to be effective. (jneurosci.org)
  • Scientists are interested in placebo responses because the effects of belief on human experience and behavior provide an entry point for studying internal control of affective, sensory, and peripheral processes. (jneurosci.org)
  • Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). (wikipedia.org)
  • A 2001 Cochrane Collaboration meta-analysis of the placebo effect looked at trials in 40 different medical conditions, and concluded the only one where it had been shown to have a significant effect was for pain. (wikipedia.org)
  • Measuring the extent of the placebo effect is difficult due to confounding factors. (wikipedia.org)
  • A 2009 Scientific American article describes how the placebo effect reduced the size of tumors. (wanttoknow.info)
  • Prof Abbott says this highlights the power of the placebo effect. (menopause.org.au)
  • The placebo effect can have a very profound arrangement on the way that someone perceives their symptoms," he says. (menopause.org.au)
  • We're very keen to try and better understand how that happens and how the placebo effect works. (menopause.org.au)
  • These results suggest the oral loading of divalproex leads to a more rapid antimanic effect when compared with standard-titration divalproex, lithium, or placebo and is better tolerated than olanzapine and as well tolerated as lithium or standard-titration divalproex. (psychiatrist.com)
  • Thus, we have to look for different mechanisms in different conditions, because there is not a single placebo effect but many. (jneurosci.org)
  • a multicenter RCT was conducted in Type 2 diabetics, who were clinically stable on a SU, to compare the effect of a hypocaloric diet plus either orlistat or placebo. (medscape.com)
  • [ 85 ] A later 1-year, multicenter RCT to assess the effect of orlistat and hypocaloric diet in Type 2 diabetics on metformin showed that orlistat-treated patients lost significantly more weight at 1 year compared with placebo (4.7 ± 0.3 kg vs 1.8 ± 0.3 kg, respectively). (medscape.com)
  • The placebo effect typically occurs more with subjective responses (eg, pain, nausea) rather than objective ones (eg, rate of healing of leg ulcers, infection rate of burn wounds). (msdmanuals.com)
  • and often makes them feel better-due to the placebo effect or spontaneous improvement. (msdmanuals.com)
  • According to the recent surveys, from 2008 to 2018, the number of randomized placebo-clinical trials has always shown an upward trend [ 1 ]. (hindawi.com)
  • to be meaningful, a clinically and statistically significant difference is required. (msdmanuals.com)
  • Sixty consecutive patients with a first anterior STEMI, who underwent primary percutaneous coronary intervention 2-12 h after symptom onset, with LV ejection fraction (LVEF) ≤45% measured by echocardiography within 12 h after successful revascularisation (TIMI flow score ≥2), were randomised 1:1 to G-CSF (5 µg/Kg body weight b.i.d . ) or placebo. (bmj.com)
  • Median overall survival was 65.3 weeks (48.7-infinity) for (223)Ra and 46.4 weeks (32.1-77.4) for placebo (p=0.066, log rank). (researchgate.net)
  • Placebo (pronounced /plaˈkebo/ or /plaˈt͡ʃebo) is Latin for [I] shall be pleasing. (wikipedia.org)
  • The term placebo (Latin for "I will please") initially referred to an inactive, harmless substance given to patients to make them feel better by the power of suggestion. (msdmanuals.com)
  • A total of 450 men and women aged 52-82 years with detectable coronary artery calcification (CAC), but without manifest CVD, will be randomised (1:1) to receive daily MK-7 (333 μg/day) or placebo tablets for 3 years. (lu.se)
  • In clinical studies, the ethical consideration is whether a placebo should be given at all. (msdmanuals.com)
  • Placebos, although physiologically inactive, may have substantial effects-good and bad. (msdmanuals.com)
  • In this investigation, the novel intelligent sensory evaluation technologies including the physical property testing apparatus, computer vision system, color card, and electronic tongue (E-tongue) were employed for characterization of CQAs of HLG and its placebo. (hindawi.com)
  • Meanwhile, human sensory evaluation by test panels was used to description the HLG and its placebo in terms of appearance, color, taste, and smell. (hindawi.com)
  • The intelligent and human sensory evaluation results showed that the similarity values of HLG and its placebo about the CQAs at granule and solution status were all close to 1, which means that the two preparations have high similarities. (hindawi.com)
  • Six months after radical prostatectomy, patients treated with erythropoietin (EPO) or placebo had similar scores on a validated scale of erectile function. (medpagetoday.com)
  • the existence of placebo effects suggests that we must broaden our conception of the limits of endogenous human capability. (jneurosci.org)
  • In a controlled setting, parents of young children with autism are unable to distinguish the short term behavioural effects of secretin from placebo. (bmj.com)
  • In total, 972 patients were recruited and randomised to topical chloramphenicol ointment (n=488) or placebo (n=484). (bmj.com)
  • Six families saw no difference after either infusion, and offered no guess. (bmj.com)
  • correlations between personality characteristics and response to placebos have been theorized but not well established. (msdmanuals.com)
  • Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)
  • In an experimental model of pain ( Amanzio and Benedetti, 1999 ), the placebo response could be blocked by naloxone if it was induced by strong expectation cues, whereas if the expectation cues were reduced, it was insensitive to naloxone. (jneurosci.org)
  • We thought there would be some pain relief, but overall there was no difference. (wskg.org)
  • In short-term clinical trials, the most commonly reported adverse reactions (≥2% and greater than placebo) were: musculoskeletal pain, nausea/vomiting, upper respiratory infection, diarrhea, and headache. (nih.gov)
  • [ 18 ] For instance, VDBP levels were significantly lower in blacks than in whites when using the monoclonal antibody immunoassay, whereas no racial differences were detected when using polyclonal antibody immunoassay or proteomics. (medscape.com)
  • No significant differences in one-day muscle fatigue were found with intervention use. (cdc.gov)