NauseaProlongation or ventricular cardiacAbdominalVentricular fibrillationPolymorphic ventricularIntervalPseudomembranous colitisClarithromycinTricyclic antidepressantsAcuteCongenitalTachycardiaSudden cardiCardiac arrestPatientsFatalCardiovascularHypomagnesemiaSevereImodiumArrhythmiaSymptomsRiskMedicationsElectrolyteHypertensionWateryDisordersVentriclesPotentiallyHeartHistoryLoperamideTherapy
Nausea5
- Most of the adverse reactions leading to discontinuation were related to the gastrointestinal tract, e.g., nausea, vomiting, diarrhea, or abdominal pain. (medlibrary.org)
- Overall, the most common adverse reactions in adult patients receiving a multiple-dose regimen of azithromycin were related to the gastrointestinal system with diarrhea/loose stools (5%), nausea (3%), and abdominal pain (3%) being the most frequently reported. (medlibrary.org)
- This form of recycling can lead to a buildup of the product and cause nausea and GI distress, such as diarrhea. (picmonic.com)
- GI disturbances like diarrhea, nausea, vomiting, and abdominal pain are common with macrolide use like erythromycin because it is a motilin agonist, encouraging hypermotility and the unpleasant collateral damage. (picmonic.com)
- Nausea, vomiting, diarrhoea. (azurewebsites.net)
Prolongation or ventricular cardiac1
- QT prolongation or ventricular cardiac arrhythmias, including torsade de pointes. (wikipedia.org)
Abdominal2
- Patients with AIDS treated with this medicine for diarrhoea should have therapy stopped at the earliest signs of abdominal distension. (medicines.org.uk)
- Gastrointestinal side effects may include vomiting, diarrhea, or abdominal pain. (entirelypetspharmacy.com)
Ventricular fibrillation3
- Potassium levels below 3,0 mmol/l cause significant Q-T interval prolongation with subsequent risk of torsade des pointes, ventricular fibrillation and sudden cardiac death. (shakuhachi.net)
- Serious cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, torsades de pointes, and QT prolongation have been reported in patients taking cisapride. (rxlist.com)
- Although Torsades de Pointes (TdP) is a rare ventricular arrhythmia , it can degenerate into ventricular fibrillation , leading to death without rapid medical intervention. (wikidoc.org)
Polymorphic ventricular2
- Torsades de pointes is defined as the presence of polymorphic ventricular tachycardia with a prolonged QT segment on EKG . (wikidoc.org)
- Polymorphic ventricular tachycardia is distinguished from torsades de pointes by the absence of prolongation of the QT segment. (wikidoc.org)
Interval9
- Prolongation of QT interval and cases of torsades de pointes have been reported. (nih.gov)
- This risk which can be fatal should be considered in patients with certain cardiovascular disorders including known QT prolongation or history torsades de pointes, those with proarrhythmic conditions, and with other drugs that prolong the QT interval. (nih.gov)
- Prolonged QT interval reflects prolonged cardiac repolarization, which is a pathogenic factor in the genesis of torsade de pointes. (shakuhachi.net)
- Any abnormality that prolongs the QT interval increases the risk of a dangerous heart rhythm called torsades de pointes ventricular tachycardia. (msdmanuals.com)
- Trisenox can cause QTc interval prolongation, complete atrioventricular block and torsade de pointes, which can be fatal. (centerwatch.com)
- Drug-Induced QT Interval Prolongation and Torsades de Pointes: Role of the pharmacists in risk assessment, prevention and management. (ubc.ca)
- Macrolides, especially erythromycin and clarithromycin, adversely perpetuate the QT interval and can progress to a potentially fatal torsade de pointes if untreated. (picmonic.com)
- Concurrent use of other QT interval-prolonging drugs may ↑ risk of torsades de pointes. (unboundmedicine.com)
- Obtain ECG at baseline, after 2 weeks, then monthly during treatment, or more frequently when used concurrently with other QTc interval prolonging drugs or in at-risk patients (e.g. torsades de pointes, congenital long QT syndrome). (azurewebsites.net)
Pseudomembranous colitis1
- Stomach or bowel problems (eg, dysentery, enterocolitis caused by bacteria, pseudomembranous colitis, stomach pain without diarrhea, ulcerative colitis)-Should not be used in patients with these conditions. (mayoclinic.org)
Clarithromycin1
- Macrolides, especially erythromycin and clarithromycin, also have an effect on QT prolongation, which can lead to torsade de pointes if untreated. (picmonic.com)
Tricyclic antidepressants2
- Other drugs that can induce torsades de pointes VT include tricyclic antidepressants, phenothiazines, and certain antivirals and antifungals (see CredibleMeds for an up-to-date list). (shakuhachi.net)
- Drug interactions such as erythromycin or Avelox, taken concomitantly with inhibitors like nitroimidazole , diarrhea , dietary supplements, and various medications like methadone , lithium , tricyclic antidepressants or phenothiazines may also contribute to causing torsades de pointes. (wikidoc.org)
Acute6
- Loperamide is used to control and relieve the symptoms of acute diarrhea. (mayoclinic.org)
- For the symptomatic treatment of acute diarrhoea in adults and children aged 12 years and over. (medicines.org.uk)
- For the symptomatic treatment of acute episodes of diarrhoea associated with Irritable Bowel Syndrome in adults aged 18 years and over following initial diagnosis by a doctor. (medicines.org.uk)
- The priority in acute diarrhoea is the prevention or reversal of fluid and electrolyte depletion. (medicines.org.uk)
- This is particularly important in young children and in frail and elderly patients with acute diarrhoea. (medicines.org.uk)
- In acute diarrhoea, if clinical improvement is not observed within 48 hours, the administration of Imodium should be discontinued and patients should be advised to consult their doctor. (medicines.org.uk)
Congenital1
- Long QT syndrome is a risk factor for developing torsades de pointes, and can either be inherited as congenital mutations of ion channels carrying the cardiac impulse/action potential, or acquired as a result of drugs that block these cardiac ion currents. (wikidoc.org)
Tachycardia6
- Torsades de pointes is a ventricular tachycardia, meaning that it is a fast heartbeat with the electrical activity from the ventricles. (shakuhachi.net)
- When the heart beats faster than usual, as in a case of torsades de pointes, it is called tachycardia. (shakuhachi.net)
- pain unrelieved by rest suggests mechanical dysfunction of ventricular tachycardia torsade de pointes ventricular tachycardia. (surgicalimpex.com)
- The term "torsade de pointes" was first described by Dessertenne in 1966, based on the characteristic "twisting" pattern of ventricular tachycardia seen on EKG . (wikidoc.org)
- The physical exam during or directly after an episode of torsade de pointes, may reveal pallor and diaphoresis , loss of consciousness , and bradycardia followed by tachycardia . (wikidoc.org)
- Rarely, erythromycin has been associated with the production of ventricular arrhythmias, including ventricular tachycardia and torsades de pointes, in individuals with prolonged QT intervals.Allergic reactions ranging from urticaria to anaphylaxis have occurred. (drugcentral.org)
Sudden cardi2
- Loperamide also was tied to increased reporting of QTc prolongation/torsade de pointes, which could lead to sudden cardiac death, according to researchers led by Mori Krantz, MD, who conducted the study while working for Clario, a healthcare research technology company involved in clinical trials. (tctmd.com)
- Patients who are being evaluated for torsades de pointes should be asked about a history of syncope, and family history of long QT syndrome , sudden cardiac death , or sudden infant death syndrome . (wikidoc.org)
Cardiac arrest4
- QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
- Two of those alternatives-loperamide, an over-the-counter opioid used to treat diarrhea, and kratom, a widely available herbal substance containing the opioid mitragynine-were associated with disproportionate reports of ventricular arrhythmias and cardiac arrest in pharmacovigilance databases from the US and Canada between 2015 and 2021. (tctmd.com)
- Changes in the electrical activity of your heart called QT prolongation, torsades de pointes, and your heart stopping (cardiac arrest). (dsiaccesscentral.com)
- VANFLYTA is available only through a restricted program called the VANFLYTA Risk Evaluation and Mitigation Strategy (REMS) due to the risk of QT prolongation, torsades de pointes, and cardiac arrest. (dsiaccesscentral.com)
Patients4
- It is also used to treat chronic diarrhea in patients with inflammatory bowel disease. (mayoclinic.org)
- Clostridium difficile -Associated Diarrhea: Evaluate patients if diarrhea occurs. (nih.gov)
- Patients with chronic diarrhea or with Grade 2 or greater diarrhea despite appropriate medical management. (stanford.edu)
- During post-marketing surveillance, there have been very rare cases of QT prolongation and torsade de pointes in patients taking fluconazole. (tajgenerics.com)
Fatal1
- Toremifene has caused very serious (possibly fatal) heart rhythm problems (QT prolongation in the EKG, torsades de pointes). (imedix.com)
Cardiovascular2
- Management or Monitoring Precaution: Cardiovascular-Increased risk of torsades de pointes. (webmd.com)
- There have been reports of QT prolongation and torsades de pointes , and cardiovascular death. (medlibrary.org)
Hypomagnesemia2
- The electrolyte disturbances that have been reported to precipitate torsade include hypokalemia and hypomagnesemia. (shakuhachi.net)
- Common causes for torsades de pointes include hypomagnesemia and hypokalemia . (wikidoc.org)
Severe1
- This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. (imedix.com)
Imodium2
- Treatment of diarrhoea with Imodium is only symptomatic. (medicines.org.uk)
- He began supplementing with Imodium (loperamide), an anti-diarrhea drug, to cope with withdrawal symptoms when he could not get heroin or fentanyl. (lebendigefluesse.at)
Arrhythmia1
- Laborotory tests obtained in a person with torsade de pointes will vary depending on the most likely etiology for their arrhythmia. (wikidoc.org)
Symptoms2
- Torsades de pointes is associated with a fall in blood pressure, which often gives rise to syncopal symptoms. (wikidoc.org)
- The VANFLYTA Patient Wallet Card lists signs and symptoms of QT prolongation and torsades de pointes. (dsiaccesscentral.com)
Risk1
- Being on certain medications also pose a risk for developing torsades de pointes. (wikidoc.org)
Medications1
- Anti-diarrhea medications are cheap, legal and can be bought easily in large quantities without raising suspicion. (lebendigefluesse.at)
Electrolyte1
- Which electrolyte imbalance is associated with torsades de pointes? (shakuhachi.net)
Hypertension1
Watery1
- Call your doctor right away if you get watery diarrhea, diarrhea that does not go away, or bloody stools. (rxwiki.com)
Disorders1
- Torsades de pointes should be differentiated from other conditions or disorders that may present in a similar way, such as other arrhythmias , drug toxicity, syncope and other cardiac conditions. (wikidoc.org)
Ventricles3
- In the case of torsades de pointes (TdP), the heart's two lower chambers, called the ventricles, beat faster than and out of sync with the upper chambers, called the atria. (shakuhachi.net)
- Torsades de pointes is French for "twisting of points" and refers to when the heart's two lower chambers or ventricles, beat faster than the upper chambers, which are known as the atria. (shakuhachi.net)
- During Torsade de pointes the ventricles depolarize in a circular fashion resulting in QRS complexes with a continuously turning heart axis around the baseline (hence the name Torsade de Pointes ). (wikidoc.org)
Potentially1
- Since persistent diarrhoea can be an indicator of potentially more serious conditions, this medicine should not be used for prolonged periods until the underlying cause of the diarrhoea has been investigated. (medicines.org.uk)
Heart1
- What happens to the heart during torsades de pointes? (shakuhachi.net)
History1
- history of torsades de pointes. (azurewebsites.net)
Loperamide1
- Loperamide helps stop diarrhea by slowing down the movements of the intestines. (mayoclinic.org)
Therapy1
- Intravenous magnesium is the first-line pharmacologic therapy in Torsades de Pointes. (shakuhachi.net)