DNA Mutational AnalysisMolecular Sequence DataAmino Acid SequenceMutationMutagenesis, Site-DirectedBase SequenceBinding SitesDelayed DiagnosisModels, MolecularProtein Structure, TertiaryPrenatal DiagnosisSequence Homology, Amino AcidEarly DiagnosisMutagenesisSensitivity and SpecificityProtein BindingPoint MutationAmino Acid SubstitutionConserved SequenceStructure-Activity RelationshipCell LineSequence AlignmentDNA-Binding ProteinsDiagnosisSequence DeletionPromoter Regions, GeneticBacterial ProteinsPolymerase Chain ReactionEscherichia coliAmino Acid MotifsTranscription FactorsRecombinant ProteinsPlasmidsTranscription, GeneticRetrospective StudiesProtein ConformationTransfectionMutation, MissenseRecombinant Fusion ProteinsDNA PrimersNucleic Acid ConformationProtein Structure, SecondaryPhenotypeCloning, MolecularDiagnostic ErrorsSaccharomyces cerevisiaePolymorphism, Single-Stranded ConformationalCrystallography, X-RayAlanineGene Expression Regulation, BacterialDNATomography, X-Ray ComputedTime FactorsPedigreeCatalytic DomainBiopsyNursing DiagnosisViral ProteinsExonsDiagnosis, Computer-AssistedSubstrate SpecificityReproducibility of ResultsMutagenesis, InsertionalPredictive Value of TestsEscherichia coli ProteinsMembrane ProteinsDimerizationRNA, ViralConsensus SequenceGenetic Complementation TestNuclear ProteinsHeLa CellsSequence Analysis, DNAPrognosisCOS CellsInfant, NewbornCarrier ProteinsKineticsRepressor ProteinsCatalysisGene DeletionMutant ProteinsRestriction MappingPreimplantation DiagnosisProspective StudiesSaccharomyces cerevisiae ProteinsTrans-ActivatorsTranscriptional ActivationTreatment OutcomeEnhancer Elements, GeneticPhosphorylationDNA, BacterialRNA, MessengerGenes, BacterialMagnetic Resonance ImagingOligodeoxyribonucleotidesCercopithecus aethiopsFollow-Up StudiesCohort StudiesRisk Factors