Diagnostic humoral immunity active monoclonal antibody immunity active. Medical search. Frequent questions

We also identified a rare class of ZIKV-cross-reactive human monoclonal antibodies with increased somatic hypermutation and broad neutralization against multiple flaviviruses. (bvsalud.org)
Human monoclonal antibodies are characterized to study the humoral immune response in these disorders. (umassmed.edu)
Not only do we generate new human monoclonal antibodies for our studies, but also for a large number of laboratories throughout the world for research on infectious diseases, cancer and autoimmune disease. (umassmed.edu)
We collaborate with Drs. Greiner, Brehm and Luban here at UMMS and Dr. Leonard Schultz at Jackson Laboratories on humanized mouse models for the generation of human monoclonal antibodies and as models for passive immunotherapy for bacterial or viral infections. (umassmed.edu)
The laboratory has also been involved in pharmacokinetic and pharmacodynamic studies of IgG and IgA human monoclonal antibodies, in several bacterial and viral infections. (umassmed.edu)
Enterotoxigenic Escherichia coli,, Bordetella pertussis, Klebsiella pneumonia), she is also inventor of two human monoclonal antibodies against Staphylococcus aureus and Pseudomonas aeruginosa. (umassmed.edu)

Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)
In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)
Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
Adjuvants are generally used with soluble protein antigens to increase antibody titers and induce a prolonged response with accompanying memory. (wikidoc.org)
The disease is generally categorized as warm or cold, depending on the thermal reactivity of the autoantibodies Autoantibodies Antibodies that react with self-antigens (autoantigens) of the organism that produced them. (lecturio.com)
To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. (wikipedia.org)
Innate and adaptive immune system: Cells and molecules involved in innate and adaptive immunity, antigens, antigenicity and immunogenicity. (pathfinderacademy.in)

In recent years, there has been a renaissance in the use of antibodies for therapy: 10 monoclonal antibodies (MAbs) are currently licensed and dozens are in the developmental pipeline ( 4 ). (cdc.gov)
The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
Our initial screen of MassBiologics' existing panel of SARS-CoVspecific antibodies resulted in Mabs with ELISA binding activity to the receptor binding domain of the SARS-CoV-2 Spike protein. (umassmed.edu)

Pertussis results in substantial morbidity among adults and adolescents whose immunity to past childhood vaccination or B. pertussis infection might have waned and who have not received booster immunization for pertussis with adult tetanus, reduced diphtheria, and acellular pertussis (Tdap) vaccine ( 1 , 2 ). (cdc.gov)
The only currently available intervention that could provide a state of immediate immunity is passive immunization with protective antibody. (cdc.gov)
JEV virus-like particle immunization in mice further confirmed that such cross-reactive antibodies, mainly IgG3 isotype, can be induced and proliferate through heterologous dengue virus (DENV) serotype 2 virus-like particle stimulation. (bvsalud.org)
Hypersensitivity, active and passive immunization. (pharmawiki.in)
These antibodies are typically produced by immunization of a suitable mammal , such as a mouse, rabbit or goat. (wikidoc.org)
In addition, our group has also used our panel of well characterized monoclonal antibodies against S. mutans P1, a recognized target of protective immunity and widely studied candidate vaccine antigen, to demonstrate that exogenously administered antibodies included as part of an immune complex prior to immunization can be used in a directed and practical manner to alter the host antibody response against the bacteria towards one of increased efficacy. (ufl.edu)
Formulation Studies to Develop Low-Cost, Orally-Delivered Secretory IgA Monoclonal Antibodies for Passive Immunization Against Enterotoxigenic Escherichia coli. (umassmed.edu)
Serological analyses demonstrated that homologous hemagglutination inhibition and microneutralization antibody titers were detectable in the ferrets after the first immunization with the AS03-adjuvanted vaccines that were further boosted by the second immunization. (nature.com)

Many of these factors stem from the location of the epitope that can affect accessibility of the antibody to the epitope at a cellular or molecular level, direct inhibition of target antigen activity, conservation of function despite escape mutations, and even non-competitive inhibition sites. (preprints.org)
Here, we longitudinally analyzed humoral and cellular immune responses at each BNT162b2 mRNA vaccine injection in 47 HM patients under therapy. (bvsalud.org)
Spike-specific cellular immune responses were detectable in only 63% and correlated with humoral response. (elifesciences.org)
Previous SARS-CoV-2 infection substantially increased antibody responses after one vaccine and antibody and cellular responses remained 28-fold and 3-fold higher, respectively, after dual vaccination. (elifesciences.org)
It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
The loss of CD4 helper/inducer T cell function probably underlies the profound defects in cellular and humoral immunity leading to the opportunistic infections and malignancies characteristic of the acquired immunodeficiency syndrome (AIDS) (Lane et al. (justia.com)

This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)
Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)
Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
However, the riches sources of biotin as egg yolk, leading to high biotin concentrations in samples, harming the accuracy of diagnostic and proteins concentrations tests. (preprints.org)
The expertise at MassBiologics, particularly in the areas of Discovery and Process Development, has allowed rapid production of SARS CoV-2 proteins (including several spike proteins and N protein) and human antibodies and nanobodies , contributing to the evaluation and development of therapeutics and diagnostics. (umassmed.edu)
It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. (lookformedical.com)
The neutralization test exhibited produced antibodies' potency to bind the virus proteins. (ajmb.org)
According to the present study, recombinant proteins, either RBD alone or in combination with N adequately stimulated the immune response, and the raised antibodies could neutralize the virus in in vitro test. (ajmb.org)
Immunology and virology 101 have taught us over a century that natural immunity confers protection against a respiratory virus's outer coat proteins, and not just one, e.g. the SARS-CoV-2 spike glycoprotein. (petersmanjak.com)

Repurposed drugs and monoclonal antibodies targeting specific cytokines acting on different aspects of the pro- and anti-inflammatory cascades are under evaluation. (bvsalud.org)

Published science examining the power of naturally acquired immunity to COVID and its variants via a COVID infection continues to show how strong natural immunity really is. (thepulse.one)
We should not force COVID vaccines on anyone when the evidence shows that naturally acquired immunity is equal to or more robust and superior to existing vaccines. (petersmanjak.com)

[2] [3] Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. (wikipedia.org)
The RPA-T4 antibody recognizes a different epitope than the OKT4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. (thermofisher.com)

Available data also do not indicate whether Tdap-induced transplacental maternal antibodies provide early protection against pertussis to infants or interfere with an infant's immune responses to routinely administered pediatric vaccines. (cdc.gov)
Unlike vaccines, which require time to induce protective immunity and depend on the host's ability to mount an immune response, passive antibody can theoretically confer protection regardless of the immune status of the host. (cdc.gov)
Persons with impaired immunity are often unable to generate effective response to vaccination, and certain vaccines may be contraindicated for them ( 1 ). (cdc.gov)
For example, the vaccine against hepatitis B does not elicit an antibody response in approximately 10% of vaccines, and the percentage of nonresponders is substantially higher in immunocompromised persons ( 1 ). (cdc.gov)
The Military Infectious Diseases Research Program (MIDRP) focuses on vaccines, anti-parasitic drugs, deployable field clinical diagnostics (human and vector), prophylactics and novel therapeutics to treat multidrug-resistant organisms in combat wound infections, as well as vector control pertinent to naturally occurring endemic diseases with demonstrated or potential capability to decrease military operational effectiveness. (globalbiodefense.com)
Given the tepid interest of the pharmaceutical industry to develop and market vaccines for diseases in areas of low commercial gain, the MIDRP is also interested in proposals and products toward finding treatment options for infectious diseases that are likely to lead to U.S. Food and Drug Administration-licensable, broadly active therapeutics against multiple endemic disease threats. (globalbiodefense.com)
Through the incorporation of novel computational methods for predicting antigen changes to model-informed drug discovery and development, superior vaccines and antibody-based therapeutics or diagnostics can now be more easily designed to mitigate failures. (preprints.org)
In addition, heterologous antibody titers against older H7 subtype viruses of the North American lineage (H7N7, H7N3) and newer H7 subtype viruses of the Eurasian lineage (H7N9) were detected in the animals receiving the AS03-adjuvanted vaccines. (nature.com)
In conclusion, this study demonstrated that the AS03-adjuvanted H7N9 vaccines elicited high levels of homologous and heterologous antibodies and protected against H7N9 virus damage post-challenge. (nature.com)
The Case Definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) in the context of active development of vaccines for SARS-CoV-2 vaccines and other emerging pathogens. (cov19longhaulfoundation.org)

This may be due to ELISA Ab measuring Schistosoma exposure and is thus unable to distinguish past from active infection. (bvsalud.org)
ELISA Ab is more useful in surveillance particularly in low-endemicity areas where determination of exposure is more important than differentiating past from active infection. (bvsalud.org)
The cells were observed for cytopathic effect (CPE) and infection visualized by direct immunofluorescence test using FITC Moab a-BRSV (Bio-X Diagnostics, Rochefort, Belgium). (datexis.com)
Many scenarios, including infection, aberrant immunity, cancer and cancer immunotherapy, are associated with cytokine storm, also known as cytokine release syndrome (CRS) or hypercytokinaemia. (nature.com)
In the United States, published studies of sexually active females screened during visits to health-care providers indicate that age is the sociodemographic factor most strongly associated with chlamydial infection. (cdc.gov)
CDC Director Rochelle Walensky, for example, was deceptive in her October 2020 published LANCET statement that "there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection" and that "the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future. (thepulse.one)
Moreover, existing immunity should be assessed before any vaccination, via an accurate, dependable, and reliable antibody test (or T cell immunity test) or be based on documentation of prior infection (a previous positive PCR or antigen test). (petersmanjak.com)

Our findings highlight the role of prior immunity in JEV and DENV in shaping the breadth of humoral response and provide insights for future vaccination strategies in flavivirus-endemic countries. (bvsalud.org)
Vaccination has thus far been unsuccessful due to unrealized antigenic characters and unknown mechanisms that nematodes use to circumvent host immunity. (frontiersin.org)
A combination of DNA vaccination and a recombinant adenovirus serotype 5 boost resulted in cross-protective immunity in non-human primates. (biomedcentral.com)
Given the low anti-SARSCoV-2 IgG titers post-vaccination, the COVID-19 threat prompted the prophylactic use of engineered anti-SARS-CoV-2 monoclonal antibodies. (bvsalud.org)
Such would be evidence of immunity that is equal to that of vaccination and the immunity should be provided the same societal status as any vaccine-induced immunity. (petersmanjak.com)

The 2016 National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and fluorescence in situ hybridization (FISH) for del 13, del 17p13, t(4;14), t(11;14), 1q21 amplification as part of the initial diagnostic workup. (medscape.com)
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia. (lookformedical.com)
The antibody titer of the blood serum from control and immunized mice groups was determined by ELISA technique. (ajmb.org)

After an antigen binds to a BCR, the B cell activates to proliferate and differentiate into either plasma cells , which secrete soluble antibodies with the same paratope, or memory B cells , which survive in the body to enable long-lasting immunity to the antigen. (wikipedia.org)
In several examples, the α4 integrin antagonist is a monoclonal antibody that specifically binds to a α4, β1 or β7 integrin subunit or a cyclic hexapeptide with the amino acid sequence of CWLDVC. (justia.com)
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)

The target of an antibody plays a significant role in the success of antibody-based therapeutics and diagnostics, and to an extent, that of vaccine development. (preprints.org)

This article reviews the activity of humoral immunity against several biological agents, discusses the advantages and disadvantages of an antibody-based defense strategy ( Table ), and proposes stockpiling specific antibodies for use in the event of biological attacks. (cdc.gov)
Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2. (thermofisher.com)

Applications Tested: The J43 antibody has been tested by flow cytometric analysis of Con A-simulated mouse splenocytes and mouse PD-1 transfected cells. (thermofisher.com)
Applications Tested: This RPA-T4 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)

Polyclonal antibodies are antibodies that are derived from different B- cell lines. (wikidoc.org)
Many methodologies exist for polyclonal antibody production in laboratory animals. (wikidoc.org)
For several reasons there is a growing interest in the scientific community in immunoglobulin Y as antibiotic alternative and their oral administration in the polyclonal antibody (pAb) format, to maintain animal health and performance, do not require IgY purification for large-scale production, resulting in protein impurities and high concentration of biotin in the samples. (preprints.org)

An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. (lookformedical.com)

Classifying MAS using the immunological disease continuum model, with strict boundaries that define the limits of innate and adaptive immunity, at one boundary is MAS with loss of immune function, as occurs in the 'perforinopathies' and some cases of sJIA-AOSD. (nature.com)
This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. (lidsen.com)

Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions such as delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft versus host disease for a variety of organs. (medscape.com)
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)

Inflammation and immunity are key factors for the development and complications of atherosclerosis, and therefore, the whole atherosclerotic process is a target for diagnosis and treatment. (hindawi.com)

The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. (biorxiv.org)
This follow-up chart is the most updated and comprehensive library list of 140 of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity as compared to the COVID-19 vaccine-induced immunity and allow you to draw your own conclusion. (petersmanjak.com)

Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. (thermofisher.com)
Description: The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. (thermofisher.com)

The following product was used in this experiment: CD279 (PD-1) Monoclonal Antibody (J43), Biotin, eBioscience™ from Thermo Fisher Scientific, catalog # 13-9985-82, RRID AB_467023. (thermofisher.com)
The following product was used in this experiment: CD4 Monoclonal Antibody (RPA-T4), PE-Cyanine7, eBioscience™ from Thermo Fisher Scientific, catalog # 25-0049-42, RRID AB_1659695. (thermofisher.com)

Public health officials and the medical establishment with the help of the politicized media are misleading the public with assertions that the COVID-19 shots provide greater protection than natural immunity. (thepulse.one)
Brownstone Institute had previously documented 30 studies on natural immunity as it relates to Covid-19. (thepulse.one)
They have now provided a follow up chart that they claim , 'is the most updated and comprehensive library list of 106 of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity. (thepulse.one)
Why hasn't government health policy acknowledged the power of natural immunity? (thepulse.one)
Even the CDC recognizes natural immunity for chicken-pox and measles, mumps, and rubella , but not for COVID-19. (petersmanjak.com)

First described in 1848, MM is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein (M protein). (medscape.com)
Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes. (pathfinderacademy.in)
Antibodies against 4 Atypical Post-Translational Protein Modifications in Patients with Rheumatoid Arthritis. (mdbioproducts.com)
With purified recombinant protein production and peptide synthesis to display limited/selected epitopes, intrinsic factors that can affect the functioning of resulting antibodies can be more easily selected for. (preprints.org)
Structure of a transmission blocking antibody in complex with Outer surface protein A from the Lyme disease spirochete, Borreliella burgdorferi. (umassmed.edu)

These data demonstrate that the mRNA vaccine platform delivers strong humoral immunity in people up to 96 years of age and retains broad efficacy against the P.1 variant of concern. (elifesciences.org)
TWiV 1045: Less Lassa, CRISPR RNA viruses September 17, 2023 TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. (microbe.tv)

The antibody recognizes a unique molecule of the pathogen, called an antigen . (wikipedia.org)

We have moved on to nanobody discovery for broadly neutralizing antibodies against all variants of concern and interest. (umassmed.edu)

Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. (medscape.com)
Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. (lookformedical.com)

The only available countermeasure that can provide immediate immunity against a biological agent is passive antibody. (cdc.gov)
Passive antibody therapy has substantial advantages over antimicrobial agents and other measures for postexposure prophylaxis, including low toxicity and high specific activity. (cdc.gov)
Passive antibody therapy was widely used in the pre-antibiotic era but was largely abandoned with the advent of antimicrobial chemotherapy ( 2 , 3 ). (cdc.gov)
Several of the above-mentioned activities are connected with the solution of essential environmental problems: prevention of the generation and/or treatment of toxic waters polluted by heavy metals, radionuclides, arsenic, oil, organochemicals, etc. by means of active and/or passive systems, reactive zones, rock filters, etc. (oaji.net)
In addition, the laboratory is interested in developing active and passive forms of immunotherapy for the treatment of these disease areas. (umassmed.edu)

Tacrolimus suppresses humoral immunity (T lymphocyte) activity. (medscape.com)

We have characterized multiple conformational epitopes recognized by monoclonal antibodies against the P1 adhesin of S. mutans and demonstrated that the an intra-molecular interaction between the amino-terminal alanine-rich repeat and central proline-rich repeat domains is necessary for the structural integrity, surface localization and function of the molecule. (ufl.edu)

The primary goal of antibody production in laboratory animals is to obtain high titer , high affinity antisera for use in experimentation or diagnostic tests. (wikidoc.org)

Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)

Together with B and T cells , antibodies comprise the most important part of the adaptive immune system . (wikipedia.org)

Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic. (covidreference.com)
Protecting Pregnant Women and Their Infants From COVID-19: Clues From Maternal Viral Loads, Antibody Responses, and Placentas. (covidreference.com)

Bovine clinical samples used in this study were submitted to KSVDL for routine diagnostic testing. (datexis.com)
However, proposals dealing with novel drug delivery systems (i.e., sustained-release and methods of targeting drugs to reduce toxicity or delivery of drugs of clinical importance to the active sites) would be considered. (globalbiodefense.com)
The widespread use of highly active antiretroviral therapy (HAART) has dramatically improved the clinical course for many individuals infected with HIV (Berrey et al. (justia.com)

Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). (wikipedia.org)

The constant region at the trunk of the antibody includes sites involved in interactions with other components of the immune system. (wikipedia.org)
To further develop Dr. Cavacini's background in mucosal immunology, included in this work is structural modeling of antibody/antigen interactions to improve the design of immunotherapeutic antibodies and development of a platform for production of dimeric and secretory IgA. (umassmed.edu)

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles ' by Syed, A., et al. (asm.org)

Initially, all antibodies are of the first form, attached to the surface of a B cell - these are then referred to as B-cell receptors (BCR). (wikipedia.org)

Des préparations d'antigènes bruts de Setaria equina ont été utilisées dans le cadre des méthodes ELISA et transfert Western afin d'étudier la réaction croisée avec des sérums humains en provenance de zones endémiques pour la filariose de Bancroft. (who.int)
OBJECTIVES: This study aimed to describe the prevalence and seroprevalence of schistosomiasis in Siargao Island, Surigao del Norte and to compare the performance of enzyme-linked immunosorbent assay antibody test (ELISA Ab) and loop-mediated isothermal amplification assay (LAMP) for diagnosis of schistosomiasis. (bvsalud.org)
Diagnostic performance of LAMP assay using stool specimen was evaluated using Kato-Katz technique and PCR assay as the composite reference standard, while PCR assay was used as the reference standard to evaluate LAMP assay and ELISA Ab using blood specimens. (bvsalud.org)
According to ELISA results, related antibodies were traced to a dilution of 1/64000 in immunized sera. (ajmb.org)

In the section below the evidence that humoral immunity is active against important biological agents is reviewed. (cdc.gov)
There is even strong evidence for the persistence of antibodies . (petersmanjak.com)

The monoclonals, so produced, were not only more efficient in controlling tumor growth but minimized the development of a HAMA response. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
however, how sequential exposures to different flaviviruses shape the cross-reactive humoral response against an antigen from a different serocomplex has yet to be explored. (bvsalud.org)
Antibodies from different classes also differ in where they are released in the body and at what stage of an immune response. (wikipedia.org)

Trials of anti-interleukin-6 receptor antibodies show promising mortality benefit in hospitalized COVID-19 patients. (bvsalud.org)

At this time, the pathogenesis, host responses and immunity to SARS-CoV-2 are still being evaluated and are not fully understood. (cov19longhaulfoundation.org)

the necessary characteristics [e.g., class, subclass (isotype), complement fixing nature] of the antibodies to be made. (wikidoc.org)

By contrast, monoclonal antibodies are derived from a single cell line. (wikidoc.org)
In contrast, the remainder of the antibody is relatively constant. (wikipedia.org)

Anatomy36

Organisms17

Diseases10

Chemicals and Drugs105

Analytical, Diagnostic and Therapeutic Techniques and Equipment45

Phenomena and Processes47

Disciplines and Occupations2

Information Science3

Health Care4

Human monoclonal antibodies6

Antigens9

MAbs3

Immunization8

Cellular6

Proteins12

Cytokines1

Naturally acquired immunity2

Epitope2

Vaccines10

Infection7

Vaccination5

Serum3

Binds3

Therapeutics and diagnostics1

Specific Antibodies2

Tested by flow cytometric analysis2

Polyclonal3

Immunoglobulin4

Immunological2

Cell-mediated immune2

Inflammation1

Vaccine-induced2

Reacts2

EBioscience2

Natural Immunity5

Protein5

MRNA vaccine2

Recognizes1

Variants1

Gammopathy2

Passive5

Lymphocyte1

Epitopes1

Titer1

Glycoproteins1

Adaptive1

Viral2

Clinical3

Neutralize1

Interactions2

Mutations1

Receptors1

ELISA4

Evidence2

Response4

COVID1

Pathogenesis1

Complement1

Contrast2