Tofranil, imipramine hydrochloride USP, the original tricyclic antidepressant, is a member of the dibenzazepine group of compounds. (nih.gov)
Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. (nih.gov)
Imipramine (im ip' ra meen) is a dibenzazepine derived tricyclic antidepressant which acts by inhibition of serotonin and norepinephrine reuptake within synaptic clefts in the central nervous system, thus increasing brain levels of these neurotransmitters. (nih.gov)
Hydrochloride2
Anyone considering the use of imipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. (nih.gov)
Imipramine hydrochloride USP is a white to off-white, odorless, or practically odorless crystalline powder. (nih.gov)
Compounds1
The possibility of cross-sensitivity to other dibenzazepine compounds should be kept in mind. (nih.gov)
Depression1
The first TCA reported for the treatment of depression was imipramine, a dibenzazepine analogue of chlorpromazine code-named G22355. (wikipedia.org)
Mechanism2
The mechanism of action of Tofranil is not definitely known. (nih.gov)
The mechanism by which imipramine causes serum aminotransferase elevation is not known. (nih.gov)
Patients2
When it is desired to substitute Tofranil in patients receiving a monoamine oxidase inhibitor, as long an interval should elapse as the clinical situation will allow, with a minimum of 14 days. (nih.gov)
Liver test abnormalities have been reported to occur in up to 20% of patients on long term therapy with imipramine, but elevations are uncommonly above 3 times the upper limit of normal. (nih.gov)