SynthesisAmmoniaGlacialEthanolamineTertiaryCarboxylic acidSolubleSulfuric acidDerivativesMethanolSodium SaltMechanismFattyHydrogenReactionAminoSaltsGroupsMediaStrongGroupPositionFormCarboxylic acidsBoronicBenzylMethylEthanolIUPACCatalystsAcetoacetateChlorineReactsChloridesAssayProcessesEsterSolutionsWaterFormationDirectly
Synthesis6
- The original Knorr synthesis employed two equivalents of ethyl acetoacetate, one of which was converted to ethyl 2-oximinoacetoacetate by dissolving it in glacial acetic acid, and slowly adding one equivalent of saturated aqueous sodium nitrite, under external cooling. (wikipedia.org)
- R1 and R3 (as well as R2 and "Et") can be varied by the application of appropriate β-ketoesters readily made by a synthesis emanating from acid chlorides, Meldrum's acid, and the alcohol of one's choice. (wikipedia.org)
- Ethyl and benzyl esters are easily made thereby, and the reaction is noteworthy in that even the highly hindered tert-butyl alcohol gives very high yields in this synthesis. (wikipedia.org)
- George Kleinspehn reported that the Fischer-Fink connectivity could be forced to occur exclusively, by the use of diethyl oximinomalonate in the synthesis, with 2,4-pentanedione, or its 3-alkyl substituted derivatives. (wikipedia.org)
- Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants. (chemicalbook.com)
- Step 1: Synthesis of tert-butyl 5-hydroxypentylcarbamate (AU)[0558] To a stirred solution of 5-aminopentan-l-ol (AT, 3.1 g, 30.05 mmol) in dichloromethane (30 mL) was added di-tert-butyl dicarbonate (6.56 g, 30.06 mmol) at 0 °C. The resulting mixture was then stirred at rt for 4h. (ambeed.com)
Ammonia1
- Ethanolamines were prepared in 1860 by Wurtz from ethylene chlorohydrin and aqueous ammonia. (chemicalbook.com)
Glacial2
- Modern practice is to add the oxime solution resulting from the nitrosation and the zinc dust gradually to a well-stirred solution of ethyl acetoacetate in glacial acetic acid. (wikipedia.org)
- The 5-methyl group can be variously oxidized to chloromethyl, aldehyde, or carboxylic acid functionality by the use of stoichiometric sulfuryl chloride in glacial acetic acid. (wikipedia.org)
Ethanolamine2
- Ethanolamine is a kind of viscous hygroscopic amino alcohol contains both amine and alcohol chemical groups. (chemicalbook.com)
- Various product ranges available with us are Acetophenone, Acetonitrile, Adipic Acid, Acrylonitrile and Amino Ethyl Ethanolamine. (chemical-supplier.net)
Tertiary2
- Benzyl groups can be removed by catalytic hydrogenolysis over palladium on carbon, and tertiary-butyl groups can be removed by treatment with trifluoroacetic acid, or boiling aqueous acetic acid. (wikipedia.org)
- It is a member of ethanolamines, a tertiary amino compound and a primary alcohol. (lookchem.com)
Carboxylic acid1
- If there is another functional group at a carbon, it may be named with the Greek letter, e.g., the gamma-amine in gamma-aminobutyric acid is on the third carbon of the carbon chain attached to the carboxylic acid group. (wikipedia.org)
Soluble1
- Plus, when functional groups are more electronegative than atoms they attach to, the functional groups will become polar, and the otherwise nonpolar molecules containing these functional groups become polar and so become soluble in some aqueous environment. (wikipedia.org)
Sulfuric acid1
- Dissolving Knorr's pyrrole in concentrated sulfuric acid, and then pouring the resulting solution into water will hydrolyze the 4-ester group selectively. (wikipedia.org)
Derivatives1
- Large quantities are used in the production of formaldehyde and other chemical derivatives such as acetic acid, methyl halides and terephthalate, methyl methacrylate, and methylamines. (chemicalbook.com)
Methanol3
- Methanol is the simplest fatty alcohol. (chemicalbook.com)
- Methanol has the general properties of a primary aliphatic alcohol. (chemicalbook.com)
- Methanol is also used as a gasoline additive, as a component of lacquer thinners, in antifreeze preparations of the "nonpermanent" type, and in canned heating preparations of jellied alcohol. (chemicalbook.com)
Sodium Salt1
- Sodium Alginate is the sodium salt form of alginic acid and gum mainly extracted from the cell walls of brown algae, with chelating activity. (kuwaityellowpagesonline.com)
Mechanism2
- The mechanism requires zinc and acetic acid as catalysts. (wikipedia.org)
- My teacher told me that the following is the mechanism for oxidation of primary alcohols to carboxylic acids: I've searched in books and online and didn't find a similar mechanism. (stackexchange.com)
Fatty1
- drugs and pharmaceuticals, and fatty acid. (lookchem.com)
Hydrogen3
- Why can't alcohols form hydrogen-bonded dimers like carboxylic acids? (stackexchange.com)
- The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. (chemicalbook.com)
- Most of the caustic soda produced on a commercial scale is based on the electrolysis of aqueous sodium chloride (brine), which also generates chlorine and hydrogen as co-products (chlor-alkali processes). (intratec.us)
Reaction1
- The reaction mixture was diluted with saturated aqueous NaHCC>3 (90 mL) and extracted with EtOAc (400 mL). (ambeed.com)
Amino2
- In a human body, 90% of an essential amino acid, tryptophan, is metabolized into kynurenine and subsequently into 3OH-kynurenine, quinolinic acid, and the like in the kynurenine pathway, the initiation step of which involves IDO. (justia.com)
- To a 1.0 L one-neck round-bottom flask containing a solution of 5 -amino- 1-pentanol (15.0 g, 145.4 mmol) in water (140 mL) and saturated aqueous NaHCC>3 (1.4 mL), a solution of di-tert-butyl dicarbonate (33.3 g, 152.7 mmol) in THF (280 mL) was added. (ambeed.com)
Salts1
- Since Caustic Soda solution is highly alkaline, it is widely used to neutralize acid solutions forming sodium salts. (intratec.us)
Groups1
- The two ester positions can be more smoothly differentiated by incorporating benzyl or tert-butyl groups via the corresponding acetoacetate esters. (wikipedia.org)
Media2
- While oral administration is a preferred route of drug delivery, many CBi receptor compounds suffer from poor oral bioavailability as a consequence of their limited solubility in aqueous media and their metabolic lability. (allindianpatents.com)
- This high lipophilicity leads to poor solubility in aqueous media which limits oral absorption and bioavailability. (allindianpatents.com)
Strong1
- Incompatible with strong oxidizing agents, acids. (lookchem.com)
Group1
- The compound is 3,4-dihydronaphthalen-1-one substituted in position 5 with a 3-( tert -butylamino)-2-hydroxypropoxyl group. (sciendo.com)
Position1
- IUPAC conventions call for numeric labeling of the position, e.g. 4-aminobutanoic acid. (wikipedia.org)
Form1
- Carboxylic acids such as acetic acid are capable of forming dimers: I'm wondering why alcohols like ethanol don't generally form dimers. (stackexchange.com)
Carboxylic acids2
- This disclosure relates to processes to form arylcyclopropyl carboxylic acids useful in forming molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda. (justia.com)
- A method for the preparation of N -acylpyrroles involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. (organic-chemistry.org)
Boronic2
- 37 4-Chloro-2-(4-chloro-quinolin-2-yl)-phenol 2,4-Dichloroquinoline (0.29 g, 1.5 mmol), 2-hydroxy-5-chloro boronic acid (0.24 g, 1.44 mmol), sodium carbonate (0.31 g, 3 mmol) and palladium tetrakistriphenylphosphine (0.086 g, 0.075 mmol) were suspended in a previously degassed mixture of toluene (3 mL) and water (1 mL). (ambeed.com)
- 27 {(R)-2-[2-(5-Chloro-2-hydroxy-phenyl)-pyrimidin-4-ylamino]-1-methyl-ethyl}-carbamic acid benzyl ester (5-Chloro-2-hydroxyphenyl)boronic acid (0.6 mmol, 0.1 g) and palladium tetrakistriphenylphosphine (0.01 mmol, 0.011 g) were weighed into a tube and placed under a nitrogen atmosphere. (ambeed.com)
Benzyl3
- The two ester positions can be more smoothly differentiated by incorporating benzyl or tert-butyl groups via the corresponding acetoacetate esters. (wikipedia.org)
- Benzyl groups can be removed by catalytic hydrogenolysis over palladium on carbon, and tertiary-butyl groups can be removed by treatment with trifluoroacetic acid, or boiling aqueous acetic acid. (wikipedia.org)
- Ethyl and benzyl esters are easily made thereby, and the reaction is noteworthy in that even the highly hindered tert-butyl alcohol gives very high yields in this synthesis. (wikipedia.org)
Methyl2
- The 5-methyl group can be variously oxidized to chloromethyl, aldehyde, or carboxylic acid functionality by the use of stoichiometric sulfuryl chloride in glacial acetic acid. (wikipedia.org)
- Providing you the best range of liquid cyclohexanone chemical, n propanol (npa), n methyl aniline (mma), industrial grade acrylic acid 200 kg, hydrogen peroxide 50% inmppmported solvents and liquid acetonitrile fresh with effective & timely delivery. (crystalchemitrade.com)
Ethanol4
- For the use of ethanol as a fuel, see alcohol fuel . (wikidoc.org)
- Ethanol , also known as ethyl alcohol , drinking alcohol or grain alcohol , is a flammable, colorless, slightly toxic chemical compound , and is best known as the alcohol found in alcoholic beverages . (wikidoc.org)
- Michael Faraday prepared ethanol by the acid-catalyzed hydration of ethylene in 1828, in a process similar to that used for industrial ethanol synthesis today. (wikidoc.org)
- Ethanol served as lamp fuel in the United States as early as 1840, although taxes levied during the Civil War on industrial alcohol rendered the practice uneconomical. (wikidoc.org)
IUPAC3
- crylic acid (IUPAC: propenoic acid) is an organic compound with the formula CH 2 =CHCOOH. (crystalchemitrade.com)
- Chlorosulfuric acid ( IUPAC name: sulfurochloridic acid) is the inorganic compound with the formula HSO 3 Cl. (crystalchemitrade.com)
- What should be the correct IUPAC name of diethyl chloromethane? (samacheer-kalvi.com)
Catalysts2
- The mechanism requires zinc and acetic acid as catalysts. (wikipedia.org)
- The use of ruthenium-based pincer-type catalysts enables the synthesis of substituted pyrroles via dehydrogenative alcohol functionalization reactions. (organic-chemistry.org)
Acetoacetate2
- The original Knorr synthesis employed two equivalents of ethyl acetoacetate, one of which was converted to ethyl 2-oximinoacetoacetate by dissolving it in glacial acetic acid, and slowly adding one equivalent of saturated aqueous sodium nitrite, under external cooling. (wikipedia.org)
- Modern practice is to add the oxime solution resulting from the nitrosation and the zinc dust gradually to a well-stirred solution of ethyl acetoacetate in glacial acetic acid. (wikipedia.org)
Chlorine1
- It is also known as chlorosulfonic acid, being the sulfonic acid of chlorine. (crystalchemitrade.com)
Reacts1
- Phosgene reacts with water to form corrosive acids, reacts with most metals in the presence of moisture, liberating hydrogen, an extremely flammable gas, and reacts violently with alkalis. (lookchem.com)
Chlorides1
- R1 and R3 (as well as R2 and "Et") can be varied by the application of appropriate β-ketoesters readily made by a synthesis emanating from acid chlorides, Meldrum's acid, and the alcohol of one's choice. (wikipedia.org)
Assay1
- Consequently, the extracts were significantly more effective to bleach β-carotene in the β-carotene-linoleic acid assay in comparison with the control. (csic.es)
Processes1
- Commercial manufacturing processes generate aqueous solutions containing 70-87% urea, which may be directly used as fertilizer or, most commonly, further processed into granules, prills, flakes, etc. (intratec.us)
Ester1
- Dissolving Knorr's pyrrole in concentrated sulfuric acid, and then pouring the resulting solution into water will hydrolyze the 4-ester group selectively. (wikipedia.org)
Solutions1
- It is usually available as aqueous solutions in concentrations of 3, 30 or 90 percent by weight. (sabinaorganizasyon.com)
Water2
- The aqueous layer was extracted with another portion of ethyl acetate (100 mL), the organics were combined, washed with water (100 mL) and brine (100 mL), dried with magnesium sulfate, filtered, and evaporated to give a pale red solid. (ambeed.com)
- Gold-catalyzed cyclizations of diols and triols to the corresponding hetero- or spirocycles take place in an aqueous medium within nanomicelles, where the hydrophobic effect is operating, thereby driving the dehydrations, notwithstanding the surrounding water. (organic-chemistry.org)
Formation1
- Similarly, 3-ketobutyraldehyde diethyl acetal led to the formation of ethyl 5-methylpyrrole-2-carboxylate. (wikipedia.org)
Directly1
- It is the simplest unsaturated carboxylic acid, consisting of a vinyl group connected directly to a carboxylic acid terminus. (crystalchemitrade.com)